Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement
Turgut Durduran, Arjun G Yodh, Turgut Durduran, Arjun G Yodh
Abstract
Diffuse correlation spectroscopy (DCS) uses the temporal fluctuations of near-infrared (NIR) light to measure cerebral blood flow (CBF) non-invasively. Here, we provide a brief history of DCS applications in the brain with an emphasis on the underlying physical ideas, common instrumentation and validation. Then we describe recent clinical research that employs DCS-measured CBF as a biomarker of patient well-being, and as an indicator of hemodynamic and metabolic responses to functional stimuli.
Keywords: Cerebral blood flow; Cerebral metabolic rate of oxygen extraction; Diffuse correlation spectroscopy; Diffuse optics; Functional neuroimaging; Ischemic stroke; Near-infrared spectroscopy; Neonatalogy; Neurocritical care.
Conflict of interest statement
disclosures
The authors are co-inventors in patents about DCS/NIRS technologies, but they do not currently receive any royalties. There no other conflicting financial or ethical issues to disclose.
Copyright © 2013 Elsevier Inc. All rights reserved.
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Source: PubMed