Oral hyaluronan relieves knee pain: a review

Mariko Oe, Toshiyuki Tashiro, Hideto Yoshida, Hiroshi Nishiyama, Yasunobu Masuda, Koh Maruyama, Takashi Koikeda, Reiko Maruya, Naoshi Fukui, Mariko Oe, Toshiyuki Tashiro, Hideto Yoshida, Hiroshi Nishiyama, Yasunobu Masuda, Koh Maruyama, Takashi Koikeda, Reiko Maruya, Naoshi Fukui

Abstract

Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength. The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA.

Figures

Fig. 1
Fig. 1
The structure of hyaluronan
Fig. 2
Fig. 2
Mechanism of improve the arthritis. Oral administration of hyaluronan modulates inflammation by upregulating suppressor of cytokine signaling-3 expression and down-regulating pleiotrophin expression via Toll-like receptor-4 in intestinal epithelial cells
Fig. 3
Fig. 3
Oral hyaluronan improve knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Twenty-one subjects (≤70 years of age) were randomly divided into two groups (hyaluronan group, n = 11; placebo group, n = 10). Variations in the total Japanese Knee Osteoarthritis Measure score relative to baseline are shown. □ hyaluronan; ■ placebo. Values are presented as the mean ± SE. ∗p < 0.05 vs. baseline; #p < 0.05 vs. placebo group

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