Current aspects of the spectrum of acute heart failure syndromes in a real-life setting: the OFICA study
Damien Logeart, Richard Isnard, Matthieu Resche-Rigon, Marie-France Seronde, Pascal de Groote, Guillaume Jondeau, Michel Galinier, Geneviève Mulak, Erwan Donal, François Delahaye, Yves Juilliere, Thibaud Damy, Patrick Jourdain, Fabrice Bauer, Jean-Christophe Eicher, Yannick Neuder, Jean-Noël Trochu, Heart Failure of the French Society of Cardiology, Ache Papillon Chantal, Aissaoudi Nadia, Aupetit Jean François, Baietto Christian, Baille Noe, Baleynaud Serge, Ballout Jacques, Barnay Claude, Bauer Fabrice, Belhameche Mohammed, Belle Loïc, Bentzinger Sandrine, Bergere Alain, Bernadet Philippe, Perron Jean Marie, Bernasconi François, Berranen Samia, Bineau-Jorisse Annick, Serrano Michel, Boureux Christian, Boutalba Salim, Bouvier Erik, Bouvier Jean Marc, Bragard Marie François, Brunel Philippe, Carlioz Roland, Charniot Jean, Chavelas Christophe, Cheggour Saıda, Chevalet Pascal, Ciobotaru Vlad, Codjia Rene, Cohen Solal Alain, Coulon Patrick, Czitrom Daniel, Dahdal Nicolas, De Corbiere Philippe, De Groote Pascal, Sauniere Olivier, Deforet Marie France, Lassabe Alain, Mansour Michel, Chuzeville Michel, Dellinger Arnaud, Denis Jacques, Dentan Gilles, Desruennes Michele, Destrac Sylvain, Dib Jean Claude, Doazan Jean Philippe, Donal Erwan, Matali Pierre, Dujardin Jean Jacques, Gallois Herve, Durand Eric, Desnos Michel, Durand Sophie, Dutoit Laurent, Faveau Elodie, Escande Miche, Ettori Jean, Fauchier Laurent, Favier Jean-Pierre, Fontan Bertrand, Fromage Philippe, Galinier Michel, Garbarz Erik, Garcon Philippe, Garnier Daniel, Georger Fre, Gervais Renaud, Ghanem Nachwan, Gibelin Pierre, Brocker Patrice, Goudjil Mohand, Hanon Olivier, Hittinger Luc, Issa Adi, Jamal Muntaser, Jondeau Guillaume, Jourdain Patrick, Joussen Jean Marc, Juillard Alain, Kenizou David, Lambert Barbara, Zelinsky Robin, Lagorce Pierre, Lescure Maryse, Larrazet Fabrice, Laurent Evelyne, Assyag Patrick, Lemoine Julien, Lequeux Benoit, Lhernault Guillaume, Machuron Christine, Mai Nam, Makki Hamid, Malou Mounia, Marier J Jacques, Martelet Michel, Metz Damien, Meune Christophe, Mimran Catherine, Moreau Christophe, Belmin Joe, Perchicot Eric, Peyrot Sandrine, Poirette Laurent, Prunier Fabrice, Randriamora Mamy, Raphael Pierre, Raynaud Jean Charles, Remond Michel, Sal Robert, Souk Aloun Jocelyn, Spillemaecker Benoit, Srour Adel, Tabet Jean Yves, Tartiere Jean Michel, Tibi Thierry, Trochu Jean Noe, Verbrugge Eric, Vinchon François, Yaici Khelil, Damien Logeart, Richard Isnard, Matthieu Resche-Rigon, Marie-France Seronde, Pascal de Groote, Guillaume Jondeau, Michel Galinier, Geneviève Mulak, Erwan Donal, François Delahaye, Yves Juilliere, Thibaud Damy, Patrick Jourdain, Fabrice Bauer, Jean-Christophe Eicher, Yannick Neuder, Jean-Noël Trochu, Heart Failure of the French Society of Cardiology, Ache Papillon Chantal, Aissaoudi Nadia, Aupetit Jean François, Baietto Christian, Baille Noe, Baleynaud Serge, Ballout Jacques, Barnay Claude, Bauer Fabrice, Belhameche Mohammed, Belle Loïc, Bentzinger Sandrine, Bergere Alain, Bernadet Philippe, Perron Jean Marie, Bernasconi François, Berranen Samia, Bineau-Jorisse Annick, Serrano Michel, Boureux Christian, Boutalba Salim, Bouvier Erik, Bouvier Jean Marc, Bragard Marie François, Brunel Philippe, Carlioz Roland, Charniot Jean, Chavelas Christophe, Cheggour Saıda, Chevalet Pascal, Ciobotaru Vlad, Codjia Rene, Cohen Solal Alain, Coulon Patrick, Czitrom Daniel, Dahdal Nicolas, De Corbiere Philippe, De Groote Pascal, Sauniere Olivier, Deforet Marie France, Lassabe Alain, Mansour Michel, Chuzeville Michel, Dellinger Arnaud, Denis Jacques, Dentan Gilles, Desruennes Michele, Destrac Sylvain, Dib Jean Claude, Doazan Jean Philippe, Donal Erwan, Matali Pierre, Dujardin Jean Jacques, Gallois Herve, Durand Eric, Desnos Michel, Durand Sophie, Dutoit Laurent, Faveau Elodie, Escande Miche, Ettori Jean, Fauchier Laurent, Favier Jean-Pierre, Fontan Bertrand, Fromage Philippe, Galinier Michel, Garbarz Erik, Garcon Philippe, Garnier Daniel, Georger Fre, Gervais Renaud, Ghanem Nachwan, Gibelin Pierre, Brocker Patrice, Goudjil Mohand, Hanon Olivier, Hittinger Luc, Issa Adi, Jamal Muntaser, Jondeau Guillaume, Jourdain Patrick, Joussen Jean Marc, Juillard Alain, Kenizou David, Lambert Barbara, Zelinsky Robin, Lagorce Pierre, Lescure Maryse, Larrazet Fabrice, Laurent Evelyne, Assyag Patrick, Lemoine Julien, Lequeux Benoit, Lhernault Guillaume, Machuron Christine, Mai Nam, Makki Hamid, Malou Mounia, Marier J Jacques, Martelet Michel, Metz Damien, Meune Christophe, Mimran Catherine, Moreau Christophe, Belmin Joe, Perchicot Eric, Peyrot Sandrine, Poirette Laurent, Prunier Fabrice, Randriamora Mamy, Raphael Pierre, Raynaud Jean Charles, Remond Michel, Sal Robert, Souk Aloun Jocelyn, Spillemaecker Benoit, Srour Adel, Tabet Jean Yves, Tartiere Jean Michel, Tibi Thierry, Trochu Jean Noe, Verbrugge Eric, Vinchon François, Yaici Khelil
Abstract
Aims: To improve knowledge of epidemiological data, management, and clinical outcome of acute heart failure (AHF) in a real-life setting in France.
Methods and results: We conducted an observational survey constituting a single-day snapshot of all unplanned hospitalizations because of AHF in 170 hospitals throughout France (the OFICA survey). A total of 1658 patients (median age 79 years, 55% male) were included. Family doctors were the first medical contact in 43% of cases, and patients were admitted through emergency departments in 64% of cases. Clinical scenarios were mainly acutely decompensated HF (48%) and acute pulmonary oedema (38%) with similar clinical and biological characteristics as well as outcome. Characteristics were different and severity higher in both shock and right HF. Infection and arrhythmia were the most frequent precipitating factors (27% and 24% of cases); diabetes and chronic pulmonary disease were the most frequent co-morbidities (31% and 21%). Over 80% of patients underwent both natriuretic peptide testing and echocardiography. LVEF was preserved (>50%) in 36% of patients and associated with specific characteristics and lower severity. Median hospital stay was 13 days; in-hospital mortality was 8.2%, and independent predictors were age, blood pressure, and creatinine. Treatment at discharge in patients with reduced LVEF included ACE inhibitors/ARBs, beta-blockers, and aldosterone inhibitors in 78, 67, and 27% cases. Non-surgical devices were reported in <20% of potential candidates.
Conclusion: This comprehensive survey analysing AHF in real life emphasizes the heterogeneous nature and overall high severity of AHF. It could be a useful tool to identify unsolved medical issues and improve outcome.
Trial registration: NCT01080937.
Source: PubMed