Elevated transpulmonary gradient and cardiac magnetic resonance-derived right ventricular remodeling predict poor outcomes in sickle cell disease

Kim-Lien Nguyen, Xin Tian, Shoaib Alam, Alem Mehari, Steve W Leung, Catherine Seamon, Darlene Allen, Caterina P Minniti, Vandana Sachdev, Andrew E Arai, Gregory J Kato, Kim-Lien Nguyen, Xin Tian, Shoaib Alam, Alem Mehari, Steve W Leung, Catherine Seamon, Darlene Allen, Caterina P Minniti, Vandana Sachdev, Andrew E Arai, Gregory J Kato

No abstract available

Keywords: cardiomyopathy; magnetic resonance imaging; pulmonary hypertension; right ventricle; sickle cell disease.

Figures

Figure 1.

Hemodynamic and CMR predictors of mortality in patients with sickle cell disease. (A) Kaplan-Meier survival curve illustrates decreased survival among sickle cell patients with CMR-derived RVEF P=0.001) versus the three remaining groups. Using PAWP ≥15mmHg vs. PAWP <15mmHg alone to dichotomize mortality showed no statistical significance (59% [16 out of 27 deaths] vs. 41% [11 out of 27 deaths], P=0.121). All subjects were censored at 7.9 years. Median followup time was 4.7 years.

Figure 2.

CMR markers of right ventricular remodeling in sickle cell patients with an elevated transpulmonary gradient (TPG). Compared to sickle cell patients with a transpulmonary gradient (TPG)