Clinical Trials on ALK-activated Tumors

Total 438870 results

National Institute of Allergy and Infectious Diseases...

Completed

A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients

HIV Infections | Leukoencephalopathy, Progressive Multifocal

United States
Memorial Sloan Kettering Cancer Center

Completed

Adaptive Radiotherapy for Head and Neck Cancer

Head and Neck Cancer | Nasopharynx Cancer | Oropharynx Cancer | Oral Cavity Cancer | Larynx Cancer | Paranasal Sinus Cancer | Hypopharynx Cancer

United States
University of Alabama at Birmingham
National Institute of Nursing Research (NINR)

Completed

Individualized Cognitive Training in HIV (TOPS)

Cognitive Impairment | Aging | Cognitive Decline | Attention Impaired | Cognitive Deficit in Attention | HIV-Associated Cognitive Motor Complex | Processing, Visual Spatial | Cognitive Disorder in Remission

United States
Dr. Richard H. Swartz
Canadian Institutes of Health Research (CIHR)

Active, not recruiting

DOC Utility: Screening of Depression, Obstructive Sleep Apnea and Cognitive Impairment

Depression | Stroke | Cognitive Impairment | Transient Ischemic Attack | Obstructive Sleep Apnea

Canada
Bicetre Hospital

Completed

Hemodynamic Characteristics of Patients With SARS-CoV-2 (PiCCOVID)

COVID-19 | Shock | Acute Respiratory Distress Syndrome | SARS-CoV-2 | Fluid Overload | Coronavirus | Left Ventricular Dysfunction | Acute Circulatory Failure

France
Steno Diabetes Center Copenhagen

Enrolling by invitation

Diabetic Neuropathy Screening Study 1.1 + Substudy 1.2-1.3-1.4 (DANES)

Diabetic Foot | Diabetic Neuropathies | Foot Deformities | Autonomic Neuropathy | Distal Peripheral Sensory Neuropathy | CAN

Denmark
University Hospital, Clermont-Ferrand
Groupe Hospitalier Pitie-Salpetriere; University Hospital Schleswig-Holstein; Hospital Clínico Universitario de Valencia

Completed

Inhaled Sedation in COVID-19-related Acute Respiratory Distress Syndrome (ISCA): an International Research Data Study in the Recent Context of Widespread Disease Resulting From the 2019 (SARS-CoV2) Coronavirus Pandemics (COVID-19) (ISCA)

Acute Respiratory Distress Syndrome | Sedation | Invasive Mechanical Ventilation | Critically Illness

United States, France, Spain, Germany, Switzerland
Merck Sharp & Dohme LLC

Completed

A Trial of Pembrolizumab (MK-3475) in Participants With Blood Cancers (MK-3475-013/KEYNOTE-013)

Follicular Lymphoma | Diffuse Large B-Cell Lymphoma | Multiple Myeloma | Hodgkin Lymphoma | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Primary Mediastinal B-Cell Lymphoma
Fundación para la Investigación del Hospital Clínico...

Terminated

Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection (SEVO-COVID19)

Acute Respiratory Distress Syndrome | COVID19 Infection

Spain
Robert Lowsky
National Cancer Institute (NCI)

Completed

CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Acute Myeloid Leukemia | Hodgkin Lymphoma | Chronic Lymphocytic Leukemia | Myelodysplastic Syndrome | B-Cell Non-Hodgkin Lymphoma | Myeloproliferative Neoplasm | T-Cell Non-Hodgkin Lymphoma

United States
Shire

Completed

Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment (AIM-IT)

Hunter Syndrome

Spain, United States, Canada, United Kingdom, France, Australia, Mexico
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Active, not recruiting

Treo/Flu/TBI With Donor Stem Cell Transplant for Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia

Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome | Myelodysplastic/Myeloproliferative Neoplasm | Minimal Residual Disease | Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable | Acute Myeloid Leukemia in Remission

United States
RedDress Ltd.

Completed

A Prospective, Open Label, Multicenter Trial for Evaluating the Efficacy of Treating and Managing Wounds in Elderly Population in Specialized Nursing Facilities Using RD1

Trauma Injury | Diabetic Foot Ulcer | Venous Leg Ulcer | Pressure Ulcer | Skin Tear | Chronic Ulcer

United States
Curis, Inc.
The Leukemia and Lymphoma Society

Completed

Study to Assess the Safety, Tolerability and Pharmacokinetics of Fimepinostat (CUDC-907) in Patients With Lymphoma

Lymphoma | Refractory Lymphoma | Relapsed Lymphoma | Relapsed and/or Refractory Lymphoma | Relapsed Ddiffuse Large B-Cell Lymphoma (DLBCL) | Refractory Diffuse Large B-Cell Lymphoma (DLBCL) | Relapsed and/or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) | Double-hit Lymphoma (DHL) | Triple-hit Lymphoma... and other conditions

United States
University of Limerick

Completed

Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis

Multiple Sclerosis | Urinary Bladder, Overactive | Lower Urinary Tract Symptoms | Urinary Incontinence | Urinary Bladder, Neurogenic | Urinary Incontinence, Urge | Nocturia | Bladder Dysfunction | Neurogenic Bladder Dysfunction | Urinary Frequency More Than Once at Night

Ireland
Helsinki University Central Hospital

Completed

Outcome of COVID-19 Patients After Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome

COVID-19 | Acute Respiratory Distress Syndrome | Extracorporeal Membrane Oxygenation Complication

Sweden, Finland, Germany, Italy, United Kingdom, France
Beijing Anzhen Hospital

Completed

Tissue Oxygenation During Treatment of Infant Congenital Heart Defects

Acute Kidney Injury | Hypoxia-Ischemia, Brain | Mesenteric Ischemia

China
Abbott Medical Devices

Completed

XIENCE 28 Global Study

Coronary Artery Disease | Renal Insufficiency | Anemia | Thrombocytopenia | Coagulation Disorder | Stroke, Ischemic | Stroke Hemorrhagic | Bleeding Disorder | Hematological Disease

China, Spain, Belgium, Germany, Portugal, Switzerland, Hong Kong, United Kingdom, Austria, Italy, Netherlands, Singapore, Taiwan
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Unknown

Autologous Fat Grafting in the Treatment of Critical Limb Ischaemia

Diabetic Foot | Scleroderma, Systemic | Ischemic Leg | Critical Limb Ischemia | Ischemic Ulcer | Ischemic Feet | Peripheral Arterial Disease - PAD | Thrombo Angiitis Obliterans

Italy
Tulane University
National Kidney Foundation

Completed

Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes

Depression | Quality of Life | Pain | Generalized Anxiety Disorder | End Stage Renal Disease | Anxiety | Blood Pressure | Major Depressive Disorder | Compliance, Patient | Compliance, Medication | Mood | Heart Rate Fast | Energy Supply; Deficiency

United States
Queen Mary University of London

Unknown

Identification of Autoantigens in EGPA and Severe Eosinophilic Asthma (IDEA)

Eosinophilic Esophagitis | Churg-Strauss Syndrome | Eosinophilic Asthma | Eosinophilic Pneumonia

United Kingdom
University of Puerto Rico
National Institutes of Health (NIH)

Completed

Use of Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)

Familial Adenomatous Polyposis

Puerto Rico
University of Southern California
National Cancer Institute (NCI)

Withdrawn

Nutritional Preferences and Product Accessibility in Oral Nutritional Supplements in Participants With Breast, Colorectal, Upper Gastrointestinal, or Prostate Cancer

Cholangiocarcinoma | Breast Carcinoma | Gastric Carcinoma | Colorectal Carcinoma | Pancreatic Carcinoma | Prostate Carcinoma | Malignant Digestive System Neoplasm

United States
H. Lee Moffitt Cancer Center and Research Institute
National Cancer Institute (NCI)

Completed

Bone Marrow Transplant in Treating Patients With Hematologic Cancers

Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Myelodysplastic/Myeloproliferative Neoplasms | Multiple Myeloma and Malignant Plasma Cell Neoplasms

United States
OHSU Knight Cancer Institute
Oregon Health and Science University

Completed

Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease

Gastroesophageal Reflux Disease | Metaplasia | Barrett Esophagus | Esophageal Adenocarcinoma | Esophageal Squamous Cell Carcinoma | Dysplasia

United States
Uptown Eye Specialists

Unknown

Diabetic Macular Edema - Obstructive Sleep Apnea Relationship Study (DME-OSA)

Diabetic Macular Edema | Sleep Apnea | Non Proliferative Diabetic Retinopathy

Canada
University of Texas at Austin

Unknown

Peer Support for Post Intensive Care Syndrome Self-Management (PS-PICS)

Sepsis | Shock | Critical Illness | Shock, Septic | Respiratory Failure | Chronic Disease | Respiratory Distress Syndrome, Adult | Shock, Hypovolemic

United States
University Hospital, Montpellier

Unknown

Evaluation of Post Infectious Inflammatory Reaction (PIIR) Concerning Children After Streptococcus Pneumoniae, Streptococcus Pyogenes and Neisseria Meningococcus Invasive Infection (RIPI)

Streptococcus Pyogenes Infection | Streptococcus Pneumonia | Neisseria Meningitides Meningitis

France
Hope Pharmaceuticals

Withdrawn

Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite

COVID-19 | Acute Respiratory Distress Syndrome | Acute Respiratory Failure

United States
University of Waterloo
YMCA; Royal Bank of Canada

Completed

Determining the Feasibility of Implementing a Combined Cognitive and Exercise Training Program for Older Adults in a Community Setting.

Obesity | Diabetes | Chronic Obstructive Pulmonary Disease | Fibromyalgia | Osteoporosis | High Blood Pressure | Osteo Arthritis | Joint Replacement | Stable Heart Conditions

Canada
Beijing Tiantan Hospital

Unknown

Efficacy and Safety of Ferrous Iron on the Prevention of Vascular Cognitive Impairment Among Patients With Cerebral Infarction/TIA (FAVORITE) (FAVORITE)

Iron-deficiency | Cerebral Infarction | Dementia, Vascular | TIA | Vascular Cognitive Impairment

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Pfizer

Terminated

Bosutinib in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase After Frontline TKI Failure

Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Blasts Under 15 Percent of Bone Marrow Nucleated Cells | Blasts Under 15 Percent of Peripheral Blood White Cells | Blasts Under 30 Percent of Bone Marrow Nucleated Cells | Blasts Under 30 Percent of Peripheral Blood White Cells

United States
Mayo Clinic

Completed

Pasireotide LAR in Severe Polycystic Liver Disease (SOM230)

Autosomal Dominant Polycystic Kidney Disease | Polycystic Liver Disease | Autosomal Dominant Polycystic Liver Disease | Somatostatin Analogs

United States
Jeffrey L Zitsman, MD

Completed

LAGB as a Treatment for Morbid Obesity in Adolescents

Obstructive Sleep Apnea Syndrome | Metabolic Syndrome | Insulin Resistance | Morbid Obesity | Nonalcoholic Fatty Liver Disease

United States
National Cancer Institute (NCI)

Terminated

Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thymic Neoplasms, and Malignant Pleural Mesotheliomas

Sarcoma | Esophageal Cancer | Thymic Carcinoma | Lung Cancer | Malignant Pleural Mesothelioma

United States
Assistance Publique - Hôpitaux de Paris
Centre National de la Recherche Scientifique, France

Completed

Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS) (SPEECH-ALS)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Kennedy's Disease

France
Kartal Kosuyolu Yuksek Ihtisas Education and Research...
Trakya University

Completed

The Use of Midazolam and Remifentanil During Dialysis Access Procedures

Chronic Kidney Diseases | Patient Satisfaction | Arteriovenous Fistula | Adverse Reaction to Drug | Analgesic Adverse Reaction | Sedative Adverse Reaction | Midazolam Adverse Reaction
AbbVie

Completed

A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in Treatment-Naive and Treatment-Experienced, Non-Cirrhotic Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With or Without Human Immunodeficiency Virus Co-Infection (VOYAGE-1)

Hepatitis C Virus (HCV)

China, Korea, Republic of, Singapore
National Institute on Deafness and Other Communication...

Terminated

Central Mechanisms in Speech Motor Control Studied With H215O PET

Healthy | Tourette Syndrome | Stuttering | Communication Disorder | Voice Disorder

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Phase I/II Trial of Early Infusion of Rapidly-generated Multivirus Specific T Cells (MVST) to Prevent Post Transplant Viral Infections

Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | MDS (Myelodysplastic Syndrome) | CML (Chronic Myelogenous Leukemia) | AML (Acute Myelogenous Leukemia)

United States
National Cancer Institute (NCI)

Terminated

Tumor Cell Vaccines With ISCOMATRIX Adjuvant and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers and Malignant Pleural Mesotheliomas

Esophageal Cancer | Thymoma | Lung Cancer | Thoracic Sarcomas | Mesolthelioma

United States
GlaxoSmithKline

Completed

Study to Determine the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals; Infanrix Hexa at 2, 4 and 6 Months of Age in Healthy Infants

Hepatitis B | Tetanus | Diphtheria | Acellular Pertussis | Poliomyelitis | Haemophilus Influenzae Type b

United States
National Institute of Allergy and Infectious Diseases...

Terminated

Evaluation and Long-Term Follow-Up of Patients With Allergic and Inflammatory Disorders

Asthma | Allergy | Allergic Rhinitis | Atopic Dermatitis | Food Allergy | Mastocytosis

United States
Bausch Health Americas, Inc.

Terminated

Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome

Psychosis | Velo-cardio-facial Syndrome

United States
National Cancer Institute (NCI)

Terminated

CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer

Cervical Cancer | Pancreatic Cancer | Ovarian Cancer | Lung Cancer | Mesothelioma

United States
GlaxoSmithKline

Completed

Study to Evaluate the Immunogenicity and Reactogenicity of a Booster Dose of GSK2036874A Vaccine in Healthy Toddlers

Hepatitis B | Tetanus | Diphtheria | Haemophilus Influenzae Type b | Whole Cell Pertussis | Poliomyelitis Vaccines

Philippines
Shenzhen Geno-Immune Medical Institute

Unknown

Lentiviral Gene Therapy for X-ALD

X-linked Adrenoleukodystrophy

China
National Cancer Institute (NCI)

Completed

Nivolumab in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Cancer

Recurrent Nasopharynx Carcinoma | Stage III Nasopharyngeal Carcinoma AJCC v7 | Stage IV Nasopharyngeal Carcinoma AJCC v7 | Stage IVA Nasopharyngeal Carcinoma AJCC v7 | Stage IVB Nasopharyngeal Carcinoma AJCC v7 | Stage IVC Nasopharyngeal Carcinoma AJCC v7 | Nasopharyngeal Nonkeratinizing Carcinoma

United States, Singapore, China
University of Arizona

Completed

Reduced Intensity Allogeneic PBSCT to Treat Hematologic Malignancies and Hematopoietic Failure States (ALBUM)

Hematologic Neoplasms | Multiple Myeloma | Myelofibrosis | Anemia, Aplastic | Hemoglobinuria, Paroxysmal

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Terminated

Genetic Sequencing-Informed Targeted Therapy in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer

Stage IIIB Non-small Cell Lung Cancer | Recurrent Non-small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer | Malignant Pleural Effusion | Malignant Pericardial Effusion

United States

Clinical Trials on ALK-activated Tumors

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