Clinical Trials on BRCA 1/2

Total 15896 results

Chang Gung Memorial Hospital
Intuitive Surgical

Active, not recruiting

Pilot Study of Single-port Robot-assisted Nipple-sparing Mastectomy

Breast Cancer | BRCA1 Mutation | BRCA2 Mutation | Nipple-sparing Mastectomy | Prophylactic Mastectomy

Taiwan
Columbia University
American Cancer Society, Inc.

Completed

Decision Support for BRCA Testing in Ethnically Diverse Women

Breast Cancer | Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation

United States
University College London Hospitals

Completed

Carboplatin or Docetaxel in Treating Women With Metastatic Genetic Breast Cancer

Breast Cancer | Hereditary Breast/Ovarian Cancer (brca1, brca2) | brca1 Mutation Carrier | brca2 Mutation Carrier

Australia, Israel, United Kingdom, Spain, Sweden, Portugal
Erasmus Medical Center

Recruiting

Bilateral Prophylactic Mastectomy; Should we Preserve the Pectoral Fascia? (PROFAS)

Seroma | BRCA1/2 Mutation | Bilateral Prophylactic Mastectomy | Pectoral Fascia

Netherlands
The University of Texas Health Science Center at...

Withdrawn

Combination of Carboplatin, Eribulin and Veliparib in Stage IV Cancer Patients

Ovarian Cancer | Breast Cancer Stage IV | BRCA1 Mutation | BRCA2 Mutation
Hubei Biological Medicine Industrial Technology...

Unknown

Phase I Clinical Study of HWH340 Tablet in Patients With Advanced Solid Tumors

Advanced Solid Tumors | HRD | BRCA Mutation

China
Hoffmann-La Roche

Completed

European, Open-label, Prospective, Multinational, Multicenter Study in Adult Subjects With Type 1 or Type 2 Diabetes Previously on MDI or CSII Therapy. Subjects Home Setting is Considered Routine Practice.

Type 2 Diabetes, Type 1 Diabetes

Austria, United Kingdom
Abramson Cancer Center at Penn Medicine

Active, not recruiting

HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer

Advanced Breast Cancer | Metastatic Breast Cancer | BRCA1 Mutation | BRCA2 Mutation | Locally Advanced Breast Cancer

United States
Sanofi

Completed

Comparison of SAR341402 to NovoLog/NovoRapid in Adult Patients With Diabetes Mellitus Also Using Insulin Glargine (GEMELLI1)

Type 1 Diabetes Mellitus-Type 2 Diabetes Mellitus

Hungary, Russian Federation, Germany, Poland, Japan, United States, Finland
University Health Network, Toronto

Suspended

Surgical and Patient Reported Outcomes of Robotic Nipple-Sparing Mastectomy (RNSM)

Breast Cancer | Breast Diseases | Genetic Predisposition to Disease | Surgery | Surgery--Complications | BRCA1 Mutation | BRCA2 Mutation

Canada
University Medical Center Nijmegen

Recruiting

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention (TUBA-WISP-II)

Ovarian Cancer | BRCA1 Gene Mutation | BRCA2 Gene Mutation | RAD51C Gene Mutation | RAD51D Gene Mutation | BRIP1 Gene Mutation

Netherlands, United States, Belgium, Norway, Poland, Italy, Australia, Mexico, Brazil, Sweden, Uruguay
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Talazoparib Before Standard Therapy in Treating Patients With Invasive, BRCA-Mutated Breast Cancer

Invasive Breast Carcinoma | HER2/Neu Negative | Breast Adenocarcinoma | Deleterious BRCA1 Gene Mutation | Deleterious BRCA2 Gene Mutation

United States
Seoul National University Hospital
Bayer; Korean Society of Breast Imaging & Korean Society For Breast Screening

Unknown

Abbreviated Breast MRI for Second Breast Cancer Detection in Women With BRCA Mutation Testing

Breast Cancer | BRCA1 Mutation | BRCA2 Mutation | Recurrent Breast Cancer | Metachronous Neoplasm

Korea, Republic of
Samsung Medical Center
AstraZeneca

Completed

BRCA 1/2 Mutation in Korean Patients With Epithelial Ovarian Cancer

To Investigate the Prevalence of BRCA 1/2 Mutation Among Ovarian Cancer
UNICANCER

Completed

Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation (LIBER)

Breast Cancer | Hereditary Breast/Ovarian Cancer (brca1, brca2) | brca1 Mutation Carrier | brca2 Mutation Carrier

France
European Organisation for Research and Treatment...
AstraZeneca

Withdrawn

Chemo-free BRCA-targeted Neoadjuvant Strategy

BRCA1 Mutation | BRCA2 Mutation | TNBC - Triple-Negative Breast Cancer
Indiana University
Community Health Network; Boys & Girls Clubs of Indianapolis

Recruiting

Sankofa Paradigm: A Therapeutic Theatre Program for Girls

Mental Health Wellness 1 | Child Behavior | Adolescent Behavior | Mental Health Wellness 2

United States
AstraZeneca

Completed

An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

United States
Hoffmann-La Roche
Roche Diagnostics

Completed

A Study Evaluating the Perception of Insertion Pain With Accu-Chek FlexLink and FlexLink Plus Insulin Pump Devices Under Real Life Conditions in Diabetic Patients.

Diabetes Mellitus Type 2, Diabetes Mellitus Type 1

Germany
Mayo Clinic
Allergan

Completed

Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction

Neoplasms | Pain, Postoperative | Breast Cancer | Breast Diseases | BRCA1 Mutation | BRCA2 Mutation

United States
Severance Hospital
Samsung Medical Center; Changhua Christian Hospital; European Institute of Oncology

Completed

Surgical and Oncologic Outcomes After Robotic Nipple Sparing Mastectomy and Immediate Reconstruction (SORI)

Recurrence | Postoperative Complications | Breast Cancer | Breast Neoplasms | Surgery | Surgery--Complications | BRCA1 Mutation | BRCA2 Mutation

Korea, Republic of
Alexandru Eniu
Iuliu Hatieganu University of Medicine and Pharmacy

Completed

BRCA1 and BRCA2 Mutation in Romanian Population: a Study of Genotype - Phenotype Correlation at Diagnosis With Prospective Disease Outcome and Survival

To Determine the Prevalence, Penetrance of BRCA1 and BRCA2 Mutations in Romanian Womens With Breast or Ovarian Cancer

Romania
Rutgers, The State University of New Jersey

Recruiting

Internet Assisted Career-Oriented Soft-skills Training for Transition Age Youth With Mental Health Conditions (iCareer)

Mental Health Wellness 1 | Occupational Problems | Mental Health Wellness 2

United States
Beijing InnoCare Pharma Tech Co., Ltd.

Active, not recruiting

A Study of Tyrosine Kinase Inhibitor Orelabrutinib (ICP-022) in Patients With r/r B-Cell Malignancies

Part 1：r/r B-cell Malignancies | Part 2：B-cell Malignancies

United States, Poland, Israel, Ukraine
Center for International Blood and Marrow Transplant...
Patient-Centered Outcomes Research Institute; National Marrow Donor Program

Completed

Randomized Study of Individualized Care Plans for Hematopoietic Cell Transplant Survivors

Adult Hematopoietic Cell Transplant (HCT) Survivors 1-2 Yrs Post Most Recent HCT

United States
Translational Research Center for Medical Innovation...
Okayama University; Japanese Gynecologic Oncology Group (JGOG)

Recruiting

Prospective Cohort Study of Germline Variant Carriers With BRCA1 or BRCA2

Fallopian Tube Carcinoma | Peritoneal Carcinoma | Ovarian Carcinoma | BRCA1 and/or BRCA2 Variant Carriers

Japan
Mannkind Corporation

Terminated

Pulmonary Function Substudy for Subjects Enrolled in Studies MKC-TI-161, MKC-TI-162 or MKC-TI-166

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

United States
Institute of Cancer Research, United Kingdom
Cancer Research UK; National Institute for Health Research, United Kingdom

Recruiting

The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a BRCA Gene Mutation. (GENPET)

Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation

United Kingdom
Assistance Publique - Hôpitaux de Paris

Completed

Study of the Relationship Between Dose-concentration-effect of Delta-9-tetrahydrocannabinol (THC) and the Ability to Drive in Chronic or Occasional Cannabis Users (VIGICANN)

Occasional (1-2 Joints Per Week) and Chronic (1-2 Joints Per Day) Cannabis Users

France
Philipps University Marburg Medical Center

Completed

Do Videos That Aim to Optimize Expectations Alter the Effectivess of PMR?

Control Group | Experimental Group 1 (Video Personal Expert) | Experimental Group 2 (Video Factual Expert)

Germany
Northwestern University
Northwestern Memorial Hospital; Saint Joseph Hospital, Chicago, Illinois

Recruiting

Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage

Breast Cancer | BRCA Mutation

United States
Wael Elbanna Clinic
Fetal Medicine Research Center, Spain

Recruiting

Comparison Between Biopsied and Non-biopsied Intracytoplasmatic Sperm Injection (ICSI) Embryos and Natural Pregnancy Embryos (BNB-ICSI)

Women Conceiving by: 1- ICSI-PGS 2- ICSI-non-PGS 3- Spontaneously Conceiving Women

Egypt
Sintetica SA
Cross S.A.

Completed

Dose-finding Study of Intrathecal Paracetamol Administered Immediately Before Spinal Anaesthesia

Phase 1: Pain Management | Phase 2: Pain Management

Switzerland
Mayo Clinic
National Cancer Institute (NCI)

Completed

Rituximab With or Without Yttrium Y-90 Ibritumomab Tiuxetan in Treating Patients With Untreated Follicular Lymphoma

Ann Arbor Stage I Grade 1 Follicular Lymphoma | Ann Arbor Stage I Grade 2 Follicular Lymphoma | Ann Arbor Stage III Grade 1 Follicular Lymphoma | Ann Arbor Stage III Grade 2 Follicular Lymphoma | Ann Arbor Stage IV Grade 1 Follicular Lymphoma | Ann Arbor Stage IV Grade 2 Follicular Lymphoma | Ann... and other conditions

United States
Severance Hospital
Samsung Medical Center; Asan Medical Center; Kyungpook National University Chilgok...

Recruiting

Prospective Study of MAstectomy With Reconstruction Including Robot Endoscopic Surgery (MARRES)

Breast Neoplasms | Benign Breast Disease | Germline BRCA1 Gene Mutation | Germline BRCA2 Gene Mutation | Germline Mutation Abnormality

Korea, Republic of
Mondelēz International, Inc.
Reading Scientific Services Ltd.

Withdrawn

Blood Glucose and Insulin Responses to Snack Food Products

Study Focus 1:Glycaemic Index | Study Focus 2:Glycaemic Response | Study Focus 3:Insulinemic Response

United Kingdom
Rana McKay, MD
University of California, San Diego; AstraZeneca

Recruiting

Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With BRCA1/2 Gene Alterations (NePtune)

Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation | Prostatic Adenocarcinoma | High-Risk Cancer

United States
The National Institute of Lymphology
The DrMarga Practice Group; The Center for Restorative Breast Surgery, LLC

Unknown

Outcomes After Perforator Flap Reconstruction for Breast Reconstruction and/or Lymphedema Treatment

Breast Cancer | Hereditary Breast/Ovarian Cancer (brca1, brca2) | Congenital Lymphedema | Acquired Lymphedema

United States
Institute of Child Health

Completed

The Effect of Caudal Volumes on the Anatomical Spread of Caudals in Children

Asa 1 and 2 Patients for Elective Surgery Requiring Caudal as Part of Their Care

United Kingdom
Medical University of Graz

Completed

Prolonged Fasting on Glucose Metabolism and Hormonal Regulation in Healthy, Obese and Subjects With Type 2 Diabetes (PROLOG)

Healthy | Obesity | Type 2 Diabetes Mellitus | Type 1 Diabetes

Austria
University of Southern California
Project Angel Food; United American Indian Involvement, Inc.

Active, not recruiting

Native American Diabetes Project

Diabetes Mellitus, Type 2 | Diabetes Mellitus | Diabetes | Diabetes Mellitus, Type 1 | Diabetes Type 1 | Diabete Type 2

United States
Medtronic Diabetes

Withdrawn

A Performance Evaluation of the Harmony 1 Sensors in Adults and Pediatrics

Type 1 Diabetes | Type 2 Diabetes
Institute of Child Health

Completed

Pain of Injection of Lipuro Propofol in Children Aged 1-7 Years

ASA 1-2 Requiring Intravenous Cannulation for General Anaesthesia

United Kingdom
Merck Sharp & Dohme LLC

Recruiting

Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-2870-008)

Non-small Cell Lung Cancer | Solid Tumors | Programmed Cell Death-1 (PD1, PD-1) | Programmed Cell Death 1 Ligand 1(PDL1, PD-L1) | Programmed Cell Death 1 Ligand 2 (PDL2, PD-L2)

Japan
Medtronic Diabetes

Completed

Adult Accuracy Study of the Enlite 3 Glucose Sensor (E3)

Type 1 Diabetes | Type 2 Diabetes

United States
Istanbul Medeniyet University

Completed

Comparison of Th1 Cytokine Levels Between Type 1 and Type 2 Diabetes

Type 1 Diabetes | Type 2 Diabetes

Turkey
LifeScan

Completed

Remote Monitoring in Diabetes Disease Management

Type 1 Diabetes | Type 2 Diabetes

United States
Joslin Diabetes Center
Cambridge Medical Technologies, LLC

Recruiting

The PRECISION II Study: Evaluating the Accuracy of the LabPatch Glucose Sensing System

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

United States
Lannett Company, Inc.
Parexel; FARMOVS (Pty) Ltd

Completed

A Study to Demonstrate Pharmacokinetic and Pharmacodynamic Biosimilarity Between HEC-Glargine and US-Lantus® in Healthy Male Volunteers

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

South Africa
Merck Sharp & Dohme LLC

Completed

Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001)

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

United States

Clinical Trials on BRCA 1/2

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