Clinical Trials on Biochemical and Genetic Markers in Liver Diseases in United Kingdom

Total 12684 results

University of Pennsylvania
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Acute Effects of E-Cigarette Aerosol Inhalation

Endothelial Dysfunction | Biochemical Markers

United States
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust; University of Oxford; Queen Mary University... and other collaborators

Recruiting

The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment (PROFILE)

Prostate Cancer | Genetic Counselling | Genetic Markers | Prostate Biopsy

United Kingdom
Royal College of Surgeons, Ireland
The Hospital for Sick Children; Imperial College London; Erasmus Medical Center; University College Dublin and other collaborators

Active, not recruiting

Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER) (RECOVER)

Cystic Fibrosis | Adherence, Medication | Cystic Fibrosis Gastrointestinal Disease | Cystic Fibrosis in Children | Cystic Fibrosis Liver Disease

United Kingdom, Ireland
Manchester University NHS Foundation Trust

Recruiting

The Use of Novel Diagnostic Tools to Increase Detection of Early Fibrosis in Cystic Fibrosis Related Liver Disease to Improve Clinical Management

Cystic Fibrosis | Liver Fibroses | Cystic Fibrosis Liver Disease

United Kingdom
National Institute of Mental Health (NIMH)

Completed

Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers

fMRI | Brain Disease | Brain Mapping | Genotype | Allelic Frequencies of Genetic Markers

United States
St Mary's University College
Fulham Football Club

Completed

Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football

Tendon Injuries | Apophysitis | Genetic Predisposition | Ligament Injury | Muscle Strain | Fractures in Children

United Kingdom
Alnylam Pharmaceuticals

Terminated

A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Antitrypsin Deficiency Liver Disease

United Kingdom
Alnylam Pharmaceuticals

Terminated

A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

United Kingdom
Albireo

Completed

An Open Label, Single-dose, Single Period ADME Study of A4250 in Healthy Subjects

Primary Biliary Cirrhosis | Alagille Syndrome | Progressive Familial Intrahepatic Cholestasis | Orphan Cholestatic Liver Diseases

United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust; Cancer Research UK; Ronald and Rita McAulay...

Active, not recruiting

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

Prostate Cancer in BRCA1 and BRCA2 Carriers

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
King's College London

Completed

Safety and Efficacy Study of Regulatory T Cell Therapy in Liver Transplant Patients (ThRIL)

End-stage Liver Disease

United Kingdom
King's College Hospital NHS Trust
Samsung Medison

Recruiting

Effectiveness of Ultrasound in Liver Stiffness and Fat Quantification

Hepatitis | Liver Fat | NAFLD | Fibrosis, Liver | Liver Disease Chronic | Liver Steatoses | NASH With Fibrosis

United Kingdom
Natera, Inc.
Ferring Pharmaceuticals

Terminated

Impact of Parental Support on Pregnancy Outcomes (IPSO) Trial- Day 3 Preimplantation Genetic Screening (PGS) With Day 5 Fresh Transfer (IPSO)

In Vitro Fertilization (IVF) | Preimplantation Genetic Diagnosis (PGD) | Preimplantation Gentic Screening (PGS)

United States
Imperial College London

Enrolling by invitation

Smart Watch Insights for Prevention of Exacerbations and Enhance Rehabilitation - Movement Study (SWIPER-MOVES)

Cardiovascular Diseases | Diabetes | Respiratory Disease | Non-Alcoholic Fatty Liver Disease

United Kingdom
University College London Hospitals
Medical Research Council

Unknown

Predictive Utility of DASIMAR as a Prognostic Biomarker in Acute-on-chronic Liver Failure (ACLF) (DASIMAR)

Liver Cirrhosis

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
King's College London; Medical Research Council; Guts UK

Recruiting

Impact of Cold Exposure on Metabolic Regulation in Children With Non Alcoholic Fatty Liver Disease (NAFLD) (ICE BAT)

Non-Alcoholic Fatty Liver Disease

United Kingdom
Imperial College London
King's College London

Completed

Impact of FMT on the Phenome in Patients With NAFLD and Fibrosis

Non-Alcoholic Fatty Liver Disease | Fecal Microbiota Transplantation

United Kingdom
Imperial College London
National Health Service, United Kingdom

Terminated

Rifaximin in Fatty Liver Disease (RiFL)

NAFLD | Nonalcoholic Fatty Liver Disease | Nonalcoholic Steatohepatitis

United Kingdom
Imperial College London

Completed

Macrophage-mediated Inflammation in White Adipose Tissue and Non-alcoholic Fatty Liver Disease.

Non-Alcoholic Fatty Liver Disease

United Kingdom
Nottingham University Hospitals NHS Trust

Recruiting

Prospective Single Centre Observational Study to Compare the Diagnostic Yield of Different Modalities of Liver Biopsy

Liver Diseases | Liver Fibrosis

United Kingdom
King's College London
Pfizer

Unknown

An Observational Cohort Study Evaluating Fatty Liver Disease and Liver Fibrosis in Moderate to Severe Psoriasis (CORE)

Fatty Liver | Non-alcoholic Fatty Liver Disease | Liver Fibrosis | Psoriasis Chronic

United Kingdom
King's College Hospital NHS Trust

Active, not recruiting

Contingency Management to Incentivise Treatment Adherence in Alcohol-related Liver Disease

Alcohol-related Liver Disease

United Kingdom
University of Oxford

Recruiting

MRI and Stable Isotope Tracer Studies for Detecting the Progression of Non-Alcoholic Steatohepatitis (NASH) (MRI-Detect)

Non-Alcoholic Fatty Liver Disease

United Kingdom
University Hospital Southampton NHS Foundation...
National Institute for Health Research, United Kingdom

Completed

Treatment of Non Alcoholic Fatty Liver Disease With n-3 Fatty Acids (WELCOME)

Non-Alcoholic Fatty Liver Disease

United Kingdom
University of Florida

Terminated

The Role of Non-Alcoholic Fatty Liver Disease in Gestational Diabetes

Gestational Diabetes Mellitus in Pregnancy

United States
University of Oxford

Completed

Effects of Dietary Intervention and Surgery on NAFLD (Non-Alcoholic Fatty Liver Disease) (EDISON)

Obesity, Morbid | Bariatric Surgery Candidate | Non-Alcoholic Fatty Liver Disease | Non Alcoholic Fatty Liver

United Kingdom
University of Nottingham
Mediplus Ltd UK; Enteric healthcare technology Co-operative

Completed

Evaluation of 'Melody' Paracentesis Device for Ascites Therapy (EMPATHY)

Ascites Hepatic | Cirrhosis and Chronic Liver Disease

United Kingdom
Pfizer

Terminated

A Study Of Early Markers Of Choroidal Neovascularization

Age-related Macular Degeneration (AMD) | Choroidal Neovascularization (CNV) | Early Markers

Italy, Portugal, United Kingdom
University of Leeds
The Leeds Teaching Hospitals NHS Trust; University of Sheffield

Unknown

Hepatectomy Risk Assessment With Functional Magnetic Resonance Imaging (HEPARIM)

Liver Failure | Hepatectomy | Liver Metastases | Liver Cancer

United Kingdom
King's College Hospital NHS Trust

Not yet recruiting

Sexual Dysfunction in Patients With Chronic Liver Disease

Liver Diseases | Liver Cirrhosis

United Kingdom
Owlstone Ltd
Clinical Research and Trials Unit (Norfolk & Norwich University Hospital,... and other collaborators

Not yet recruiting

Early Liver Disease Breath Detection

Liver Diseases | Liver Fibrosis | NASH

United Kingdom
University of Nottingham

Recruiting

Low GI Diet Effects on Non-Alcoholic Fatty Liver Disease (LGI-NAFLD)

Fatty Liver | Nutritional and Metabolic Disease

United Kingdom
Imperial College London

Completed

Adult Stem Cell Therapy in Liver Insufficiency

Liver Cirrhosis

United Kingdom
Imperial College London

Completed

The Effect of Protein-enriched Diet on Body Composition and Appetite (ProteinRich)

Overweight | Metabolic Syndrome | Obese | Non Alcoholic Fatty Liver Disease

United Kingdom
Manchester University NHS Foundation Trust
University of Nottingham; University of Manchester; Innovate UK

Recruiting

Integrated Diagnostics for Early Diagnosis of Liver Disease (ID LIVER)

Alcoholic Liver Disease | Non-Alcoholic Fatty Liver Disease | Non-alcoholic Steatohepatitis | Liver Fibroses

United Kingdom
Nottingham University Hospitals NHS Trust

Active, not recruiting

REpurposing SirolimUS in Compensated Advanced Chronic Liver Disease. The RESUS Proof of Concept Study (RESUS)

Advanced Chronic Liver Disease

United Kingdom
University of Oxford
Oxford University Hospitals NHS Trust; Imunon

Completed

Targeted Chemotherapy Using Focused Ultrasound for Liver Tumours (TARDOX)

Liver Tumour

United Kingdom
University of Nottingham
Nottingham University Hospitals NHS Trust; National Institute for Health Research...

Completed

Effects of Carnitine Supplementation on Liver and Muscle (ECLIPSE)

Insulin Resistance | Non-Alcoholic Fatty Liver Disease

United Kingdom
Arrowhead Pharmaceuticals

Active, not recruiting

Study of Fazirsiran (TAK-999, ARO-AAT) in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD)

Alpha 1-Antitrypsin Deficiency

Austria, Germany, United Kingdom
Matthew Armstrong
Queen Elizabeth Hospital NHS Foundation Trust

Completed

Impact of Exercise Therapy on Functional Capacity in Patients Listed for Liver Transplantation

Liver Cirrhosis | Liver Dysfunction

United Kingdom
University of Oxford
Quadram Institute Bioscience

Recruiting

Sulforaphane Supplementation Study (FAMOUS)

Obesity | Metabolic Syndrome | Non-Alcoholic Fatty Liver Disease

United Kingdom
Imperial College London

Recruiting

Volatile Organic Compounds for the Assessment of Liver Disease (VOCAL)

Hepatocellular Carcinoma | Cirrhosis | Fibrosis, Liver | Cirrhosis, Liver | Hepatocellular Cancer

United Kingdom
Jazz Pharmaceuticals

Completed

Study to Evaluate the Effect of GWP42003 on Liver Fat Levels in Participants With Fatty Liver Disease

Fatty Liver

United Kingdom
University Hospital, Basel, Switzerland
Swiss National Science Foundation

Recruiting

MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease

Liver Failure | Acute-On-Chronic Liver Failure | Liver Disease | Cirrhosis of the Liver

Switzerland, United Kingdom
Perspectum

Active, not recruiting

Precision Medicine for Liver Tumours With Quantitative Magnetic Resonance Imaging and Whole Genome Sequencing (Precision1)

Liver Cancer | Liver Metastasis Colon Cancer

United Kingdom
University of Aberdeen

Completed

The Utility of Breath Biopsy as a Screening Tool for HCC (BrtH-C)

HCC | Cirrhosis, Liver

United Kingdom
King's College Hospital NHS Trust
European Association for the Study of the Liver

Recruiting

Liver Disease in Pregnancy

Cirrhosis, Liver | HELLP Syndrome | Intrahepatic Cholestasis of Pregnancy | Pregnancy Disease | AFLP - Acute Fatty Liver of Pregnancy

United Kingdom
University of Nottingham
National Institute for Health Research, United Kingdom

Completed

Biomarkers for the Prognosis of Decompensated Alcoholic Liver Disease (BANDED)

Decompensated Cirrhosis | Alcoholic Liver Diseases

United Kingdom
University of Leeds
The Leeds Teaching Hospitals NHS Trust

Unknown

Functional MRI to Determine Severity of Cirrhosis

Liver Cirrhosis | Liver Fibrosis

United Kingdom
The Leeds Teaching Hospitals NHS Trust
Genomic Medicine Services Alliance

Completed

Modified Delphi for Genomic Bereavement Care

Genetic Disease | Bereavement | Fetal Anomaly

United Kingdom

Clinical Trials on Biochemical and Genetic Markers in Liver Diseases in United Kingdom

Sponsors and Collaborators

Medical Conditions

Drug Interventions

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CROs in South Africa

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