Clinical Trials on Cavernous Angioma, Familial

Total 2053 results

University of Chicago
Johns Hopkins University; Mayo Clinic; National Institute of Neurological Disorders... and other collaborators

Completed

CASH (Cavernous Angiomas With Symptomatic Hemorrhage) Trial Readiness

Cerebral Cavernous Malformation | Cavernous Angioma | Cavernoma | CCM | Cerebral Cavernous Malformations 1 | Cerebral Cavernous Malformations 2 | Cerebral Cavernous Malformations 3

United States
University of California, San Francisco
University of Chicago; National Institute of Neurological Disorders and Stroke... and other collaborators

Recruiting

Modifiers of Disease Severity in Cerebral Cavernous Malformations

Cerebral Cavernous Malformations | Cavernous Angioma, Familial | Cerebral Cavernous Hemangioma

United States
University of New Mexico
National Institute of Neurological Disorders and Stroke (NINDS); University...

Terminated

Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins

Cerebral Cavernous Malformations | Cavernous Angioma, Familial | Cerebral Cavernous Hemangioma

United States
University of Chicago
Mayo Clinic; National Institute of Neurological Disorders and Stroke (NINDS); University of California, San Francisco and other collaborators

Recruiting

Biomarkers of CASH

Cerebral Cavernous Malformation | Cavernous Angioma | Hemorrhagic Microangiopathy

United States
University of California, San Francisco

Completed

Influence of MMP on Brain AVM Hemorrhage

Arteriovenous Malformations | Cavernous Angiomas | Brain Aneurysms

United States
yuanli Zhao
Peking University International Hospital

Recruiting

Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy (CRESS)

Epilepsy | Seizures | Seizures, Epileptic | Cavernous Malformation, Cerebral | Cavernous Angioma | Cavernous Hemangioma | Cavernous Hemangioma of Brain

China
University of Chicago
Johns Hopkins University

Active, not recruiting

Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial (AT CASH EPOC)

Cerebral Cavernous Malformation

United States
Assiut University

Unknown

Pattern and Management of Intracranial Cavernoma

Management of Intracranial Cavernous Hemangioma
Southwest Hospital, China

Completed

A Prospective Controlled Study on Treatment of Giant Cavernous Hemangiomas of the Liver

Laparoscopic Hepatectomy | Liver | Radio-frequency Ablation | Giant Cavernous Hemangiomas

China
Shanghai Zhongshan Hospital

Unknown

Gastroesophageal Varices in Cavernoma

Portal Hypertension | Myeloproliferative Neoplasm | Gastroesophageal Varices | Portal Caver Cavernoma

China
Sklifosovsky Institute of Emergency Care

Recruiting

Functional Navigation in Surgery of Cerebral Tumors and Vascular Malformations (FUN)

Arteriovenous Malformations | Tumor, Brain | Cavernoma

Russian Federation
St. Joseph's Hospital and Medical Center, Phoenix

Terminated

Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation

Cerebral Cavernous Malformations

United States
First Affiliated Hospital of Fujian Medical University

Recruiting

Treatments and Outcomes of Untreated Cerebral Cavernous Malformations in CHina. (TOUCH)

Cerebral Cavernous Malformations

China
University of Virginia

Unknown

Oral Propanolol for Surgically Inaccessible Cavernous Malformations

Cavernous Malformations,Cerebral and/or Spinal

United States
Sklifosovsky Institute of Emergency Care

Recruiting

Sonography-guided Resection of Brain Mass Lesions (SOMALI)

Arteriovenous Malformations | Tumor, Brain | Cavernoma | Intracerebral Hematoma

Russian Federation
Sklifosovsky Institute of Emergency Care

Recruiting

Intraoperative Brain Shift Calculation Study (BRASH)

Arteriovenous Malformations | Tumor, Brain | Cavernoma | Intracerebral Hematoma

Russian Federation
Recursion Pharmaceuticals Inc.

Active, not recruiting

The Symptomatic Cerebral Cavernous Malformation Trial of REC-994 (SYCAMORE)

Cerebral Cavernous Malformation

United States
University of New Mexico
University of California, San Francisco

Recruiting

Functional Magnetic Resonance Imaging (fMRI) Vascular Reactivity in Cerebral Cavernous Malformations (CCM)

Cerebral Cavernous Malformation

United States
Mario Negri Institute for Pharmacological Research
IFOM, The FIRC Institute of Molecular Oncology

Completed

Treat_CCM: Propranolol in Familial Cerebral Cavernous Malformation (Treat_CCM)

Cerebral Cavernous Malformation

Italy
Texas Tech University Health Sciences Center, El...

Terminated

CCM Blood Biomarker Validation Study

Cerebral Cavernous Malformation | Hemorrhagic Stroke, Intracerebral

United States
Sun Yat-sen University

Unknown

Cavernous Transformation of Portal Vein： Etiology, Diagnosis, Management and Prognosis

Portal Vein, Cavernous Transformation Of

China
Seoul National University Hospital
Asan Medical Center; Johannes Gutenberg University Mainz; Gyeongsang National... and other collaborators

Active, not recruiting

CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study (CHOCOOATE)

Intracerebral Hemorrhage | Cerebral Cavernous Malformation

Korea, Republic of
Northwestern University

Completed

Comparison of Electrodessication, Potassium Titanyl Phosphate (KTP) Laser and Pulsed Dye Laser for Treatment of Cherry Angiomata

Cherry Angioma

United States
Sun Yat-sen University

Unknown

Percutaneous Transhepatic Intrahepatic Portosystemic Shunt for Treatment of Portal Vein Occlusion With Symptomatic Portal Hypertension After Splenectomy

Hypertension, Portal | Portal Vein, Cavernous Transformation Of

China
Sun Yat-sen University

Unknown

Interventional Radiology for the Treatment of Symptomatic Portal Hypertension in Patients With Cavernous Transformation of Portal Vein

Hypertension, Portal | Portal Vein, Cavernous Transformation Of

China
Cutera Inc.

Completed

Clinical Evaluation of the Treatment of Spider Angioma

Spider Angioma

United States
Huashan Hospital

Not yet recruiting

Hemorrhagic Brainstem Cavernous Malformations Treatment With Sirolimus: a Single Centre, Randomised, Placebo-controlled Trial (CALM)

Cavernous Malformations | Brain Stem Hemorrhage

China
Beijing Tiantan Hospital
Beijing Friendship Hospital; RenJi Hospital; Qilu Hospital of Shandong University and other collaborators

Recruiting

Study on Treatment Decision-Making and Prognostic Follow-Up for Untreated Cerebral Cavernous Malformations

Hemangioma, Cavernous, Central Nervous System

China
Assistance Publique Hopitaux De Marseille

Not yet recruiting

Familial Aortopathies and Cellular Exploration (FACE)

Familial Aortopathies

France
Northwestern University
Gilead Sciences

Completed

Ranolazine and Pulmonary Hypertension

Pulmonary Arterial Hypertension | Angina

United States
National Medical Research Center for Therapy and...
Moscow State University of Medicine and Dentistry

Recruiting

Genetic Testing and Motivational Counseling for FH (GENMOTIV-FH)

Medication Adherence | Adherence, Medication | Treatment Adherence | Familial Hypercholesterolemia | Motivational Interviewing | Adherence, Patient | Treatment Adherence and Compliance | Patient Compliance | Adherence | Hypercholesterolemia, Familial | Patient Adherence | Hypercholesterolemia, Autosomal Dominant and other conditions

Russian Federation
Alnylam Pharmaceuticals

Completed

The Study of an Investigational Drug, Revusiran (ALN-TTRSC), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Whose Disease Has Continued to Worsen Following Liver Transplant

ATTR Amyloidosis | Transthyretin (TTR)-Mediated Amyloidosis | Familial Amyloidotic Polyneuropathy (FAP) | Familial Amyloid Neuropathies

France, Germany, Portugal, United Kingdom, Sweden, Spain
Leiden University Medical Center
Jacobijn Gussekloo, Prof. dr.; Simon P. Mooijaart, Prof. dr.

Recruiting

Longevity Families of the Netherlands (LOF-NL)

Aging | Extreme Longevity | Longevity | Familial Longevity

Netherlands
CENTOGENE GmbH Rostock
Alnylam Pharmaceuticals

Recruiting

TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive Subjects (TRAMmoniTTR)

Cardiomyopathies | Polyneuropathies | Transthyretin Amyloidosis | Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy | Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy

Germany, Austria, Switzerland
Boston University
National Institute of Neurological Disorders and Stroke (NINDS); Food and Drug...

Completed

The Effect of Diflunisal on Familial Amyloidosis

Familial Amyloid Polyneuropathy | Familial Amyloidosis

United States, Italy, Japan, Sweden, United Kingdom
Pfizer

Completed

The Effect Of Tafamidis For The Transthyretin Amyloid Polyneuropathy Patients With V30M Or Non-V30M Transthyretin

Transthyretin Familial Amyloid Polyneuropathy

Japan
Regeneron Pharmaceuticals
Sanofi

Terminated

Long Term Safety Study of PRALUENT

Heterozygous Familial Hypercholesterolemia | Non-familial Hypercholesterolemia

United States, Bulgaria, Estonia, Russian Federation, South Africa, Ukraine
Merck Sharp & Dohme LLC

Terminated

A Study of Extended-release (ER) Niacin/Laropiprant in Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0524A-158)

Hypercholesterolemia, Familial | Heterozygous Familial Hypercholesterolemia
Eidos Therapeutics, a BridgeBio company

Withdrawn

Efficacy and Safety of Acoramidis (AG10) in Subjects With Transthyretin Amyloid Polyneurophathy (ATTRibute-PN)

Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy
Institut Investigacio Sanitaria Pere Virgili

Recruiting

Early Detection of Familial Hypercholesterolemia in Children (DECOPIN)

Familial Hypercholesterolemia | Familial Hypercholesterolemia - Homozygous | Familial Hypercholesterolemia - Heterozygous

Spain
Novartis Pharmaceuticals

Active, not recruiting

Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Homozygous Familial Hypercholesterolemia (ORION-13)

Familial Hypercholesterolemia - Homozygous

Greece, Lebanon, Turkey, France, Canada, Malaysia, Netherlands, United States
Eidos Therapeutics, a BridgeBio company

Withdrawn

Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Polyneurophathy (ATTRibute-PN)

Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy

United States
SOM Innovation Biotech SA
Hospital Vall d'Hebron

Completed

Study of SOM0226 in Familial Amyloid Polyneuropathy

Familial Amyloid Polyneuropathy (FAP)

Spain
Marcello Arca
Pfizer; Göteborg University; University of Helsinki

Not yet recruiting

In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects

Familial Hypobetalipoproteinemia | Familial Hypobetalipoproteinemia - Heterozygous Form
Erasmus Medical Center
Abbott; Pie Medical Imaging

Unknown

The FAST OCT Study

Coronary Arteriosclerosis | Unstable Angina | NSTEMI - Non-ST Segment Elevation MI | Tomography, Optical Coherence | Myocardial Revascularization | 3D-angio-based FFR

Netherlands
Novartis Pharmaceuticals

Recruiting

Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Adolescent ORION-16 or ORION-13 Studies (V-PEDS-OLE)

Heterozygous or Homozygous Familial Hypercholesterolemia

Netherlands, Israel, Hungary, Italy, Germany, Spain, United States, France, Norway, Russian Federation, South Africa, Turkey, United Kingdom, Canada, Switzerland, Brazil, Lebanon, Slovenia, Poland, Taiwan, Malaysia
Alnylam Pharmaceuticals

Completed

APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis

Amyloid Neuropathies | Amyloid Neuropathies, Familial | TTR-mediated Amyloidosis | Amyloidosis, Hereditary | Amyloidosis, Hereditary, Transthyretin-Related | Familial Amyloid Polyneuropathies

United States, Canada, Argentina, Australia, Bulgaria, Cyprus, Italy, Japan, Malaysia, Mexico, Netherlands, Portugal, Spain, Sweden, Germany, France, Brazil, Turkey, Korea, Republic of, Taiwan, United Kingdom
Intellia Therapeutics

Recruiting

Long-Term Follow-Up (LTFU) of Subjects Dosed With NTLA-2001

Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy | Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy | Wild-Type Transthyretin Cardiac Amyloidosis

United Kingdom, New Zealand, Sweden
Intellia Therapeutics

Active, not recruiting

Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)

Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy | Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy | Wild-Type Transthyretin Cardiac Amyloidosis

France, United Kingdom, New Zealand, Sweden
Alnylam Pharmaceuticals

No longer available

Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)

Amyloid Neuropathies | Amyloid Neuropathies, Familial | TTR-mediated Amyloidosis | Amyloidosis, Hereditary | Amyloidosis, Hereditary, Transthyretin-Related | Familial Amyloid Polyneuropathies

Clinical Trials on Cavernous Angioma, Familial

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