Longevity Families of the Netherlands (LOF-NL)

The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.

The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.

Study Overview

• Status: Recruiting
• Conditions: Aging; Extreme Longevity; Longevity; Familial Longevity

• Study Type: Observational
• Enrollment (Estimated): 600

Contacts and Locations

• Study Contact: Name: (Eline) P. Slagboom, Prof. dr.; Phone Number: +31(0)71 5269 730; Email: p.slagboom@lumc.nl

Study Locations

• Netherlands
  • South Holland
    • Leiden, South Holland, Netherlands, 2333ZA
      • Recruiting
      • Leiden University Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Dutch Caucasian descent:

Ages 75 and older, with siblings enriched for familial longevity, and individuals without a history of familial longevity

Description

Inclusion Criteria:

• Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity
• Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity

Exclusion Criteria:

-

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Cases - Enriched for familial longevity; Siblings of dutch Caucasian descent ages 75 and older
Controls - Non-enriched for familial longevity; Individuals of dutch Caucasian descent ages 75 and older solely in their family.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Identifying the genetic variants of Familial Longevity	To identify gene variants associated with healthy aging and protection from (multi)morbidity	through study completion, an average of 2 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component	To study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component	through study completion, an average of 2 years

Collaborators and Investigators

• Sponsor: Leiden University Medical Center
• Collaborators: Jacobijn Gussekloo, Prof. dr.; Simon P. Mooijaart, Prof. dr.

Study record dates

Study Major Dates

• Study Start (Actual): September 11, 2023
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026

Study Registration Dates

• First Submitted: March 20, 2024
• First Submitted That Met QC Criteria: April 15, 2024
• First Posted (Actual): April 18, 2024

Study Record Updates

• Last Update Posted (Actual): April 18, 2024
• Last Update Submitted That Met QC Criteria: April 15, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Other Study ID Numbers: NL81887.058.23

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No