Clinical Trials on Chromosome 5q Deletion

Total 1595 results

Thomas Jefferson University
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Androgen Effect on Klinefelter Syndrome Motor Outcome

Klinefelter Syndrome

United States
University of Colorado, Denver

Completed

Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment

Klinefelter Syndrome

United States
Novartis Pharmaceuticals

Recruiting

A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP) (ASC4START)

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

Singapore, France, Germany, United Arab Emirates, Greece, Italy, Czechia, Hungary, United States, India, Oman, Malaysia, Korea, Republic of, Turkey, Bulgaria, Canada, Slovakia, United Kingdom, Argentina, Jordan, Romania, South Africa and more
Crystal Mackall, MD
California Institute for Regenerative Medicine (CIRM)

Active, not recruiting

CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells With or Without NKTR-255 in Adults With Recurrent or Refractory B Cell Malignancies

B Acute Lymphoblastic Leukemia | Philadelphia Chromosome Positive | Minimal Residual Disease | CD19 Positive

United States
University of Colorado, Denver
National Institute of Neurological Disorders and Stroke (NINDS); Children's... and other collaborators

Completed

Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome (TestoXXY/KS)

Klinefelter Syndrome | XXY Syndrome

United States
Children's Healthcare of Atlanta

Terminated

Infant Weight Gain With Trisomy 21 and CAVC

Congenital Disorders

United States
University of Colorado, Denver
Children's Hospital Colorado

Recruiting

Generating Advancements Through Longitudinal Analysis in X and Y Variations (GALAXY) (GALAXY)

Sex Chromosome Aneuploidy

United States
Peter L Greenberg
The Leukemia and Lymphoma Society

Completed

Phase II Cont. IV of ON 01910.Na in MDS w/ Trisomy 8/Intermed-1, 2/High Risk

Myelodysplastic Syndromes

United States
Onconova Therapeutics, Inc.

Completed

Efficacy and Safety of ON 01910.Na in Myelodysplastic Syndrome (MDS) Patients With Trisomy 8 or Classified as Intermediate-1, -2 or High Risk

Myelodysplastic Syndrome

United States
Wayne State University

Unknown

Prenatal Computer-Aided Genetics Education Module (CAGEM)

Aneuploidy | Autosomal Recessive Disorder

United States
Nordic MDS Group

Completed

Lenalidomide in High-risk MDS and AML With Del(5q) or Monosomy 5

AML | MDS

Denmark, Norway, Sweden
Eyup Hakan Duran

Recruiting

Preimplantation Genetic Testing for Aneuploidy Counseling (PGT-A)

Patient Education

United States
IVI Vigo
Instituto Valenciano de Infertilidad, IVI VALENCIA; Juno Therapeutics, Inc.

Not yet recruiting

Embryos With Preimplantation Genetic Testing for Aneuploidies (PGT-A) Inconclusive Result: Clinical Implications

Embryo Disorder
The University of Hong Kong

Recruiting

RCT of niPGT for Aneuploidy and Morphology Compared With Morphology Alone in IVF

Preimplantation Diagnosis

China
Instituto Valenciano de Infertilidad, IVI VALENCIA

Completed

Embryo Aneuploidies and Ovarian Stimulation

Embryo Aneuploidies

Spain
University of Liverpool

Completed

Increasing Availability of Lower Energy Meals on Food Choice and Intake

Obesity | Diet, Healthy | Food Selection | Eating Behavior

United Kingdom
University Hospital, Antwerp

Completed

Pupillary Dilation Reflex (PDR) Evaluation During General Anesthesia

Pain

Belgium
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Phase I/II Thymus Transplantation With Immunosuppression #950 (#950)

DiGeorge Anomaly | Complete DiGeorge Anomaly | Complete DiGeorge Syndrome | Complete Atypical DiGeorge Anomaly | Complete Atypical DiGeorge Syndrome

United States
Bausch Health Americas, Inc.

Terminated

Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome

Psychosis | Velo-cardio-facial Syndrome

United States
Clinique Ovo

Active, not recruiting

DFI and Aneuploidies

Embryo Disorder

Canada
Premaitha Health

Completed

A Safer Pre-Natal Diagnosis Using Free DNA in Maternal Blood (IONA)

Aneuploidy, NIPT

United Kingdom
Taipei Veterans General Hospital, Taiwan
National Yang Ming University; National Science and Technology Council

Recruiting

Post COVID-19 Syndrome Study With Questionnaires and Instruments Measurements

Detection

Taiwan
Montclair State University

Completed

Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation

Endothelial Dysfunction
Unilever R&D
King's College London

Completed

Flow Mediated Dilation in Response to Black Tea (T)

Vascular Function

United Kingdom
Stanford University
Santa Clara Valley Medical Center

Completed

Value of Mifepristone in Cervical Preparation Prior to Dilation and Evacuation 19-24 Weeks

Abortion, Induced

United States
Ashley Turner, MD
Society of Family Planning

Completed

Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Control During Cervical Dilator Placement Prior to Dilation and Evacuation

Pain Management

United States
Hospital de Clinicas de Porto Alegre

Completed

Dry vs Wet Misoprostol for Cervical Dilation in First Trimester Abortion (MisoWet)

Abortion Early

Brazil
Planned Parenthood League of Massachusetts
Society of Family Planning

Completed

Cervical Preparation Before Dilation and Evacuation

Abortion, Induced

United States
Ibis Reproductive Health
Society of Family Planning; University of Cape Town; Tygerberg Hospital; Safe Abortion...

Completed

Cervical Priming Before Dilation & Evacuation

Abortion, Induced

South Africa
Associazione Qol-one

Recruiting

Efficacy and Safety of Luspatercept for the Treatment of Anemia Due to MDS With del5q, Refractory/Resistant/Intolerant to Prior Treatments, RBC-TD (Phoenix)

Myelodysplastic Syndromes | Anemia | Transfusion-dependent Anemia | Del(5Q)

Italy
Nanfang Hospital of Southern Medical University
Xiangya Hospital of Central South University; Peking University People's Hospital and other collaborators

Unknown

Risk-stratified Therapy Based on Molecular Cytogenetic Aberration and Treatment Response in AML

MRD | Risk-directed Therapy | Cytogenetic Abnormality | Molecular Abnormality

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Periodontitis and Inflammation in Children With Down Syndrome/Trisomy 21: Study on Biological Samples (NT21)

Periodontitis | Trisomy 21

France
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Pembrolizumab and Blinatumomab in Treating Participants With Recurrent or Refractory Acute Lymphoblastic Leukemia

Philadelphia Chromosome Positive | Recurrent Acute Lymphoblastic Leukemia | Refractory Acute Lymphoblastic Leukemia | CD19 Positive

United States
Centre Leon Berard

Active, not recruiting

Safety and Efficacy of Ponatinib Followed by Imatinib in Patients With Chronic Myelogenous Leukemia in Chronic Phase (TIPI)

Philadelphia Chromosome Positive CML | BCR-ABL Positive Chronic Myelogenous Leukemia

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

ABL001 for the Treatment of Chronic Myeloid Leukemia in Patients Who Are on Therapy With Tyrosine Kinase Inhibitor

Philadelphia Chromosome Negative, BCR-ABL1 Positive Chronic Myelogenous Leukemia

United States
Versailles Hospital

Active, not recruiting

Study of Inotuzumab Ozogamicin Combined to Chemotherapy in Older Patients With Philadelphia Chromosome-negative CD22+ B-cell Precursor ALL (EWALL-INO)

Acute Lymphoblastic Leukemia (ALL) - Philadelphia Chromosome (Ph)-Negative CD22+ B-cell Precursor (BCP)

France
National Cancer Institute (NCI)

Terminated

Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Recurrent Adult Acute Lymphoblastic Leukemia | Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia

United States
Institute of Hematology & Blood Diseases Hospital...

Recruiting

Detecting Minimal Residual Diseases (MRD) and Monitoring Clonal Evolution Using Ultrasensitive Chromosomal Aberrations Detection (UCAD) in Multiple Myeloma

Multiple Myeloma
M.D. Anderson Cancer Center
Ascentage Pharma Group Inc.

Not yet recruiting

A Phase I Study of Decitabine, Lisaftoclax, and Olverembatinib in Patients With Advanced Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid Leukemia

Advanced Chronic Myeloid Leukemia | Philadelphia Chromosome-Positive Acute Myeloid Leukemia

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Combination Chemotherapy and Inotuzumab Ozogamicin in Treating Patients With B Acute Lymphoblastic Leukemia

B Acute Lymphoblastic Leukemia | B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative | Acute Lymphoblastic Leukemia in Remission

United States
University of Roma La Sapienza

Completed

Androgen for Leydig Cell Proliferation (ALCeP)

Klinefelter Syndrome | Hypergonadotropic Hypogonadism | Hypergonadotropic Azospermia | Hypergonadotropic Cryptozoospermia

Italy
Azienda USL Modena

Completed

Human Chorionic Gonadotropin Stimulation Effects on Steroidogenesis in Men With Klinefelter Syndrome

Klinefelter Syndrome | Steroidogenesis | Human Chorionic Gonadotropin (hCG) Stimulation

Italy
Cancer Institute and Hospital, Chinese Academy...

Unknown

Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia | B-cell Childhood Acute Lymphoblastic Leukemia | Philadelphia Chromosome, Ph^1^, Absent

China
University Hospital Muenster

Completed

Epigenetics and Metabolic Disorders in Men With the Klinefelter Syndrome (IZKF-CRA03-09)

Klinefelter Syndrome, Hypogonadism
Children's Mercy Hospital Kansas City

Terminated

Use of Liquid Stable Levothyroxine in Trisomy 21 Pediatric Patients

Hypothyroidism | Trisomy 21

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Low-Intensity Chemotherapy and Blinatumomab in Treating Patients With Philadelphia Chromosome Negative Relapsed or Refractory Acute Lymphoblastic Leukemia

Recurrent B Acute Lymphoblastic Leukemia | Refractory B Acute Lymphoblastic Leukemia | Philadelphia Chromosome Negative

United States
Novartis Pharmaceuticals

Completed

A Randomized Phase III Study to Assess the Effect of a Longer Duration of Consolidation Treatment With Nilotinib on TFR in CP CML. (ENESTPath)

Philadelphia Chromosome Positive (PH+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)

Germany, Belgium, France, Italy, Spain, Hungary, Austria, Sweden, Bulgaria, Denmark, Greece, Slovenia, United Kingdom, Czechia, Romania, Serbia, Slovakia, Portugal, Finland, Norway, Poland
Nanfang Hospital of Southern Medical University
Guangxi Medical University; Peking University People's Hospital; Sun Yat-Sen... and other collaborators

Unknown

TKI Therapy Based on Molecular Monitoring in Allogeneic-HSCT Recipients With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia

Stem Cell Transplantation | Minimal Residual Disease | Philadelphia Chromosome Positive Acute Lymphocytic Leukemia

China
Memorial Sloan Kettering Cancer Center
Jazz Pharmaceuticals

Withdrawn

Intravenous Erwinia Chrysanthemi Asparaginase in Patients With Newly Diagnosed Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Aged 60 Years or Older

Acute Lymphoblastic Leukemia (ALL) | Newly Diagnosed Philadelphia Chromosome Negative | Aged 60 Years or Older

United States
Man Clinic for Andrology, Male Infertility and...

Completed

Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection

Azoospermia | Klinefelter Syndrome

Egypt

Clinical Trials on Chromosome 5q Deletion

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Italy

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations