Clinical Trials on Degenerative Disc Disease (DDD) in Switzerland

Total 152 results

Hoffmann-La Roche

Active, not recruiting

A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (AVONELLE-X)

Neovascular Age-related Macular Degeneration

United States, Korea, Republic of, United Kingdom, Japan, Canada, Turkey, Argentina, Australia, Denmark, France, Germany, Hungary, Italy, Poland, Spain, Singapore, Austria, Brazil, Hong Kong, Israel, Portugal, Russian Federation, Ta... and more
Bayer

Terminated

Regorafenib Eye Drops: Investigation of Efficacy and Safety in Neovascular Age Related Macular Degeneration (DREAM)

Macular Degeneration

Hong Kong, Korea, Republic of, United States, Canada, Switzerland, Spain, Japan, Italy, Czech Republic, Australia, Austria, Slovakia, Germany, Hungary, Israel, Chile, France, Colombia
Bayer

Completed

Efficacy and Safety of Two Different Aflibercept Regimens in Subjects With Neovascular Age-related Macular Degeneration (nAMD)

Macular Degeneration

Spain, Switzerland, Portugal, France, Canada, United Kingdom, Austria, Slovakia, Germany, Hungary, Italy, Lithuania, Czechia, Poland
Edwards Lifesciences
ICON plc

Terminated

Observational Registry on the HARPOON Device (REPLICATE)

Severe Degenerative Mitral Regurgitation Due to Mid-segment Posterior Leaflet Prolapse

Germany, Spain, Switzerland
Novartis Pharmaceuticals

Completed

Observation of Treatment Patterns With Lucentis® in Real-life Conditions in All Approved Indications (PACIFIC)

Neovascular (Wet) Age-related Macular Degeneration

Germany, Switzerland, Netherlands
University Hospital, Basel, Switzerland
Institute of Molecular and Clinical Ophthalmology Basel

Recruiting

EyeConic: Qualification for Cone-Optogenetics

Retinal Dystrophies

United States, Switzerland, China, Germany, Hungary, Italy, United Kingdom
Bayer
Regeneron Pharmaceuticals

Active, not recruiting

Study of the Effects of High Dose Aflibercept Injected Into the Eye of Patients With an Age-related Disorder That Causes Loss of Vision Due to Growth of Abnormal Blood Vessels at the Back of the Eye (PULSAR)

Neovascular Age-Related Macular Degeneration

Spain, Korea, Republic of, Czechia, Japan, Singapore, United States, China, Serbia, Lithuania, Taiwan, Australia, Estonia, Austria, Israel, France, Italy, Switzerland, Slovakia, Ukraine, Portugal, Bulgaria, Latvia, Canada, Hungary, Arge... and more
Novartis Pharmaceuticals

Completed

Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON) (TALON)

Age-related Macular Degeneration

United States, Austria, Czechia, Italy, Taiwan, Belgium, Germany, Australia, Israel, Canada, France, Spain, Korea, Republic of, United Kingdom, Portugal, Netherlands, Sweden, Argentina, Malaysia, Switzerland
Hoffmann-La Roche

Completed

A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular Degeneration (TENAYA)

Wet Macular Degeneration

United Kingdom, Germany, Japan, Netherlands, United States, Canada, Hungary, Italy, Mexico, Poland, Spain, Israel, Russian Federation, Switzerland, Turkey
University Hospital, Grenoble

Completed

Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease (META-DEM)

Healthy | Alzheimer Disease | Semantic Dementia

France, Switzerland
Allergan

Completed

A Safety and Efficacy Study of Abicipar Pegol in Participants With Neovascular Age-related Macular Degeneration (CEDAR)

Macular Degeneration

Spain, United States, Korea, Republic of, Israel, Singapore, Argentina, Germany, France, Czechia, Austria, Philippines, Switzerland, Chile, Colombia, Hong Kong, Latvia, New Zealand
Apellis Pharmaceuticals, Inc.

Active, not recruiting

An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis (VALE)

C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Dense Deposit Disease | DDD | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative...

United States, Australia, Brazil, Czechia, France, Italy, Korea, Republic of, Netherlands, Spain, Switzerland, United Kingdom
Bayer

Completed

Efficacy and Safety of Three Different Aflibercept Regimens in Subjects With Diabetic Macular Edema (DME) (VIOLET)

Macular Edema

Spain, Canada, Switzerland, Portugal, Austria, Poland, Slovakia, United Kingdom, Germany, Hungary, Italy, France, Lithuania, Czechia
Hoffmann-La Roche

Recruiting

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products (VOYAGER)

Diabetic Macular Edema | Neovascular Age-related Macular Degeneration

Spain, Germany, Croatia, Israel, Japan, United Kingdom, United States, Italy, Switzerland, France, Canada, Australia, Singapore, Puerto Rico, United Arab Emirates, Bulgaria, Chile, Czechia
Aesculap AG

Active, not recruiting

CoreHip - Post Market Clinical Follow-Up Study

Degenerative Osteoarthritis | Rheumatic Arthritis | Fractures, Hip | Necrosis, Femur Head

Germany, Switzerland
Hoffmann-La Roche

Terminated

A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (CHROMA)

Geographic Atrophy

Canada, United States, Belgium, Peru, Argentina, Australia, Austria, Denmark, France, Germany, Hungary, Italy, Mexico, Netherlands, Poland, Slovakia, Spain, Switzerland, United Kingdom
Hoffmann-La Roche

Terminated

A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (SPECTRI)

Geographic Atrophy

United States, United Kingdom, Netherlands, Germany, Belgium, Poland, Spain, Argentina, Australia, Hungary, Italy, Portugal, France, Turkey, Austria, Russian Federation, Mexico, Peru, Denmark, Slovakia, Sweden, Switzerland
Novartis Pharmaceuticals

Completed

Randomized Study for Efficacy and Safety of Ranibizumab 0.5mg in Treat-extend and Monthly Regimens in Patients With nAMD (TREND)

Age-related Macular Degeneration | Choroidal Neovascularization

Korea, Republic of, Croatia, Germany, India, Russian Federation, Turkey, United Kingdom, Egypt, Israel, Belgium, Denmark, Hungary, Slovenia, Spain, Switzerland, Italy, Portugal, Slovakia, Chile
Oxurion

Completed

A Study to Evaluate THR-317 and Ranibizumab Combination Treatment for Diabetic Macular Oedema (DME)

Diabetes Mellitus | Diabetic Retinopathy | Macular Edema

France, United Kingdom, Belgium, Spain, Germany, Slovakia, Switzerland
Apellis Pharmaceuticals, Inc.

Active, not recruiting

Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN (NOBLE)

Renal Transplant | C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative... and other conditions

United States, Australia, Austria, United Kingdom, Brazil, Argentina, France, Italy, Netherlands, Spain, Switzerland
Second Sight Medical Products
National Eye Institute (NEI)

Completed

Argus® II Retinal Stimulation System Feasibility Protocol

Retinitis Pigmentosa

United States, United Kingdom, France, Mexico, Switzerland
Hoffmann-La Roche

Recruiting

Vamikibart in Participants With Uveitic Macular Edema (Sandcat)

Uveitic Macular Edema

India, United States, Japan, Australia, Singapore, Turkey, Argentina, Germany, Czechia, Spain, France, Switzerland
Hoffmann-La Roche

Terminated

Long-Term Safety of Lampalizumab Intravitreal (ITV) Injections in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OMASPECT)

Geographic Atrophy

United States, United Kingdom, Germany, France, Turkey, Australia, Austria, Belgium, Canada, Denmark, Hungary, Italy, Poland, Slovakia, Spain, Switzerland, Portugal, Netherlands, Peru
Novartis Pharmaceuticals

Completed

To Assess the Efficacy and Safety of Intravitreal Ranibizumab in People With Vision Loss Due to Macular Edema

Macular Edema (ME)

Russian Federation, Turkey, United Kingdom, Belgium, Australia, Hungary, Switzerland, Germany, Italy, Korea, Republic of, Israel, Spain, France, Latvia, Netherlands, Slovakia, Czech Republic, Singapore, Canada
Bayer

Completed

Investigation of the Change of Vision-related Quality of Life in Subjects Treated With Aflibercept According to EU Label for DME. (AQUA)

Macular Edema

Spain, Canada, Switzerland, Portugal, Austria, Poland, Slovakia, United Kingdom, France, Czechia, Germany, Hungary, Italy, Lithuania
Bayer
Regeneron Pharmaceuticals

Completed

Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD) (VIEW 2)

Macular Degeneration

Belgium, Israel, Italy, Spain, Korea, Republic of, Switzerland, Germany, Portugal, Japan, France, Australia, Netherlands, India, Austria, Brazil, Poland, United Kingdom, Singapore, Hungary, Latvia, Mexico, Czech Republic, Colombia, Ar... and more
Jaeb Center for Health Research
Usher 1F Collaborative; Marjorie C. Adams Foundation

Active, not recruiting

Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F (RUSH1F)

Retinal Degeneration | Retinitis Pigmentosa | Eye Diseases, Hereditary

Switzerland, United States, Germany, Netherlands, Canada, France, Israel
Jaeb Center for Health Research
Foundation Fighting Blindness

Recruiting

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants (Uni-Rare)

Retinitis Pigmentosa | Inherited Retinal Degeneration

United States, United Kingdom, France, Finland, Israel, Netherlands, Switzerland, Australia, Canada, Brazil, Mexico
Janssen Research & Development, LLC

Recruiting

A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Geographic Atrophy

Netherlands, United States, Belgium, Italy, Germany, United Kingdom, Denmark, Spain, Czechia, Switzerland, Turkey, Canada, Hungary, Portugal, Australia, Sweden, Poland
Hoffmann-La Roche

Completed

A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Diabetic Macular Edema (Rhone-X)

Diabetic Macular Edema

United States, Korea, Republic of, United Kingdom, Brazil, Japan, Canada, Argentina, Australia, Austria, Denmark, France, Germany, Hungary, Italy, Poland, Slovakia, Spain, Singapore, Czechia, Hong Kong, Israel, Portugal, Russian Federation and more
Hoffmann-La Roche

Completed

A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (RHINE)

Diabetic Macular Edema

United States, Korea, Republic of, United Kingdom, Brazil, China, Canada, Argentina, Australia, Denmark, France, Italy, Poland, Spain, Germany, Singapore, Czechia, Hong Kong, Portugal, Russian Federation, Taiwan, Hungary, Switzerland and more
Pfizer

Completed

A Multi-Center Trial To Evaluate The Safety And Efficacy Of Pegaptanib Sodium(Macugen) Injected Into The Eye Every 6 Weeks For Up To 2 Years For Macular Swelling Associated With Diabetes, With An Open-Label Macugen Year Extension.

Macular Edema Associated With Diabetes Mellitus

United States, Colombia, Australia, Germany, Italy, South Africa, Greece, France, Austria, United Kingdom, Denmark, India, Portugal, Brazil, Canada, Czechia, Netherlands, Switzerland
QLT Inc.

Completed

Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT

Leber Congenital Amaurosis (LCA) | Retinitis Pigmentosa (RP)

United States, Canada, Denmark, Germany, Netherlands, Switzerland, United Kingdom
Apellis Pharmaceuticals, Inc.

Active, not recruiting

Phase III Study Assessing the Efficacy and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis (VALIANT)

C3G | IC-MPGN | C3 Glomerulopathy | C3 Glomerulonephritis | Complement 3 Glomerulopathy | Complement 3 Glomerulopathy (C3G) | Complement 3 Glomerulonephritis | Dense Deposit Disease | DDD | Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis (MPGN) | Immune Complex Membranoproliferative...

United States, Spain, France, Germany, United Kingdom, Netherlands, Brazil, Israel, Japan, Australia, Austria, Italy, Switzerland, Korea, Republic of, Czechia, Belgium, Argentina, Canada, Poland
Edwards Lifesciences

Recruiting

Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial (CLASP IID/IIF)

Mitral Regurgitation | Mitral Insufficiency | Functional Mitral Regurgitation | Degenerative Mitral Valve Disease

United States, Canada, Switzerland, Germany
Novartis Pharmaceuticals

Completed

A Study of the Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema (KITE)

Diabetic Macular Edema

Czechia, India, Russian Federation, Taiwan, Turkey, Lebanon, Denmark, Estonia, France, Germany, Hungary, Korea, Republic of, Latvia, Lithuania, Bulgaria, Norway, Belgium, Malaysia, Sweden, Slovakia, Singapore, Poland, Switzerland
Abbott Medical Devices

Active, not recruiting

The CONFIDENCE Registry

Severe Aortic Stenosis | Symptomatic Degenerative Aortic Stenosis

Spain, Italy, United Kingdom, Germany, Switzerland, Czechia, Australia, Belgium, Poland
Janssen Research & Development, LLC
Janssen Research & Development, LLC

Active, not recruiting

Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

X-Linked Retinitis Pigmentosa

United States, Canada, Israel, United Kingdom, Denmark, France, Belgium, Italy, Netherlands, Switzerland, Spain
Janssen Research & Development, LLC
Janssen Research & Development, LLC

Active, not recruiting

Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

X-Linked Retinitis Pigmentosa

Belgium, Canada, United States, Israel, United Kingdom, Denmark, France, Italy, Netherlands, Switzerland, Spain
Santhera Pharmaceuticals

Terminated

A Phase III Double-blind Study With Idebenone in Patients With Duchenne Muscular Dystrophy (DMD) Taking Glucocorticoid Steroids (SIDEROS)

Duchenne Muscular Dystrophy (DMD)

United States, Spain, Netherlands, Sweden, Germany, France, Belgium, United Kingdom, Italy, Ireland, Switzerland, Austria, Bulgaria, Hungary, Israel
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Ranibizumab in Two "Treat and Extend" Treatment Algorithms Versus Ranibizumab As Needed in Patients With Macular Edema and Visual Impairment Secondary to Diabetes Mellitus (RETAIN)

Diabetic Macular Edema

Belgium, United Kingdom, Netherlands, Ireland, Switzerland, Italy, Hungary, France, Spain, Portugal, Poland, Czech Republic, Greece
Novartis Pharmaceuticals

Completed

Ranibizumab Intravitreal Injections in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion (CRYSTAL)

Central Retinal Vein Occlusion | Macular Edema

Greece, Hungary, Turkey, Australia, Austria, Netherlands, United Kingdom, Italy, Spain, Ireland, Portugal, Slovakia, Canada, Switzerland, Czech Republic, Poland, Denmark, Sweden
Institut für Pharmakologie und Präventive Medizin
Edwards Lifesciences

Recruiting

The ReTAVI Prospective Observational Registry

Aortic Valve Stenosis | Structural Valve Degeneration | Structural Valve Deterioration

Austria, Spain, Switzerland, France, Italy, Germany, Poland, Canada, Israel, Netherlands, Portugal, United Kingdom
Novartis Pharmaceuticals

Terminated

Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Branch Retinal Vein Occlusion (RAPTOR)

Branch Retinal Vein Occlusion

China, Austria, Czechia, Russian Federation, Taiwan, United Kingdom, Canada, Japan, United States, France, Israel, Germany, Italy, Hong Kong, Spain, Denmark, Slovakia, Puerto Rico, Switzerland
KemPharm Denmark A/S

Completed

A Prospective Non-therapeutic Study in Patients Diagnosed With Niemann-Pick Disease Type C

Niemann-Pick Disease, Type C

Spain, France, United Kingdom, Switzerland, Denmark, Poland, Italy, Germany
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Ranibizumab in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia

Pathological Myopia

Germany, India, Japan, Turkey, Austria, Switzerland, Italy, Lithuania, Hungary, France, Slovakia, United Kingdom, Korea, Republic of, Portugal, Hong Kong, Canada, Singapore, Spain, Latvia, Poland
IntraBio Inc

Active, not recruiting

A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type C

Niemann-Pick Disease, Type C

United States, Australia, United Kingdom, Germany, Slovakia, Netherlands, Czechia, Switzerland
Bayer
Regeneron Pharmaceuticals

Recruiting

A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion) (QUASAR)

Macular Edema Secondary to Retinal Vein Occlusion

Korea, Republic of, Japan, China, Lithuania, United States, Italy, Spain, Hungary, Israel, Portugal, Serbia, Poland, United Kingdom, Thailand, Czechia, Austria, Turkey, Australia, Bulgaria, Estonia, France, Georgia, Germany, Latvia, Mal... and more
Johns Hopkins University
Mayo Clinic; Medical University of Graz; Radboud University Medical Center; University... and other collaborators

Recruiting

Oral N-acetylcysteine for Retinitis Pigmentosa (NAC Attack)

Retinitis Pigmentosa

United States, Austria, Mexico, Netherlands, United Kingdom, Germany, Canada, Switzerland
ZevraDenmark

Active, not recruiting

Arimoclomol Prospective Study in Participants Diagnosed With Niemann-Pick Disease Type C

Niemann-Pick Disease, Type C

United States, Spain, United Kingdom, Denmark, France, Germany, Italy, Poland, Switzerland

Clinical Trials on Degenerative Disc Disease (DDD) in Switzerland

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CROs in Vietnam

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