A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products (VOYAGER)

Real-World, Long-Term Data Collection to Gain Clinical Insights Into Roche Ophthalmology Products (VOYAGER STUDY)

The VOYAGER study is a primary data collection, non-interventional, prospective, multinational, multicenter study. It is designed to collect real-world, long-term data to explore long-term effectiveness, safety, clinical insights, treatment patterns, and factors driving the treatment decisions among patients being treated with specified Roche ophthalmology products in approved retinal indications (Faricimab for neovascular age-related macular degeneration [nAMD], diabetic macular edema [DME], and retinal vein occlusion; Port Delivery System with Ranibizumab for nAMD) in routine clinical practice. This study will not provide or make recommendations on use of any products including Roche products; treatment decisions will be determined by the treating physician and must be made independently to the decision to participate in this study. Participation in this study will not change or influence a patient's standard of care in any way.

Study Overview

• Status: Active, not recruiting
• Conditions: Central Retinal Vein Occlusion; Diabetic Macular Edema; Retinal Vein Occlusion; Neovascular Age-related Macular Degeneration; Branch Retinal Vein Occlusion; Hemi-retinal Vein Occlusion
• Intervention / Treatment: Drug: Faricimab; Combination product: Port Delivery System with Ranibizumab

• Study Type: Observational
• Enrollment (Estimated): 6000

Contacts and Locations

Study Locations

• Argentina
  • Buenos Aires, Argentina, C1056AAN
    • Instituto Oftalmologico de Buenos Aires S.A.
  • Ciudad Autonoma Buenos Aires, Argentina, C1116ABA
    • Centro Oftalmologico Dr. Charles S.A.
  • Córdoba, Argentina, 5000
    • Centro Privado de Ojos Romagosa S.A
  • San Miguel de Tucumán, Argentina, T4000IOA
    • CEO Centro de Especialidades Oftalmologicas Tucuman
  • Buenos Aires
    • Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1056
      • Salud Ocular
• Australia
  • New South Wales
    • Hurstville, New South Wales, Australia, 2220
      • Retina and Macula Specialists
    • Westmead, New South Wales, Australia, 2145
      • Sydney West Retina
  • Queensland
    • Geebung, Queensland, Australia, 4034
      • Sunshine Coast University Hospital
  • Victoria
    • East Melbourne, Victoria, Australia, 3002
      • Centre for Eye Research Australia
    • Melbourne, Victoria, Australia, 3144
      • Cabrini Hospital Malvern
    • Rowville, Victoria, Australia, 3178
      • Retina Specialists Victoria
  • Western Australia
    • Broome, Western Australia, Australia, 6725
      • Lions Outback Vision Service in Broome
    • Nedlands, Western Australia, Australia, 6009
      • The Lions Eye Institute
• Bulgaria
  • Sofia, Bulgaria, 1303
    • Medical Center for Eye Health ? Focus Ltd
  • Sofia, Bulgaria, 1319
    • Specialized Eye Hospital Pentagram
  • Sofia, Bulgaria, 1784
    • Specialized Hospital for Active Treatment of Ophthalmologic Diseases ?Zora?, OOD
  • Varna, Bulgaria, 9000
    • Eye Clinic St. Petka - Varna
  • Varna, Bulgaria, 9002
    • SHEDAT - Varna EOOD
• Canada
  • Québec, Canada, G1V 1T6
    • Centre Oculaire de Quebec
  • British Columbia
    • New Westminster, British Columbia, Canada, V3L 5H1
      • Retina Surgical Associates
  • Ontario
    • Don Mills, Ontario, Canada, M1E 4A7
      • Toronto Retina Institute
    • Hamilton, Ontario, Canada, L9C 0E3
      • St Joseph's Centre for Mountain Health Services
    • London, Ontario, Canada, N6A 4V2
      • St. Joseph's Health Care - London
    • Ottawa, Ontario, Canada, K2B 7E9
      • Retina Institute of Ottawa
    • Vaughan, Ontario, Canada, L4K 0J4
      • Clarity eye Institute
  • Quebec
    • Boisbriand, Quebec, Canada, J7H 0E8
      • Institut de L'Oeil des Laurentides
    • Montreal, Quebec, Canada, H1TY 0E2
      • Clinique d'ophtalmologie et de Retine de l'est
    • Montreal, Quebec, Canada, H4P 2S4
      • Eye Health MD (Opthalmology)
    • Sainte-Catherine, Quebec, Canada, J5C 1V9
      • Retina MD Clinic
• Chile
  • Las Condes, Chile, 7600830
    • Centro de la Vision
  • Santiago Metropolitan
    • Santiago, Santiago Metropolitan, Chile, 7620002
      • Red Salud UC Christus
• Croatia
  • Karlovac, Croatia, 47000
    • General Hospital Karlovac
  • Osijek, Croatia, 31000
    • Clinical Hospital Centre Osijek
  • Rijeka, Croatia, 51000
    • Clinical Hospital Centre Rijeka
  • Zagreb, Croatia, 10000
    • University Hospital Center Zagreb
  • Zagreb, Croatia, 10000
    • Special Hospital for Ophthalmology Svjetlost
• Czechia
  • Pardubice, Czechia, 530 03
    • Nemocnice Pardubickeho kraje a.s.
  • Prague, Czechia, 100 34
    • Fakultni nemocnice Kralovske Vinohrady
  • Zlín, Czechia, 762 75
    • Tomas Bata Regional Hospital
• Denmark
  • Aalborg, Denmark, 9100
    • Ålborg Universitets Hospital
  • Glostrup Municipality, Denmark, 2600
    • Rigshospitalet Glostrup
  • Roskilde, Denmark, 4000
    • Sjllands Universitetshospital
• Egypt
  • Cairo, Egypt, 0000
    • Egypt Air Hospital
• France
  • Aix-en-Provence, France, 13090
    • Aix Vision
  • Bordeaux, France, 33000
    • Centre Rétine Gallien
  • Créteil, France, 94010
    • Centre Hospitalier Intercommunal de Creteil
  • Floirac, France, 33270
    • Clinique des Yeux Bordeaux
  • Fontainebleau, France, 77300
    • Centre d'Ophtalmologie
  • Grenoble, France, 38000
    • Centre Optha Du Dauphine
  • La Rochelle, France, 17019
    • Hôpital Saint-Louis - La Rochelle
  • Lagord, France, 17140
    • Visiopole Private Practice
  • Lyon, France, 69002
    • Centre Ophtalmologique Rabelais
  • Lyon, France, 69006
    • Centre Ophtalmologique Kleber
  • Marseille, France, 13008
    • Centre Monticelli Paradis d Ophtalmologie
  • Montargis, France, 45200
    • Clinique de Montargis
  • Montauban, France, 82000
    • Clinique Honoré Cave
  • Montbonnot-Saint-Martin, France, 38330
    • Alpes Retine
  • Montpellier, France, 34000
    • Centre Des Arceaux
  • Nice, France, 06006
    • CHU Nice - Hôpital Saint Roch
  • Paris, France, 75006
    • Centre Ophtalmologique de L'Odeon
  • Paris, France, 75015
    • Centre Ophtalmologique d?Imagerie et de Laser
  • Poitiers, France, 86021
    • CHU Poitiers - Hôpital la Milétrie
  • Saint-Cyr-sur-Loire, France, 37540
    • Centre St Exupery
  • Saint-Herblain, France, 44800
    • Institut Sourdille
  • Saint-Jean, France, 31240
    • Clinique de l'Union
  • Toulouse, France, 31059
    • CHU Toulouse
  • Écully, France, 69130
    • Clinique du Val d'Ouest- Institut Rhône Alpin
  • Bas Rhin
    • Strasbourg, Bas Rhin, France, 67000
      • Centre Ophtalmologique Maison-Rouge
  • Bouches Du Rh(ne
    • Marseille, Bouches Du Rh(ne, France, 13285
      • CH St Joseph
  • Cte-d'Or
    • Dijon, Cte-d'Or, France, 21079
      • CHU Dijon - Hôpital François Mitterrand
  • Gironde
    • Bordeaux, Gironde, France, 33800
      • Groupe Hospitalier Pellegrin
  • Loire Atlantique
    • Nantes, Loire Atlantique, France, 44093
      • CHU de Nantes - Hotel Dieu
  • Paris
    • Nantes, Paris, France, 44300
      • Institut Ophtalmologique De l Ouest Jules Verne
  • Pays de la Loire Region
    • Saint-Étienne-de-Montluc, Pays de la Loire Region, France, 42055
      • CHU de St-Etienne - Hopital Nord
  • Rhone
    • Lyon, Rhone, France, 69004
      • Centre Hospitalier de la Croix Rousse
    • Lyon, Rhone, France, 69003
      • Hopital Edouard Herriot - CHU Lyon
  • Seine Maritime
    • Rouen, Seine Maritime, France, 76000
      • Clinique Mathilde
  • Seine Saint Denis
    • Bobigny, Seine Saint Denis, France, 93000
      • Hôpital Avicenne
  • Somme
    • Amiens, Somme, France, 80080
      • CHU Amiens Picardie, Centre de Recherche Clinique
  • Yvelines
    • Le Chesnay, Yvelines, France, 78150
      • Centre Hospitalier de Versailles
• Germany
  • Berlin, Germany, 12351
    • Vivantes Klinikum Neukoelln
  • Berlin, Germany, 10713
    • St. Gertrauden Krankenhaus Berlin, Augenheilkunde
  • Chemnitz, Germany, 09116
    • Klinikum Chemnitz gGmbH
  • Cologne, Germany, Koeln
    • Universitaetsklinikum Koeln
  • Halle, Germany, 06120
    • Universitaetsklinikum Halle (Saale)
  • Heidelberg, Germany, 69120
    • Universitaetsklinikum Heidelberg
  • Mannheim, Germany, 68305
    • Universitätsklinikum Mannheim
  • Rostock, Germany, 18057
    • Praxis Dr. Amin Gamael
  • Rostock, Germany, 18057
    • Universitaetsaugenklinik Rostock
  • Sulzbach, Germany, 66280
    • Knappschaftskrankenhaus Sulzbach
  • Bavaria
    • Erlangen, Bavaria, Germany, 91054
      • Augenklinik des Universitaetsklinikums Erlangen
    • Trier, Bavaria, Germany, 86438
      • Medical Eye Research Xpertx Institut gGmbH
    • Würzburg, Bavaria, Germany, 97080
      • Private Practice of Dr. Astrid Sader Moritz
  • Brandenburg
    • Cottbus, Brandenburg, Germany, 03048
      • Carl-Thiem-Klinikum Cottbus gGmbH - Augenklinik
    • Potsdam, Brandenburg, Germany, 14467
      • Klinikum Ernst von Bergmann gGmbH
  • Hesse
    • Frankfurt am Main, Hesse, Germany, 60590
      • Universitaetsklinikum Frankfurt Goethe-Universitaet
    • Frankfurt am Main, Hesse, Germany, 60549
      • Augenzentrum Prof. Koch GmbH
  • Lower Saxony
    • Hanover, Lower Saxony, Germany, 30625
      • Medizinische Hochschule Hannover
  • Mecklenburg-Vorpommern
    • Greifswald, Mecklenburg-Vorpommern, Germany, 17475
      • Universitaetsmedizin Greifswald
  • Rhineland-Palatinate
    • Ludwigshafen am Rhein, Rhineland-Palatinate, Germany, 67063
      • Apotheke am Klinikum Ludwigshafen
  • Saxony
    • Dresden, Saxony, Germany, 01307
      • Universitaetsklinikum Carl Gustav Carus TU Dresden
    • Leipzig, Saxony, Germany, 04103
      • Universitaetsklinikum Leipzig
    • Zschopau, Saxony, Germany, 09405
      • Augenzentrum Erzgebirge
  • Saxony-Anhalt
    • Dessau, Saxony-Anhalt, Germany, 06847
      • Martin-Luther-Universitaet Halle-Wittenberg - Staedtisches Klinikum Dessau (SKD)
  • Schleswig-Holstein
    • Lübeck, Schleswig-Holstein, Germany, 23538
      • Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
• Hong Kong
  • Hong Kong, Hong Kong, 00000
    • Grantham Hospital
  • Kowloon, Hong Kong, 000000
    • Hong Kong Eye Hospital
• Israel
  • Haifa, Israel, 31096
    • Rambam Health Care Campus
  • Holon, Israel, 58100
    • Wolfson Medical Center
  • Jerusalem, Israel, 9112001
    • Hadassah
  • Kfar Saba, Israel, 4428164
    • Meir Medical Center
  • Petah Tikva, Israel, 49100
    • Rabin MC
  • Tel Aviv, Israel, 6423906
    • Tel-Aviv Sourasky Medical Center
  • Tel Aviv, Israel, 6789140
    • Assuta Hashalom Medical Center
• Italy
  • Abruzzo
    • Chieti, Abruzzo, Italy, 66100
      • Ospedale Clinicizzato SS. Annunziata
  • Apulia
    • Bari, Apulia, Italy, 70124
      • Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari
  • Calabria
    • Catanzaro, Calabria, Italy, 88100
      • Azienda Ospedaliero Universitaria Mater Domini
  • Campania
    • Naples, Campania, Italy, 80131
      • Ospedale Monaldi - AORN dei Colli
  • Friuli Venezia Giulia
    • Udine, Friuli Venezia Giulia, Italy, 33100
      • Azienda Ospedaliera di Udine Ospedale S. Maria della Misericordia
  • Lazio
    • Rome, Lazio, Italy, 00168
      • Fondazione Policlinico Universitario Agostino Gemelli IRCCS
    • Rome, Lazio, Italy, 00133
      • Fondazione Ptv Policlinico Tor Vergata
    • Rome, Lazio, Italy, 00184
      • G. B. Bietti Fondazione - IRCCS
    • Rome, Lazio, Italy, 189
      • Azienda Ospedaliera Sant'Andrea-Universitr di Roma La Sapien
  • Liguria
    • Genoa, Liguria, Italy, 16132
      • IRCCS Ospedale Policlinico San Martino
  • Lombardy
    • Bergamo, Lombardy, Italy, 24125
      • Humanitas Gavazzeni
    • Milan, Lombardy, Italy, 20132
      • Ospedale San Raffaele
    • Milan, Lombardy, Italy, 20122
      • Fondazione IRCCS CA? Granda Ospedale Maggiore Policlinico
    • Milan, Lombardy, Italy, 20123
      • Ospedale San Giuseppe Fatebenefratelli
    • Milan, Lombardy, Italy, 20142
      • Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo (San Paolo-Polo Universitario)
    • Milan, Lombardy, Italy
      • Azienda Socio Sanitaria Territoriale Fatebenefratelli (Presidio Ospedale Sacco)
    • Monza, Lombardy, Italy, 20900
      • Fondazione IRCCS - San Gerardo dei Tintori
  • Piedmont
    • Acquaviva Delle Fonti, Piedmont, Italy, 70021
      • Ente Ecclesiastico Ospedale Generale Regionale F Miulli
    • Turin, Piedmont, Italy, 10122
      • Ospedale Oftalmico
    • Turin, Piedmont, Italy, 10126
      • Città della Salute e della Scienza di Torino. Presidio Molinette
    • Turin, Piedmont, Italy, 10128
      • Ospedale Mauriziano Umberto I
  • Sardinia
    • Sassuolo, Sardinia, Italy, 41049
      • Ospedale Di Sassuolo
  • Sicily
    • Catania, Sicily, Italy, 95123
      • Azienda Ospedaliera Universitaria "Policlinico - Vittorio Emanuele" (Presidio Gaspare Rodolico)
    • Palermo, Sicily, Italy, 90127
      • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
  • The Marches
    • Ancona, The Marches, Italy, 60126
      • Azienda Ospedaliero Universitaria delle Marche
• Japan
  • Aichi, Japan, 460-0008
    • Sugita Eye Hospital
  • Aichi, Japan, 467-8602
    • Nagoya City University Hospital
  • Aichi, Japan, 457-8510
    • Chukyo Hospital
  • Akita, Japan, 010-8543
    • Akita University Hospital
  • Chiba, Japan, 260-8677
    • Chiba University Hospital
  • Chiba, Japan, 279-0021
    • Juntendo University Urayasu Hospital
  • Chuo-shi, Japan, 409-3898
    • University of Yamanashi Hospital
  • Fukuoka, Japan, 812-8582
    • Kyushu University Hospital
  • Fukuoka, Japan, 830-0011
    • Kurume University Hospital
  • Gifu, Japan, 501-1194
    • Gifu University Hospital
  • Hiroshima, Japan, 734-8551
    • Hiroshima University Hospital
  • Hokkaido, Japan, 060-8604
    • Sapporo City General Hospital
  • Ibaraki, Japan, 305-8576
    • University of Tsukuba Hospital
  • Ibaraki, Japan, 310-0845
    • Kozawa Eye Hospital and Diabetes Center
  • Kagawa, Japan, 761-0793
    • Kagawa University Hospital
  • Meguro-ku, Japan, 152-8902
    • NHO Tokyo Medical Center
  • Mie, Japan, 514-8507
    • Mie University Hospital
  • Miyagi, Japan, 960-1295
    • Fukushima Medical University Hospital
  • Nagano, Japan, 390-8621
    • Shinshu University Hospital
  • Nagasaki, Japan, 852-8501
    • Nagasaki University Hospital
  • Nagasaki, Japan, 852-8511
    • Japanese Red Cross Nagasaki Genbaku Hospital
  • Osaka, Japan, 545-8586
    • Osaka Metropolitan University Hospital
  • Osaka, Japan, 573-1191
    • Kansai Medical University Hospital
  • Osaka, Japan, 530-8480
    • Tazuke-kofukai Medical Research Institute Kitano Hospital
  • Saitama, Japan, 350-0451
    • Saitama Medical University Hospital
  • Shiga, Japan, 520-2192
    • Shiga University of Medical Science Hospital
  • Shizuoka, Japan, 430-8558
    • Seirei Hamamatsu General Hospital
  • Suita, Japan, 565-0871
    • Osaka University Hospital
  • Takatsuki-shi, Japan, 569-8686
    • Osaka Medical and Pharmaceutical University Hospital
  • Tokushima, Japan, 770-8503
    • Tokushima University Hospital
  • Tokyo, Japan, 162-8666
    • Tokyo Women's Medical University Hospital
  • Tokyo, Japan, 113-8431
    • Juntendo University Hospital
  • Tokyo, Japan, 193-0998
    • Tokyo Medical University Hachioji Medical Center
  • Tokyo, Japan, 181-8611
    • Kyorin University Hospital
  • Yamagata, Japan, 990-9585
    • Yamagata University Hospital
  • Yamaguchi, Japan, 755-8505
    • Yamaguchi University Hospital
  • Yoshida-gun, Japan, 910-1193
    • University of Fukui Hospital
  • Aichi-ken
    • Nagakute-shi, Aichi-ken, Japan, 480-1195
      • Aichi Medical University Hospital
    • Nagoya, Aichi-ken, Japan, 466-8560
      • Nagoya University Hospital
  • Chiba
    • Sakura-shi, Chiba, Japan, 285-8741
      • Toho University Sakura Medical Center
  • Hokkaido
    • Sapporo, Hokkaido, Japan, 060-8648
      • Hokkaido University Hospital
  • Hyōgo
    • Kobe, Hyōgo, Japan, 650-0017
      • Kobe University Hospital
  • Kanagawa
    • Yokohama, Kanagawa, Japan, 232-0024
      • Yokohama City University Medical Center
  • Tochigi
    • Shimotsuke-shi, Tochigi, Japan, 329-0498
      • Jichi Medical University Hospital
  • Tokyo-To
    • Chiyoda-ku, Tokyo-To, Japan, 101-8309
      • Nihon University Hospital
    • Shinjuku-ku, Tokyo-To, Japan, 160-0023
      • Tokyo Medical University Hospital
    • Shinjuku-ku, Tokyo-To, Japan, 160-8582
      • Keio University Hospital
• Poland
  • Olsztyn, Poland, 10-424
    • Centrum Diagnostyki i Mikrochirurgii Oka Lens
  • Poznan, Poland, 61-285
    • Szpital im. Jozefa Strusia
  • Warsaw, Poland, 04-141
    • Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy
  • Wałbrzych, Poland, 58-309
    • Szpital Specjalistyczny im Soko?owskiego
• Puerto Rico
  • Arecibo, Puerto Rico, 00612
    • Emanuelli Research and Development Center
• Saudi Arabia
  • Riyadh, Saudi Arabia, 12329
    • King Khaled Eye Specialist Hospital
• Singapore
  • Singapore, Singapore, 308433
    • Tan Tock Seng Hospital
  • Singapore, Singapore, 119228
    • National University Hospital
  • Singapore, Singapore, 248649
    • Eye & Retina Surgeons
  • Singapore, Singapore, 169608
    • Singapore National Eye Centre
  • Singapore, Singapore, 329563
    • Eagle Eye Centre
• Slovenia
  • Ljubljana, Slovenia, 1000
    • Univerzitetni Klinicni Center Ljubljana Ocesna Klinika
• South Korea
  • Daegu, South Korea, 42415
    • Yeungnam University Hospital
  • Gyeonggi-do
    • Seongnam-si, Gyeonggi-do, South Korea, 13496
      • CHA Bundang Medical Center, CHA University
• Spain
  • Albacete, Spain, 02006
    • Complejo Hospitalario Universitario de Albacete
  • Barcelona, Spain, 08036
    • Hospital Clínic de Barcelona
  • Barcelona, Spain, 08025
    • Hospital de la Santa Creu i Sant Pau
  • Barcelona, Spain, 08025
    • Hospital Dos de Maig
  • Barcelona, Spain, 08035
    • Hospital Universitari Vall dHebron (CEMCAT)
  • Burgos, Spain, 09005
    • Complejo Asistencial Universitario de Burgos
  • Cadiz, Spain, 11009
    • Hospital Universitario Puerta Del Mar
  • Córdoba, Spain, 14004
    • Hospital Universitario Reina Sofia
  • Granada, Spain, 18012
    • Hospital Universitario Virgen de Las Nieves
  • Murcia, Spain, 30120
    • Hospital Universitario Virgen de la Arrixaca
  • Málaga, Spain, 29010
    • Hospital Carlos Haya
  • Seville, Spain, 41013
    • Hospital Universitario Virgen Del Rocio Sevila
  • Valladolid, Spain, 47012
    • Hospital Universitario Rio Hortega
  • Zaragoza, Spain, 50009
    • Hospital Universitario Miguel Servet
  • Balearic Islands
    • Palma de Mallorca, Balearic Islands, Spain, 07120
      • Hospital Universitari Son Espases
  • Barcelona
    • Granollers, Barcelona, Spain, 08402
      • Fundacio Privada Hospital Asil de Granollers
    • L'Hospitalet de Llobregat, Barcelona, Spain, 08907
      • Hospital Universitari de Bellvitge
  • LA Coruna
    • Ferrol, LA Coruna, Spain, 15405
      • Complejo Hospitalario Universitario de Ferrol
    • Santiago de Compostela, LA Coruna, Spain, 15706
      • Complejo Hospitalario Universitario de Santiago.
  • LAS Palmas
    • Las Palmas de Gran Canaria, LAS Palmas, Spain, 35016
      • Hospital Universitario Insular de Gran Canaria
  • La Rioja
    • Logroño, La Rioja, Spain, 26006
      • Complejo Hospitalario San Millán y San Pedro De La Rioja
  • Malaga
    • Marbella, Malaga, Spain, 29603
      • Hospital Costa Del Sol
  • Pontevedra
    • Vigo, Pontevedra, Spain, 36204
      • Hospital Xeral-Cies de Vigo
  • Tenerife
    • Santa Cruz de Tenerife, Tenerife, Spain, 38010
      • Hospital Universitario Nuestra Señora de la Candelaria
  • Vizcaya
    • Bilbao, Vizcaya, Spain, 48013
      • Hospital de Basurto
• Sweden
  • Lund, Sweden, 22185
    • Lund University Hospital
  • Stockholm, Sweden, 171 64
    • St Eriks Eye Hospital
• Switzerland
  • Aarau, Switzerland, 5001
    • Kantonsspital Aarau AG
  • Basel, Switzerland, 4031
    • Universitätsspital Basel
  • Bern, Switzerland, 3010
    • Inselspital-Universitaetsspital Bern
  • Bern, Switzerland, 3007
    • Augenklinik am Lindenhofspital
  • Binningen, Switzerland, 4102
    • Vista Augenklinik Binningen
  • Geneva, Switzerland, 1205
    • Hopitaux Universitaires de Geneve
  • Lausanne, Switzerland, 1004
    • Hôpital ophtalmique Jules-Gonin
  • Lausanne, Switzerland, 1006
    • Swiss Visio Montchoisi
  • Lucerne, Switzerland, 6000
    • LUKS Spitalbetriebe AG
  • Lugano, Switzerland, 6900
    • Ospedale Regionale di Lugano
  • Olten, Switzerland, 4600
    • Pallas Klinik Olten
  • Sankt Gallen, Switzerland, 9007
    • Kantonsspital St. Gallen
  • Zurich, Switzerland, 8055
    • Stadtspital Triemli
• Taiwan
  • Taipei, Taiwan, 220
    • Far Eastern Memorial Hospital
  • Taipei, Taiwan, 111
    • Shin Kong Wu Ho-Su Memorial Hospital
  • Taoyuan, Taiwan, 333
    • Chang Gung Memorial Hospital - Linkou
• Thailand
  • Bangkok, Thailand, 10700
    • Siriraj Hospital
  • Bangkok, Thailand, 10400
    • Ramathibodi Hospital
  • Chiang Mai, Thailand, 50200
    • Maharaj Nakorn Chiang Mai Hospital
  • Bangkok
    • Pathum Wan, Bangkok, Thailand, 10330
      • King Chulalongkorn Memorial Hospital
  • Changwat Khon Kaen
    • Muang, Changwat Khon Kaen, Thailand, 40002
      • Srinagarind Hospital
  • Changwat Songkhla
    • Hat Yai, Changwat Songkhla, Thailand, 90110
      • Songklanagarind Hospital
  • RAI Khing
    • Nakhon Pathom, RAI Khing, Thailand, 73210
      • Metta Pracharak Hospital
• United Arab Emirates
  • Abu Dhabi, United Arab Emirates, 7400
    • Burjeel Hopital
  • Dubai, United Arab Emirates, 251533
    • Medcare Eye Center - Dubai
  • Dubai Healthcare City, United Arab Emirates, 36267
    • Magrabi Eye Hospital
• United Kingdom
  • Belfast, United Kingdom, BT14 6AB
    • Mater Infirmorum Hospital
  • Birmingham, United Kingdom, B15 2TH
    • University Hospitals Birmingham NHS Foundation Trust
  • Birmingham, United Kingdom, B18 7QH
    • Birmingham Midland Eye Centre
  • Bradford, United Kingdom, BD9 6RJ
    • Bradford Royal Infirmary
  • Cardiff, United Kingdom, CF14 4XW
    • University Hospital of Wales
  • Frimley, United Kingdom, GU16 7UJ
    • Frimley Park Hospital
  • Harrow, United Kingdom, HA1 3UJ
    • North West London Hospitals NHS Trust
  • Leeds, United Kingdom, LS9 7TF
    • St James University Hospital
  • London, United Kingdom, NW3 2QG
    • Royal Free Hospital
  • London, United Kingdom, EC1V 2PD
    • Moorfields Eye Hospital
  • Manchester, United Kingdom, M13 9WL
    • Manchester Royal Eye Hospital
  • Middlesbrough, United Kingdom, TS4 3BW
    • James Cook University Hospital
  • Newcastle upon Tyne, United Kingdom, NE1 4LP
    • Royal Victoria Infirmary
  • Sheffield, United Kingdom, S10 2JF
    • Royal Hallamshire Hospital
  • Southampton, United Kingdom, SO16 6YD
    • Southampton General Hospital
  • Sunderland, United Kingdom, SR2 9HP
    • Sunderland Eye Infirmary
  • Wolverhampton, United Kingdom, WV10 0QP
    • The Royal Wolverhampton Hospitals NHS Trust
  • Avon
    • Bristol, Avon, United Kingdom, BS1 2LX
      • Bristol Eye Hospital
  • Bedfordshire
    • Bedford, Bedfordshire, United Kingdom, MK42 9DJ
      • Bedford Hospital
  • Devon
    • Torquay, Devon, United Kingdom, TQ2 7AA
      • Torbay Hospital
  • East Riding Of Yorkshire
    • Hull, East Riding Of Yorkshire, United Kingdom, HU3 2KZ
      • Hull Royal Infirmary
  • Essex
    • Colchester, Essex, United Kingdom, CO4 5JR
      • Primary Care Centre
  • Gloucestershire
    • Gloucester, Gloucestershire, United Kingdom, GL1 3NN
      • Gloucestershire Retinal Research Group
  • Greater London
    • London, Greater London, United Kingdom, SE5 9NU
      • Kings College Hospital
  • Kent
    • Maidstone, Kent, United Kingdom, ME16 9QQ
      • Maidstone Hospital
  • Merseyside
    • Liverpool, Merseyside, United Kingdom, L7 8XP
      • Royal Liverpool University Hospital
  • Norfolk
    • Gorleston-on-Sea, Norfolk, United Kingdom, NR31 6LA
      • James Paget University Hospitals NHS Foundation Trust
  • Oxfordshire
    • Headington, Oxfordshire, United Kingdom, OX3 9DU
      • John Radcliffe Hospital
• United States
  • Arizona
    • Phoenix, Arizona, United States, 85014
      • Retinal Research Institute, LLC
  • California
    • Pasadena, California, United States, 91107
      • California Eye Specialists Medical Group Inc.
    • Sacramento, California, United States, 95825
      • Retinal Consultants Medical Group
  • Florida
    • Coral Springs, Florida, United States, 33067
      • Advanced Research
    • Pensacola, Florida, United States, 32503
      • Retina Specialty Institute
  • Illinois
    • Lemont, Illinois, United States, 60439
      • University Retina and Macula Associates, PC
    • Springfield, Illinois, United States, 62703
      • Springfield Clinic, Llp
  • Kentucky
    • Lexington, Kentucky, United States, 40509
      • Retina Associates of Kentucky
  • Maryland
    • Hagerstown, Maryland, United States, 21740
      • Cumberland Valley Retina Consultants PC
  • Michigan
    • Royal Oak, Michigan, United States, 48073
      • Associated Retinal Consultants PC
  • Pennsylvania
    • Erie, Pennsylvania, United States, 16507
      • Erie Retinal Surgery
  • Tennessee
    • Nashville, Tennessee, United States, 37203
      • Tennessee Retina PC
  • Texas
    • San Antonio, Texas, United States, 78251-4551
      • Brown Retina Institute
    • Southlake, Texas, United States, 76092-1352
      • Retina Center of Texas
  • Utah
    • Salt Lake City, Utah, United States, 84132
      • University of Utah, John Moran Eye Center
  • Virginia
    • Lynchburg, Virginia, United States, 24502
      • Piedmont Eye Center
    • Norfolk, Virginia, United States, 23502-3933
      • Wagner Macula and Retina Center
  • Washington
    • Spokane, Washington, United States, 99204
      • Spokane Eye Clinical Research

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients being treated with specified Roche ophthalmology products approved in retinal indications in real-world, routine clinical practice.

Description

Inclusion Criteria:

1. Have provided informed consent, as required per local regulations 2.a) Adult patient, as defined by local regulations and local product label, who is newly initiating treatment (or initiated treatment in the previous visit) with a specified approved Roche ophthalmology product in retinal indication of interest for this study in at least one eye, according to the investigator's discretion in routine clinical practice; OR 2.b) Adult patient, as defined by local regulations and local product label, who is continuing treatment with any specified approved Roche ophthalmology product in retinal indication of interest for this study in at least one eye after initiating that treatment in a Roche interventional trial.

Exclusion Criteria:

1. Concomitant participation of the patient in an investigational ophthalmology clinical trial that includes receipt of any investigational drug or procedure within the last 28 days prior to enrollment (this restriction does not apply to patients who are rolling over from Roche interventional studies and continuing treatment with any specified approved Roche ophthalmology product in retinal indication of interest for this study)

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

5

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Cohort 1: Faricimab for nAMD	Drug: Faricimab; Faricimab will be administered as per local clinical practice and local labeling.; Other Names: VABYSMO™; RO6867461; RG7716
Cohort 2: Faricimab for DME	Drug: Faricimab; Faricimab will be administered as per local clinical practice and local labeling.; Other Names: VABYSMO™; RO6867461; RG7716
Cohort 3: Port Delivery System with Ranibizumab for nAMD	Combination product: Port Delivery System with Ranibizumab; The port delivery system with ranibizumab will be administered as per local clinical practice and local labeling.; Other Names: SUSVIMO™; RG6321
Cohort 4: Faricimab for BRVO	Drug: Faricimab; Faricimab will be administered as per local clinical practice and local labeling.; Other Names: VABYSMO™; RO6867461; RG7716
Cohort 5: Faricimab for CRVO/HRVO	Drug: Faricimab; Faricimab will be administered as per local clinical practice and local labeling.; Other Names: VABYSMO™; RO6867461; RG7716

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Visual Acuity from Baseline at 1 Year, per Approved Retinal Indication and Product	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.	Baseline and 1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cumulative Time Spent on Each Treatment per Eye, Overall and per Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other), per Approved Retinal Indication and Product		From Baseline until end of study (up to 5 years)
Number of Eyes Treated with Ocular Concomitant and Subsequent Medications by Type and Frequency During the Study, per Approved Retinal Indication and Product		From Baseline until end of study (up to 5 years)
Number of Participants with at Least One Ocular Adverse Event, by Severity and Seriousness, per Approved Retinal Indication and Product	Severity and seriousness will be independently assessed for each adverse event (AE). The terms "severe" and "serious" are not synonymous. Severity refers to the intensity of an AE (e.g., rated as mild, moderate, or severe); the event itself may be of relatively minor medical significance.	From Baseline until end of study (up to 5 years)
Number of Participants with at Least One Non-Ocular Adverse Event, by Severity and Seriousness, per Approved Retinal Indication and Product	Severity and seriousness will be independently assessed for each adverse event (AE). The terms "severe" and "serious" are not synonymous. Severity refers to the intensity of an AE (e.g., rated as mild, moderate, or severe); the event itself may be of relatively minor medical significance.	From Baseline until end of study (up to 5 years)
Change in Visual Acuity from Baseline Over Time, per Approved Retinal Indication and Product	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Percentage of Eyes on Each Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other) Over Time, per Approved Retinal Indication and Product		Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Number of Treatments Over Time, per Approved Retinal Indication and Product		At 3, 6, and 12 months, and annually thereafter (up to 5 years)
Percentage of Eyes with Treatment Switch by Reason for Switch Over Time, per Approved Retinal Indication and Product		At 3, 6, and 12 months, and annually thereafter (up to 5 years)
Percentage of Eyes with Treatment Regimen Switch (Fixed, Treat-and-Extend, As Needed, or Other) by Reason for Switch Over Time, per Approved Retinal Indication and Product		At 3, 6, and 12 months, and annually thereafter (up to 5 years)
Total Number of Visits per Year, per Approved Retinal Indication and Product		Annually (up to 5 years)
Number of Visits With or Without Treatment per Year, per Approved Retinal Indication and Product		Annually (up to 5 years)
Time Interval Between Treatments per Year, per Approved Retinal Indication and Product		Annually (up to 5 years)
Change in Visual Acuity from Baseline Over Time, According to Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other), per Approved Retinal Indication and Product	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Change in Visual Acuity from Baseline Over Time, According to Number of Treatments, per Approved Retinal Indication and Product	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Change in Visual Acuity from Baseline Over Time, According to Total Number of Visits, per Approved Retinal Indication and Product	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Change in Visual Acuity from Baseline Over Time, According to Treatment Schedule, per Approved Retinal Indication and Product	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Change in Central Subfield Thickness (CST) from Baseline Over Time, per Approved Retinal Indication and Product		Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)

Collaborators and Investigators

• Sponsor: Hoffmann-La Roche
• Investigators: Study Director: Clinical Trials, Hoffmann-La Roche

Study record dates

Study Major Dates

• Study Start (Actual): November 21, 2022
• Primary Completion (Estimated): November 30, 2026
• Study Completion (Estimated): November 30, 2027

Study Registration Dates

• First Submitted: July 25, 2022
• First Submitted That Met QC Criteria: July 25, 2022
• First Posted (Actual): July 27, 2022

Study Record Updates

• Last Update Posted (Actual): June 9, 2026
• Last Update Submitted That Met QC Criteria: June 5, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Vascular Diseases; Cardiovascular Diseases; Eye Diseases; Embolism and Thrombosis; Retinal Diseases; Venous Thrombosis; Thrombosis; Retinal Vein Occlusion; Amino Acids, Peptides, and Proteins; Proteins; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Serum Globulins; Globulins; Ranibizumab; faricimab
• Other Study ID Numbers: MR41927

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: For eligible studies, qualified researchers may request access to individual patient level clinical data. See Roche's commitment to transparency of clinical study information here: https://go.roche.com/data_sharing

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: Yes