Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease (META-DEM)

This study aims at exploring patients' ability to monitor their own memory performance depending on their primary deficit and the type of memory involved in the criterion task. The goal is to evaluate if semantic dementia (SD) and Alzheimer's disease (AD) differently affect patients' awareness of their memory abilities.

Study Overview

• Status: Completed
• Conditions: Healthy; Alzheimer Disease; Semantic Dementia
• Intervention / Treatment: Other: Metacognition tests

Detailed Description

Patients who will give their informed non-opposition will be included. Participants will undergo 6 metacognitive tasks in which they will be tested on newly learnt information (i.e., episodic memory) or prior knowledge (i.e., semantic memory) and asked to evaluate their performance either prior or after the test. Correlation between their evaluation and their actual performance will be measured. Performance and correlations will be compared across groups.

• Study Type: Observational
• Enrollment (Actual): 40

Contacts and Locations

• Study Contact: Name: Olivier MOREAUD; Phone Number: (33)4.76.76.57.90; Email: omoreaud@chu-grenoble.fr
• Study Contact Backup: Name: Céline SOUCHAY; Phone Number: 33 (0)6 72 23 12 97; Email: celine.souchay@univ-grenoble-alpes.fr

Study Locations

• France
  • Angers, France, 49 933
    • CHU Angers
  • Bordeaux, France, 33000
    • CHU Bordeaux
  • Bron, France, 69677
    • Hôpital Neurologique de Lyon
  • Colmar, France, 68024
    • Hôpitaux Civils Colmar
  • Grenoble, France, 38043
    • Chu Grenoble Alpes
  • Rennes, France, 35033
    • CHU Rennes
• Switzerland
  • Lausanne, Switzerland, 1011
    • CHU vaudois

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Patients with Alzheimer's disease will be patients at the CHU of Grenoble.

Patients with Alzheimer's disease will be recruited in the CHU Grenoble, CHU Angers, CHU Bordeaux, CHU Colmar, CHU Lyon, CHU Rennes and CHUV Lausanne.

Controls will be recruited via the database "Seniors pour la Science ", https://seniorspourlascience.fr/

Description

Inclusion Criteria:

• native French-speakers
• normal or corrected-to-normal vision
• for patients ONLY : doctor-approved diagnosis of semantic dementia or Alzheimer's disease
• for healthy participants ONLY: score above 27 on the MMSE
• non-opposition in participation

Exclusion Criteria:

• other neurological/ psychiatric disorder, or cognitive disorder that might affect general cognition
• drug or alcohol abuse

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Prospective

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Semantic dementia; Diagnosis of semantic dementia (revised criteria Moreaud et al., 2008; based on Neary et al., 1998)	Other: Metacognition tests; Test on episodic or semantic memory
Alzheimer's disease; NIAAA 2011 criteria	Other: Metacognition tests; Test on episodic or semantic memory
Control; MMSE above 27, no neurological or psychiatric disorder	Other: Metacognition tests; Test on episodic or semantic memory

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Metacognitive bias on the episodic predictive judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Metacognitive accuracy on the episodic predictive judgment task	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.	End of study : around May 2022
Metacognitive bias on the semantic predictive judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Metacognitive accuracy on the semantic predictive judgment task	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.	End of study : around May 2022
Metacognitive bias on episodic global judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Metacognitive bias on semantic global judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Metacognitive bias on the episodic retrospective judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Metacognitive accuracy on the episodic retrospective judgment task	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.	End of study : around May 2022
Metacognitive bias on the semantic retrospective judgment task	Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).	End of study : around May 2022
Metacognitive accuracy on the semantic retrospective judgment task	Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.	End of study : around May 2022

Collaborators and Investigators

• Sponsor: University Hospital, Grenoble
• Investigators: Principal Investigator: Olivier MOREAUD, University Hospital, Grenoble

Study record dates

Study Major Dates

• Study Start (Actual): October 16, 2020
• Primary Completion (Actual): April 27, 2022
• Study Completion (Actual): April 27, 2022

Study Registration Dates

• First Submitted: October 1, 2020
• First Submitted That Met QC Criteria: October 16, 2020
• First Posted (Actual): October 22, 2020

Study Record Updates

• Last Update Posted (Actual): August 7, 2023
• Last Update Submitted That Met QC Criteria: August 4, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Metabolic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurologic Manifestations; Neurobehavioral Manifestations; Neurocognitive Disorders; Neurodegenerative Diseases; TDP-43 Proteinopathies; Proteostasis Deficiencies; Tauopathies; Language Disorders; Communication Disorders; Speech Disorders; Frontotemporal Lobar Degeneration; Aphasia; Dementia; Alzheimer Disease; Frontotemporal Dementia; Aphasia, Primary Progressive; Pick Disease of the Brain
• Other Study ID Numbers: 38RC20.282; 2020-A02236-33 (Other Identifier: ID RCB)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No