Clinical Trials on Drug-withdrawal. in South Africa

Total 120 results

Centers for Disease Control and Prevention
Yale University; Columbia University; University of KwaZulu

Completed

TBTC Study 30: Safety and Tolerability of Low Dose Linezolid in MDR TB (LiMiT)

Multi-drug Resistant Tuberculosis | Extensively Drug Resistant Tuberculosis

South Africa
University of Missouri-Columbia
National Center for Complementary and Integrative Health (NCCIH); University...

Completed

A Safety Study of Lessertia Frutescens in Adults.

Drug Safety

South Africa
Centers for Disease Control and Prevention
Boston University; Pfizer; Columbia University; University of Texas; University of... and other collaborators

Completed

Linezolid Pharmacokinetics (PK) in Multi-Drug Resistant (MDR)/Extensively-Drug Resistant (XDR) Tuberculosis (TB) (S30PK)

Multi-Drug Resistant Tuberculosis | Extensively Drug Resistant Tuberculosis

South Africa
University of Cape Town
Medical Research Council, South Africa

Completed

A Trial Of Intravenous N-Acetylcysteine In The Management Of Antituberculous Drug-Induced Hepatitis (NAC in TB DIH)

Drug-Induced Liver Injury

South Africa
Boston University
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Completed

Rewards for Tuberculosis Contact Screening (RECON)

Tuberculosis | Drug-resistant Tuberculosis

South Africa
T. John Winhusen, PhD
National Institute on Drug Abuse (NIDA); The Emmes Company, LLC

Active, not recruiting

Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs)

Pregnancy Related | Opioid-Related Disorders | Substance Abuse | Drug Abuse | Drug Addiction | Neonatal Abstinence Syndrome | Drug Abuse in Pregnancy | Neonatal Opioid Withdrawal Syndrome

United States
T. John Winhusen, PhD
National Institute on Drug Abuse (NIDA); The Emmes Company, LLC

Active, not recruiting

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study (MOMs-CMA)

Pregnancy Related | Opioid-Related Disorders | Substance Abuse | Drug Abuse | Drug Addiction | Neonatal Abstinence Syndrome | Drug Abuse in Pregnancy | Neonatal Opioid Withdrawal Syndrome

United States
T. John Winhusen, PhD
National Institute on Drug Abuse (NIDA); The Emmes Company, LLC

Recruiting

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study (MOMs-INO)

Pregnancy Related | Opioid-Related Disorders | Substance Abuse | Drug Abuse | Drug Addiction | Neonatal Abstinence Syndrome | Neonatal Opiate Withdrawal Syndrome | Drug Abuse in Pregnancy

United States
University of Cape Town
University of Stellenbosch; University of Cape Town Lung Institute; University... and other collaborators

Completed

An Open-label RCT to Evaluate a New Treatment Regimen for Patients With Multi-drug Resistant Tuberculosis (NEXT)

Tuberculosis | Multidrug Resistant Tuberculosis | Extensively-drug Resistant Tuberculosis

South Africa
University of Alabama at Birmingham
Merck Sharp & Dohme LLC; University of Washington; Wits Reproductive Health and...

Active, not recruiting

Evaluation of Pharmacokinetic Drug-drug Interactions Between Hormonal Contraceptives and Doravirine-containing ART Among Women Living With HIV in South Africa (EPIC)

HIV Infections | Contraception | Drug-drug Interaction

South Africa
Columbia University
Centre for the AIDS Programme of Research in South Africa

Not yet recruiting

An Adaptive Randomized Controlled Trial (ADAP-TIV)

HIV Infections | Multi Drug Resistant Tuberculosis

South Africa
Boston Medical Center
Boston University; National Institute of Allergy and Infectious Diseases (NIAID) and other collaborators

Enrolling by invitation

Transmission of Tuberculosis Among Illicit Drug Use Linkages (TOTAL)

Tuberculosis | Illicit Drug Use

South Africa
Wits Health Consortium (Pty) Ltd
University of Cape Town; Perinatal HIV Research Unit of the University of the... and other collaborators

Active, not recruiting

Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline, Delamanid and Linezolid) With the Current South African Standard of Care

Tuberculosis | Multi Drug Resistant Tuberculosis | Rifampicin Resistant Tuberculosis | Extensively Drug-Resistant Tuberculosis | Pre-XDR-TB

South Africa
Qurient Co., Ltd.

Completed

A Phase 2 Study to Evaluate Early Bactericidal Activity, Safety, Tolerability, and Pharmacokinetics of Multiple Oral Doses of Telacebec (Q203)

Treatment-naïve, Sputum Smear-positive Patients With Drug-sensitive Pulmonary TB

South Africa
Universiteit Antwerpen
Aurum Institute; University of Stellenbosch; University of the Free State; Free...

Recruiting

Sequencing Mycobacteria and Algorithm-determined Resistant Tuberculosis Treatment Trial (SMARTT)

Drug-resistant Tuberculosis | Rifampicin Resistant Tuberculosis | Pulmonary Tuberculoses | Multidrug Resistant Tuberculosis

South Africa
University of California, San Francisco
National Institute of Allergy and Infectious Diseases (NIAID); University Hospital... and other collaborators

Not yet recruiting

Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis (TSELiOT)

Drug-resistant Tuberculosis | Cost-Benefit Analysis | HIV Coinfection

South Africa
Faculty of Medicine

Completed

Uterotonic Efficacy of Oxytocin 2.5 Versus 10 Units During Caesarean Section at Mulago Hospital

Uterine Hemorrhage | Adverse Effect of Oxytocic Drugs | Inappropriate Dose of Drug Administered

Uganda
National Institute on Alcohol Abuse and Alcoholism...

Completed

Comparing the Treatment of Alcohol Withdrawal Syndrome Using Gabapentin Versus Lorazepam

Alcohol Withdrawal Syndrome(AWS)

United States
RTI International
University of Cape Town

Completed

Treating South African Pregnant Women for Methamphetamine

HIV | Drug Addiction

South Africa
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University College, London; University... and other collaborators

Active, not recruiting

PRACTECAL-PKPD Sub Study (PRACTECAL-PKPD)

Multi-drug Resistant Tuberculosis | Pulmonary Tuberculosis | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa
Foundation for Innovative New Diagnostics, Switzerland

Completed

Evaluation of Centralised TB Assay Solutions

Tuberculosis | Drug-resistant Tuberculosis

Georgia, Germany, India, Moldova, Republic of, South Africa
Walter Sisulu University
Medical University of Graz; Nelson Mandela Academic Hospital; Umtata General...

Not yet recruiting

Cardiometabolic Health of Children Exposed to Anti-retroviral Therapy (ART) in Utero (ARTMOMSBABES)

In Utero Drug Exposure

South Africa
Johns Hopkins University
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

Bring BPaL2Me Trial Comparing Nurse-Led RR-TB Treatment to Physician-Led RR-TB Treatment

Drug Resistant Tuberculosis

South Africa
Kevin Watt
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Pharmacokinetics of Multiple Dose Methadone in Children Treated for Opiate Withdrawal (MTH01)

Opiate Withdrawal Syndrome

United States
University of Stellenbosch
Stanley Medical Research Institute

Completed

Ethyl-Eicosapentaenoic Acid and Tardive Dyskinesia

Schizophrenia | Dyskinesia

South Africa
University of Cape Town
Institute of Tropical Medicine, Belgium; Epicentre; Medecins Sans Frontieres,... and other collaborators

Recruiting

Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis-PandrTB Tuberculosis (PandrTB)

Multi-drug Resistant Tuberculosis

Vietnam, Kazakhstan, Lesotho, Pakistan, Peru, South Africa
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University of Liverpool; Ministry... and other collaborators

Completed

Economic Evaluation of New MDR TB Regimens (PRACTECAL-EE)

Multi-drug Resistant Tuberculosis | Pulmonary Tuberculoses | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa, Uzbekistan
Advancing Clinical Trials in Neonatal Opioid Withdrawal...
National Institutes of Health (NIH)

Active, not recruiting

Eating, Sleeping, Consoling for Neonatal Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach ((ESC-NOW))

Neonatal Opiate Withdrawal Syndrome

United States
Spark Biomedical, Inc.
Medical University of South Carolina; University of Texas Southwestern Medical...

Recruiting

Neurostimulation to Improve NOWS Outcomes (SPROUT)

Neonatal Abstinence Syndrome | Neonatal Opioid Withdrawal Syndrome

United States
RTI International
Medical Research Council, South Africa

Completed

Cape Town Young Women's Health CoOp

Human Immunodeficiency Virus (HIV) | Condomless Sex | Alcohol and Drug Use | Sexually Transmitted Infections (STIs) | Violence and Victimization | Access and Linkage to Healthcare | Education Advancement

South Africa
Global Alliance for TB Drug Development

Active, not recruiting

A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary Tuberculosis Volunteers (PaSEM)

Tuberculosis | Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Tuberculosis, MDR | Drug-Resistant Tuberculosis

Georgia, South Africa
National Institute on Drug Abuse (NIDA)

Completed

Quiting Marijuana Use: Self-report Study of Quitting Straegies and Withdrawal Symptoms

Cannabis Dependence | Cannabis Abuse

United States
Mirum Pharmaceuticals, Inc.

Completed

Safety and Efficacy Study of LUM001 (Maralixibat) With a Drug Withdrawal Period in Participants With Alagille Syndrome (ALGS) (ICONIC)

Alagille Syndrome

France, Belgium, Poland, Australia, Spain, United Kingdom
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); University of Miami; Weill Medical College... and other collaborators

Recruiting

Project Khanya: Peer-Delivered Intervention to Improve HIV Medication Adherence and Substance Use in South Africa

Alcohol-Related Disorders | Substance Use | Drug Use | Human Immunodeficiency Virus

South Africa
Advancing Clinical Trials in Neonatal Opioid Withdrawal...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)

Neonatal Opioid Withdrawal Syndrome

United States
Medical University of South Carolina
UCB Pharma

Withdrawn

Efficacy of Keppra in Acute Alcohol Related Seizure Control--A Pilot Study

Seizure, Alcohol Related

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Open-Label, Safety Study of Lofexidine (NU LEAF)

Opioid Withdrawal

United States
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); University of Cape Town

Completed

Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa

Alcohol-Related Disorders | Drug Use | Human Immunodeficiency Virus

United States, South Africa
Centre for the AIDS Programme of Research in South...
Amsterdam Institute for Global Health and Development; Global Alliance for... and other collaborators

Recruiting

Triage Test for All Oral DR-TB Regimen (TRiAD Study)

Tuberculosis | Drug Resistant Tuberculosis | MDR-TB | XDR-TB

Nigeria, South Africa, Ethiopia
Medical University of South Carolina
National Institute on Drug Abuse (NIDA); National Institutes of Health (NIH)

Completed

Progesterone for Cannabis Withdrawal

Cannabis Use Disorder | Cannabis Withdrawal

United States
Medical University of South Carolina
National Center for Complementary and Integrative Health (NCCIH); Office of...

Completed

Drug Interactions and Bioavailability of Cranberry

Healthy | Drug Interactions

United States
Pharmaceutical Project Solutions, Inc.

Completed

Topical Anesthetic for Procedures Through the Nose

Drug Reaction to Analgesic Nos

United States
South West Sydney Local Health District
University of Sydney; South Eastern Sydney Local Health District

Unknown

Cannabidiol (CBD) for the Treatment of Alcohol Withdrawal

Alcohol Dependence | Alcohol Withdrawal

Australia
Medical University of South Carolina

Completed

Gabapentin for Alcohol Relapse Prevention

Alcohol Use Disorder | Alcohol Withdrawal

United States
Global Alliance for TB Drug Development

Completed

Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tuberculosis (ZeNix)

Tuberculosis | Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Extensively Drug-Resistant Tuberculosis | Tuberculosis, MDR | XDR-TB | Pre-XDR-TB

South Africa, Russian Federation, Georgia, Moldova, Republic of
Sydney South West Area Health Service
The University of New South Wales

Completed

Lithium Cannabis Withdrawal Study

Cannabis Dependence | Substance Withdrawal Syndrome

Australia
Murdoch Childrens Research Institute

Recruiting

Minimising Adverse Drug Reactions and Verifying Economic Legitimacy in Children (MARVEL-PIC) (MARVEL-PIC)

Neoplasms | Bone Marrow Transplantation

Australia
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University College, London; University... and other collaborators

Completed

Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s) (TB-PRACTECAL)

Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa, Uzbekistan
Universitas Sriwijaya

Active, not recruiting

Efficacy of Extra Virgin Olive Oil (EVOO) Supplementation on Hand-Foot Syndrome Incidence in Patients With Capecitabine (EVOO)

Capecitabine | Hand and Foot Syndrome | Hand and Foot Skin Reaction

Indonesia
Brigham and Women's Hospital
University of Chicago; University of Wisconsin, Madison; University of California... and other collaborators

Completed

Multi-Center Medication Reconciliation Quality Improvement Study (MARQUIS)

Medication Administered in Error | Adverse Drug Events

United States

Clinical Trials on Drug-withdrawal. in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

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CROs in Austria

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Rare Diseases

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