Clinical Trials on Genetic Mutation in France

Total 2441 results

Assistance Publique - Hôpitaux de Paris

Completed

Clinical Trial Using Humira in Netherton Syndrome (AntiTNF-SN)

Netherton Syndrome

France
Vertex Pharmaceuticals Incorporated

Completed

A Phase 3 Rollover Study of Lumacaftor in Combination With Ivacaftor in Subjects 12 Years and Older With Cystic Fibrosis

Cystic Fibrosis, Homozygous or Heterozygous for the F508del-CFTR Mutation

United States, France, United Kingdom, Germany, Spain, Belgium, Canada, Australia, Netherlands, Denmark, Czech Republic, Italy, Austria, Ireland, Sweden
Centre Hospitalier Universitaire de Nice

Unknown

Treatment of Dowling Maera Type of Epidermolysis Bullosa Simplex by Oral Erythromycin

Epidermolysis Bullosa

France
Institut National de la Santé Et de la Recherche...
Ministry of Health, France

Completed

IDA (Immunothérapie de la Dermatite Atopique) Adult - Immunotherapy in Atopic Dermatitis (IDA-Adult)

Atopic Dermatitis

France
French Innovative Leukemia Organisation
Acute Leukemia French Association

Recruiting

Study Investigating the Efficacy and Safety of the Addition of Oral-azacitidine to Salvage Treatment by Gilteritinib in Subjects ≥18 Years of Age With Relapsed/Refractory FLT3-mutated Acute Myeloid Leukemia (OGILAR)

AML, Adult | Relapsed Adult AML | Refractory AML | FLT3-TKD Mutation | FLT3-ITD

France
United Pharmaceuticals

Active, not recruiting

Evaluation of an Adapted Formula on Atopic Dermatitis.

Atopic Dermatitis

Belgium, France
Hospices Civils de Lyon

Unknown

Genetic Predisposition to Severe Forms of COVID-19 (SARS-CoV2 Infection) (COVIDGEN)

Covid19

France
University Hospital, Toulouse

Unknown

The Validation Process for Confirmation of the French Version of the Pediatric Quality of Life Inventory :PedsQLTM. (ValPedsQLDMD)

Duchenne Muscular Dystrophy

France
Hospices Civils de Lyon

Unknown

Clinical Phenotyping and Characterization of Neural Networks and Cognitive Processes Involved in Mental Retardation X-linked (XLMR)

X-linked Mental Retardation

France
Institut National de la Santé Et de la Recherche...

Unknown

Natural History and Biological Study of Netherton Syndrome (NSnatbio)

Healthy | Netherton Syndrome

France
Centre Hospitalier Universitaire de Nice

Withdrawn

Pilot Study Evaluating the Efficiency and the Tolerance of the PDT in the Treatment of Epidermal Dysplasia for Patients Affected by Hereditary DEB

Dystrophic Epidermolysis Bullosa

France
Fondation Ophtalmologique Adolphe de Rothschild

Completed

Genetic Analysis and Multimodal Retinal Imaging of Asymptomatic Fovea Plana Cases in the General Population (APOGEE)

Albinism | Fovea Plana

France
University Hospital, Angers

Completed

Employment of Patients With Pseudoxanthoma Elasticum (MEE-PXE)

Pseudoxanthoma Elasticum | Employment

France
Hospices Civils de Lyon

Recruiting

Genetic Predisposition in Cerebral Palsy (PREGENE PC)

Cerebral Palsy

France
Centre Hospitalier Universitaire de Nice

Recruiting

Gynecological Follow-up of Patients With Dystrophic Epidermolysis Bullosa (EBD)

Dystrophic Epidermolysis Bullosa

France
University Hospital, Montpellier

Recruiting

Pre-clinical Models for Mesenchymal Stem Cell Therapy in Hemophilic Arthropathy

Hemophilia A | Hemophilia B | Arthropathy

France
University Hospital, Bordeaux

Recruiting

NGS Panel of Incomplete Forms of Ocular Albinism (DIA)

Albinism, Ocular

France
Fondation Ophtalmologique Adolphe de Rothschild

Completed

Genetic Determinant of Foveolar Hypoplasia in Parents of Albinos Children (ALAFOR)

Albinism, Ocular

France
University Hospital, Montpellier

Not yet recruiting

Total Splenectomy vs Partial Splenectomy in Non-malignant Hemoglobinopathies : Study Comparing the Effectiveness

Splenectomy; Status

France
EspeRare Foundation

Completed

Rimeporide in Patients With Duchenne Muscular Dystrophy (RIM4DMD)

Muscular Dystrophy, Duchenne

Italy, France, Spain, United Kingdom
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Randomized Controlled Trial in Patients on Long-term Colchicine With Colchicine-resistant Familial Mediterranean Fever (FMF) to Evaluate the Efficacy of On-demand Anakinra Treatment for Painful Attacks in Patients Who Refuse Continuous Daily Therapy (KIN-ATTACK-FMF)

FMF

France
Centre Hospitalier Universitaire de Saint Etienne
Pfizer; Ecole Normale Supérieure des Mines de Saint-Etienne

Completed

Thrombin Generation Numerical Models Validation in Haemophilic Case

Haemophilia A | Haemophilia B

France
University Hospital, Bordeaux

Completed

Evaluation of the Information Letter to Relatives in the Context of Genetic Assessments (LIPEG)

Transmission of Information to the Relatives After Genetic Diagnosis

France
Hospices Civils de Lyon

Not yet recruiting

Rehabilitation Program on Genetic and Degenerative Ataxia (RAPP)

Ataxia | Genetic Disease | Degenerative Disease

France
University Hospital, Toulouse

Recruiting

Injections of Botulinic Toxin in Plantar Lesions of Localized Epidermolysis Bullosa Simplex (EBTox)

Epidermolysis Bullosa Simplex

France
Assistance Publique - Hôpitaux de Paris

Completed

Effect of Oral Glutamine on Muscle Mass and Function in Duchenne Muscular Dystrophy (MDB-GLN)

Muscular Dystrophy, Duchenne

France
University Hospital, Toulouse
MedSharing

Recruiting

A Pilot Study of the Efficacy and Safety of Dupilumab Versus Placebo in Patients With Netherton Syndrome (NS-DUPI)

Netherton Syndrome

France
Holostem Terapie Avanzate s.r.l.
IRCCS San Raffaele; University of Modena and Reggio Emilia

Recruiting

Open-label, Pivotal Clinical Trial to Confirm Efficacy and Safety of Autologous Grafts Containing Stem Cells Genetically Modified for Epidermis Restoration in Patients With Junctional Epidermolysis Bullosa (HOLOGENE 5)

Junctional Epidermolysis Bullosa Non-Herlitz Type

France, Italy
AstraZeneca

Completed

To Study Clinical Effectiveness and Safety of Olaparib Monotherapy in Metastatic Breast Cancer Patients.

HER2-ve Metastatic Breast Cancer | Germline BRCA1/2 Mutations | Somatic BRCA1/2 Mutations

Italy, Spain, Poland, Taiwan, Canada, France, Germany, Korea, Republic of, Hungary, Japan, Russian Federation, Turkey, United Kingdom, United States, Bulgaria
Kerecis Ltd.
Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète and other collaborators

Completed

Kerecis Omega3 Wound Plus SOC vs. SOC Alone in Treating Severe Diabetic Foot Ulcers and Forefoot Amputations (Odinn)

Amputation | Diabetic Foot Ulcer | Dehiscence of Amputation Stump

France
Assistance Publique - Hôpitaux de Paris

Unknown

A Comparative Study of the Healing of Chronic Ulcers of Recessive Epidermolysis Bullosa : Dressing vs Amniotic Membrane (MABUL)

Ulcer | Epidermolysis Bullosa Dystrophica, Recessive

France
Assistance Publique - Hôpitaux de Paris

Completed

Natural History of Asphyxiating Thoracic Dystrophy (DTJ) (DTJ)

Asphyxiating Thoracic Dystrophy

France
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

Lung-MAP: AZD4547 as Second-Line Therapy in Treating FGFR Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer

Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7 | FGFR1 Gene Amplification | FGFR2 Gene Amplification | FGFR2 Gene Mutation | FGFR3 Gene Mutation | FGFR1 Gene Mutation | FGFR3 Gene Amplification

United States, Canada
Assistance Publique - Hôpitaux de Paris

Recruiting

Peripheral Serotonin and Albinism (SEPIAs)

Oculocutaneous Albinism

France
Genethon

Active, not recruiting

Gene Therapy for X-linked Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

France
Assistance Publique - Hôpitaux de Paris

Terminated

Dose-Dependent Effect of Thiazide in Dent's Disease Hypercalciuria (DESY)

Nephrolithiasis | Dent's Disease

France
Ramsay Générale de Santé
European Clinical Trial Experts Network

Completed

Evaluation of a Cohort of Patients With Ehlers-Danlos Syndrome Treated With Orthopedic Surgery (SED-eval) (SED-eval)

Ehlers-Danlos Syndrome

France
University Hospital, Lille

Completed

Adult Outcomes of Children With CAPS (CAPS)

Cryopyrin Associated Periodic Syndrome

France
Assistance Publique - Hôpitaux de Paris
Association Française contre les Myopathies (AFM), Paris

Completed

Nebivolol for the Prevention of Left Ventricular Systolic Dysfunction in Patients With Duchenne Muscular Dystrophy (NEBIDYS)

Heart Failure | Duchenne Muscular Dystrophy | Cardiomyopathy

France
Centre Hospitalier Universitaire de Nice

Completed

Treatment of Epidermolysis Bullosa Dystrophica by Polyphenon E (Epigallocatechin 3 Gallate)

Epidermolysis Bullosa Dystrophica

France
Pfizer

Completed

Transthyretin Amyloidosis Outcome Survey (THAOS) (THAOS)

Transthyretin Amyloidosis | Transthyretin Gene Mutations

United States, France, Spain, Taiwan, Israel, Korea, Republic of, Denmark, Canada, Netherlands, Japan, Sweden, Brazil, Mexico, Argentina, Portugal, Belgium, Bulgaria, Cyprus, Germany, Italy, Malaysia, Romania, Saudi Arabia, Turkey, United...
Assistance Publique - Hôpitaux de Paris

Completed

Study of Colchicine Resistance in Familial Mediterranean Fever (COLCHI-RESIST)

Colchicine Resistance | Mediterranean Fever

France
University Hospital, Montpellier

Unknown

Telangiectatic Palmoplantar Keratoderma in Systemic and Subacute Lupus Erythematosus

Systemic Lupus Erythematosus | Lichen Planus

France
Rennes University Hospital
Ministry of Health, France

Completed

Bone Status on Patients With Genetic Hemochromatosis: a 3 Years Descriptive and Evolutionary Study (FEROS)

Genetic Hemochromatosis

France
AstraZeneca
Daiichi Sankyo Co., Ltd.

Active, not recruiting

A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations (DPT01)

Advanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,Breast

Italy, Spain, United States, France, Korea, Republic of, Japan, Canada, Denmark, Belgium
Centre Hospitalier Régional Metz-Thionville

Completed

Comparative Results After DSAEK, UT-DSAEK and DMEK for Fuchs Endothelial Corneal Dystophy (DEMOGRAFT)

Corneal Dystrophy

France
Assistance Publique - Hôpitaux de Paris

Completed

Genetic Susceptibility to Ankylosing Spondylitis (AS) by Functional Genomics Approach (GENOSPA)

Ankylosing Spondylitis

France
Sanofi
Regeneron Pharmaceuticals

Recruiting

A Long-term Data Collection Study of Participants in France Aged 6 Years Old or More With Atopic Dermatitis Receiving Dupilumab (DUPILAB)

Atopic Dermatitis

France
University Hospital, Montpellier
Association Française contre les Myopathies Telethon

Completed

Exploiting Epigenome Editing in Kabuki Syndrome: a New Route Towards Gene Therapy for Rare Genetic Disorders (Epi-KAB)

Kabuki Syndrome 1

France
Institut National de la Santé Et de la Recherche...

Recruiting

European Cystinosis Cohort (RaDiCo-ECYSCO)

Cystinosis

France

Clinical Trials on Genetic Mutation in France

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Montenegro

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations