Clinical Trials on Hepatic Impairment in South Africa

Total 170 results

Pfizer

Completed

Pharmacokinetics Of Orally Administered Fx-1006A In Subjects With Hepatic Dysfunction

Mild Hepatic Dysfunction | Moderate Hepatic Dysfunction

South Africa
Novartis Pharmaceuticals

Completed

Single-dose Iloperidone Pharmacokinetics in Patients With Mild or Moderate Liver Disease, Compared to Healthy Volunteers

Hepatic Impairment

United States
Ono Pharma USA Inc
Ono Pharmaceutical Co. Ltd

Completed

An Open-label, Single-dose, Intravenous Administration Study of ONO-2745/CNS 7056 in Subjects With Chronic Hepatic Impairment

Healthy | Hepatic Impairment

United States
Convergence Pharmaceuticals

Completed

Efficacy and Safety of CNV2197944 Versus Placebo in Patients With Post-herpetic Neuralgia

Post-herpetic Neuralgia

South Africa
Novartis Pharmaceuticals

Completed

A Phase l Study to Evaluate the Pharmacokinetics and Safety Pasireotide in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Volunteers

Renal Impairment

Germany, South Africa
Novartis Pharmaceuticals

Completed

Pharmacokinetics and Safety of Single Subcutaneous Pasireotide (SOM230) in Subjects With Varying Degrees of Hepatic Function

Alcoholism | Hepatic Cirrhosis

Germany, Belgium, United States, South Africa
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride

Acute Intermittent Porphyria | Anti-Psychotic | Management of Manifestations of Psychotic Disorders | Treatment of Schizophrenia | Control Nausea and Vomiting | Relief of Restlessness and Apprehension Before Surgery | Adjunct in the Treatment of Tetanus | Control Manifestations of the Manic Type... and other conditions

South Africa
Novartis Pharmaceuticals

Terminated

Effect of AQW051 in Patients With Memory Impairment

Amnestic Mild Cognitive Impairment | Mild Alzheimer's Disease

Canada, United Kingdom, South Africa
Pfizer

Completed

A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Insufficiency

United States
Pfizer

Completed

A Study To Compare Pharmacokinetics Of Dacomitinib (PF-00299804) Between Healthy Subjects And Subjects With Mild And Moderate Hepatic Impairment

Healthy | Otherwise Healthy Volunteers With Mild or Moderate Hepatic Dysfunction

United States
Medical University of South Carolina
Emory University

Completed

Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant

Liver Failure

United States
Alnylam Pharmaceuticals

Completed

EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)

Acute Hepatic Porphyria

United States, Belgium, Bulgaria, France, Italy, Mexico, Spain, Taiwan, United Kingdom, Netherlands, Korea, Republic of, Switzerland, Czechia, Poland, Finland, Australia, Germany, Israel, Norway, South Africa
Mateon Therapeutics

Completed

Safety Study of Increasing Doses of Combretasatin A1 Diphosphate (OXi4503) as Monotherapy in Subjects With Hepatic Tumor Burden (OXi4503)

Neoplasm Metastasis

Australia
University of Athens

Recruiting

Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock (CORVICTES-ΥΜ)

Septic Shock

Greece
Cochlear
Avania

Completed

CP1150 Sound Processor Speech Perception Compared With the Next Generation of Signal Processing Technology

Hearing Impairment, Sensorineural

Australia
University of Texas Southwestern Medical Center
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Terminated

Study of N-Acetylcysteine in Acute Liver Failure (ALF) (ONAC)

Acute Liver Failure | Fulminant Hepatic Failure

United States
VA Office of Research and Development

Completed

rTMS for Emotional Difficulties in Verterans (rTMS)

Depression | PTSD | Anxiety | Mental Health | Psychosocial Impairment | rTMS

United States
William Lee
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

A Multi-Center Trial to Study Acute Liver Failure in Adults (ALFSG)

Acute Liver Failure | Fulminant Hepatic Failure | Acute Liver Injury

United States, Canada
The George Institute
Chinese University of Hong Kong; Monash University; The Alfred; University of Sydney and other collaborators

Recruiting

Statin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER)

Neurocognitive Impairment, Mild

Australia
Medical University of South Carolina
National Institute on Alcohol Abuse and Alcoholism (NIAAA); National Institutes...

Recruiting

rTMS in Older Adults With MCI and AUD

Transcranial Magnetic Stimulation | Mild Cognitive Impairment | Alcohol Use Disorder

United States
Medical University of South Carolina
National Center of Neuromodulation for Rehabilitation

Completed

Plasticity Using Stimulation and Habit: A Pilot Open-label rTMS Study for MCI (PUSH-Pilot)

Mild Cognitive Impairment

United States
The University of New South Wales

Completed

Transcranial Direct Current Stimulation to Enhance Cognition in Mild Cognitive Impairment

Mild Cognitive Impairment

Australia
Bausch Health Americas, Inc.

Completed

Rifaximin Soluble Solid Dispersion (SSD) Tablets Plus Lactulose for the Treatment of Overt Hepatic Encephalopathy (OHE) (OHE)

Overt Hepatic Encephalopathy

United States
Medical University of South Carolina
National Institute on Aging (NIA)

Recruiting

Transcranial Magnetic Stimulation for MCI (PUSH2)

Depression | Mild Cognitive Impairment

United States
Nutricia Research

Unknown

Neocate In Infants and Children With Complex Conditions (NICC)

Complex Conditions, Including Impairment of the GI Tract

United Kingdom, United States, Germany
iN Therapeutics Co., Ltd.

Recruiting

A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients.

Pain | Osteoarthritis | Chronic Pain | Neuropathic Pain | Post Herpetic Neuralgia

Australia
Medical University of South Carolina

Completed

Transradial Versus Transfemoral Arterial Access in Liver Cancer Embolization: Randomized Trial to Assess Patient Outcomes and Satisfaction (BEST ACCESS Trial). (ACCESS)

Hepatic Carcinoma | Chemoembolizaton | Transarterial Embolization

United States
Ocera Therapeutics, Inc.

Completed

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE) (STOP-HE)

Hepatic Encephalopathy | Acute Episode of Overt Hepatic Encephalopathy

Belgium, Germany, Italy, Spain, United States, France, Austria, Russian Federation, Czechia, Australia, Hungary, Israel, Netherlands, Bulgaria, Estonia, Denmark, New Zealand
Medical University of South Carolina
National Institutes of Health (NIH)

Recruiting

Learning in Stroke

Stroke | Sensorimotor Impairment

United States
Ocera Therapeutics

Completed

AST-120 Used to Treat Mild Hepatic Encephalopathy (ASTUTE)

Mild Hepatic Encephalopathy

United States
University of Western Sydney

Completed

Memory Encoding Strategies for People With Mild Cognitive Impairments

Mild Cognitive Impairment | Mild Dementia

Hong Kong, Australia
The George Institute

Completed

Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS (FluDReSS)

Septic Shock | Critically Ill

Australia
Westat
United States Social Security Administration

Completed

Supported Employment Demonstration (SED)

Mental Impairment

United States
Eisai Inc.
Eisai Limited

Completed

Efficacy and Safety of Donepezil Hydrochloride in Preadolescent and Adolescent Children With Attention Impairment Following Cancer Treatment

Attention Impairment

United States, Netherlands, France, Spain, United Kingdom, Germany, Argentina, Canada, Australia, Chile
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

Breast Cancer | Cognitive Impairments

United States
University of Athens
Naval Hospital, Athens; General Hospital of Nikaia "Saint Panteleimon"

Recruiting

Vitamin C, Hydrocortisone and Thiamine for Septic Shock (CORVICTES)

Shock, Septic

Greece
Sheffield Children's NHS Foundation Trust

Completed

Assessment of an Augmented Reality Low Visual Aid in Children and Young People With Visual Impairment

Vision Disability

United Kingdom
University of Western Sydney

Active, not recruiting

Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia

Mild Cognitive Impairment | Mild Dementia | Healthy Older Adults

Australia
Clemson University
University of Alabama at Birmingham; National Institute on Aging (NIA); Penn...

Recruiting

Elucidating the Necessary Active Components of Training (ENACT)

Cognitive Impairment | Cognitive Change | Alzheimer Disease

United States
Woolcock Institute of Medical Research

Recruiting

Digital Sleep Therapy for Older Adults With Cognitive Impairment (ExCEED)

Cognitive Impairment | Insomnia Type; Sleep Disorder

Australia
Bausch Health Americas, Inc.

Active, not recruiting

Study to Assess Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis (RED-C-3131)

Hepatic Encephalopathy

United States, Australia, Canada, Puerto Rico
The George Institute for Global Health, Australia

Completed

Days Alive and Out of Hospital for Patients With Sepsis

Sepsis | Septic Shock

Australia
Medical University of South Carolina
National Center for Advancing Translational Sciences (NCATS)

Completed

SUPPORT-D Intervention for Persons With Alzheimer's Disease and Their Caregivers

Alzheimer Disease | Mild Cognitive Impairment

United States
Medical University of South Carolina
National Cancer Institute (NCI)

Recruiting

Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT (BRIGHT)

Head and Neck Cancer | Body Image Disturbance | Body Image | Psychosocial Impairment | Survivorship | Mental Health Issue

United States
Albert Einstein Healthcare Network
Patient-Centered Outcomes Research Institute

Recruiting

Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD) (PAL-LIVER)

End Stage Liver Disease

United States
Axcella Health, Inc

Terminated

Efficacy and Safety of AXA1665 in Cirrhotic Subjects With Prior Overt Hepatic Encephalopathy (EMMPOWER)

Hepatic Encephalopathy

Spain, United States, Canada, Italy, Hungary, Poland, United Kingdom
Lateral Pharma Pty Ltd

Completed

Oral LAT8881 in Neuropathic Pain

Neuropathic Pain | Diabetic Peripheral Neuropathy (DPN) | Post Herpetic Neuralgia (PHN)

Australia, United Kingdom
Medical University of South Carolina

Completed

Safety and Efficacy of ProQuad® in Children 6-24 Month Being Evaluated for Solid Organ Transplant (ProQuad®)

RENAL INSUFFICIENCY, CHRONIC | LIVER FAILURE, ACUTE | HEART DISEASE

United States
AstraZeneca

Completed

A Study to Prevent Rebleeding After Initial Successful Primary Endoscopic Haemostasis of a Bleeding Peptic Ulcer

Gastrointestinal Hemorrhage

Sweden, Russian Federation, South Africa, Spain, Turkey, United Kingdom, Germany, Romania, Finland, Norway, Hong Kong, Austria, Denmark, Netherlands, Greece, France
Memory Pharmaceuticals

Unknown

Study to Evaluate the Safety and Efficacy of MEM 3454 as Adjunctive Treatment in Combination With a Preexisting Antipsychotic in Patients With Cognitive Impairment Associated With Schizophrenia

Cognitive Impairment Associated With Schizophrenia

United States

Clinical Trials on Hepatic Impairment in South Africa

Sponsors and Collaborators

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Drug Interventions

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CROs in Bosnia & Herzegovina

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