Memory Encoding Strategies for People With Mild Cognitive Impairments

Perceptual and Semantic Memory Encoding Strategies for People With Mild Cognitive Impairment

The purposes of the study are:

• To evaluate the effectiveness of a perceptual-based training program in enhancing cognitive and everyday functioning of older adults with mild cognitive impairment and mild dementia
• To evaluate the effectiveness of a semantic-based training program in enhancing cognitive and everyday functioning of older adults with mild cognitive impairment and mild dementia

Study Overview

• Status: Completed
• Conditions: Mild Cognitive Impairment; Mild Dementia
• Intervention / Treatment: Other: Behavioral: perceptual-based memory encoding training; Other: Behavioral: semantic-based memory encoding training; Other: Behavioral: Cognitive stimulation group (control group)

Detailed Description

People with dementia experience a cognitive decline that affects their functional performance. It has been identified that encoding is less effective in people with dementia. Rehabilitating at the encoding stage is, therefore, essential. A recent systematic review found that effective interventions needed to include training in individually selected memory encoding strategies. These strategies are classified as either perceptual (visual) or semantic (association) memory encoding strategies.

Based on the above literature, the chief investigator (Associate Professor Karen Liu) ran a pilot study on an integrated home and community centre cognitive training programme for 20 elderly people with memory problem using a pre-test and post-test comparison design.

Extending on the positive results, the aim of this project was to investigate the effectiveness of perceptual and semantic encoding strategies (and compare with a control intervention). It also aims to promote the understanding of memory loss and dementia and the need for early intervention for family members of the participants.

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Australia
  • New South Wales
    • Penrith, New South Wales, Australia, 2751
      • Western Sydney University
• Hong Kong
  • Hong Kong, Hong Kong
    • The Hong Kong Polytechnic University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Selection Criteria:

• are aged 60 or above;
• have no previous psychiatric or memory disorder history or other neurological illness;
• have Mini-mental State Examination score (MMSE) greater than or equal to 21;
• have Clinical Dementia Rating score (CDR) of 0.5 or 1 indicating very mild and mild dementia;
• do not show sign of depression with score below 9 out of 30 in the Geriatric Depression Scale;
• are able to communicate effectively;
• have family member who can participate in the study; and
• voluntarily consent to participate in the study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: NON_RANDOMIZED
• Interventional Model: PARALLEL
• Masking: DOUBLE

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Behavioral: perceptual-based memory encoding training; Participants receive perceptual-based memory encoding training	Other: Behavioral: perceptual-based memory encoding training; Participants are trained in the use of perceptual-based memory encoding strategies, inclusive of visual imagery and the method of loci. Visual imagery involves the creation and encoding of mental images, while the method of loci refers to linking these images with specific places to facilitate memory (Simon et al., 2012). Participants are taught to visualise performing each step of a task in a familiar environment, such as in their home (Liu et al., 2009). After participants can correctly visualise the entire task, they then progress to actually performing the task. During the intervention sessions, 2-3 tasks are covered each session, and these tasks become progressively difficult as the weeks progress. The intervention lasts for 10 weeks with one session every week. Each session runs for 90 minutes. A follow-up home training program is run once a week for 30 minutes with the participant and their care-giver.
EXPERIMENTAL: Behavioral: Semantic-based memory encoding training; Participants receive semantic-based memory encoding training	Other: Behavioral: semantic-based memory encoding training; Participants are asked to encode the steps of a task by forming an association of the steps and sequence. Participants are trained in the use of the chunking association method and honeycomb concept and perform different tasks each week, implementing this encoding strategy (Lim et al., 2012). The chunking association method breaks down information into smaller parts and helps with the encoding and retrieval of information. The honeycomb concept allows the steps to form a story in relation to place, time, characters, problem and solution and the story is verbalised. Participants then complete the task. During the intervention sessions, 2-3 tasks are covered each session, and these tasks become progressively difficult as the weeks progress. The intervention lasts for 10 weeks with one session every week. Each session runs for 90 minutes. A follow-up home training program is run once a week for 30 minutes with the participant and their care-giver.
ACTIVE_COMPARATOR: Behavioral : control group; Participants receive cognitive stimulation intervention	Other: Behavioral: Cognitive stimulation group (control group); Participants receiving cognitive stimulation intervention. It consists of eight sessions that train participants' visual attention and memory, auditory attention and memory and their application in daily activities. Two sessions are also given which allow for participants to apply the training practically in their daily lives. The intervention lasts for 10 weeks with one session every week. Each session runs for 90 minutes. A follow-up home training program is run once a week for 30 minutes with the participant and their care-giver.; Other Names: Cognitive stimulation group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Disability Assessment for Dementia	Change in Disability Assessment for Dementia to assess assistance required in basic daily tasks such as dressing, bathing	Within two days before the intervention and within two days after the 10-week intervention
Change in Instrumental Activities of Daily Living Scale	Change in Instrumental Activities of Daily Living Scale to assess assistance required in instrumental daily tasks such as laundry, meal preparation	Within two days before the intervention and within two days after the 10-week intervention

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Cognistat	Change in Cognistat to assess general cognitive function	Within two days before the intervention and within two days after the 10-week intervention
Change in Digit Span Test	Change in Digit Span Test to assess attention and working memory	Within two days before the intervention and within two days after the 10-week intervention
Change in Consortium to Establish a Registry for Alzheimer's Disease	Change in Consortium to Establish a Registry for Alzheimer's Disease to assess cognitive function in verbal fluency, memory	Within two days before the intervention and within two days after the 10-week intervention

Collaborators and Investigators

• Sponsor: University of Western Sydney

Study record dates

Study Major Dates

• Study Start: May 1, 2010
• Primary Completion (ACTUAL): October 1, 2015
• Study Completion (ACTUAL): October 1, 2015

Study Registration Dates

• First Submitted: September 21, 2016
• First Submitted That Met QC Criteria: November 1, 2016
• First Posted (ESTIMATE): November 3, 2016

Study Record Updates

• Last Update Posted (ESTIMATE): November 3, 2016
• Last Update Submitted That Met QC Criteria: November 1, 2016
• Last Verified: November 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Neurocognitive Disorders; Cognition Disorders; Cognitive Dysfunction
• Other Study ID Numbers: Memory encoding

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO