Clinical Trials on High-grade Gliomas

Total 5148 results

National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)

Completed

Talampanel in Treating Patients With Recurrent High-Grade Glioma

Brain and Central Nervous System Tumors

United States
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI)

Terminated

Erlotinib in Treating Patients With Progressive Glioblastoma Multiforme

Brain and Central Nervous System Tumors

United States
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

High Light and Low Light Dose PDT in Glioma

Brain and Central Nervous System Tumors

United States
Assistance Publique - Hôpitaux de Paris

Completed

Radiotherapy for Malignant Astrocytomas in the Elderly

Glioblastoma Multiforme | Anaplastic Astrocytoma | Primary Brain Tumor

France
University of Washington
National Cancer Institute (NCI)

Completed

Pembrolizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Diffuse Large B-cell Lymphoma or Grade 3b Follicular Lymphoma

Grade 3b Follicular Lymphoma | Stage III Follicular Lymphoma | Composite Lymphoma | Stage I Diffuse Large B-Cell Lymphoma | Stage I Follicular Lymphoma | Stage II Diffuse Large B-Cell Lymphoma | Stage II Follicular Lymphoma | Stage III Diffuse Large B-Cell Lymphoma | Stage IV Diffuse Large B-Cell Lymphoma and other conditions

United States
Nilgün Erdoğan

Recruiting

The Effect of Aromatherapy Massage on Pain, Anxiety and Comfort

Diabetes Mellitus, Type 2 | Pulmonary Disease, Chronic Obstructive | Respiratory Insufficiency | Stroke, Ischemic | High Blood Pressure

Turkey
Tourmaline Bio, Inc.

Recruiting

A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRP (TRANQUILITY)

Chronic Kidney Diseases | Chronic Renal Insufficiency | Chronic Kidney Insufficiency | C-Reactive Protein | Chronic Renal Diseases | Kidney Insufficiency, Chronic | hsCRP | High Sensitivity C-Reactive Protein | Hs-CRP

United States
University of California, Davis
National Cancer Institute (NCI); IO Biotech

Recruiting

IDO and PD-L1 Peptide Based Immune-Modulatory Therapeutic (IO102-IO103) in Combination With Pembrolizumab for BCG-Unresponsive or Intolerant, Non-Muscle Invasive Bladder Cancer

Stage 0a Bladder Cancer AJCC v8 | Stage 0is Bladder Cancer AJCC v8 | Stage I Bladder Cancer AJCC v8 | High Risk Non-Muscle Invasive Bladder Urothelial Carcinoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Glutaminase Inhibitor CB-839 and Azacitidine in Treating Patients With Advanced Myelodysplastic Syndrome

Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome | High Risk Myelodysplastic Syndrome | Acute Myeloid Leukemia With Multilineage Dysplasia | Blasts 20-30 Percent of Bone Marrow Nucleated Cells | Blasts 20-30 Percent of Peripheral Blood White Cells | IPSS Risk Category Intermediate-2

United States
University of Waterloo
YMCA; Royal Bank of Canada

Completed

Determining the Feasibility of Implementing a Combined Cognitive and Exercise Training Program for Older Adults in a Community Setting.

Obesity | Diabetes | Chronic Obstructive Pulmonary Disease | Fibromyalgia | Osteoporosis | High Blood Pressure | Osteo Arthritis | Joint Replacement | Stable Heart Conditions

Canada
Threshold Pharmaceuticals

Completed

Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias

Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | High-risk Myelodysplastic Syndrome | Advanced Myelofibrosis

United States
Jasper Gerritsen
Massachusetts General Hospital; Universitaire Ziekenhuizen KU Leuven; University... and other collaborators

Recruiting

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302) (RECSUR)

Glioblastoma | Glioblastoma Multiforme | Recurrent Glioblastoma | Glioblastoma, IDH-wildtype | Glioblastoma Multiforme, Adult | Glioblastoma Multiforme of Brain | Astrocytoma of Brain | Astrocytoma, Malignant

United States, Germany, Netherlands, Switzerland, Belgium
Jona Hattangadi-Gluth

Recruiting

Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients

Glioma | Meningioma | Primary Brain Tumor | Schwannoma

United States
Attikon Hospital

Recruiting

A Ketogenic Diet as a Complementary Treatment on Patients With High-grade Gliomas and Brain Metastases

Cancer | Brain

Greece
Dartmouth-Hitchcock Medical Center

Recruiting

Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas

Glioblastoma | Astrocytoma | Brain Cancer | Anaplastic Oligoastrocytoma | Oligoastrocytoma | Anaplastic Astrocytoma | Oligodendroglioma | Brain Tumors | Anaplastic Oligodendroglioma

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
Bristol-Myers Squibb; National Cancer Institute (NCI)

Completed

Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)

Glioblastoma | Gliosarcoma | Recurrent Brain Neoplasm

United States
University of Maryland, Baltimore
NovoCure Ltd.

Terminated

Optune(NOVOTTF-100A)+ Bevacizumab+ Hypofractionated Stereotactic Irradiation Bevacizumab-Naive Recurrent Glioblastoma (GCC 1344)

Brain Tumor | RECURRENT GLIOBLASTOMA

United States
M.D. Anderson Cancer Center
Cortice Biosciences, Inc.

Terminated

Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent Glioblastoma

Brain Neoplasms | Central Nervous System Neoplasms

United States
Providence Health & Services
Aduro Biotech, Inc.

Completed

Phase I Study of Safety and Immunogenicity of ADU-623

Brain Tumor | Glioblastoma Multiforme | Anaplastic Astrocytoma | Astrocytic Tumors

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Terminated

Pharmacokinetics in Patients With Newly Diagnosed High-Grade Glioma Receiving Temozolomide and Radiation Therapy

Thrombocytopenia | Brain and Central Nervous System Tumors

United States
National Cancer Institute (NCI)

Completed

GW572016 to Treat Recurrent Malignant Brain Tumors

Glioma | Brain Tumor | Glioblastoma Multiforme | Gliosarcoma | GBM | GS

United States
Xenova Biomedix

Unknown

Immunotoxin Therapy in Treating Children With Progressive or Recurrent Glioblastoma Multiforme or Anaplastic Astrocytoma

Brain and Central Nervous System Tumors

United States
University of California, San Francisco
National Cancer Institute (NCI)

Completed

Temozolomide in Treating Patients With Recurrent High-Grade Glioma

Recurrent Central Nervous System Neoplasm

United States
University of California, Davis
National Cancer Institute (NCI); NovoCure Ltd.

Withdrawn

NovoTTF-100A With Bevacizumab and Carmustine in Treating Patients With Glioblastoma Multiforme in First Relapse

Recurrent Adult Brain Neoplasm | Adult Brain Glioblastoma

United States
National Cancer Institute (NCI)

Completed

A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas

Adult Anaplastic Astrocytoma | Adult Giant Cell Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor

United States
St. Jude Children's Research Hospital
AstraZeneca

Completed

ZD1839 and Oral Irinotecan in Treating Young Patients With Refractory Solid Tumors

Glioblastoma | Osteosarcoma | Neuroblastoma | Rhabdomyosarcomas

United States
University of Roma La Sapienza

Not yet recruiting

Vesical Imaging-Reporting and Data System (VI-RADS) Followed by Photodynamic Trans-urethral Resection of Bladder Tumours (PDD-TURBT) to Avoid Secondary Resections (Re-TURBT) in Non-Muscle Invasive Bladder Cancers (NMIBCs) (CUT-less)

Non-muscle-invasive Bladder Cancer | Non-Muscle Invasive Bladder Urothelial Carcinoma | High Risk Non-Muscle Invasive Bladder Urothelial Carcinoma
University Hospital, Basel, Switzerland

Recruiting

Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases (AiD-GLIO)

Glioblastoma (GBM)

Switzerland
Shanghai Pudong Hospital

Recruiting

Efficacy and Safety Evaluation of Percutaneous Ommaya Capsule Injection of Autologous Bi-dimensional Specific T Cells in the Treatment of Glioma and in Combination With Pemetrexed in the Treatment of Brain/Meningeal Metastases

Glioma | Brain Metastases

China
Nova Scotia Health Authority
Canadian Cancer Society (CCS)

Enrolling by invitation

The Impact of Resistance ExerciSe on Muscle Mass in GlioblaSToma Survivors (RESIST)

Brain Cancer | Glioblastoma Multiforme of Brain

Canada
Gary Archer Ph.D.
National Cancer Institute (NCI)

Completed

Vaccine Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme (ATTAC)

Malignant Neoplasms of Brain

United States
National Cancer Institute (NCI)

Completed

O6-Benzylguanine and Temozolomide in Treating Young Patients With Recurrent or Progressive Gliomas or Brain Stem Tumors

Brain and Central Nervous System Tumors

United States
Grupo Español de Investigación en Neurooncología
Pfizer

Completed

Safety and Efficacy of PF-299804 (Dacomitinib), a Pan-HER Irreversible Inhibitor, in Patients With Recurrent Glioblastoma With EGFR Amplification or Presence of EGFRvIII Mutation. A Phase II CT.

Glioblastoma | Brain Tumor, Recurrent

Spain
Ann & Robert H Lurie Children's Hospital of Chicago

Completed

Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors

Glioblastoma | Astrocytoma | Supratentorial Neoplasms | Rhabdoid Tumor | Pineoblastoma

United States
Angiochem Inc

Completed

ANG1005 in Patients With Recurrent High-Grade Glioma

Glioma | Glioblastoma | Brain Tumor, Recurrent

United States
Cedars-Sinai Medical Center

Terminated

Pilot Study of Vardenafil and Carboplatin in Patients With Gliomas and Brain Metastases (LevitraCarbo)

Glioma | Brain Neoplasms | Brain Metastasis

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Children With Progressive Brain Tumors

Brain Tumors | Central Nervous System Tumors

United States, Canada, Australia, Switzerland, Netherlands, New Zealand
Michael Prados
National Cancer Institute (NCI); Genentech, Inc.

Terminated

Erlotinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

Adult Brain Tumors

United States
AstraZeneca

Completed

Phase I : Cediranib in Combination With Lomustine Chemotherapy in Recurrent Malignant Brain Tumour

Brain Tumor | Recurrent Glioblastoma

United States, United Kingdom
Chimerix
National Institutes of Health (NIH)

Recruiting

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Glioblastoma | Neuroectodermal Tumors | Neuroectodermal Tumors, Primitive | Central Nervous System Neoplasms | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Pleomorphic Xanthoastrocytoma | Pleomorphic Xanthoastrocytoma | Oligodendroglioma | Choroid Plexus Neoplasms | Diffuse Astrocytoma | Anaplastic... and other conditions

United States
Emory University

Completed

Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors (AflacST1501)

Diffuse Intrinsic Pontine Glioma | Brain Tumor, Recurrent | Solid Tumor, Recurrent | Neuroblastoma, Recurrent, Refractory | Ewing Sarcoma, Recurrent, Refractory | Rhabdomyosarcoma, Recurrent, Refractory | Osteosarcoma, Recurrent, Refractory | Rhabdoid Tumor, Recurrent, Refractory

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer

Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult... and other conditions

United States, Italy
Hoffmann-La Roche
Chugai Pharmaceutical Co.

Recruiting

A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Satralizumab In Patients With Anti-N-Methyl-D-Aspartic Acid Receptor (NMDAR) Or Anti-Leucine-Rich Glioma-Inactivated 1 (LGI1) Encephalitis (Cielo)

NMDAR Autoimmune Encephalitis | LGI1 Autoimmune Encephalitis

United States, Korea, Republic of, China, Japan, Czechia, Italy, Poland, Austria, Brazil, Argentina, Netherlands, Taiwan, Denmark, France, Ghana
Centre Leon Berard

Recruiting

Profiling Program of Cancer Patients With Sequential Tumor and Liquid Biopsies (PLANET) (PLANET)

Glioblastoma | Advanced / Metastic Solid Tumors | Chronic Leukemia Lymphocytic

France
Sümeyye Sezer

Recruiting

Educating Brain Tumor Patients Using Patient-specific Actual-size Three-dimensional Printed Models (IMAGE-3D)

Glioma | Glioblastoma | Astrocytoma | Brain Tumor | Oligodendroglioma | Decision Making, Shared | Patient Education as Topic | Neoplasm, Brain

Netherlands
Northwell Health

Recruiting

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

Glioblastoma | Brain Cancer | Brain Tumor | GBM | Brain Neoplasm | Brain Neoplasm, Malignant | EGFR Gene Overexpression

United States
The Hospital for Sick Children

Completed

COZMOS:Phase I/Ib Trial of Combined 5'Azacitidine and Carboplatin for Recurrent/Refractory Pediatric Brain/Solid Tumors (COZMOS)

Childhood Solid Tumor | Recurrent Childhood CNS Tumor | Ependymoma, Recurrent Childhood

United States, Canada, Australia
National Cancer Institute (NCI)

Completed

Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers

Sarcoma | Leukemia | Astrocytoma | Brain Cancer | Glioblastomas

United States
Stanford University

Completed

Phase 1-2 of Temozolomide and Hypofractionated Radiotherapy in Tx of Supratentorial Glioblastoma Multiform (Tx-Treatment)

Glioblastoma | Glioblastoma Multiforme | Cancer of Brain and Nervous System

United States
St. Joseph's Hospital and Medical Center, Phoenix
Novartis; Wayne State University; Translational Genomics Research Institute

Completed

Preoperative Ceritinib (LDK378) in Glioblastoma Multiforme and CNS Metastasis

Glioblastoma | Brain Metastases

United States

Clinical Trials on High-grade Gliomas

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