Clinical Trials on Immune-mediated Diseases

Total 380608 results

Mayo Clinic

Recruiting

Blood-Based Biomarkers to Inform Treatment and Radiation Therapy Decisions for HPV Associated Oropharyngeal Squamous Cell Head and Neck Cancers

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Oropharyngeal Human Papillomavirus-Positive Squamous...

United States
Arizona State University
Karen L. Sweazea; Brendan Miller

Completed

Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure

High Blood Pressure | Flow Mediated Dilation

United States
Third Affiliated Hospital, Sun Yat-Sen University

Recruiting

Efficacy and Safety of ALSS Treatment for ICIs-LF in Patients With HCC

Liver Failure | Hepatocellular Carcinoma | Immune-Mediated Hepatitis

China
Rutgers, The State University of New Jersey
National Cancer Institute (NCI)

Active, not recruiting

Swallowing Outcomes and Circulating Tumor DNA in Patients With HPV Related Oropharyngeal Cancer Treated With Transoral Surgery and Reduced Intensity Adjuvant Therapy

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Oropharyngeal Human Papillomavirus-Positive Squamous...

United States
University Hospital, Lille

Not yet recruiting

Characterization of Rhythmicity Profiles of Bradykinin-mediated Angioedema Attacks Using a Tracking Smartphone Application. (ANGIOAPP)

Bradykinin-mediated Angioedema
ENTrigue Surgical, Inc.

Completed

ENTact™ Septal Stapler Shelf Life Extension (SSLE)

Deviated Nasal Septum

United States
Lee S Nguyen

Completed

HEart trAnsplantation Registry of piTie-Salpetriere University Hospital (HEARTS)

Heart Failure | Cardiac Death | Cardiac Allograft Vasculopathy | Acute Cellular Graft Rejection | Cardiac Transplant Disorder | Immune Tolerance | Heart Transplant Rejection | Antibody-Mediated Graft Rejection
Sanofi

Completed

Retrospective Study on Caplacizumab-treated Pediatric Patients With Immune-mediated Thrombocytopenic Purpura (iTTP)

Immune-mediated Thrombocytopenic Purpura

France
Gladwin, Mark, MD

Terminated

Endothelial Injury and Development of Coronary Intimal Thickening After Heart Transplantation

Cardiac Allograft Vasculopathy | Antibody Mediated Rejection

United States
Ionis Pharmaceuticals, Inc.
AstraZeneca

Active, not recruiting

CARDIO-TTRansform Magnetic Resonance Imaging (MRI) Sub-study

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

United States, United Kingdom, Italy, Spain
University Hospital, Basel, Switzerland

Recruiting

Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases (NEUTROSKIN)

Inflammatory Dermatoses | Neutrophil-mediated Inflammatory Dermatoses

Switzerland
University of Alabama at Birmingham

Completed

Vascular Function, Insulin Sensitivity, and Vitamin D (VIVID)

Insulin Sensitivity | Arterial Stiffness | Flow-mediated Dilation

United States
National Cancer Institute (NCI)
NRG Oncology

Suspended

De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

Oropharyngeal Squamous Cell Carcinoma | Squamous Cell Carcinoma | Basaloid Squamous Cell Carcinoma | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Papillary Squamous Cell Carcinoma | Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC... and other conditions

United States, Canada
Ionis Pharmaceuticals, Inc.
AstraZeneca

Active, not recruiting

The CARDIO-TTRansform Scintigraphy Sub-study

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

United States, Spain
Washington University School of Medicine
American Diabetes Association

Withdrawn

Effects of Xenin-25 on Insulin Secretion and Gastric Emptying in Humans With and Without a Complete Truncal Vagotomy

Does the Vagus Nerve Mediate the Effects of Xenin-25

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...
Princess Beatrix Muscle Foundation

Recruiting

Add-on Intravenous Immunoglobulins in Early Myositis (TIMEISMUSCLE)

Myositis | Dermatomyositis | Polymyositis | Antisynthetase Syndrome | Immune-Mediated Necrotizing Myopathy | Inflammatory Myopathy, Idiopathic

Netherlands
Federico II University

Unknown

Effects of FSH on Endothelial Function (FEND) (FEND)

Change in Flow Mediated Dilation

Italy
Columbia University
Merck Sharp & Dohme LLC

Completed

Cytokine Production and Immunity to Varicella Zoster Virus (VZV) in Elderly Recipients of Zoster Vaccine

Immunity; Defect Due to Antibody or Cell Mediated Immune Defect

United States
Cabaletta Bio

Recruiting

RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy

Idiopathic Inflammatory Myopathy | Dermatomyositis | Immune-Mediated Necrotizing Myopathy | Anti-Synthetase Syndrome

United States
Federal University of Minas Gerais
Fundação de Amparo à Pesquisa do estado de Minas Gerais

Completed

Vascular Effect of Estradiol Valerate Versus Placebo Evaluated by Flow-mediated Dilatation of Brachial Artery (VEDILA)

Flow-mediated Dilation Evaluation of the Brachial Artery

Brazil
Amyndas Pharmaceuticals S.A.

Completed

First-In-Human Clinical Study of the C3 Complement Inhibitor AMY- 101 in Healthy Male Volunteers

Complement Mediated Diseases

United States
Chinese University of Hong Kong

Completed

The Role of IGRA in Screening and Monitoring for TB During Anti TNF Therapy in Patients With IMID (IGRA)

Tuberculosis | Crohn Disease | Ulcerative Colitis | Inflammatory Bowel Disease | Immune-mediated Inflammatory Disease

Hong Kong
Kafrelsheikh University

Unknown

Superomedial Pedicle Versus Inferior Pedicle Techniques in Wise Pattern Reduction Mammaplasty :A Comparison Study

To Compare Complications of Both Techniques in Wise Pattern Reduction Mammaplasty and to Correlate Between Complications and Patient Mediated Factors

Egypt
Federal University of Minas Gerais

Completed

Vascular Effect of Tibolone Versus Placebo Evaluated by Flow-mediated Dilatation of Brachial Artery

Flow-mediated Dilation Evaluation of the Brachial Artery

Brazil
GE Healthcare

Completed

IMPROVE Critical Care Study (Pilot)

Sedated ICU Patients

United Kingdom
Evelyne Vinet
McGill University Health Centre/Research Institute of the McGill University... and other collaborators

Recruiting

At the Heart of the Matter - Speckle Tracking Echocardiography in Lupus Mothers and Their Offspring

Cardiovascular Diseases | Systemic Lupus Erythematosus | Pregnancy Complications | Cardiovascular Morbidity | Hydroxychloroquine | Cardiovascular Complication | Placenta-mediated Pregnancy Complications | Speckle Tracking Echocardiography

Canada
University of Alabama at Birmingham

Completed

Vitamin D, Insulin Sensitivity, and Vascular Associations in Adolescents (DIVA)

Insulin Sensitivity | Arterial Stiffness | Flow-mediated Dilation

United States
Stanley Jordan, MD

Completed

Clazakizumab for Chronic and Active Antibody Mediated Rejection Post-Kidney Transplant

Kidney Transplant Rejection | Kidney Transplant; Complications | Antibody-mediated Rejection | Transplant Glomerulopathy | Transplant Glomerulopathy - Late Form | Transplant Glomerulopathy - Early Form

United States
argenx

Recruiting

A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy (ALKIVIA+)

Myositis | Dermatomyositis | Polymyositis | Antisynthetase Syndrome | Immune-Mediated Necrotizing Myopathy | Active Idiopathic Inflammatory Myopathy

Korea, Republic of, Thailand, United States, Bulgaria, Taiwan, Argentina, Belgium, Cyprus, Denmark, France, Georgia, Germany, Greece, Italy, Lithuania, Czechia, Sweden
argenx

Recruiting

A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy. (ALKIVIA)

Myositis | Dermatomyositis | Polymyositis | Antisynthetase Syndrome | Immune-Mediated Necrotizing Myopathy | Active Idiopathic Inflammatory Myopathy

United States, Germany, Spain, Korea, Republic of, Austria, Turkey, Lithuania, Australia, Thailand, Serbia, Poland, Italy, France, Netherlands, Argentina, United Kingdom, Georgia, Belgium, Bulgaria, Canada, Cyprus, Denmark, Greece, Hu... and more
Ohio State University Comprehensive Cancer Center
National Cancer Institute (NCI)

Withdrawn

Digital PET Scan for the Prediction of Outcomes in Patients With Locally Advanced Oropharyngeal Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma... and other conditions

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Metabolic Profiling of Immune Responses in Immune-mediated Diseases

Psoriasis | Primary Immunodeficiency | Atopic Dermatitis | Immune-mediated Diseases

United States
Charles M Knudson

Recruiting

Biorepository and Registry for Plasma Exchange Patients

Antibody-mediated Rejection | CIDP | NMO Spectrum Disorder | TTP

United States
Alnylam Pharmaceuticals

Completed

A Safety and Tolerability Study of an Investigational Drug, ALN-TTRSC02, in Healthy Subjects

Transthyretin-mediated Amyloidosis (ATTR Amyloidosis)

United Kingdom
Akcea Therapeutics

Recruiting

TEGSEDI Pregnancy Surveillance Program

Pregnancy | Hereditary Transthyretin-mediated Amyloidosis With Polyneropathy

United States
Ionis Pharmaceuticals, Inc.
AstraZeneca

Recruiting

An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

United States, Austria, Belgium, Canada, France, Germany, Israel, Italy, Portugal, Spain, Sweden, United Kingdom, Australia, Greece
Alnylam Pharmaceuticals

Recruiting

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis) (ConTTRibute)

Transthyretin-Mediated Amyloidosis | ATTR Amyloidosis

Israel, Italy, Netherlands, Spain, United States, France, Denmark, Germany, Portugal, Brazil, Taiwan
Ionis Pharmaceuticals, Inc.

Active, not recruiting

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

United States, Australia, Spain, Canada, Germany, Japan, Italy, Israel, Argentina, France, Portugal, Austria, Brazil, Greece, United Kingdom, Czechia, Sweden, Belgium, Denmark, Poland, Puerto Rico
Mayo Clinic

Recruiting

Allogeneic BM-MSC's in Patients With Lumbar Facet Arthropathy

Facet-Mediated Low Back Pain

United States
Mayo Clinic

Active, not recruiting

Allogeneic BM-MSCs in Patients With Lumbar Facet Arthropathy (Cellkine)

Facet-Mediated Low Back Pain

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
Celgene Corporation

Completed

A Trial of Oral 5-azacitidine in Combination With Romidepsin in Advanced Solid Tumors, With an Expansion Cohort in Virally Mediated Cancers and Liposarcoma

Solid Tumors | Virally Mediated Cancers and Liposarcoma

United States
Chugai Pharmaceutical

Not yet recruiting

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

Antiphospholipid Syndrome (APS) | Immune Thrombocytopenia (ITP) | Dermatomyositis (DM) | Bullous Pemphigoid (BP) | Behçet's Syndrome (BS) | Immune-mediated Necrotizing Myopathy (IMNM)

United States, Japan
Alnylam Pharmaceuticals

No longer available

Expanded Access Protocol to Provide Patisiran to Patients With Transthyretin-mediated Amyloidosis With Cardiomyopathy

Transthyretin-mediated Amyloidosis With Cardiomyopathy | ATTR Amyloidosis With Cardiomyopathy

United States
Samsung Medical Center

Unknown

Perioperative Administration of Pregabalin for Pain After Septoplasty

Deviated Nasal Septum

Korea, Republic of
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma

Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7 | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma... and other conditions

United States
Englewood Hospital and Medical Center

Terminated

BIS-Guided Sedation Monitoring

Patients Who Are Mechanically Ventilated and Sedated

United States
Hadassah Medical Organization
Oridion

Unknown

Quantitive And Qualitive Assessment Of The Oxygen Delivery And EtCO2 Sampling With The Smart Bite Block Mark III During An Upper Endoscopic Procedure Under Sedation

Ventilatory Status of Deeply Sedated ERCP Patients

Israel
Zhengzhou University
Fundamenta Therapeutics, Ltd.

Not yet recruiting

Safety, Efficacy and Pharmacokinetics of ThisCART19A in Patients With Refractory or Relapsed B Cell Lymphoma

Allogeneic, CAR-T, Protein Sequestration, Non-gene Edited, r/r B-NHL
Catharina Ziekenhuis Eindhoven
Alloksys Life Sciences B.V.

Completed

Efficacy and Safety Study on bIAP (APPIRED)

Coronary Artery Disease | Endotoxin-mediated Complications From Cardiopulmonary Bypass Surgery

Netherlands
Bayside Health

Completed

The Impact of Bispectral Index Monitoring on Sedation Administration in Mechanically Ventilated Patients

Mechanically Ventilated Patients | Intensive Care | Sedated Patients

Australia

Clinical Trials on Immune-mediated Diseases

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