- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01041547
Vascular Function, Insulin Sensitivity, and Vitamin D (VIVID)
Vitamin D, Vascular Function, and Insulin Sensitivity in Adults [The VIVID Study
The overall objectives of this study are to examine the relationships between circulating vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine whether vitamin D deficiency in African Americans (AA) and White Hispanics (WH) is responsible for ethnic differences in insulin sensitivity and hypertension in AA, WH and European Americans (EA), as well as mechanisms underlying the association between insulin resistance and blood pressure. We hypothesize that 1) serum 25(OH)D is associated with insulin sensitivity and vascular functioning, independent of adiposity, 2) lower insulin sensitivity and vascular functioning in AA and WH relative to EA is due to lower circulating 25(OH)D in AA, and 3) the relationship between insulin resistance and vascular dysfunction is mediated by 25(OH)D.
Acronyms: African American (AA), European American (EA), White Hispanics (WH), Serum 25-hydroxy vitamin D (25()H)D, Body mass index (BMI), Alabama (AL).
Study Overview
Status
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Alabama
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Birmingham, Alabama, United States, 35243
- University of Alabama
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
- Healthy adults with BMI below 32
- Both males and females
- Ages 19-60 years
- Race: African Americans, White Hispanics, European Americans
Description
Inclusion Criteria:
- African American (AA), White Hispanic (WH), and European American (EA) race
- Ages 19-60 years
- Negative urine pregnancy test
- No evidence of diabetes
- Not on medications that can affect vascular functioning or insulin sensitivity
Exclusion Criteria:
- BMI > 32 kg/m2
- Diabetes or any chronic diseases
- Use of medication(s) known to influence body composition, vascular function, or glucose metabolism
- Regular smoking
- Regular use of illegal drugs and pregnancy
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Healthy adults
healthy adults with BMI below 32, between ages 19-60 yrs, both males and females
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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Insulin sensitivity
Time Frame: Cross sectional study: at first study visit
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Cross sectional study: at first study visit
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
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Vascular function
Time Frame: Cross sectional study: at second study visit, within 2 weeks of first study visit
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Cross sectional study: at second study visit, within 2 weeks of first study visit
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Collaborators and Investigators
Investigators
- Principal Investigator: Ambika Ashraf, MD, University of Alabama at Birmingham
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- F091023002
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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