Clinical Trials on Immunological Deficiency

Total 9143 results

Boris Juelg, MD PhD
National Institute of Allergy and Infectious Diseases (NIAID); The University... and other collaborators

Recruiting

Safety, Immunogenicity, Efficacy of Ad26.Mos4.HIV, MVA-BN-HIV and PGT121, PGDM1400, and VRC07-523LS in HIV-1-Infected Adults

Acquired Immunodeficiency Syndrome | Sexually Transmitted Diseases, Viral | Retroviridae Infections | HIV | Immunologic Deficiency Syndrome, Acquired

United States
PATH

Not yet recruiting

Developing a Screening Tool for Primary Immunodeficiency Disease (PID) in Pakistan

Primary Immunodeficiency Diseases

Pakistan
University Children's Hospital, Zurich
University Hospital, Geneva; University Children's Hospital Basel

Recruiting

Genetic Study of Immunodeficiency: Search for New Genetic Causes for Primary Immunodeficiencies (GSI)

Immunologic Deficiency Syndromes

Switzerland
Octapharma
Premier Research Group plc

Completed

A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases

Primary Immunodeficiency Diseases

United States
Prothya Biosolutions

Completed

Pharmacokinetics and Safety of IVIG Nanogam 100 mg/ml (Nanogam)

Primary Immunodeficiency

Netherlands
Prothya Biosolutions

Completed

Kinetics, Efficacy and Safety of IVIG-L in Hypogammaglobulinemia Patients

Hypogammaglobulinemia

Netherlands
Willem Daniel Francois Venter
Bill and Melinda Gates Foundation

Completed

Dose Optimisation of Stavudine for the Treatment of HIV Infection (D4T)

Human Immunodeficiency Virus | Acquired Immune Deficiency Syndrome

South Africa, India, Uganda
King's College London
University of Sheffield; University of Manchester; National Health Service, United... and other collaborators

Recruiting

The Experience of Screening for SCID

Severe Combined Immunodeficiency

United Kingdom
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Genetic Basis of Immunodeficiency

Severe Combined Immunodeficiency

United States
David Williams
University of California, Los Angeles; Boston Children's Hospital; Children's...

Completed

Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral Vector

Severe Combined Immunodeficiency

United States
St. Jude Children's Research Hospital

Completed

Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency Syndrome

Severe Combined Immunodeficiency

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Genetic Analysis of Immune Disorders

Immunodeficiency | GATA2 | DOK 8 | STAT1 | STAT3

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Immune Regulation in Patients With Common Variable Immunodeficiency and Related Syndromes

CVID | XLA

United States
Universidade Metodista de Piracicaba

Completed

Electromiography Study in the Respiratory Muscle Training in Human Lymphotropic Virus Type 1

HTLV-I Infections

Brazil
Jasper Therapeutics, Inc.

Recruiting

JSP191 Antibody Targeting Conditioning in SCID Patients

SCID

United States
Taiga Biotechnologies, Inc.

Not yet recruiting

Safety and Early Efficacy Study of TBX-1400 in Patients With Severe Combined Immunodeficiency

Severe Combined Immunodeficiency

Israel
Ghady Haidar
AstraZeneca

Active, not recruiting

PREP (Pre-Exposure Prophylaxis) of COVID-19 (PrEP)

COVID-19 | Immuno-Deficiency

United States
Donald B. Kohn, M.D.
National Institutes of Health (NIH); FDA Office of Orphan Products Development

Completed

MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID

Severe Combined Immunodeficiency

United States
Gazi University

Recruiting

Investigation of the Effects of Pulmonary Rehabilitation in Children With Primary Immunodeficiency

Primary Immunodeficiency

Turkey
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Composition and Function of Gut Microbiota in Porto-sinusoidal Vascular Disease Associated With Variable Common Immunodeficiency (MI-MVPS)

Vascular Diseases | Common Variable Immunodeficiency

France
Grifols Therapeutics LLC

Completed

A Study to Evaluate IGSC 20% Biweekly Dosing in Treatment-Experienced Participants and Loading/Maintenance Dosing in Treatment-Naïve Participants With Primary Immunodeficiency

Primary Immunodeficiency

United States
Novartis Pharmaceuticals

Completed

Study of Efficacy of CDZ173 in Patients With APDS/PASLI

Common Variable Immunodeficiency (CVID), APDS / PASLI

Germany, Russian Federation, Ireland, Italy, United Kingdom, Belarus, Netherlands, Czechia, United States
Grifols Therapeutics LLC

Completed

Safety and Pharmacokinetics of IGSC 20% in Subjects With Primary Immunodeficiency

Primary Immunodeficiency

United States, Canada
O & O Alpan LLC

Unknown

Investigation of Immune Disorders and Deficiencies

Autoimmune Diseases | Hypogammaglobulinemia | Inflammatory Diseases | Primary Immune Deficiencies | Common Variable Immune Deficiencies

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)

Idiopathic CD4 Lymphopenia

United States
Octapharma

Completed

CLINICAL PHASE III STUDY TO MONITOR THE SAFETY, TOLERABILITY AND EFFICACY OF SUBCUTANEOUS HUMAN IMMUNOGLOBULIN (OCTANORM) IN PATIENTS WITH PRIMARY IMMUNODEFICIENCY DISEASES, INCLUDING (BUT NOT LIMITED TO) THOSE WHO HAVE COMPLETED THE SCGAM-01 TRIAL

Primary Immunodeficiency

United States, Canada
Assiut University

Completed

Minipooled-IVIG in Primary Immunodeficiency Disease

Primary Immunodeficiency

Egypt
CSL Behring

Completed

Safety and Tolerability of Higher Infusion Parameters of IgPro20 (Hizentra) in Subjects With Primary Immunodeficiency (PID)

Primary Immunodeficiency

United States, Canada
University Hospital, Lille

Completed

Evolution of Interleukin 7, Fat Mass and Metabolic Profile Before and After Transplantation (IL-7tran)

Immunodeficiency Secondary to Organ Transplantation

France
Assistance Publique - Hôpitaux de Paris

Completed

Idiopathic CD4 Lymphocytopenia (Lympho-4)

Idiopathic CD4 Lymphocytopenia

France
IMMUNOe Research Centers

Completed

The Benefit of 5% IVIG for Patients With Primary Immunodeficiency Disorders Who Experience Adverse Events on 10% IVIG Preparations

Primary Immunodeficiency
Grifols Therapeutics LLC

Completed

Pharmacokinetics, Safety, and Tolerability of Subcutaneous GAMUNEX-C in Pediatric Subjects With Primary Immunodeficiency (KIDS)

Primary Immunodeficiency

United States
University of California, San Francisco

Recruiting

Autologous Gene Therapy for Artemis-Deficient SCID

Severe Combined Immunodeficiency

United States
St. Jude Children's Research Hospital

Active, not recruiting

Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)

Severe Combined Immunodeficiency

United States
ANRS, Emerging Infectious Diseases
Institut National de la Santé Et de la Recherche Médicale, France

Active, not recruiting

Covid-19 Vaccine Cohort in Specific Populations (COV-POPART)

Immune Deficiency

France
Association Pour l'Aide a la Recherche en Immunologie...

Completed

Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow Allograft (LymphImaging)

Severe Combined Immunodeficiency

France
University of California, San Francisco

Terminated

Hematopoietic Stem Cell Transplantation (HSCT) for Children With SCID Utilizing Alemtuzumab, Plerixafor & Filgrastim

Severe Combined Immunodeficiency

United States
National Human Genome Research Institute (NHGRI)

Completed

Influences on Female Adolescents' Decisions Regarding Testing for Carrier Status of XSCID

Severe Combined Immunodeficiency

United States
Shanghai Children's Medical Center

Unknown

Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China

Severe Combined Immunodeficiency

China
National Human Genome Research Institute (NHGRI)

Completed

Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History Study

Severe Combined Immunodeficiency

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies

Primary Immunodeficiency

United States, Turkey, Italy
National Institute of Allergy and Infectious Diseases...

Recruiting

Immunogenicity of the 9-Valent Human Papillomavirus Recombinant Vaccine in People With Idiopathic CD4 T Cell Lymphocytopenia

Idiopathic CD4 T Cell Lymphocytopenia

United States
Prometic Biotherapeutics, Inc.
Atlantic Research Group

Completed

Study of ProMetic BioTherapeutics Immune Globulin Intravenous (Human) 10%

Primary Immunodeficiency

United States
Grifols Therapeutics LLC

Completed

Efficacy, Pharmacokinetics, Safety, and Tolerability of IGSC 20% in Subjects With Primary Immunodeficiency

Primary Immunodeficiency

Spain, France, Germany, United Kingdom, Australia, Czechia, Hungary, Poland, Sweden
University Hospital, Lille
Shire

Completed

IgG Level in Primary Immunodeficiency Switching From Standard SCIG to Every Other Week HyQvia

Primary Immunodeficiency

France
National Institute of Allergy and Infectious Diseases...

Completed

STA-5326 Meslylate to Treat Gut Inflammation Associated With Common Variable Immunodeficiency

Common Variable Immunodeficiency

United States
ASIS Corporation

Unknown

ASIS for GAMMAGARD in Primary Immunodeficiency (ASISinPI)

Primary Immunodeficiency

United States
Azidus Brasil
Boya Bio Pharmaceutical Group Co Ltd

Not yet recruiting

Efficacy and Safety and Pharmacokinetics of Boya IVIG (Boya)

Primary Immunodeficiency Disease
Azidus Brasil
Sichuan Yuanda Shuyang Pharmaceutical Co., Ltd.

Not yet recruiting

Efficacy, Safety, and Pharmacokinetics of Shu Yang IVIG (Imunoforte)

Primary Immunodeficiency Disease
Dr Medhat Khafagy

Completed

Etiology of Lymphopenia in Covid19 Infection

Lymphopenia

Egypt

Clinical Trials on Immunological Deficiency

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