Clinical Trials on Liver Function in Netherlands

Total 471 results

Ology Bioservices

Completed

Safety and Immunogenicity Study of a Ross River Virus (RRV) Vaccine

Ross River Virus Disease (RRVD)

Netherlands, Austria, Belgium
Novo Nordisk A/S

Recruiting

Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease

Alcohol-related Liver Disease

Czechia, Denmark, Italy, Netherlands, Canada, Spain, United States, Australia, Japan, Greece, France, Poland, Bulgaria, Germany
Hoffmann-La Roche

Completed

A Study of RO5428029 in Healthy Volunteers and Patients With Chronic Hepatitis C

Hepatitis C, Chronic, Healthy Volunteer

Poland, France, Netherlands
European Organisation for Research and Treatment...
Roche Pharma AG; Amgen

Terminated

Efficacy of FOLFOX Alone, FOLFOX Plus Bevacizumab and FOLFOX Plus Panitumumab in Patients With Resectable Liver Metastases (BOS2)

Colorectal Cancer Metastatic | Liver Metastases | KRAS Wild Type Colorectal Cancer

France, Belgium, Austria, Netherlands, Spain, Switzerland
Fondazione Policlinico Universitario Agostino Gemelli...
Mayo Clinic; Hospital Italiano de Buenos Aires; University of California, Los... and other collaborators

Not yet recruiting

Developing Prediction Models for Allograft Failure After Liver Transplantation (IMPROVEMENT)

Liver Transplant Disorder

United States, Argentina, Brazil, Canada, China, India, Italy, Japan, Netherlands, Spain, United Kingdom
Genfit
Premier Research Group plc; Naturalpha

Completed

Phase IIb Study to Evaluate the Efficacy and Safety of GFT505 Versus Placebo in Patients With Non-Alcoholic Steatohepatitis (NASH)

Non-Alcoholic Steatohepatitis (NASH)

United States, Belgium, France, Germany, Italy, Netherlands, Romania, Spain, United Kingdom
Bristol-Myers Squibb

Completed

A Study of Continuous Infusions of HNO (Nitroxyl) Donor in Patients With Heart Failure and Impaired Systolic Function

Heart Failure | Cardiac Failure | Reduced Ventricular Ejection Fraction

United States, United Kingdom, Japan, Netherlands
Arrowhead Pharmaceuticals

Terminated

A Study of ARC-AAT in Healthy Volunteer Subjects and Patients With Alpha-1 Antitrypsin Deficiency (AATD)

Alpha-1 Antitrypsin Deficiency

Australia, Netherlands, Germany, United Kingdom
Boehringer Ingelheim

Terminated

A Study to Test Whether BI 685509 Alone or in Combination With Empagliflozin Helps People With Liver Cirrhosis Caused by Viral Hepatitis or Non-alcoholic Steatohepatitis (NASH) Who Have High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)

Liver Diseases | Hypertension, Portal

Spain, Denmark, Singapore, Germany, Italy, Austria, Canada, Netherlands, China, Israel, Belgium, United States, Japan, Argentina, France, Romania
AbbVie

Completed

Real World Evidence of the Effectiveness of Paritaprevir/r - Ombitasvir, ± Dasabuvir, ± Ribavirin and Patient Support Program in Patients With Chronic Hepatitis C (3DUTCH)

Chronic Hepatitis C

Netherlands
Novartis Pharmaceuticals

Terminated

Study of Safety and Efficacy of Tropifexor (LJN452) in Patients With Non-alcoholic Steatohepatitis (NASH) (FLIGHT-FXR)

Non-alcoholic Steatohepatitis (NASH)

Belgium, Germany, Taiwan, Austria, United States, Spain, Korea, Republic of, Argentina, Australia, Italy, Japan, Singapore, Netherlands, Slovakia, France, Canada, India
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of PDR001 in Patients With Advanced or Metastatic, Well-differentiated, Non-functional Neuroendocrine Tumors of Pancreatic, Gastrointestinal (GI), or Thoracic Origin or Poorly-differentiated Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC)

Well-differentiated Non-functional NET of Thoracic Origin | Well-differentiated Non-functional NET of Gastrointestinal Origin | Well-differentiated Non-functional NET of Pancreatic Origin | Poorly-differentiated Gastroenteropancreatic Neuroendocrine Carcinoma

United States, Italy, Spain, Japan, Belgium, Netherlands, Germany, France, Canada, Austria, United Kingdom, Australia
Public Health Service of Amsterdam
ZonMw: The Netherlands Organisation for Health Research and Development; Amsterdam... and other collaborators

Recruiting

Interventions to Curb Hepatitis C Reinfections Among Men Who Have Sex With Men (ICECREAM)

Hepatitis C Virus Infection

Netherlands, France
Intercept Pharmaceuticals

Completed

Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis (POISE)

Primary Biliary Cirrhosis

United States, Spain, United Kingdom, Austria, Netherlands, Australia, Italy, Germany, Poland, Sweden, France, Canada, Belgium
Radboud University Medical Center

Active, not recruiting

Preservation of Ovarian Cortex Tissue in Girls With Turner Syndrome

Turner Syndrome | Premature Ovarian Failure | Fertility Preservation | Live Birth | Ovarian Tissue Cryopreservation

Netherlands
argenx

Recruiting

Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children With Generalized Myasthenia Gravis (ADAPT Jr +)

Generalized Myasthenia Gravis

United States, Netherlands, Belgium, Poland, United Kingdom
Novo Nordisk A/S

Completed

Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis.

Non-alcoholic Steatohepatitis | Hepatobiliary Disorders

United States, Russian Federation, United Kingdom, Denmark, Sweden, Netherlands, Austria, Belgium, Spain, France, Bulgaria, Canada, Australia, Greece, Japan, Finland, Puerto Rico
Inventiva Pharma

Active, not recruiting

Placebo-controlled, Proof-of-concept Study to Evaluate the Safety and Efficacy of Lanifibranor Alone and in Combination With SGLT2 Inhibitor EmpaGliflozin in patiEnts With NASH and Type 2 Diabetes Mellitus (LEGEND)

Diabetes Mellitus, Type 2 | NASH - Nonalcoholic Steatohepatitis

United States, Belgium, France, Netherlands, United Kingdom
Foundation for Liver Research
Hoffmann-La Roche

Completed

PEG-interferon Alfa-2a add-on Study in HBeAg Negative Chronic Hepatitis B Patients (PAS)

Chronic Hepatitis B

Netherlands, Canada
AstraZeneca

Recruiting

Zibotentan and Dapagliflozin Combination, EvAluated in Liver Cirrhosis (ZEAL Study) (ZEAL)

Liver Cirrhosis

Denmark, Spain, Germany, United States, France, Australia, China, Netherlands, Belgium, Switzerland, Austria, United Kingdom, Taiwan, Canada, Czechia
Novartis Pharmaceuticals

Completed

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension (CONTRAIL I)

Liver Transplant Rejection

United States, Belgium, Germany, Spain, Argentina, Netherlands, Italy, Hungary, France, Czechia
Enyo Pharma
CPR Pharma Services Pty Ltd, Australia

Completed

Evaluation of the Safety and Pharmacology of EYP001 in HBV Subjects

Hepatitis B, Chronic

Thailand, Netherlands, Australia, Poland
Bayer

Completed

Observational Study to Evaluate, Under Real-world Practice Conditions, the Safety and Effectiveness of Regorafenib in Patients Diagnosed With Unresectable Hepatocellular Carcinoma (uHCC)

Liver Neoplasms

United States, Canada, Japan, Spain, Sweden, Belgium, Argentina, Austria, Greece, Italy, Korea, Republic of, Netherlands, Russian Federation, Taiwan, Turkey, China, Denmark, Egypt, France, Saudi Arabia, Thailand
Astellas Pharma Global Development, Inc.

Active, not recruiting

A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-Positive, HER2-Negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW)

Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer | Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer | Metastatic Gastric Adenocarcinoma or Cancer | Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

United States, Korea, Republic of, China, Spain, Taiwan, Japan, Argentina, Canada, Croatia, Greece, Ireland, Malaysia, Netherlands, Portugal, Romania, Thailand, Turkey, United Kingdom
GlaxoSmithKline

Completed

A Mechanistic Study of GSK3228836 With Fine Needle Aspiration (FNA) in Participants With Chronic Hepatitis B (B-Fine)

Hepatitis B

United States, Netherlands, United Kingdom, Canada
Novo Nordisk A/S

Recruiting

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) (ESSENCE)

Non-alcoholic Steatohepatitis

United States, Korea, Republic of, Australia, Taiwan, Italy, Israel, Canada, Netherlands, Czechia, Malaysia, Spain, Denmark, China, United Kingdom, Singapore, Japan, Puerto Rico, Portugal, Switzerland, Ireland, Belgium, Romania, Ger... and more
Clasado
CR2O B.V.

Recruiting

GOS to Reduce Symptom Severity in IBS (EGIS)

Irritable Bowel Syndrome | Irritable Bowel Syndrome - Constipation | Irritable Bowel Syndrome - Diarrhoea | Irritable Bowel Syndrome - Mixed

Belgium, Netherlands, United Kingdom
AstraZeneca

Recruiting

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function (BalanceD-HF)

Heart Failure and Impaired Kidney Function

Spain, France, Germany, Italy, United States, Argentina, Czechia, Vietnam, Peru, China, Philippines, Saudi Arabia, Australia, Austria, Canada, Japan, Malaysia, Poland, Taiwan, Thailand, Israel, Brazil, Finland, Greece, Mexico, United Kingdom and more
Erasmus Medical Center
Radboud University Medical Center; University Medical Center Groningen; Maastricht... and other collaborators

Completed

Dutch Acute HCV in HIV Study (DAHHS) (DAHHS)

Hepatitis C | Human Immunodeficiency Virus

Netherlands
University of Birmingham
University of Oslo; The Leeds Teaching Hospitals NHS Trust; University of Padova and other collaborators

Active, not recruiting

Paediatric Hepatic International Tumour Trial (PHITT)

Carcinoma, Hepatocellular | Hepatoblastoma

United Kingdom, France, Austria, Israel, Spain, Belgium, Czechia, Finland, Germany, Ireland, Netherlands, Norway, Poland, Switzerland
Radboud University Medical Center
Leiden University Medical Center

Active, not recruiting

Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis (CAMARO)

Autoimmune Hepatitis

Netherlands, Belgium
University Medical Center Groningen
Cisbio Bioassays

Completed

Head-to-head Comparison of Two Fecal Biomarkers to Screen Children for IBD (CACATU)

Irritable Bowel Syndrome | Abdominal Pain | Diarrhea | Crohn's Disease | Ulcerative Colitis | Inflammatory Bowel Disease | Rectal Bloodloss

Netherlands, Belgium
Gilead Sciences

Terminated

Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis (STELLAR-3)

Nonalcoholic Steatohepatitis

Hong Kong, United States, Spain, United Kingdom, Australia, Taiwan, Belgium, Canada, India, Japan, Korea, Republic of, Singapore, Puerto Rico, France, Israel, Austria, Germany, Italy, Malaysia, New Zealand, Mexico, Poland, Switzerland, Netherlan... and more
AstraZeneca

Active, not recruiting

Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer

Gastrointestinal Neoplasms | Esophagogastric Junction

Belgium, Denmark, Spain, United Kingdom, Canada, United States, Taiwan, Turkey, France, Germany, Korea, Republic of, Brazil, Hungary, Japan, Peru, Poland, Russian Federation, Netherlands, Chile, Argentina
Foundation for Liver Research

Completed

Augmenting Response to Entecavir With Peginterferon a-2a for the Treatment of HBeAg-positive Chronic Hepatitis B (ARES)

Chronic Hepatitis B

Netherlands, China, Romania, Turkey, Poland
Kamada, Ltd.
Syneos Health

Recruiting

Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD (InnovAATe)

Alpha 1-Antitrypsin Deficiency

United Kingdom, Sweden, Ireland, Netherlands, Belgium, Finland
Amgen

Completed

Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Advanced Malignancies and Hepatic Impairment

Hepatic Impairment | Solid Tumors | Hematologic Malignancies

United Kingdom, Netherlands, United States, France
Zimmer Biomet

Active, not recruiting

G7 BiSpherical Acetabular Shell PMCF Study

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Femoral Neck Fractures | Trochanteric Fractures | Noninflammatory Degenerative Joint Disease | Correction of Functional Deformity | Non-Union Fracture

Netherlands, France, Germany, Switzerland
Astellas Pharma Europe Ltd.

Completed

A 5 Year Follow-up of Patients Who Were Previously Enrolled Into an Advagraf Trial Following a Liver or Kidney Transplant (ADDRESS)

Liver Transplant | Kidney Transplant

Italy, Spain, Belgium, Germany, Latvia, Canada, Korea, Republic of, Czechia, Austria, Finland, Belarus, Estonia, France, Hungary, Ireland, Netherlands, Poland, Portugal, Romania, Russian Federation, Slovakia, Sweden, Switzerland, United...
Clinuvel Pharmaceuticals Limited

Completed

Phase III Confirmatory Study in Erythropoietic Protoporphyria (EPP)

Erythropoietic Protoporphyria

Netherlands, Finland, France, Germany, Ireland, United Kingdom
GlaxoSmithKline

Completed

Safety and Immunogenicity of 3 Lots of GSK Biologicals' HBV-MPL Vaccine and Engerix™-B in Healthy Volunteers ≥ 15y

Hepatitis B

Australia, Czech Republic, Germany, Italy, Netherlands, Switzerland, United Kingdom
AbbVie
Ironwood Pharmaceuticals, Inc.

Enrolling by invitation

Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-C

Irritable Bowel Syndrome With Constipation | Functional Constipation

United States, Canada, Israel, Netherlands
AstraZeneca

Recruiting

Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

Gastric Cancer | Pancreatic Ductal Adenocarcinoma | Esophageal Adenocarcinoma | Gastro-esophageal Junction Cancer

Korea, Republic of, United States, Japan, Taiwan, China, United Kingdom, Netherlands
Boehringer Ingelheim

Completed

A Study to Test Safety and Efficacy of BI456906 in Adults With Non-alcoholic Steatohepatitis (NASH) and Fibrosis (F1-F3)

Non-alcoholic Steatohepatitis (NASH)

United States, Spain, Korea, Republic of, United Kingdom, Australia, Canada, Singapore, Germany, Italy, Malaysia, China, France, Japan, Taiwan, Netherlands, Austria, Israel, New Zealand, Poland, Hong Kong, Belgium, Czechia, Greece, Hu... and more
Erasmus Medical Center

Recruiting

Self-testing for HCV Re-infection in MSM (SELFIE)

HIV-1-infection | Hepatitis C Recurrent

Netherlands
Escient Pharmaceuticals, Inc

Active, not recruiting

Study to Evaluate EP547 in Subjects With Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis (PACIFIC)

Pruritus

United States, United Kingdom, Belgium, Spain, Israel, France, Canada, Netherlands
Gilead Sciences

Completed

Evaluation of the Safety, Tolerability, Pharmacokinetics, and Activity of GS-9450 in Subjects With Chronic HCV

HCV Infection

United States, Netherlands, Germany
Sucampo Pharma Americas, LLC
Takeda

Completed

Lubiprostone for Children With Constipation

Constipation - Functional

United States, United Kingdom, Netherlands, Poland, Belgium, France, Canada
Astellas Pharma Europe Ltd.

Completed

Study to Ascertain if Prolonged Release Tacrolimus (FK506E - MR4) is Safe and Effective When Used in the Long Term and in Combination With Other Immunosuppressive Drugs in Patients Who Have Received a Transplant

Liver Transplantation | Kidney Transplantation | Heart Transplantation

Spain, Australia, France, Germany, Canada, Italy, United Kingdom, Belgium, South Africa, Switzerland, Sweden, United States, Austria, Brazil, Czechia, Denmark, Finland, Hungary, Ireland, Mexico, Netherlands, New Zealand, Poland
Enanta Pharmaceuticals, Inc
Pharmaceutical Research Associates; Triangle Biostatistics

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Primary Biliary Cholangitis

Primary Biliary Cholangitis

United States, Spain, Canada, Australia, United Kingdom, Germany, Netherlands, Belgium, Austria, France

Clinical Trials on Liver Function in Netherlands

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