Clinical Trials on Lower Gastrointestinal Tract in South Africa

Total 7443 results

National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Safety, Tolerability, and Pharmacokinetics of Bedaquiline and Delamanid, Alone and in Combination, For Drug-Resistant Pulmonary Tuberculosis

HIV Infections | Tuberculosis

Peru, South Africa
The Aurum Institute NPC
Johns Hopkins University

Recruiting

Rifapentine and Isoniazid TB Preventive Therapy (3HP) for Children Taking Dolutegravir-based Antiretroviral Treatment (DOLPHIN KIDS) (DOLPHIN KIDS)

HIV | Tuberculosis

South Africa
GlaxoSmithKline

Completed

Clinical Endpoint Trial Investigating Once Daily and Bronchodilator Dosing

Asthma

New Zealand, South Africa
MedImmune LLC

Completed

A Study to Evaluate the Safety of MEDI2338 in Subjects With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

United Kingdom, South Africa
University of Stellenbosch
University of Rochester; Fogarty International Center of the National Institute...

Recruiting

A Pilot Study of Metformin to Reduce Cerebrovascular Dysfunction in Participants With HIV and Metabolic Syndrome. (SMART)

Metabolic Syndrome | HIV Seropositivity

South Africa
ElectroCore INC

Terminated

Noninvasive Neurostimulation of the Vagus Nerve for the Relief of Acute Bronchoconstriction Due to Asthma (BC-SA-01)

Asthma

South Africa
LigaChem Biosciences, Inc.
Radboud University Medical Center; University of California, San Francisco; Ludwig-Maximilians...

Completed

PanACEA DElpazolid Dose-finding and COmbination DEvelopment (DECODE) (DECODE)

Pulmonary Tuberculosis | Infections and Infestations

Tanzania, South Africa
South African National Blood Service

Unknown

Therapeutic Use of Convalescent Plasma in the Treatment of Patients With Moderate to Severe COVID-19

COVID-19 | SARS-CoV-2 Infection | Severe Acute Respiratory Syndrome Coronavirus 2

South Africa
Novartis Pharmaceuticals

Completed

Study to Compare the Pharmacokinetics of Mometasone Furoate Alone and in Combination With Indacaterol in Patients ≥ 6 to < 12 Years Old With Asthma

Asthma

South Africa, Hungary
University of Liverpool
Radboud University Medical Center; University of Cape Town; UNITAID; Liverpool... and other collaborators

Completed

Dolutegravir in Pregnant HIV Mothers and Their Neonates (DolPHIN-2)

Pregnancy Related | HIV-1-infection

Uganda, South Africa
University of Cape Town
Merck Sharp & Dohme LLC

Completed

Typing of Human Papilloma Virus (HPV) From Female Genital Warts

Genital Warts | Human Papilloma Virus

South Africa
Brown University
Rhode Island Hospital; University of Cape Town; Medical Research Council, South... and other collaborators

Active, not recruiting

Our Family Our Future: A Resilience-oriented Family Intervention to Prevent Adolescent HIV/STI Infection and Depression in South Africa

Depression | Sexually Transmitted Diseases | Human Immunodeficiency Virus

South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); University of Miami; Weill Medical College... and other collaborators

Recruiting

Project Khanya: Peer-Delivered Intervention to Improve HIV Medication Adherence and Substance Use in South Africa

Alcohol-Related Disorders | Substance Use | Drug Use | Human Immunodeficiency Virus

South Africa
Eli Lilly and Company

Completed

A Study of LY2623091 in Male and Females With Chronic Kidney Disease

Chronic Kidney Disease

Bulgaria, South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); Medical Research Council, South Africa

Active, not recruiting

Siyakhana Peer: Evaluating a Peer Recovery Coach Model to Reduce Substance Use Stigma in South African HIV Care

Substance-Related Disorders | HIV | Substance Use | Substance Use Disorders | Treatment Adherence | Treatment Adherence and Compliance | Stigmatization | Delivery of Health Care | Stigma, Social | Attitude of Health Personnel | Community Health Workers | Health Personnel | Health Personnel Attitude | Health Care Seeking... and other conditions

South Africa
The Aurum Institute NPC
Karolinska Institutet; Ludwig-Maximilians - University of Munich; University... and other collaborators

Unknown

TB Sequel: Pathogenesis and Risk Factors of Long-term Sequelae of Pulmonary TB (TBSEQUEL)

Respiratory Tract Infections | Tuberculosis, Pulmonary

Mozambique, South Africa, Tanzania, Gambia
University of Stellenbosch
Thrasher Research Fund

Unknown

The Effect of Bacille Calmette Guerin (BCG) Vaccination on Immune Responses in HIV-Exposed and Unexposed Infants

HIV Infections

South Africa
Vaccine Company, Inc.

Active, not recruiting

Study of VXCO-100, a SARS-CoV Candidate Vaccine, in Adults in the Republic of South Africa

SARS-CoV-2 | SARS-CoV

South Africa
Boehringer Ingelheim

Completed

Trial to Evaluate Steady State Pharmacokinetic Parameters, Efficacy and Safety of Nevirapine in Antiretroviral Drug naïve Pediatric Patients

HIV Infections

South Africa
Eastern Virginia Medical School
University of Pittsburgh; United States Agency for International Development... and other collaborators

Recruiting

Safety and PK Multi-dose Study of TAF/EVG Vaginal Insert

Safety Issues

United States, Kenya, South Africa
Derek Yellon

Completed

Can RIC Prevent Deterioration to Critical Care in Covid19

Ischemia | Covid19

Brazil, South Africa, United Kingdom
GlaxoSmithKline

Completed

The Study To Test The Effect of Standardization Of Fluid Intake In Female Patients With Overactive Bladder

Overactive Bladder

Australia
University of Maryland, College Park
National Institute of Mental Health (NIMH); Medical Research Council, South...

Completed

Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa (Siyakhana)

Substance-Related Disorders | Depression | Tuberculosis | Hiv | Mental Health Disorder | Mental Disorder | Health Care Utilization | Treatment Adherence and Compliance | Social Stigma | Attitude of Health Personnel | Community Health Workers | Health Care Delivery

South Africa
ApoPharma

Completed

Evaluation of the Safety, Efficacy, and Pharmacokinetics of Intravenous Deferiprone in HIV-Positive Subjects

Asymptomatic HIV Infection

South Africa
Michael Hoelscher
Radboud University Medical Center; German Federal Ministry of Education and... and other collaborators

Completed

Evaluation of SQ109, High-dose Rifampicin, and Moxifloxacin in Adults With Smear-positive Pulmonary TB in a MAMS Design

Tuberculosis, Pulmonary

South Africa, Tanzania
GlaxoSmithKline

Completed

Assess the Immune Response Following Primary Vaccination With GSK Biologicals' Tritanrix™-HepB/Hib-MenAC vs Tritanrix™-HepB/Hiberix™ Given at 6,10 & 14 Wks of Age to Infants Who Received Hepatitis B Vaccine at Birth

Diphtheria; Haemophilus Influenzae Type b; Hepatitis B; Tetanus; Whole Cell Pertussis

South Africa
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Peripheral Electrical Stimulation for the Treatment of Overactive Bladder (PESTOB)

Idiopathic Overactive Bladder

United Kingdom
International Agency for Research on Cancer
World Health Organization; Cheikh Anta Diop University, Senegal; Walter Sisulu... and other collaborators

Active, not recruiting

The Study for the "Cervical Cancer Screening and Treatment Algorithms Study Using HPV Testing in Africa" (CESTA)

HPV Infection

Senegal, South Africa
Barbara Ensoli, MD
Italian Ministry of Foreign Affairs - Dir. Gen. for Cooperation and Development

Completed

Study to Assess the Seroprevalence of Anti-Tat Antibodies in HIV-infected Patients (ISS OBS T-004)

HIV Infection

South Africa
University of Cape Town
Radboud University Medical Center; University of Stellenbosch; Foundation for... and other collaborators

Recruiting

Evaluating the Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Community-based Active Case Finding for TB and COVID-19

HIV Infections | COVID-19 | Tuberculosis

Zambia, Zimbabwe, South Africa
GlaxoSmithKline

Completed

A 2 Part Study Examining Doses Of GSK961081 In Healthy Volunteers And Then In COPD Patients

Pulmonary Disease, Chronic Obstructive

South Africa, Germany
University of Stellenbosch
Amsterdam Institute for Global Health and Development; Makerere University; University...

Recruiting

Cough Audio Classification as a TB Triage Test (CAGE-TB)

Tuberculosis

South Africa, Uganda
Novartis
Genentech, Inc.; Tanox

Completed

A Study of Efficacy of New Doses of Xolair to Protect From Allergen Challenge in Groups of Asthma Patients Defined by IgE Levels

Asthma

Germany, Netherlands, South Africa
University of Washington
Harvard Medical School (HMS and HSDM); National Institute of Mental Health... and other collaborators

Completed

The Prevention Options for Women Evaluation Research (POWER) Cohort

HIV/AIDS

Kenya, South Africa
University of KwaZulu
King's College London; University of Oxford; University of East Anglia; University... and other collaborators

Recruiting

ENHANCE-EvideNce Led Co-created HeAlth Systems interventioNs for MLTCs CarE (ENHANCE)

Depression | Myocardial Infarction | HIV Infections | Stroke | Hypertension | Diabetes Mellitus | Asthma

South Africa
Aeras
Statens Serum Institut

Completed

A Phase I Study of Safety & Immunogenicity of AERAS-456 in HIV-Neg. Adults Treated for Drug-susceptible Pulmonary TB (C-037-456)

Tuberculosis

South Africa
Boston Scientific Corporation

Completed

Safety and Efficacy Study for the Treatment of BPH (Enlarged Prostate) (REZUM)

Benign Prostatic Hyperplasia | Lower Urinary Tract Symptom

United States
Population Council
United States Agency for International Development (USAID); Bill and Melinda...

Completed

Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission

HIV Infections | Sexually Transmitted Diseases | AIDS | HIV Seroconversion

South Africa
Novavax
Bill and Melinda Gates Foundation

Completed

A Study Looking at the Effectiveness and Safety of a COVID-19 Vaccine in South African Adults

COVID-19 | SARS-CoV-2 Infection

South Africa
Hoffmann-La Roche

Completed

An Observational Study of Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) in Stage V Chronic Kidney Disease Participants on Hemodialysis

Anemia

South Africa
Antiva Biosciences

Completed

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection.

Cervical Cancer | Human Papilloma Virus | HSIL, High Grade Squamous Intraepithelial Lesions | Cervical Dysplasia | HSIL of Cervix | High-Grade Cervical Intraepithelial Neoplasia | HIV Negative | CIN - Cervical Intraepithelial Neoplasia | Cervical Neoplasm

South Africa
Ferring Pharmaceuticals

Completed

Study Investigating the Impact Burden of Nocturia Using the Nocturia Impact Diary (IMPACT)

Nocturia

United States
NYU Langone Health
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Interferon-Gamma on Cavitary Pulmonary Tuberculosis in the Lungs

Tuberculosis | AIDS-related Complex

United States, South Africa
FHI 360
University of Cape Town; City University of New York, School of Public Health

Completed

Comparison of Two Intrauterine Devices (IUDs) Among Cape Town HIV-positive Women

HIV

South Africa
Foundation for Professional Development (Pty) Ltd
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes

HIV/AIDS | Pregnancy | Cost-effectiveness | Antenatal Care | Chlamydia Trachomatis | Vaginal Microbiome | Birth Outcomes | Sexually Transmitted Infection | Neisseria Gonorrhoeae | Trichomonas Vaginalis

South Africa
MedtronicNeuro

Completed

Evaluation of Implantable Tibial Neuromodulation (TITAN 1) Feasibility Study (TITAN 1)

Overactive Bladder

United States
Zenflow, Inc.

Active, not recruiting

Safety and Effectiveness Study of the Zenflow Spring System (BREEZE)

BPH (Benign Prostatic Hyperplasia) | Lower Urinary Tract Symptoms (LUTS)

United States
Norwegian Institute of Public Health
University of Stellenbosch; European and Developing Countries Clinical Trials... and other collaborators

Recruiting

Evaluation of a Rapid Point-of-Care Serological Triage Test for Active TB (SeroSelectTB)

Tuberculosis, Pulmonary

South Africa, Tanzania, Ethiopia
Qurient Co., Ltd.

Terminated

A Phase 2 Study to Evaluate Biomarker Change, Efficacy, Pharmacokinetics, Safety and Tolerability of Telacebec (Q203) in Covid-19 Patients

COVID-19 Virus Infection

South Africa
Alessa Therapeutics Inc.

Completed

A Study to Establish the Feasibility of Biolen for the Local Delivery of Bicalutamide in Patients With Prostate Cancer (Biolen-PC)

Lower Urinary Tract Symptoms | Prostate Adenocarcinoma

United States, Australia, New Zealand

Clinical Trials on Lower Gastrointestinal Tract in South Africa

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