Clinical Trials on MGMT-Methylated Glioblastoma

Total 1675 results

National Cancer Institute (NCI)

Suspended

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

Recurrent Glioblastoma, IDH-Wildtype | MGMT-Methylated Glioblastoma | Recurrent MGMT-Methylated Glioblastoma

United States
Istituto Oncologico Veneto IRCCS
Bayer S.p.A

Recruiting

Regorafenib With Temozolomide With or Without RT in MGMT-Methylated, IDH Wild-type GBM Patients (REGOMA-2)

Glioblastoma, IDH-wildtype | MGMT-Methylated Glioblastoma

Italy
Marco G Paggi, MD, PhD
Istituto Oncologico Veneto IRCCS; Regina Elena Cancer Institute; Carlo Besta...

Recruiting

Repurposing Chlorpromazine in the Treatment of Glioblastoma (RACTAC)

Glioblastoma Multiforme | MGMT-Unmethylated Glioblastoma

Italy
Sidney Kimmel Comprehensive Cancer Center at Johns...

Withdrawn

6 Months Adjuvant Temozolomide (TMZ) vs No Adjuvant TMZ in Newly Diagnosed MGMT Methylated Glioblastoma (GBM)

MGMT-Methylated Glioblastoma
Northwestern University
National Cancer Institute (NCI); Moleculin Biotech, Inc.

Not yet recruiting

WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

MGMT-Unmethylated Glioblastoma | Glioblastoma, IDH-Wildtype

United States
National Cancer Institute (NCI)
NRG Oncology

Active, not recruiting

Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

Gliosarcoma | MGMT-Unmethylated Glioblastoma

United States
The Affiliated Nanjing Drum Tower Hospital of Nanjing...
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

Study of AK105 With Anlotinib and Radiotherapy Adjuvant Therapy in MGMT Unmethylated Newly Diagnosed Glioblastoma.

MGMT-Unmethylated Glioblastoma

China
Basilea Pharmaceutica
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Terminated

Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Glioblastoma | MGMT-Unmethylated Glioblastoma

United States
Darell Bigner
Rockefeller University

Recruiting

D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients

Newly Diagnosed MGMT Unmethylated Glioblastoma

United States
Zhongnan Hospital

Not yet recruiting

Etoposide Plus Cisplatin Compared With Temozolomide in Patients With Glioblastoma

MGMT-Unmethylated Glioblastoma
Second Affiliated Hospital, School of Medicine,...

Recruiting

Anlotinib Combined With STUPP for MGMT Nonmethylated Glioblastoma

MGMT-Unmethylated Glioblastoma

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma

Glioblastoma | Gliosarcoma | MGMT-Unmethylated Glioblastoma

United States
Northwestern University
National Cancer Institute (NCI)

Recruiting

Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma

Glioblastoma | Astrocytoma | Recurrent Glioblastoma | MGMT-Unmethylated Glioblastoma | Glioblastoma, IDH-Wildtype

United States
NYU Langone Health

Completed

Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma

GBM | MGMT-unmethylated Glioblastoma (GBM)

United States
Hideho Okada, MD, PhD
National Cancer Institute (NCI); California Institute for Regenerative Medicine...

Recruiting

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

Glioblastoma | Recurrent Glioblastoma | EGFR Gene Mutation | MGMT-Unmethylated Glioblastoma

United States
National Cancer Institute (NCI)

Recruiting

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Glioblastoma | Gliosarcoma | Recurrent Glioblastoma | MGMT-Unmethylated Glioblastoma

United States
European Organisation for Research and Treatment...
Amgen

Withdrawn

Phase II Trial of Romiplostim for Thrombocytopenia Induced by Lomustine at First Progression of MGMT Promoter-meth Glioblastoma (RIGOLETTO)

First Progression of MGMT Promoter-methylated Glioblastoma

Spain, Switzerland
Sheba Medical Center
Prof. Ronit Satchi-Fainaro, Director, Cancer Biology Research Center, Tel...

Recruiting

Crizanlizumab Alone or in Combination With Nivolumab for Glioblastoma and Melanoma With Brain Metastases (14)

Advanced Glioblastoma | MGMT-Unmethylated Glioblastoma | Metastatic Melanoma in the Central Nervous System

Israel
Northern Sydney and Central Coast Area Health Service
Merck KGaA, Darmstadt, Germany

Unknown

Temozolomide and Procarbazine With Cilengitide for Patients With Glioblastoma Multiforme Without Methylation of the MGMT Promoter Gene (ExCentric)

Newly Diagnosed Non Methylated Glioblastoma Multiforme Grade 4

Australia
Washington University School of Medicine
Incyte Corporation; PapiVax Biotech, Inc.

Recruiting

Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma

Unmethylated Glioblastoma

United States
Grupo Español de Investigación en Neurooncología

Completed

Neo-adjuvant Treatment With Temozolomide and Bevacizumab Previous to Temozolomide Plus Radiation Plus Bevacizumab Therapy in Unresectable Glioblastoma

Glioblastomas

Spain
Neurological Surgery, P.C.

Unknown

Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma (HBO)

Gliosarcoma | Glioblastomas

United States
University Hospital Muenster
Isotope Technologies Munich (ITM) Oncologics; Helmholtz Zentrum München Deutsches...

Recruiting

Radioimmunotherapy With Lu-177 Labeled 6A10 Fab-fragments in Patients With Glioblastoma After Standard Treatment (RIT in GBM)

Glioblastom WHO Grade 4

Germany
Centre Leon Berard

Unknown

Feasibility Study of 68Ga-PSMA PET-CT and 18F-FDOPA PET-CT in Glioblastoma's Patients (PAraDiGM)

Glioblastomas

France
Merck KGaA, Darmstadt, Germany

Terminated

Cilengitide Imaging Trial in Glioblastoma

Supratentorial Newly Diagnosed Inoperable Gliobastoma

Germany
Tocagen Inc.

Terminated

A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients With Solid Tumors or Lymphoma (Toca 6)

Melanoma | Sarcoma | Lymphoma | Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Bladder Cancer | Triple Negative Breast Cancer | IDH1 Mutated Solid Tumors | IDH1 Mutated or MGMT Methylated Recurrent HGG (Not Recruiting)

United States
Huashan Hospital

Unknown

Study About the Validity of MRS-guided Resection on Prognosis High-grade Glioma Gliomas

Glioma | Anaplastic Oligoastrocytoma | Glioblastomas (GBM)
Celldex Therapeutics

Completed

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma (ReACT)

Glioblastoma | Gliosarcoma | Recurrent Glioblastoma | Small Cell Glioblastoma | Giant Cell Glioblastoma | Glioblastoma With Oligodendroglial Component | Relapsed Glioblastoma

United States
Lawrence Recht
Nektar Therapeutics

Completed

Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma

Anaplastic Astrocytomas | Glioblastomas (GBM) | Anaplastic Oligodendrogliomas

United States
Juan M Garcia-Gomez
Hospital Universitario 12 de Octubre; Hospital Clínico Universitario de Valencia

Recruiting

BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels (BIOhabitats)

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Astrocytoma, Grade IV | Glioblastoma, IDH-mutant | Glioblastoma, IDH-wildtype | Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype | Glioblastoma IDH (Isocitrate Dehydrogenase) Mutant

Spain
Jasper Gerritsen
Massachusetts General Hospital; Universitaire Ziekenhuizen KU Leuven; University... and other collaborators

Recruiting

The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202) (RESBIOP)

Glioblastoma | Glioblastoma Multiforme | Glioblastoma, IDH-wildtype | Glioblastoma Multiforme, Adult | Glioblastoma Multiforme of Brain

United States, Belgium, Switzerland, Germany, Netherlands
Jasper Gerritsen
Massachusetts General Hospital; Universitaire Ziekenhuizen KU Leuven; University... and other collaborators

Recruiting

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302) (RECSUR)

Glioblastoma | Glioblastoma Multiforme | Recurrent Glioblastoma | Glioblastoma, IDH-wildtype | Glioblastoma Multiforme, Adult | Glioblastoma Multiforme of Brain | Astrocytoma of Brain | Astrocytoma, Malignant

United States, Germany, Netherlands, Switzerland, Belgium
Leland Metheny
National Cancer Institute (NCI)

Recruiting

hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM) (hSTAR GBM)

Glioblastoma Multiforme | Supratentorial Gliosarcoma | Glioblastoma Multiforme, Adult | Supratentorial Glioblastoma

United States
Northwestern University
Agenus Inc.; CarThera

Recruiting

Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

Glioblastoma Multiforme | Gliosarcoma | Newly Diagnosed Glioblastoma | Glioblastoma, Isocitric Dehydrogenase (IDH)-Wildtype

United States
University Hospital, Geneva

Active, not recruiting

Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma (IMA950-106)

Glioblastoma Multiforme | Glioblastoma Multiforme of Brain | Glioma of Brain | Glioblastoma, Adult

Switzerland
Milton S. Hershey Medical Center

Recruiting

Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas

Glioblastoma | Glioblastoma Multiforme | Glioblastoma Multiforme, Adult | Glioblastoma Multiforme of Brain

United States
Milton S. Hershey Medical Center
National Cancer Institute (NCI)

Recruiting

Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial

Glioblastoma | Glioblastoma Multiforme | Glioblastoma Multiforme, Adult | Glioblastoma Multiforme of Brain

United States
Orbus Therapeutics, Inc.

Recruiting

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma

Glioblastoma | Glioblastoma Multiforme | GBM | Glioblastoma, IDH-wildtype | Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

United States
Jasper Gerritsen
Massachusetts General Hospital; Universitaire Ziekenhuizen KU Leuven; University... and other collaborators

Recruiting

The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203) (PALSUR)

Glioblastoma | Glioblastoma Multiforme | Glioblastoma, IDH-wildtype | Glioblastoma Multiforme, Adult

United States, Belgium, Switzerland, Germany, Netherlands
Celldex Therapeutics

Completed

Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma (ACT IV)

Glioblastoma | Gliosarcoma | Small Cell Glioblastoma | Giant Cell Glioblastoma | Glioblastoma With Oligodendroglial Component

United States, Canada, Australia, Israel, Taiwan, United Kingdom, Belgium, France, Spain, Germany, Austria, Brazil, Colombia, Czechia, Greece, Hungary, India, Italy, Mexico, Netherlands, New Zealand, Peru, Switzerland, Thailand
University of Liverpool
Vitaflo International, Ltd; Walton Centre NHS Foundation Trust

Completed

Ketogenic Diets as an Adjuvant Therapy in Glioblastoma (KEATING)

Glioblastoma | Glioblastoma Multiforme | Glioblastoma, Adult

United Kingdom
Sunnybrook Health Sciences Centre

Recruiting

UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3) (UNITED-3)

Glioblastoma Multiforme, Adult

Canada
Hebei Senlang Biotechnology Inc., Ltd.

Recruiting

The Safety Study of Autologous TILs Therapy for Patients With Glioblastoma Multiforme.

Glioblastoma Multiforme, Adult

China
Polaris Group

Recruiting

ADI-PEG 20 Plus Radiotherapy and Temozolomide in Subjects With Glioblastoma Multiforme (GBM)

Glioblastoma Multiforme (GBM)

Taiwan
University of Iowa
Eisai Inc.

Terminated

Gliadel Wafers and Temodar in the Treatment of Glioblastoma Multiforme (Temodar)

Primary Glioblastoma Multiforme

United States
Laminar Pharmaceuticals
Laboratory Corporation of America; Northern Institute for Cancer Research,... and other collaborators

Recruiting

LAM561 With RT and TMZ for Adults With Glioblastoma (CLINGLIO)

Glioblastoma Multiforme | Primary Glioblastoma

Spain, Italy, United Kingdom, France, Israel
Northwestern University
Bristol-Myers Squibb; Lantheus Medical Imaging; CarThera

Recruiting

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma (SC9/ABX)

Glioblastoma | Glioblastoma Multiforme | Gliosarcoma | GBM | Recurrent Glioblastoma | Glioblastoma, IDH-wildtype

United States
Jonsson Comprehensive Cancer Center
Bristol-Myers Squibb; Northwest Biotherapeutics; Brain Tumor Funders Collaborative

Withdrawn

Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen Vaccine and Nivolumab in Treating Patients With Recurrent Glioblastoma

Gliosarcoma | Recurrent Glioblastoma | Oligodendroglioma | Small Cell Glioblastoma | Giant Cell Glioblastoma

United States
TVAX Biomedical
FDA Office of Orphan Products Development

Recruiting

Study of Neoantigen-specific Adoptive T Cell Therapy for Newly Diagnosed MGMT Negative Glioblastoma Multiforme (GBM)

Glioblastoma Multiforme of Brain

United States
Shenzhen Geno-Immune Medical Institute

Enrolling by invitation

Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme

Glioblastoma Multiforme | Glioblastoma Multiforme of Brain

China

Clinical Trials on MGMT-Methylated Glioblastoma

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