Clinical Trials on Mechanisms of Telomter Homeostasis

Total 49 results

Meir Medical Center

Unknown

The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

High Risk Pregnancies | Telomere Length | Mechanisms of Telomter Homeostasis

Israel
Balance Therapeutics

Completed

A Study to Investigate the Mass Balance of BTD-001 (HV103)

Molecular Mechanisms of Pharmacological Action

United Kingdom
University of Pennsylvania
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Completed

Heritability of Sleep Homeostasis in Twins

Hereditability of Sleep Homeostasis in Twins
University of Malaya
Ministry of Health, Malaysia

Unknown

Pharmacometabolomics of Andrographis Paniculata And Metformin In Healthy Volunteers Under Fasting Condition

Pharmacokinetics | Molecular Mechanisms of Pharmacological Action

Malaysia
Brigham and Women's Hospital
Harvard Medical School (HMS and HSDM)

Recruiting

Revisiting the Mechanism of the Anti-inflammatory Effect of Colchicine

Colchicine Mechanism of Action

United States
California Pacific Medical Center Research Institute

Completed

Role of Serotonin in Acute and Subacute MDMA Effects

MDMA Mechanism of Action

United States
King Faisal Specialist Hospital & Research Center
King AbdulAziz City for Science and Technology

Completed

Measuring Placebo Effect by Elimination and Investigating Mechanism of Action

Placebo Effect | Placebo Mechanisms of Action

Saudi Arabia
University of Maryland, Baltimore

Completed

Low-Dose Galantamine to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine (GalaNic)

Basic Science Study of the Mechanisms of Attentional Enhancement by Compounds Acting on the Nicotinic Receptor

United States
University Hospital, Brest

Completed

Auto-administered Questionnaire by Screening of Disorder of the Haemostasis in Preoperative (HEMOSTASE)

Preoperative Assessment of Hemostasis

France
Vascular Solutions LLC

Completed

Safety and Efficacy Study Comparing Thrombin for Arterial Sealing

Hemostasis of Arterial Punctures

United States
Synapse bv
Maastricht University

Completed

The Effect of Strenuous Exercise on Coagulation.

The Effect of Strenuous Exercise on Haemostasis.

Netherlands
Oslo University Hospital
Helse Sor-Ost

Completed

Comparison Study of Compression Devices Used in Transradial Coronary Angiography

Hemostasis | Injury of Radial Artery | Peripheral Artery Occlusion

Norway
Takeda

Completed

A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935

Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents

United States
Sha Research Foundation

Active, not recruiting

Subtle Energy Transmission and Tao Calligraphy Mindfulness in Telomere Length in Peripheral Blood Leukocytes

Quality of Life | Telomere Length

Canada
University of Sao Paulo

Suspended

Effects of Chronic Leucine Supplemetion on Glucose Homeostasis, Body Compositin, Muscle Mass and Strength of Healthy and Young Subjects

Effect of Chronic Leucine Supplementation on Glucose Homeostasis, Lipid Profile, Body Composition, and Muscle Mass and Strenght

Brazil
Second Affiliated Hospital, School of Medicine,...

Unknown

MRI Study of Antidepressants in the Treatment of Refractory Functional Dyspepsia

Therapeutic Mechanism of Antidepressants for Refractory FD

China
University of Oxford

Completed

Effects of Seven Day Prucalopride Administration in Healthy Volunteers

Mental Disorders | Depressive Disorder | Depression | Mood Disorders | Molecular Mechanisms of Pharmacological Action | Cognition | Antidepressive Agents

United Kingdom
The University of Hong Kong

Unknown

Desmopressin for Bleeding Related to Low Body Temperature

Hypothermia Induced Impairment of Primary Haemostasis

China
Seattle Children's Hospital

Withdrawn

Pharmacology of Exenatide in Pediatric Sepsis (PEPS)

Inflammation | Septic Shock | Glucose Homeostasis | Organ Dysfunction | Health-related Quality of Life

United States
Philippe Gauthier

Completed

Pericapsular Nerve Group Block: An Imaging Study for Determination of the Spread of the Injectate Using 3-D CT Scan

Post Operative Pain | Mechanisms of Analgesia

Belgium
University of Oxford
University of Bath

Unknown

Citalopram and Self Emotional Processing

Depressive Disorder | Depression | Molecular Mechanisms of Pharmacological Action | Mental Disorder | Cognition | Antidepressive Agents

United Kingdom
Southwest Hospital, China
West China Second University Hospital

Completed

RF-assisted Splenic Preservation VS Conventional Treatment of Blunt Splenic Injury.

Radiofrequency Can be Used to Treat Splenic Trauma Because of Its Excellent Coagulation Hemostasis

China
University of Oxford

Completed

Effects of Acute Prucalopride Administration in Healthy Volunteers

Depressive Disorder | Depression | Mood Disorders | Molecular Mechanisms of Pharmacological Action | Mental Disorder | Cognition | Antidepressive Agents

United Kingdom
Second Affiliated Hospital of Wenzhou Medical University

Unknown

Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection

Mental Disorders | Pathologic Processes | Postoperative Complications | Delirium | Neurocognitive Disorders | Dexmedetomidine | Molecular Mechanisms of Pharmacological Action | Physiological Effects of Drugs | Analgesics | Hypnotics and Sedatives

China
Fudan University

Not yet recruiting

The Maintenance Treatment of Apatinib/Capecitabine Versus Observation in Advanced Gastric Cancer

Neoplasms | Stomach Neoplasms | Gastrointestinal Neoplasms | Digestive System Neoplasms | Stomach Diseases | Molecular Mechanisms of Pharmacological Action | Capecitabine | Apatinib
Centre for Addiction and Mental Health

Completed

Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence

Smoking Cessation | Tobacco Smoking | Tobacco Use Disorder | Substance Use Disorders | Molecular Mechanisms of Pharmacological Action | Tobacco Dependence | Physiological Effects of Drugs

Canada
Universitätsklinikum Hamburg-Eppendorf

Completed

The Effect of Oxytocin on Placebo Analgesia: an Experimental Study in Healthy Volunteers

Mechanisms and Modulators of Placebo Analgesia in Healthy Volunteers

Germany
Coramed Technologies LLC

Completed

Equivalency Study of the TEG and CORA Hemostasis Systems

Heart Disease | Focus is on Testing Performance of CORA Hemostasis System.

United States
Luye Pharma Group Ltd.

Completed

Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder

Mental Disorders | Psychotic Disorders | Mood Disorders | Schizophrenia | Schizophrenia Spectrum and Other Psychotic Disorders | Molecular Mechanisms of Pharmacological Action | Tranquilizing Agents | Physiological Effects of Drugs | Psychotropic Drugs | Antipsychotic Agents | Neurotransmitter Agents | Central...

United States
Tianjin Medical University

Terminated

Clinical Research on Retinal Neovascularization of Diabetic Retinopathy

The Mechanism of Retinal Neovascularization of Diabetic | Retinopathy.

China
Taewoong Medical Co., Ltd.

Terminated

Effectiveness and Safety Confirmation Between FASTSEAL® Bioabsorbable VCD and Perclose® ProGlide SMC System

The Patients Who Needed Hemostasis at the Puncture Site of Common Femoral Artety(CFA) Caused by Femoral Angiogram or Intervention After the Catheter Removal

Korea, Republic of
Luye Pharma Group Ltd.

Completed

Relative Bioavailability of LY03010 Compared to Listed Drug

Mental Disorders | Psychotic Disorders | Mood Disorders | Schizophrenia | Molecular Mechanisms of Pharmacological Action | Tranquilizing Agents | Physiological Effects of Drugs | Psychotropic Drugs | Antipsychotic Agents | Central Nervous System Depressants | Neurotransmitter Agents | Schizophrenia Spectrum

United States
University Hospital Tuebingen
German Research Foundation

Unknown

Insulin Sensitivity of the Brain in Pathogenesis of Diabetes Mellitus Type 2

Human Physiology of Energy Homeostasis

Germany
Sunnybrook Health Sciences Centre
University Health Network, Toronto; McMaster University; London Health Sciences...

Recruiting

Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients (CODEX)

Mental Disorders | Nervous System Diseases | Neurologic Manifestations | Delirium | Confusion | Neurobehavioral Manifestations | Neurocognitive Disorders | Cognitive Dysfunction | Dexmedetomidine | Molecular Mechanisms of Pharmacological Action | Signs and Symptoms | Physiological Effects of Drugs | Analgesics,... and other conditions

Canada
Zhonghua Chen,MD
China (Zhejiang) Health technology RESEARCH and development and transformation...

Recruiting

Effect and Mechanism of Remimazolam Benzenesulfonate on Enhanced Recovery After Surgery in Patients Undergoing Radical Gastrectomy for Gastric Cancer

Remimazolam Benzenesulfonate on Nenhanced Recovery After Surgery | Possible Molecular Mechanism of Remimazolam Benzenesulfonate

China
Zhonghua Chen,MD
China (Zhejiang) Health technology RESEARCH and development and transformation...

Recruiting

Effect of Ultrasound-guided Left Stellate Ganglion Block on Rapid Recovery in Patients With Liver Lobectomy and Its Mechanism

Left Stellate Ganglion Block on Rapid Recovery | Possible Molecular Mechanism of Left Stellate Ganglion Block

China
Tianjin Medical University General Hospital

Not yet recruiting

Propranolol on Post Stroke Immune Status and Infection

Cardiovascular Diseases | Stroke | Cerebrovascular Disorders | Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Ischemic Stroke | Molecular Mechanisms of Pharmacological Action | Physiological Effects of Drugs | Propranolol | Immunologic Factors | Beta Blocker

China
Meir Medical Center

Unknown

Targeting ER-Golgi Homeostasis in an Advantageous Therapeutic Strategy in Lung Cancer

The Combined Effect of Hsp90 Inhibitor and HDAC/Proteasome Inhibitors on Lung Cancer Cell Fate and ER-Golgi Homeostasis Will be Examined.

Israel
Zhonghua Chen,MD
Shaoxing Hospital of Zhejiang University

Active, not recruiting

Effect of Ultrasound-guided Left Stellate Ganglion Block on Rapid Recovery of Patients Undergoing Cardiac Valve Replacement and Its Mechanism

Possible Molecular Mechanism of Left Stellate Ganglion Block | Left Stellate Ganglion Block Can Quickly Restore the Left Stellate Ganglion

China
Sichuan Cancer Hospital and Research Institute

Recruiting

TACE, Sorafenib and PD-1 Monoclonal Antibody in the Treatment of HCC

Liver Diseases | Digestive System Neoplasms | Liver Neoplasms | Hepatocellular Carcinoma | Antineoplastic Agents | Molecular Mechanisms of Pharmacological Action | Protein Kinase Inhibitors | Sorafenib

China
Celularity Incorporated

Terminated

Natural Killer Cell (CYNK-001) IV Infusion or IT Administration in Adults With Recurrent GBM (CYNK001GBM01)

Glioblastoma Multiforme | Molecular Mechanisms of Pharmacological Action | Giant Cell Glioblastoma | Astrocytoma, Grade IV | Physiological Effects of Drugs | Peripheral Nervous System Agents | Analgesics | Analgesics, Non-narcotic | Cyclophosphamide | Immunosuppressive Agents | Immunologic Factors | Antiviral... and other conditions

United States
National Cancer Institute, Slovakia
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in Refractory Testicular Germ Cell Cancer.

Neoplasms | Gonadal Disorders | Neoplasms, Germ Cell and Embryonal | Testicular Neoplasms | Testicular Diseases | Antineoplastic Agents | Molecular Mechanisms of Pharmacological Action

Slovakia
The Hospital for Sick Children
Children's Hospital Los Angeles

Active, not recruiting

Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure

Cardiopulmonary Bypass | Palliation of Congenital Heart Diseases | Chest Wall Mechanics | Neonatal Delayed Sternal Closure

Canada
Guizhi Du

Recruiting

The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved

Colorectal Cancer Metastatic | Survival Rate | General Anesthetics Toxicity | Lymphocyte Destruction | Molecular Mechanism of Pharmacological Action

China
Maimonides Medical Center

Recruiting

Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome (PWS-GXR)

Aggression | Behavioral Symptoms | Pathologic Processes | Nervous System Diseases | Obesity | Neurologic Manifestations | Neurobehavioral Manifestations | Congenital Abnormalities | Overnutrition | Nutrition Disorders | Genetic Diseases, Inborn | Intellectual Disability | Self-Injurious Behavior | Abnormalities, Multiple and other conditions

United States
Klinikum Nürnberg

Recruiting

A Study to Investigate the Mechanistic Effects of Dapagliflozin Alone or in Combination With Balcinrenone, Compared to Balcinrenone and Placebo on Body Fluid and Electrolyte Handling and Energy Metabolism in Participants Over 50 Years of Age With Chronic Kidney Disease. (DapaBalci-Leap)

Chronic Renal Failure | Mechanistic Effects of SGLT2 Inhibition and/ or MR Antagonism on Body Fluid and Electrolyte Homeostatis

Germany, France
Xiaoxiang Chen

Unknown

Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian Cancer (AVANIRA3)

Neoplasms | Neoplasms by Histologic Type | Urogenital Neoplasms | Neoplasms by Site | Carcinoma | Neoplasms, Glandular and Epithelial | Genital Neoplasms, Female | Endocrine System Diseases | Ovarian Diseases | Adnexal Diseases | Gonadal Disorders | Endocrine Gland Neoplasms | Ovarian Neoplasms | Fallopian Tube Neoplasms and other conditions

China
Silesian Centre for Heart Diseases
Medical Research Agency, Poland

Not yet recruiting

Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)

Heart Failure | Breast Cancer | Breast Diseases | Cardiotoxicity | Molecular Mechanisms of Pharmacological Action | Angiotensin Receptor Antagonists | Neoplasm, Breast | Cardiac Toxicity | Angiotensin II Type 1 Receptor Blockers | Cancer, Therapy-Related | Antihypertensive Agents | Sacubitril/Valsartan | Cancer...

Poland
Anova Enterprises, Inc

Recruiting

AnovaOS Network Powered Patient Registry

Neoplasms | Infectious Disease | External Causes of Morbidity and Mortality | Pregnancy, Childbirth and the Puerperium | Diseases of the Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) | Endocrine, Nutritional and Metabolic Diseases (E00-E89) | Mental... and other conditions

United States

Clinical Trials on Mechanisms of Telomter Homeostasis

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