Clinical Trials on Metastatic Brain Cancer in United Kingdom

Total 37407 results

M.D. Anderson Cancer Center

Completed

Surgery Versus Stereotactic Radiosurgery in the Treatment of Single Brain Metastasis: A Randomized Trial

Brain Cancer

United States
Barts & The London NHS Trust
Harvard Medical School (HMS and HSDM); Brigham and Women's Hospital

Unknown

Neurosurgical Transitional Care Programme (TCP)

Brain Diseases | Spinal Diseases | Brain Cancer | Brain Tumor | Surgery | Spinal Stenosis | Aneurysm | Fusion of Spine | Brain Metastases | Spinal Fusion | Trigeminal Neuralgia | Brain Tumor, Recurrent | Hydrocephalus | Spinal Cord Neoplasms | Brain Lesion | SPINAL Fracture | Brain Pathology | Spinal Instability | Spinal Curvature | Chiari; Net and other conditions

United Kingdom
Tesaro, Inc.

Active, not recruiting

Study of Niraparib, TSR-022, Bevacizumab, and Platinum-Based Doublet Chemotherapy in Combination With TSR-042

Neoplasms | Solid Tumor | Non Small Cell Lung Cancer | Metastatic Cancer | Advanced Cancer | Non Small Cell Lung Cancer Stage IIIB | Non Small Cell Lung Cancer Metastatic

United States
University of California, San Francisco

Withdrawn

Electronic Patient Reported Outcomes in Patients With Gastrointestinal Cancers

Gastrointestinal Cancers | Gastrointestinal Cancer Metastatic

United States
Sandy Srinivas
Wyeth is now a wholly owned subsidiary of Pfizer; American Society of Clinical... and other collaborators

Terminated

Temsirolimus to Reverse Androgen Insensitivity for Castration-resistant Prostate Cancer

Prostatic Neoplasms | Prostate Cancer | Metastatic Disease | Hormone-refractory Prostate Cancer | Castrate-resistant Prostate Cancer (CRPC) | Androgen-insensitive Prostate Cancer

United States
Yale University
National Cancer Institute (NCI)

Terminated

Non-invasive Measurement of PD-L1 Levels With Positron Emission Tomography (PET) in Head and Neck Malignancies and Intracranial Metastases

Cancer Head Neck | Metastatic Cancer | Metastatic Lung Cancer

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Portal Vein Embolization in Treating Patients With Liver Metastases From Primary Colorectal Cancer

Colorectal Cancer | Metastatic Cancer

United States
IGF Oncology, LLC

Completed

Study of Insulin-like Growth Factor (IGF)-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R

Melanoma | Breast Cancer | Brain Cancer | Head and Neck Cancers | Gastrointestinal Cancers | Gynecologic Cancers | Genitourinary Cancers | Thoracic Cancers

United States
Northwestern University
National Cancer Institute (NCI)

Not yet recruiting

Elacestrant vs Elacestrant Plus a CDK4/6 Inhibitor in Patients With ERpositive/HER2-negative Advanced or Metastatic Breast Cancer

Metastatic Breast Cancer | Estrogen-receptor-positive Breast Cancer | HER2/Neu-Negative Breast Cancer | Advanced Breast Cancerv

United States
University of Leeds
Edinburgh Molecular Imaging Ltd

Completed

EMI-137 in Laparoscopic Colonic Resections

Colonic Cancer | Metastasis to Lymph Node

United Kingdom
Institute of Cancer Research, United Kingdom
Sun Pharmaceutical Industries Limited

Terminated

Abiraterone Acetate in Combination With Tildrakizumab (ACTIon)

Metastatic Castration Resistant Prostate Cancer

United Kingdom, Switzerland
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors

Brain and Central Nervous System Tumors | Metastatic Cancer

United States
Massachusetts General Hospital

Completed

Pre-Operative Nodal Staging of Thyroid Cancer Using USPIO MRI: Preliminary Study

Papillary Carcinoma of Thyroid Gland | Metastatic Medullary Thyroid Cancer | Follicular Thyroid Cancer Lymph Node Metastasis

United States
Mirati Therapeutics Inc.
Novartis

Active, not recruiting

Adagrasib in Combination With TNO155 in Patients With Cancer (KRYSTAL 2)

Metastatic Cancer | Advanced Cancer | Malignant Neoplastic Disease

United States
New Approaches to Brain Tumor Therapy Consortium
National Cancer Institute (NCI)

Completed

Carmustine Implants in Treating Patients With Brain Metastases

Unspecified Adult Solid Tumor, Protocol Specific | Metastatic Cancer

United States
Philogen S.p.A.

Completed

131I-L19SIP Radioimmunotherapy (RIT) in Combination With External Beam Radiation in Patients With Multiple Brain Metastases From Solid Tumors

Brain Metastases From Solid Tumors

Italy, United Kingdom
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Fludeoxyglucose F 18-PET Imaging for Early Detection of Residual Disease in Patients Undergoing Radiofrequency Ablation of Liver Metastases From Colorectal Cancer

Colorectal Cancer | Metastatic Cancer

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Floxuridine, Dexamethasone, and Irinotecan After Surgery in Treating Patients With Liver Metastases From Colorectal Cancer

Colorectal Cancer | Metastatic Cancer

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer

Colorectal Cancer | Metastatic Cancer

United States
National Cancer Institute (NCI)

Active, not recruiting

Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases

Recurrent Breast Carcinoma | Metastatic Triple-Negative Breast Carcinoma | Metastatic Malignant Neoplasm in the Brain | Stage IV Breast Cancer AJCC v6 and v7 | Metastatic Breast Carcinoma | Metastatic BRCA-Associated Breast Carcinoma

United States, Puerto Rico
Imperial College London

Recruiting

Measuring Treatment Response in Metastatic Renal Cell Cancer Using FPIA PET/CT

Metastatic Renal Cell Carcinoma

United Kingdom
Bayer

Recruiting

A Study to Learn How Safe the Study Treatment Actinium-225-macropa-pelgifatamab (BAY3546828) is, How it Affects the Body, How it Moves Into, Through and Out of the Body, and About Its Anticancer Activity in Men With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)

Metastatic Castration-resistant Prostate Cancer

United Kingdom, Netherlands, Finland
Baptist Health South Florida
Blue Earth Diagnostics

Recruiting

18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery (FACILITATE)

Brain Cancer | Brain Metastases | Brain Metastases, Adult

United States
Mayo Clinic

Completed

A Vaccine (PolyPEPI1018 Vaccine) and TAS-102 for the Treatment of Metastatic Colorectal Cancer

Metastatic Colorectal Adenocarcinoma | Metastatic Colon Adenocarcinoma | Metastatic Colorectal Carcinoma | Metastatic Rectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Metastatic... and other conditions

United States
Indiana University

Completed

Mindfulness to Enhance Quality of Life and Support Advance Care Planning (MEANING)

Quality of Life | Metastatic Cancer | Palliative Care | Supportive Care | Meditation | Mindfulness | Advance Care Planning | Family Caregiver

United States
The University of Texas Health Science Center at...

Withdrawn

Adjuvant High-intensity Interval Training During Chemotherapy in Metastatic Prostate Cancer Patients (HIIT PCa)

Metastatic Prostate Cancer | Prostate Cancer Metastatic | Metastatic Prostate Adenocarcinoma | Castrate Resistant Prostate Cancer

United States
Novartis Pharmaceuticals

Terminated

A Dose-escalation Pharmacokinetic Study of Intravenous ASA404 in Adult Advanced Cancer Patients With Impaired Renal Function and Patients With Normal Renal Function

Metastatic Cancer

United States
Ellipses Pharma

Recruiting

Phase 1/2 Study to Evaluate EP0062 in Patients With Relapsed Locally Advanced or Metastatic Androgen Receptor Positive (AR+)/HER2-/ER+ Breast Cancer

Metastatic Breast Cancer | Hormone Receptor-positive Breast Cancer | Hormone Receptor Positive HER-2 Negative Breast Cancer

United States, Spain, United Kingdom
Queen Mary University of London

Completed

Severe Head Injury Brain Analysis (SHIBA)

Brain Injury Traumatic Severe

United Kingdom
Ipsen

Completed

A Study With Tasquinimod Treating Patients With Hepatocellular, Ovarian, Renal Cell and Gastric Cancers

Metastatic Renal Cell Cancer | Advanced or Metastatic Hepatocellular Cancer | Advanced or Metastatic Ovarian Cancer | Advanced or Metastatic Gastric Carcinoma

Belgium, Canada, France, Spain, United Kingdom
Queen Mary University of London

Unknown

A Phase II Study Investigating Upfront Pazopanib In Metastatic Renal Cancer Renal Cancer (Panther) (Panther)

Metastatic Clear Cell Renal Cancer

United Kingdom
Baptist Health South Florida
Blue Earth Diagnostics

Recruiting

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

Brain Cancer | Brain Metastases | Brain Metastases, Adult

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI); University of Medicine and Dentistry of New...

Active, not recruiting

Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer

Colorectal Cancer | Metastatic Cancer

United States
Barts & The London NHS Trust
University College London Hospitals

Completed

Carboplatin AUC-10 With Early PET Scanning in Metastatic Seminoma (Car-PET)

Metastatic Seminoma

United Kingdom
University of Rochester

Completed

A Study For Using Radiosurgery On Limited Metastases

Neoplasms, Metastatic

United States
London School of Hygiene and Tropical Medicine

Recruiting

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults (CRASH-4)

Traumatic Brain Injury

United Kingdom
Queen Mary University of London

Active, not recruiting

Nutritional Treatment for the Amelioration of Traumatic Brain Injury (NUTRA-TBI)

Traumatic Brain Injury

United Kingdom
Imperial College London

Completed

The Relationship Between Traumatic Brain Injury and Dopamine (a Chemical in the Brain)

Traumatic Brain Injury

United Kingdom
Hoffmann-La Roche

Active, not recruiting

Study To Evaluate Safety, Pharmacokinetics, Pharmacodynamics, And Preliminary Anti-Tumor Activity Of RO7122290 In Combination With Cibisatamab With Obinutuzumab Pre-Treatment

Metastatic Colorectal Cancer

Korea, Republic of, Spain, Denmark, United Kingdom, Netherlands
OHSU Knight Cancer Institute
Merck Sharp & Dohme LLC; Oregon Health and Science University

Terminated

Pembrolizumab and Magnetic Resonance Imaging With Ferumoxytol in Treating Patients With Non-small Cell Lung Cancer and Brain Metastases

Stage IV Lung Non-Small Cell Cancer AJCC v7 | Lung Carcinoma Metastatic in the Brain

United States
Washington University School of Medicine
United States Department of Defense; Aclaris Therapeutics, Inc.

Not yet recruiting

Zunsemetinib in Combination With Capecitabine in Patients With Hormone Receptor-Positive and HER2-Negative Metastatic Breast Cancer With Bone Metastasis

Hormone Receptor Positive HER-2 Negative Metastatic Breast Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Lung Small Cell Carcinoma

United States
Dana-Farber Cancer Institute
Breast Cancer Research Foundation; Array BioPharma

Completed

ARRY-380 + Trastuzuamab for Breast w/ Brain Mets

Advanced HER2-positive Breast Cancer | Brain Metastases From HER2 and Breast Cancer

United States
Syndax Pharmaceuticals

Completed

A Phase 1 Study to Investigate Axatilimab Alone or in Combination With Durvalumab in Patients With Solid Tumors

Solid Tumor | Unresectable Malignant Neoplasm | Locally Advanced Malignant Neoplasm | Metastatic Tumor

United States
HCA International Limited

Withdrawn

Botulinum Toxin and Saliva Management in Tracheotomised Patients

Traumatic Brain Injury

United Kingdom
Institute of Cancer Research, United Kingdom
Cancer Research UK; Philips Medical Systems

Withdrawn

Magnetic Resonance Guided High Intensity Focused Ultrasound (MRgHIFU) for Pain Palliation of Bone Metastases (HIFU-Bone)

Cancer | Bone Metastases

United Kingdom
David Piccioni, M.D., Ph.D
Pfizer

Terminated

A Phase II Study of Dacomitinib in Progressive Brain Metastases

Brain Cancer

United States
City of Hope Medical Center
National Cancer Institute (NCI); Palo Alto Research Center

Completed

Characterization of Circulating Tumor Cells (CTC-s) in Patients With Locally Advanced or Metastatic Stage IV Breast Cancer

Locally Advanced Breast Cancer | Metastatic (Stage IV) Breast Cancer | Stage III-IV Breast Cancer or Inflammatory

United States
Shanghai Miracogen Inc.

Recruiting

A Study of MRG002 in Patients With HER2-Positive Advanced Solid Tumors and Locally Advanced or Metastatic Gastric/Gastroesophageal Junction (GEJ) Cancer

Advanced Solid Tumors | Advanced or Metastatic Gastric Cancer | Advanced or Metastatic Gastroesophageal Junction Cancer

United States
OncoTherapy Science, Inc.

Completed

Phase 1 Study of OTS167 in Patients With Solid Tumors

Solid Tumors | Metastatic Tumors

United States

Clinical Trials on Metastatic Brain Cancer in United Kingdom

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