Clinical Trials on Metastatic Colon/Rectum Cancer

Total 11056 results

Region Skane

Recruiting

On-treatment Biomarkers in Metastatic Colorectal Cancer for Life (On-CALL)

Metastatic Colorectal Cancer | Lung Metastases | Chemotherapy Effect | Peritoneal Metastases | Liver Metastasis Colon Cancer

Sweden
Washington University School of Medicine

Active, not recruiting

Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal Precancerous and Malignant Polyps

Rectal Cancer | Colon Cancer | Cancer of the Colon | Cancer of the Rectum | Precancerous Polyp | Malignant Polyp

United States
National Cancer Institute (NCI)

Completed

GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific | Stage IIIC Rectal Cancer | Stage IIIC Colon Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
M.D. Anderson Cancer Center
Bayer; Xencor, Inc.

Withdrawn

Regorafenib and XmAb20717 in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy (RX-CROME)

Colorectal Cancer | Colon Cancer | Rectum Cancer

United States
Compass Therapeutics

Active, not recruiting

A Study of CTX-009 in Adult Patients With Metastatic Colorectal Cancer (COMPANION-003)

Metastatic Colorectal Cancer | Rectal Cancer | Colon Cancer

United States
Mast Therapeutics, Inc.

Unknown

Phase III Randomized Study of 5-FU, CoFactor, and Avastin vs. 5-FU, LV and Avastin for First-Line Colorectal Cancer.

Metastatic Colorectal Cancer | Rectal Cancer | Colon Cancer

United States, Former Serbia and Montenegro
National Cancer Institute (NCI)
Eastern Cooperative Oncology Group; NCIC Clinical Trials Group; Cancer and Leukemia... and other collaborators

Terminated

Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line Therapy

Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer Receiving Combination Chemotherapy

Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
Gilead Sciences

Terminated

Study of Labetuzumab Govitecan in Participants With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer | Rectal Cancer | Colon Cancer

United States
Amgen

Completed

Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer

Metastatic Colorectal Cancer | Colorectal Cancer | Rectal Cancer | Colon Cancer

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S1417CD Financial Impact Assessment Tool in Patients With Metastatic Colorectal Cancer

Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
Surgimab
Erasmus Medical Center; Catharina Ziekenhuis Eindhoven; Leiden University Medical... and other collaborators

Completed

Phase I of SGM-101 in Patients With Cancer of the Colon, Rectum or Pancreas

Metastatic Colorectal Cancer | Colon Cancer | Pancreas Cancer | Recurrent Colorectal Carcinoma | Rectum Cancer

Netherlands
City of Hope Medical Center
National Cancer Institute (NCI); Array BioPharma

Completed

MEK Inhibitor MEK162 in Combination With Leucovorin Calcium, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Metastatic Colorectal Cancer

Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
Amgen

Completed

Conatumumab/Panitumumab Combination Metastatic Colorectal Cancer Study

Metastatic Colorectal Cancer | Colorectal Cancer | Rectal Cancer | Colon Cancer | Oncology
Treviso Regional Hospital
Gaetano Gallo; Gian Luca Di Tanna

Completed

Delayed Colorectal Cancer Care During Coronavirus Disease (COVID-19) Pandemic (DECOR-19) (DECOR-19)

Rectal Cancer | Surgery | Colon Cancer | Colo-rectal Cancer | Oncology

Italy
Roswell Park Cancer Institute
National Cancer Institute (NCI); Boehringer Ingelheim; National Comprehensive...

Completed

Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal Cancer

Recurrent Colon Carcinoma | Recurrent Rectal Carcinoma | Rectal Adenocarcinoma | Colon Adenocarcinoma | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
Amsterdam UMC, location VUmc

Recruiting

COLLISION XL: Unresectable Colorectal Liver Metastases (3-5cm): Stereotactic Body Radiotherapy vs. Microwave Ablation (COLLISION-XL)

Colorectal Cancer Metastatic | Liver Metastasis Colon Cancer

Netherlands
Stanford University

Completed

Evaluation of EverLift in the Performance of Polypectomy for Polyps 4-9mm

Polyp of Colon | Colo-rectal Cancer | Adenomatous Polyp of Colon

United States
Amgen

Completed

PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors

Metastatic Colorectal Cancer | Colorectal Cancer | Rectal Cancer | Colon Cancer

United States, Belgium, Canada, Italy, Germany, Spain
National Cancer Institute (NCI)

Completed

Selumetinib and Cetuximab in Treating Patients With Refractory Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific | Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
University of Pittsburgh
Bristol-Myers Squibb

Completed

Irinotecan and Cetuximab for Colorectal Cancer as Second Line Therapy

Colon Cancer | Rectum Cancer

United States
Hospital da Senhora da Oliveira

Completed

Comparison of Two Preparations for the Study of the Colon Through Colonoscopy

Colon Cancer | Colon Adenoma | Colon Polyp | Colon Rectal Cancer

Portugal
Freenome Holdings Inc.

Active, not recruiting

Prevention of Colorectal Cancer Through Multiomics Blood Testing (PREEMPT CRC)

Rectal Diseases | Colorectal Cancer | Adenoma | Rectal Cancer | Colon Cancer | Colon Polyp | Colon Lesion | Colon Neoplasm | Polyp | Colon Diseases | Gastrointestinal Tract Cancers

United States, United Arab Emirates
Hôpital Edouard Herriot
Medtronic; National Cancer Institute, France

Recruiting

Efficacy of Colonoscopy, Colon Capsule and Fecal Immunological Test for Colorectal Cancer Screening (FAMCAP)

Colon Cancer | Rectum Cancer

France
Sheba Medical Center

Not yet recruiting

Hepatopulmonary Radio-sterilization With Immunotherapy (TROS-8)

Rectal Cancer | Colon Cancer | Liver Metastasis Colon Cancer

Israel
Yonsei University

Recruiting

A Study of Bevacizumab, Infusional Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan (A-FOLFOXIRI) Compared With Bevacizumab, Infusional Fluorouracil, Leucovorin, and Irinotecan/Oxaliplatin (A-FOLFIRI/FOLFOX) as First-line Treatment for Metastatic Right-sided Colon Cancer

Unresectable Metastatic Right-sided Colon Cancer Starting First-line Combination Chemotherapy | Unresectable Metastatic Right-sided Colon Cancer, Stage IV

Korea, Republic of
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Survivorship Care Planning in Patients With Colorectal or Non-Small Cell Lung Cancer

Stage IIA Rectal Cancer | Stage IIB Rectal Cancer | Stage IIC Rectal Cancer | Stage IIIA Rectal Cancer | Stage IIIB Rectal Cancer | Stage IIIC Rectal Cancer | Stage IIIA Non-small Cell Lung Cancer | Stage IIIB Non-small Cell Lung Cancer | Stage IIIA Colon Cancer | Stage IIIB Colon Cancer | Stage IIIC Colon... and other conditions

United States
UNICANCER

Completed

EXPRESS: EXcePtional RESponSe - Exceptional and Unexpected Response to Targeted Therapies (EXPRESS)

Metastatic Cancers

France
Amgen

Completed

Panitumumab Combination Study With Rilotumumab or Ganitumab in Wild-type Kirsten Rat Sarcoma Virus Oncogene Homolog (KRAS) Metastatic Colorectal Cancer (mCRC)

Metastatic Colorectal Cancer | Colorectal Cancer | Rectal Cancer | Colon Cancer | Gastrointestinal Cancer
University of Chicago
National Cancer Institute (NCI)

Completed

Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies

Mucinous Adenocarcinoma of the Rectum | Signet Ring Adenocarcinoma of the Rectum | Stage IIIA Rectal Cancer | Stage IIIB Rectal Cancer | Stage IIIC Rectal Cancer | Acinar Cell Adenocarcinoma of the Pancreas | Duct Cell Adenocarcinoma of the Pancreas | Stage III Pancreatic Cancer | Stage IV Pancreatic... and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Radiolabeled Monoclonal Antibody Therapy, Combination Chemotherapy, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

United States
National Cancer Institute (NCI)

Completed

Imatinib Mesylate in Treating Patients With Stage IV Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

United States
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France

Unknown

BASE HSP110 : A New Therapeutic Target and a New Marker for Prognosis of Type MSI Colorectal Cancer (BASE HSP110)

Cancer of Colon | Rectum Cancer

France
Hutchmed

Active, not recruiting

A Multi-Center, Open-Label Study of Fruquintinib in Solid Tumors, Colorectal, and Breast Cancer

Rectal Cancer | Advanced Solid Tumors | Metastatic Breast Cancer | Triple Negative Breast Cancer | Metastatic Colon Cancer | Hormone Receptor Positive Breast Carcinoma | HER2-negative Breast Cancer

United States
Virginia Commonwealth University

Terminated

Colorectal Health Research Champions

Cancer of Colon | Cancer of Rectum

United States
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI); Wellcome Trust; University...

Completed

Developing and Evaluating Product Messaging

Cancer of Colon | Cancer of Rectum

United States
Howard S. Hochster, MD

Recruiting

Microbiotic Product to Promote Microbiome Health and Improve Chemotherapy Delivery

Stage IV Colon Cancer AJCC v8 | Stage IVA Colon Cancer AJCC v8 | Stage IVB Colon Cancer AJCC v8 | Stage IVC Colon Cancer AJCC v8 | Metastatic Colon Carcinoma

United States
Amgen

Completed

A Phase 2, Randomized, Double Blind, Placebo Controlled Study of AMG 386 in Combination With FOLFIRI in Subjects With Previously Treated Metastatic Colorectal Carcinoma

Carcinoma | Cancer | Metastatic Colorectal Cancer | Colorectal Cancer | Rectal Cancer | Metastatic Cancer | Colon Cancer | Gastrointestinal Cancer | Oncology | Metastases
National Cancer Institute (NCI)

Completed

Suberoylanilide Hydroxamic Acid, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Progressive Metastatic or Unresectable Colorectal Cancer or Other Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific | Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage III Colon Cancer | Stage III Rectal Cancer

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Sorafenib and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

United States
University of Southern California
Novartis

Terminated

Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Who Did Not Respond to Previous Fluorouracil-Based Chemotherapy

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

United States
National Cancer Institute (NCI)

Completed

Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

United States
National Cancer Institute (NCI)

Completed

RO4929097 in Treating Patients With Metastatic Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer

Progressive Disease | Recurrent Colorectal Carcinoma | Metastatic Colon Adenocarcinoma | Metastatic Rectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Stage III Colorectal Cancer... and other conditions

United States
Rutgers, The State University of New Jersey
National Cancer Institute (NCI)

Active, not recruiting

TAS-102 and Oxaliplatin for the Treatment of Refractory Stage IV Colon Cancer

Recurrent Colon Carcinoma | Metastatic Colorectal Carcinoma | Stage IV Colon Cancer AJCC v7 | Stage IVA Colon Cancer AJCC v7 | Stage IVB Colon Cancer AJCC v7 | Refractory Colorectal Carcinoma

United States
University of Washington
National Cancer Institute (NCI)

Terminated

A Trial of Maintenance ADAPT Therapy With Capecitabine and Celecoxib in Patients With Metastatic Colorectal Cancer (ADAPT)

Recurrent Colon Carcinoma | Recurrent Rectal Carcinoma | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
University Hospital, Rouen

Not yet recruiting

De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer (DIAMOND)

Metastatic Colon Cancer
University of Rome Tor Vergata

Recruiting

REVERT - taRgeted thErapy for adVanced colorEctal canceR paTients (REVERT)

Metastatic Colon Cancer

Italy, Spain, Romania
University of Campania "Luigi Vanvitelli"

Completed

Phase II Randomized Study Evaluating the Efficacy of Panitumumab (VEctibix ) and Trifluridine-Tipiracil (LOnsurf) in Pretreated RAS Wild Type Metastatic Colorectal Cancer Patients: the VELO Trial (VELO)

Metastatic Colon Cancer

Italy
University of Alabama at Birmingham

Withdrawn

Imaging With [89Zr]Panitumumab-PET/MRI in Patients With Newly Diagnosed Colorectal Cancer (Panitumumab)

Metastatic Colon Cancer

United States

Clinical Trials on Metastatic Colon/Rectum Cancer

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