Clinical Trials on Musculoskeletal Abnormalities

Total 52924 results

National Cancer Institute (NCI)

Recruiting

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Stage IV Colorectal Cancer AJCC v8 | Stage III Colorectal Cancer AJCC v8 | Metastatic Microsatellite Stable Colorectal Carcinoma | Advanced Microsatellite Stable Colorectal Carcinoma | Hematopoietic and Lymphatic System...

United States
Princess Maxima Center for Pediatric Oncology
Innovative Therapies For Children with Cancer Consortium; IBFM; Fight Kids Cancer

Recruiting

HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies (HEM-iSMART D)

Acute Lymphoblastic Leukemia, in Relapse | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory

Netherlands
Adaptimmune

Recruiting

SPEARHEAD-3 Pediatric Study

Osteosarcoma | Neuroblastoma | Synovial Sarcoma | Malignant Peripheral Nerve Sheath Tumor (MPNST)

United States
National Cancer Institute (NCI)

Recruiting

Testing Obeticholic Acid for Familial Adenomatous Polyposis

Familial Adenomatous Polyposis | Colorectal Carcinoma | Attenuated Familial Adenomatous Polyposis | Duodenal Carcinoma

United States, Puerto Rico
Masonic Cancer Center, University of Minnesota

Not yet recruiting

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise (FLASHLITE)

Chronic Obstructive Pulmonary Disease | Acute Lymphoblastic Leukemia | Chronic Lung Disease | Heart Transplant
Allegheny Singer Research Institute (also known...
ElectroCore INC; Chuck Noll Foundation

Recruiting

Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress

Traumatic Brain Injury | Acute Respiratory Distress Syndrome | Acute Lung Injury | Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)

United States
NextCell Pharma Ab
Karolinska Trial Alliance

Recruiting

Treatment of Respiratory Complications Associated With COVID19,Influenza ,Metapneumovirus,RSV Infection Using ProTrans®

Influenza A | Respiratory Syncytial Virus (RSV) | COVID-19 Acute Respiratory Distress Syndrome | Metapneumovirus Pneumonia

Sweden
Sanofi

Recruiting

A Non-Interventional National Study in Pediatric Patients With Unexplained Enlarged Spleen (OPPUS)

Acid SphingoMyelinase Deficiency | Gaucher Disease, Splenomegaly

France
Princess Anna Mazowiecka Hospital, Warsaw, Poland
Medical University of Warsaw; Institute of Mother and Child

Recruiting

Targeted vs Standard Fortification of Breast Milk

Weight Gain | BPD - Bronchopulmonary Dysplasia | NEC - Necrotizing Enterocolitis | VLBW - Very Low Birth Weight Infant | ROP - Retinopathy of Prematurity

Poland
University of Minnesota
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Washington... and other collaborators

Recruiting

Natural History and Structural Functional Relationships in Fabry Renal Disease Treatment Outcomes(Changes)in Fabry Renal Disease Study (LDN6702)

Fabry Disease

United States
University of Pittsburgh

Recruiting

Blood, Urine, and Tissue Collection for Cutaneous Lymphoma, Eczema, and Atopic Dermatitis Research

Eczema | Mycosis Fungoides | Sezary Syndrome | Cutaneous T-cell Lymphoma | Atopic Dermatitis

United States
Princess Maxima Center for Pediatric Oncology
Innovative Therapies For Children with Cancer Consortium; IBFM; Fight Kids Cancer

Withdrawn

HEM-iSMART-A: Decitabine / Venetoclax and Navitoclax in Pediatric Patients With Relapsed or Refractory Hematological Malignancies (HEM-iSMART A)

Acute Lymphoblastic Leukemia, in Relapse | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory

Netherlands
Universitätsklinikum Hamburg-Eppendorf

Completed

Psychosocial Situation of Children With Rare Solid Abdominal Tumors and Their Families (PsyRareCare)

Neuroblastoma | Hepatoblastoma | Nephroblastoma

Germany
University Hospital, Ghent

Completed

Quality of Life 1y and 2 y After VV-ECMO for COVID-19

Quality of Life | Death | Extracorporeal Membrane Oxygenation Complication | COVID-19 Acute Respiratory Distress Syndrome

Belgium
Technical University of Munich

Completed

Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers (LIBRE)

Hereditary Breast and Ovarian Cancer

Germany
Ohio State University
Pfizer; PTEN Research

Active, not recruiting

Sirolimus for Cowden Syndrome With Colon Polyposis

Cowden Syndrome | Polyposis | PTEN Gene Mutation | PTEN Hamartoma Tumor Syndrome | PTEN Hamartoma Syndrome | Bannayan Syndrome | Bannayan Zonana Syndrome

United States
The Cleveland Clinic

Active, not recruiting

Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis (MED-hATTR)

AL Amyloidosis | Amyloidosis | Amyloid Neuropathies, Familial | Amyloid | Transthyretin Amyloidosis | Amyloid Cardiomyopathy | Amyloid - Primary

United States
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Terminated

A Clinical Trial to Evaluate the Safety and Efficacy of AL2846 Capsules in Chinese Patients With Type I Neurofibromatosis

Neurofibromatosis and Malignant Peripheral Nerve Sheath Tumors

China
Pharvaris Netherlands B.V.

Active, not recruiting

Dose-ranging Study of Oral PHA-022121 for Prophylaxis Against Angioedema Attacks in Patients With Hereditary Angioedema Type I or Type II (HAE CHAPTER-1)

Hereditary Angioedema | Hereditary Angioedema Type I | Hereditary Angioedema Type II | Hereditary Angioedema Types I and II | Hereditary Angioedema Attack | Hereditary Angioedema With C1 Esterase Inhibitor Deficiency | Hereditary Angioedema - Type 1 | Hereditary Angioedema - Type 2 | C1 Esterase Inhibitor... and other conditions

United States, Poland, Germany, Austria, Bulgaria, Canada, Ireland, Italy, United Kingdom
APR Applied Pharma Research s.a.
Lavin Consulting, LLC

Completed

Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure (COVID-AIV)

Acute Lung Injury | Corona Virus Infection | Acute Respiratory Distress Syndrome (ARDS) | Critical COVID-19 With Respiratory Failure

United States
Centre Oscar Lambret
CTD-CNO; Laboratoire PRISM

Active, not recruiting

Radical Fimbriectomy for Young BRCA Mutation Carriers (Fimbriectomy)

BRCA1 Mutation | BRCA2 Mutation | Hereditary Breast and Ovarian Cancer

France
Assistance Publique Hopitaux De Marseille

Completed

Acute Kidney Dysfunction in COVID-19 and Non-COVID-19 Related ARDS (URICOV)

COVID-19 Acute Respiratory Distress Syndrome | Acute Kidney Injury Due to COVID-19

France
National Cancer Institute (NCI)

Terminated

A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer

Breast Cancer | Ovarian Cancer | Prostate Cancer

United States
Exvastat Ltd.

Withdrawn

A Randomized Study to Investigate the Effect of Intravenous Imatinib on the Amount of Oxygen in the Lungs and Blood of Adults With COVID-19 Needing Mechanical Ventilation and Supportive Care. (IMPRESS COVID)

Covid19 | Acute Respiratory Distress Syndrome | ARDS | COVID-19 Acute Respiratory Distress Syndrome | Pulmonary Oedema

India
Oslo University Hospital
The Research Council of Norway

Completed

Survival Rates and Longterm Outcomes After COVID-19

Covid19 | Acute Respiratory Distress Syndrome | Acute Respiratory Failure | Survivorship | Post Intensive Care Unit Syndrome

Norway
Immunovia, Inc.

Completed

A Study of IMMray™ PanCan-d Test for Early Detection of Pancreatic Cancer in High-risk Groups

Pancreatic Ductal Adenocarcinoma | Familial Pancreatic Cancer | FAMMM - Familial Atypical Mole Malignant Melanoma Syndrome

United States, Sweden, Canada, Spain, United Kingdom
University of California, San Francisco

Completed

Study of Melphalan Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients

Sickle Cell Disease | Hemoglobinopathies | Thalassemia | Hematologic Malignancies | Immunodeficiencies | Fanconi's Anemia | Nonmalignant Diseases | Genetic Inborn Errors of Metabolism

United States
Azienda Usl di Bologna
Lorenzo Gamberini

Completed

Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome

COVID-19 | Quality of Life | Sedation | Mechanical Ventilation | Complication of Treatment | Radiologic Increased Density of Lung

Italy
Boston Children's Hospital
Beth Israel Deaconess Medical Center; Winchester Hospital

Terminated

Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk

Hypoglycemia | Hypoxic-Ischemic Encephalopathy | Neonatal Abstinence Syndrome

United States
Mendel Tuchman
Children's Hospital of Philadelphia; University of California, Los Angeles; Icahn... and other collaborators

Completed

Short-Term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia (STO)

Methylmalonic Acidemia | Carbamoyl-Phosphate Synthase I Deficiency Disease | Propionic Acidemia, Type I and/or Type II | Ornithine Carbamoyltransferase Deficiency

United States
University of Calgary
Alberta Health services

Unknown

CORONA (COvid pRONe hypoxemiA): Prone Positioning for Hypoxemic COVID-19 Patients With Do-not-intubate Goals (CORONA)

COVID-19 | Acute Respiratory Distress Syndrome | ARDS | Severe Acute Respiratory Syndrome Coronavirus 2 | Hypoxemic Respiratory Failure

Canada
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Terminated

Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies

Myeloid Leukemia | Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | Myelodysplastic Syndrome | Lymphoid Leukemia

United States
National Cancer Institute (NCI)

Completed

Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous Polyposis

Colorectal Cancer | Familial Adenomatous Polyposis

United States
bluebird bio

Terminated

Observational Study to Evaluate Allogeneic HSCT Outcomes for Cerebral Adrenoleukodystrophy (CALD)

Cerebral Adrenoleukodystrophy (CALD) | Adrenoleukodystrophy (ALD) | X-Linked Adrenoleukodystrophy (X-ALD)

United States, United Kingdom, Argentina, Canada, Germany, Italy, Netherlands
Masonic Cancer Center, University of Minnesota
National Marrow Donor Program

Completed

Stem Cell Transplant for Hemoglobinopathy

Sickle Cell Disease | Thalassemia | Severe Congenital Neutropenia | Diamond-Blackfan Anemia | Shwachman-Diamond Syndrome

United States
Copenhagen University Hospital, Hvidovre

Completed

Endoscopic Evaluation of Duodenal Polyposis in Patients With Familial Adenomatous Polyposis (FAP)

Duodenal Cancer | Duodenal Polyposis | Familial Adenomatous Polyposes

Denmark
University Hospital, Rouen

Unknown

Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation (VONIVOO)

Obesity | Acute Respiratory Failure | Hypercapnic Respiratory Failure | Apnea, Obstructive | Hypoventilation Syndrome | Respiratory Acidosis
Institut Claudius Regaud

Unknown

Evaluation of the Adhesion to the GENEPY Network (GENEPY)

Hereditary Breast and Ovarian Cancer | Hereditary Cancer Syndrome | Hereditary Colorectal Endometrial Cancer Syndrome

France
National Taiwan University Hospital

Completed

Application of Amyloid PET in Cerebral Amyloid Angiopathy (CAA)

Alzheimer Disease | Intracranial Hemorrhages | Cerebral Amyloid Angiopathy

Taiwan
Oregon Health and Science University

Terminated

Dietary Cholesterol and Defects in Cholesterol Synthesis in Mevalonate Kinase Deficiency

Immune System Diseases | Lipid Metabolism, Inborn Errors | Mevalonic Aciduria | Mevalonate Kinase Deficiency | Periodic Fever Syndromes, Hereditary

United States
University of Minnesota
GE Healthcare

Completed

Detecting Dopaminergic Deficits in Individuals At-risk for Parkinsonism

Parkinson Disease | Gaucher Disease | Idiopathic Rapid Eye Movement Sleep Disorder

United States
Lei Li

Unknown

MSI in Circulatory DNA of Endometrial Cancer

Lynch Syndrome | Endometrial Cancer | Microsatellite Instability | Circulating Tumor Cell

China
Masonic Cancer Center, University of Minnesota

Completed

Stem Cell Transplant for Bone Marrow Failure Syndromes

Diamond-Blackfan Anemia | Shwachman-Diamond Syndrome | Kostmann's Neutropenia

United States
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Terminated

Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Neoplasms | Unusual Cancers of Childhood

United States
National Human Genome Research Institute (NHGRI)

Completed

Microarray Analysis for Human Genetic Disease

Melanoma | Breast Neoplasm | Ovarian Neoplasm | Hereditary Neoplastic Syndrome

United States, Finland, Iceland, Sweden
Genzyme, a Sanofi Company

Completed

A Study To Assess ZD6474 (ZACTIMA™) Monotherapy In Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer

Thyroid Cancer

Italy, Spain, Romania, Netherlands, Canada, United States, Switzerland, Australia
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

No longer available

Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease

Lymphoma | Myelodysplastic Syndromes | Leukemia | Multiple Myeloma and Plasma Cell Neoplasm | Precancerous Condition | Secondary Myelofibrosis

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Traumeel® S in Preventing and Treating Mucositis in Young Patients Undergoing Stem Cell Transplantation

Sarcoma | Lymphoma | Kidney Cancer | Leukemia | Neuroblastoma | Oral Complications

United States, Israel, Australia, Canada
Gynecologic Oncology Group
National Cancer Institute (NCI)

Withdrawn

Research Study in Patients With Advanced Ovarian Epithelial Cancer

Ovarian Serous Cystadenocarcinoma | Stage IIIA Ovarian Cancer | Stage IIIB Ovarian Cancer | Stage IIIC Ovarian Cancer | Stage IV Ovarian Cancer | Ovarian Serous Surface Papillary Adenocarcinoma

United States
University of Michigan

Terminated

Ultraviolet (UVA and UVB) Light Therapy in the Treatment of Inflammatory Skin Conditions

Psoriasis | Mycosis Fungoides | Atopic Dermatitis | Alopecia | Urticaria | Stretch Marks | Dermatoses

United States

Clinical Trials on Musculoskeletal Abnormalities

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mexico

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Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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