Clinical Trials on Neurosurgical Repairs

Total 586 results

National Human Genome Research Institute (NHGRI)

Withdrawn

Quality of Life and Neuropsychiatric Sequelae in Patients Treated With Gene Therapy for ADA-SCID and in Their Parents

ADA-SCID
University of Washington
John L. Locke Jr. Charitable Trust

Terminated

Text Message Intervention to Improve Cardiac Rehab Participation

Myocardial Infarction | Percutaneous Coronary Intervention | Coronary Artery Bypass Surgery | Chronic Stable Angina | Left Ventricular Assist Device | Heart Transplant | Chronic Stable Heart Failure | Heart Valve Repair or Replacement

United States
Ohio State University Comprehensive Cancer Center

Completed

Ohio Colorectal Cancer Prevention Initiative (OCCPI)

Colorectal Cancer | Lynch Syndrome

United States
National Human Genome Research Institute (NHGRI)

Completed

Psychosocial Aspects of Genetic Testing for Hereditary Nonpolyposis Colon Cancer

HNPCC | Hereditary Nonpolyposis Colon Cancer

United States
Vejle Hospital

Completed

Molecular Screening for Lynch Syndrome in Southern Denmark

Colorectal Cancer | Lynch Syndrome | HNPCC

Denmark
University Medical Center Groningen
Maastricht University Medical Center; Erasmus Medical Center; Medtronic - MITG; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) and other collaborators

Completed

Capsule Endoscopy to Screen for Small Bowel Neoplasia in Lynch Syndrome (CELSIUS)

Lynch Syndrome | Small Bowel Neoplasia

Netherlands
M.D. Anderson Cancer Center
National Cancer Institute (NCI); National Institutes of Health (NIH)

Recruiting

A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

Colorectal Cancer | Lynch Syndrome | T Cells

United States
University Hospital, Strasbourg, France

Recruiting

Growth Curves in Cockayne Syndrome Type 1 and Type 2 (Curves-CS)

Cockayne Syndrome, Type I and II

France
Wageningen University
Dutch Cancer Society; Wereld Kanker Onderzoek Fonds; Funding: Biobanking and...

Recruiting

The GEOLynch Cohort Study (GEOLynch)

Neoplasms | Colorectal Neoplasms | Lynch Syndrome | Hereditary Nonpolyposis Colorectal Cancer

Netherlands
Vejle Hospital

Completed

Molecular Screening for Lynch Syndrome in Denmark

Colorectal Cancer | Lynch Syndrome | HNPCC

Denmark
Prof. Evelien Dekker, MD, PhD
Dutch Digestive Diseases Foundation

Completed

Identifying Patients With Hereditary and Familial Colorectal Cancer by Using an Online Risk Tool (FR-QUENT)

Colorectal Cancer | Lynch Syndrome | Familial Colorectal Cancer
Kaiser Permanente
M.D. Anderson Cancer Center; Dana-Farber Cancer Institute; Vanderbilt University and other collaborators

Completed

Integrating Genetic Testing for Lynch Syndrome in a Managed Care Setting (HNPCC)

Lynch Syndrome | Colon Cancer

United States
Baylor College of Medicine
Center for Cell and Gene Therapy, Baylor College of Medicine

Terminated

Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders (MASCI)

Severe Combined Immunodeficiency Disease | Severe Primary Immunodeficiency Disorder | Undefined T Cell Deficiency Disorder | Wiskott-Aldrick Syndrome

United States
National Cancer Institute (NCI)

Completed

Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers

Colorectal Neoplasm | Hereditary Nonpolyposis

United States
London North West Healthcare NHS Trust

Completed

Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance

Colorectal Neoplasms, Hereditary Nonpolyposis

United Kingdom
State Scientific Centre of Coloproctology, Russian...
The Loginov MCSC MHD; Pirogov National Medical and Surgical Center; Moscow City... and other collaborators

Recruiting

Prospective Multicenter Registry Study to Assess the Frequency of Lynch Syndrome Among Patients With Colorectal Cancer (MSIRus22)

Colorectal Cancer | Lynch Syndrome | Hereditary Colorectal Cancer | MSI

Russian Federation
National Cancer Institute (NCI)

Withdrawn

Testing Nivolumab and BMS-986016 (Relatlimab) as Potentially Targeting Treatment in Cancers That Are LAG-3+ and Have Mismatch Repair Deficiency (MATCH - Subprotocol Z1M)

Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma
Hospital Clinic of Barcelona
European Society of Gastrointestinal Endoscopy

Recruiting

Evaluation of ArTificial Intelligence System (Gi-Genius) for adenoMa dEtection in Lynch Syndrome. (Timely)

Lynch Syndrome

Spain
Memorial Sloan Kettering Cancer Center
Boston Children's Hospital; Fred Hutchinson Cancer Center; Children's Hospital... and other collaborators

Completed

Hematopoietic Stem Cell Transplantation for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine

Leukemia | Myelodysplastic Syndrome | Aplastic Anemia

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Completed

Educational CD-ROM Compared With Standard Informed Consent for Patients With Colorectal Cancer or a Family History of Colorectal Cancer

Colorectal Cancer | Hereditary Non-polyposis Colon Cancer

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome (AAS-Lynch)

Lynch Syndrome

France
University of California, San Francisco
Merck Sharp & Dohme LLC

Completed

Pembrolizumab, Capecitabine, and Bevacizumab in Treating Patients With Microsatellite Stable Colorectal Cancer That Is Locally Advanced, Metastatic, or Cannot Be Removed by Surgery

Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7 | Microsatellite Stable | Stage III Colorectal Cancer AJCC v7 | Stage IIIB Colorectal Cancer AJCC v7 | Stage IIIC Colorectal Cancer AJCC v7 | Mismatch Repair Protein Proficient

United States
Quince Therapeutics S.p.A.
Biotrial

Not yet recruiting

To Evaluate the Effects of EryDex in Patients With A-T (NEAT)

Ataxia Telangiectasia

Belgium, United States, Denmark, Germany, Italy, Norway, Poland, Spain, United Kingdom
Sun Yat-sen University
Guangdong Provincial Hospital of Traditional Chinese Medicine; Fujian Cancer... and other collaborators

Recruiting

PD-1 Antibody for The Prevention of Adenomatous Polyps and Second Primary Tumors in Lynch Syndrome Patients

Lynch Syndrome

China
Erydel

Recruiting

Open-label, Long-term, Extension Treatment Using Intra-Erythrocyte Dexamethasone Sodium Phosphate in Patients With Ataxia Telangiectasia Who Participated in the IEDAT-02-2015 Study (OLE-IEDAT)

Ataxia Telangiectasia

United States, Australia, Belgium, Germany, India, Italy, Poland, Spain, Tunisia
Tel-Aviv Sourasky Medical Center
Rambam Health Care Campus; Rabin Medical Center; Sheba Medical Center; Soroka University...

Not yet recruiting

Finding the Best Dose of Aspirin to Prevent Lynch Syndrome Cancers (CaPP3 Israel)

Lynch Syndrome I (Site-specific Colonic Cancer)

Israel
Acasti Pharma Inc.

Active, not recruiting

Comparative Bioavailability of Betamethasone Oral Solution Metered Spray (GTX-102) in Healthy Subjects

Ataxia Telangiectasia

Canada
University Hospital, Akershus
Oslo University Hospital; University Hospital of North Norway; University of... and other collaborators

Active, not recruiting

NAD Supplementation to Prevent Progressive Neurological Disease in Ataxia Telangiectasia

Ataxia Telangiectasia

Norway
Assistance Publique - Hôpitaux de Paris
EuroFancolen

Completed

Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and Plerixafor (FancoMob)

Fanconi Anemia

France
Masonic Cancer Center, University of Minnesota

Completed

TBI Dose De-escalation for Fanconi Anemia

Fanconi Anemia

United States
Johann Wolfgang Goethe University Hospital

Unknown

Neurofilament Light- Chain in Ataxia Telangiectasia

Ataxia Telangiectasia

Germany
Children's Hospital Medical Center, Cincinnati
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and AMD3100

Fanconi Anemia

United States
Shenzhen Geno-Immune Medical Institute

Unknown

FANCA Gene Transfer for Fanconi Anemia Using a High-safety, High-efficiency, Self-inactivating Lentiviral Vector

Fanconi Anemia

China
Medical College of Wisconsin
Memorial Sloan Kettering Cancer Center

Completed

Hematopoietic Stem Cell Transplant for Fanconi Anemia (FA)

Fanconi Anemia

United States
Medical University Innsbruck

Unknown

Prevalence of Constitutional Mismatch-repair Deficiency Among Suspected Neurofibromatosis Type 1/Legius Syndrome Children Without a Malignancy and Without a NF1 or SPRED1 Mutation (CMMRD in NF1)

Neurofibromatosis Type 1
Neena Kapoor, M.D.

Withdrawn

Unrelated HSCT in Patients With Fanconi Anemia

Fanconi Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Gene Therapy for the Treatment of Fanconi's Anemia Type C

Pancytopenia | Fanconi's Anemia

United States
Boston Children's Hospital
National Heart, Lung, and Blood Institute (NHLBI); Children's Hospital Medical...

Completed

Bone Marrow Cell Gene Transfer in Individuals With Fanconi Anemia

Fanconi Anemia

United States
Erydel

Completed

International Ataxia Rating Scale in Younger Patients

Ataxia Telangiectasia

Italy, United States, India, Israel
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Cyclophosphamide in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Fanconi's Anemia

Fanconi Anemia

United States, Brazil
Children's Hospital Medical Center, Cincinnati
FDA Office of Orphan Products Development

Completed

Oxandrolone for the Treatment of Bone Marrow Aplasia in Fanconi Anemia

Fanconi Anemia

United States
University of Minnesota

Unknown

Phase I Pilot Study of CD34 Enriched, Fanconi's Anemia Complementation Group C Gene Transduced Autologous Peripheral Blood Stem Cell Transplantation in Patients With Fanconi's Anemia

Fanconi's Anemia
National Cancer Institute (NCI)

Recruiting

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Lynch Syndrome | Malignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Refractory Ependymoma | Refractory Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Refractory Diffuse Intrinsic Pontine Glioma | Recurrent Brain Neoplasm | Refractory Brain Neoplasm | Constitutional...

United States, Canada
The University of Queensland

Not yet recruiting

Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside (ATNAD)

Ataxia Telangiectasia

Australia
Tampere University Hospital
Tampere University

Recruiting

Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)

Lynch Syndrome | Urothelial Carcinoma

Canada, Finland
University of Nottingham
Nottingham University Hospitals NHS Trust; Action for A-T

Completed

Whole Body MRI for Cancer Surveillance in A-T

Ataxia Telangiectasia

United Kingdom
Boston Children's Hospital

Completed

Pilot Study of Metformin for Patients With Fanconi Anemia

Fanconi Anemia

United States
Masonic Cancer Center, University of Minnesota

Completed

Hematopoietic Stem Cell Transplantation in High Risk Patients With Fanconi Anemia

Fanconi Anemia

United States
University of Nottingham
Nottingham University Hospitals NHS Trust; Royal Papworth Hospital

Active, not recruiting

A National Retrospective Population Based Cohort Study of the Natural History of Ataxia Telangiectasia (N-HAT)

Ataxia Telangiectasia

United Kingdom
National Cancer Institute (NCI)

Completed

Testing Nivolumab as a Potential Targeted Treatment in Cancers With Mismatch Repair Deficiency (MATCH-Subprotocol Z1D)

Hematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Plasma Cell Myeloma

United States

Clinical Trials on Neurosurgical Repairs

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