Clinical Trials on Normal Human Subjects in Singapore

Total 101 results

Alnylam Pharmaceuticals

Terminated

A Study of ALN-HBV in Healthy Adult Volunteers and Non-cirrhotic Patients With Chronic Hepatitis B Virus (HBV) Infection

Hepatitis B | Chronic Hepatitis B | Hepatitis B, Chronic | HBV | Hepatitis B Infection

United Kingdom, New Zealand, Singapore, Korea, Republic of, Australia, Hong Kong
GlaxoSmithKline

Completed

Adefovir Dipivoxil For The Treatment Of Patients With Chronic Hepatitis B Related Advanced Fibrosis Or Cirrhosis

Fibrosis | Chronic Hepatitis B | Hepatitis B, Chronic | Cirrhosis

Taiwan, Korea, Republic of, Singapore, Hong Kong, Vietnam
Pfizer

Terminated

Safety And Efficacy Of Oral PF-4136309 In Patients With Chronic Hepatitis C Infection And Abnormal Liver Enzymes

Hepatitis C, Chronic

Taiwan, Singapore, India, Korea, Republic of, Hong Kong
GlaxoSmithKline

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3389404 in Chronic Hepatitis B (CHB) Subjects

Hepatitis B

Singapore, China, Hong Kong, Japan, Korea, Republic of, Philippines
Vir Biotechnology, Inc.

Completed

Study of VIR-3434 in Healthy Volunteers and Patients With Chronic Hepatitis B Virus Infection

Chronic Hepatitis B

Germany, Hong Kong, Korea, Republic of, New Zealand, Romania, Singapore, United Kingdom
Novartis
Novartis Pharmaceuticals

Completed

Telbivudine Versus Adefovir Dipivoxil in Adults With HBegAg-Positive, Compensated Chronic Hepatitis B

Chronic Hepatitis B

Australia, Canada, France, United States, Taiwan, Korea, Republic of, Singapore, Thailand, China
Janssen Research & Development, LLC

Completed

Efficacy and Safety of Combinations of AL-335, Odalasvir (ODV) and Simeprevir (SMV) in the Treatment of Chronic Hepatitis C Infection

Hepatitis C, Chronic

Poland, Belgium, Germany, Spain, Canada, Singapore
Gilead Sciences

Completed

Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Participants With Chronic HCV

Hepatitis C Virus Infection

Singapore, Vietnam, China, Thailand, Malaysia
Hoffmann-La Roche

Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7049389 in Healthy Volunteers and Chronic Hepatitis B Virus (HBV) Infected Participants

Hepatitis B, Chronic

Australia, New Zealand, Singapore, Thailand, Taiwan, China, Bulgaria, Hong Kong
Novartis
Novartis Pharmaceuticals

Completed

Switching Therapy From Lamivudine to Telbivudine Versus Continued Lamivudine in Adults With Chronic Hepatitis B

Chronic Hepatitis B

United States, United Kingdom, China, Taiwan, Canada, Singapore, New Zealand, Australia, France, Israel, Thailand
Adamas Pharmaceuticals, Inc.

Completed

Oral Triple Combination Antiviral Drug Therapy for Treatment of Influenza A in Immunocompromised Subjects (PO206)

Influenza

United States, Australia, Canada, Netherlands, Singapore
Hoffmann-La Roche

Completed

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of RO7062931in Healthy Volunteers and Subjects With Chronic Hepatitis B

Chronic Hepatitis B

Australia, Hong Kong, Korea, Republic of, Taiwan, Thailand, New Zealand, Singapore
Boehringer Ingelheim

Terminated

A Study to Test Whether BI 685509 Alone or in Combination With Empagliflozin Helps People With Liver Cirrhosis Caused by Viral Hepatitis or Non-alcoholic Steatohepatitis (NASH) Who Have High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)

Liver Diseases | Hypertension, Portal

Spain, Denmark, Singapore, Germany, Italy, Austria, Canada, Netherlands, China, Israel, Belgium, United States, Japan, Argentina, France, Romania
Gilead Sciences
Vir Biotechnology, Inc.

Active, not recruiting

Study to Evaluate the Safety and Efficacy of Selgantolimod (SLGN)-Containing Combination Therapies for the Treatment of Chronic Hepatitis B (CHB)

Chronic Hepatitis B

Hong Kong, Korea, Republic of, Denmark, Australia, Thailand, Singapore, United Kingdom, New Zealand
AbbVie

Completed

A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in Treatment-Naive and Treatment-Experienced, Non-Cirrhotic Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With or Without Human Immunodeficiency Virus Co-Infection (VOYAGE-1)

Hepatitis C Virus (HCV)

China, Korea, Republic of, Singapore
Hoffmann-La Roche

Completed

A Retrospective Biomarker Study of Stored Samples Obtained From Patients With Chronic Hepatitis B

Hepatitis B, Chronic

Hong Kong, Taiwan, Singapore, Korea, Republic of, New Zealand, France, Thailand, Russian Federation, Australia, Italy
Boehringer Ingelheim

Terminated

A Study to Test Whether Two Different Doses of Avenciguat Help People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Live

Hypertension, Portal

Spain, Denmark, United Kingdom, Singapore, Germany, Italy, Austria, Taiwan, Canada, Croatia, China, Netherlands, Belgium, United States, Japan, Argentina, France, Switzerland, Portugal, Israel, Romania, Korea, Republic of
Hoffmann-La Roche

Completed

A Follow-Up Study to WV19432, to Evaluate Long Term Post-Treatment Effects of PEGASYS (Peginterferon Alfa-2a(40KD))in Patients With HBeAg Positive Chronic Hepatitis B

Hepatitis B, Chronic

China, Hong Kong, Taiwan, Singapore, Korea, Republic of, New Zealand, Thailand, Brazil, Russian Federation, Australia
Brii Biosciences Limited
VBI Vaccines Inc.; Vir Biotechnology, Inc.

Completed

Study to Investigate the Safety and Efficacy of BRII-835 and BRII-179 Combination Therapy Treating Chronic Hepatitis B Virus (HBV) Infection

Hepatitis B, Chronic

Australia, China, Korea, Republic of, New Zealand, Singapore, Thailand
Abbott

Completed

Study of Lopinavir/Ritonavir Tablets Versus Soft Gel Capsules and Once Daily Versus Twice Daily Administration, When Coadministered With Nucleoside Reverse Transcriptase Inhibitors in Antiretroviral Naive Human Immunodeficiency Virus Type 1 Infected Subjects

Human Immunodeficiency Virus Infections

United States, Australia, Belgium, Canada, Czech Republic, France, Germany, Greece, Ireland, Italy, Netherlands, Poland, Puerto Rico, Russian Federation, Singapore, Spain, Switzerland, Taiwan, United Kingdom
Inovio Pharmaceuticals

Completed

Phase I Study of INO-1800 With or Without INO-9112 + EP in Chronic Hepatitis B Subjects

Hepatitis B

Australia, Taiwan, United States, Singapore, New Zealand, Hong Kong, Thailand, Philippines
Bristol-Myers Squibb

Completed

Comparative Trial of Entecavir Versus Adefovir in the Treatment of Chronic Hepatitis B Infection

Hepatitis B | Chronic Disease

United States, Canada, Indonesia, Singapore, Philippines, Taiwan, Hong Kong, Thailand
AbbVie

Completed

A Study of of Glecaprevir/Pibrentasvir in Adults With Chronic Hepatitis C Virus (HCV) Genotype 5 or 6 Infection (ENDURANCE-5 6)

Hepatitis C Virus (HCV)

United States, Australia, Belgium, Canada, France, New Zealand, Singapore, South Africa, Vietnam
Brii Biosciences Limited
Vir Biotechnology, Inc.

Active, not recruiting

Investigate the Efficacy and Safety of BRII-835 (VIR-2218) and PEG-IFNα Combination Therapy in Chronic HBV Patients

Chronic Hepatitis B Virus Infection

Singapore, Thailand, Australia, China, Korea, Republic of
Gilead Sciences

Completed

Study Comparing Tenofovir Disoproxil Fumarate (TDF), Emtricitabine (FTC)/TDF, and Entecavir (ETV) in the Treatment of Chronic HBV in Subjects With Decompensated Liver Disease.

Chronic Hepatitis B

United States, Canada, Spain, Singapore, Turkey, Germany, France, Taiwan, Greece, Italy, Poland
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Pharmacokinetics, Safety, and Antiviral Activity of JNJ-63623872 in Combination With Oseltamivir in Adult, and Elderly Hospitalized Participants With Influenza A Infection

Influenza A Virus

United States, France, Belgium, Germany, Hong Kong, Spain, Malaysia, Turkey, Canada, Netherlands, Singapore, Brazil, New Zealand, Australia, Sweden
GlaxoSmithKline

Recruiting

Long-term Follow-up Study to Evaluate Durability of Sustained Virologic Response (SVR) in Previous GSK3228836 Study Participants (B-Sure)

Hepatitis B

Italy, Japan, Spain, United Kingdom, France, Korea, Republic of, United States, China, Canada, Russian Federation, Thailand, Bulgaria, Hong Kong, Poland, Singapore, Romania, South Africa, Argentina, Malaysia
Novartis Pharmaceuticals

Completed

Telbivudine Versus Lamivudine in Adults With Decompensated Chronic Hepatitis B and Evidence of Cirrhosis

Hepatitis | Hepatitis B, Chronic | Cirrhosis

United States, France, United Kingdom, Taiwan, Spain, Korea, Republic of, Singapore, New Zealand, Thailand, Germany, Israel, Russian Federation, Canada, China, Latvia, Turkey, Australia, India, Malaysia, Poland, Vietnam
Gilead Sciences

Completed

A Study to Compare Tenofovir DF Versus the Combination of Emtricitabine Plus Tenofovir DF for the Treatment of Chronic Hepatitis B in Patients With Normal Alanine Aminotransferase (ALT)

Chronic Hepatitis B

Taiwan, France, Germany, Hong Kong, United States, Canada, New Zealand, Australia, Singapore, Poland, United Kingdom
Hoffmann-La Roche

Completed

A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Patients With Hepatitis Be Antigen (HBeAg) Positive Chronic Hepatitis B (CHB).

Hepatitis B, Chronic

China, Hong Kong, Australia, Germany, Taiwan, Singapore, France, United States, Korea, Republic of, New Zealand, Thailand, Russian Federation, Brazil
Bristol-Myers Squibb

Completed

Comparison of Entecavir to Adefovir in Chronic Hepatitis B Virus (HBV) Patients With Hepatic Decompensation

Hepatitis B

United States, France, India, Taiwan, Thailand, Turkey, United Kingdom, Brazil, Canada, Poland, Russian Federation, Singapore, Greece, South Africa, Hong Kong, Philippines, Indonesia
BioCryst Pharmaceuticals

Completed

Evaluation of Efficacy and Safety of Peramivir in Adults With Acute Serious or Potentially Life-threatening Influenza

Influenza

United States, Australia, Canada, Hong Kong, New Zealand, Singapore, South Africa
Novartis Pharmaceuticals
Merck Sharp & Dohme LLC

Completed

Telbivudine in Adults Previously Treated in Idenix-Sponsored Telbivudine Studies

Chronic Hepatitis B

United States, Australia, Canada, China, Czechia, France, Germany, Hong Kong, India, Israel, Italy, Korea, Republic of, New Zealand, Poland, Puerto Rico, Singapore, Spain, Taiwan, Thailand, Turkey, United Kingdom
Visterra, Inc.

Completed

Study of Efficacy and Safety of IV VIS410 Plus Oseltamivir Versus Oseltamivir in Hospitalized Adults With Influenza A

Influenza A

United States, Australia, Belarus, Belgium, Bulgaria, Canada, Estonia, France, Georgia, Latvia, Malaysia, New Zealand, Russian Federation, Serbia, Singapore, South Africa, Spain, Thailand, Turkey, Ukraine
Hoffmann-La Roche

Completed

Study to Assess Efficacy and Safety of Baloxavir Marboxil In Combination With Standard-of-Care Neuraminidase Inhibitor In Hospitalized Participants With Severe Influenza

Influenza

Spain, United States, Korea, Republic of, Belgium, Germany, Hong Kong, Serbia, China, Israel, Turkey, Estonia, Singapore, France, Netherlands, Finland, Canada, Sweden, Japan, Brazil, Mexico, Ukraine, Bulgaria, Czechia, Australia, New Zealand and more
Hoffmann-La Roche

Completed

Study to Assess the Efficacy of Baloxavir Marboxil Versus Placebo to Reduce Onward Transmission of Influenza A or B in Households

Influenza

United States, China, Poland, Puerto Rico, Hungary, Turkey, Costa Rica, India, Japan, South Africa, Mexico, New Zealand, Israel, Bulgaria, Greece, Singapore, Spain, United Kingdom
Bristol-Myers Squibb

Completed

Dose Ranging Study of Pegylated Interferon Lambda in Patients With Hepatitis B and Positive for the Hepatitis B e Antigen (LIRA-B)

Hepatitis B Virus

Australia, France, Germany, Korea, Republic of, Taiwan, United States, Canada, Italy, Netherlands, Singapore, Hong Kong
Bristol-Myers Squibb

Completed

Entecavir Plus Adefovir Combination Therapy Versus Entecavir Monotherapy vs Therapy With Adefovir Plus Lamivudine for Chronic Hepatitis B Infected Subjects With Lamivudine-resistant Virus (DEFINE)

Hepatitis B, Chronic

Australia, Korea, Republic of, Taiwan, Thailand, Hong Kong, United States, Poland, Greece, Canada, Singapore, Philippines, Brazil, India, Indonesia, Italy, Malaysia, Russian Federation, Turkey
GlaxoSmithKline

Active, not recruiting

A Study on the Safety, Efficacy and Immune Response Following Sequential Treatment With an Anti-sense Oligonucleotide Against Chronic Hepatitis B (CHB) and Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) Therapy

Hepatitis B, Chronic

Bulgaria, Belgium, Taiwan, Singapore, Spain, Germany, Thailand, Hong Kong, France, Italy, Poland, Philippines, Romania, United Kingdom, Turkey
Novartis Pharmaceuticals

Completed

Epidemiological Study in Children and Adolescents With Chronic Hepatitis B (EPIC B)

Liver Diseases | Digestive System Diseases | Virus Diseases | Hepatitis B | Hepatitis | Hepatitis, Viral, Human | DNA Virus Infections | Hepatitis, Chronic | Hepatitis B, Chronic

Spain, United States, Taiwan, Singapore, China, Romania, United Kingdom, Italy, Russian Federation, Poland, France, Thailand, Peru, Argentina, Brazil, Greece, India, Philippines
Hoffmann-La Roche

Completed

Efficacy and Safety Study of Pegasys in the Treatment of Chronic Hepatitis B

Chronic Hepatitis B

China, Korea, Republic of, Taiwan, Germany, United States, Singapore, Switzerland, Canada, Puerto Rico, Thailand, Israel, France, New Zealand, Poland, United Kingdom, Brazil, Australia
Bristol-Myers Squibb

Withdrawn

Safety and Efficacy Study of Pegylated Interferon Lambda Versus Pegylated Interferon Alfa, Plus Ribavirin in Subjects With Hepatitis C

Hepatitis C Virus (HCV)

India, Korea, Republic of, Poland, Taiwan, Spain, Canada, Russian Federation, Colombia, Singapore, Netherlands, Ireland, United Kingdom, Czech Republic, Hungary, Romania, Hong Kong, Turkey, United States, China, Egypt
Janssen Research & Development, LLC

Terminated

A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection

Influenza A

United States, France, Netherlands, United Kingdom, Korea, Republic of, Taiwan, Israel, India, Thailand, New Zealand, Vietnam, Germany, Latvia, Spain, Russian Federation, Turkey, Argentina, Singapore, Brazil, Hungary, Malaysia, Au... and more
Bristol-Myers Squibb

Completed

Safety and Efficacy Study of Pegylated Interferon Lambda With and Without Daclatasvir, Compared to Pegylated Interferon Alfa, Plus Ribavirin in Subjects With Hepatitis C Genotype 2 and 3 (PRINCIPAL)

Hepatitis C Virus (HCV)

Australia, Belgium, France, Italy, Japan, Korea, Republic of, Mexico, Russian Federation, Taiwan, United States, Chile, Hong Kong, Argentina, Netherlands, United Kingdom, Singapore, New Zealand, Finland, Greece
Human Genome Sciences Inc.
Novartis

Completed

Efficacy of Albumin Interferon Alfa-2b With Ribavirin Compared to Peg-IFN Alfa-2a With Ribavirin in IFN Naive Patients Geno2/3

Chronic Hepatitis C

Korea, Republic of, United States, Spain, Canada, France, Australia, Israel, Singapore, Thailand, Malaysia, Sweden, Belgium, Germany, Taiwan, Poland, Argentina, India, Puerto Rico, Brazil, Mexico, United Kingdom
GlaxoSmithKline

Completed

A Study of GSK3228836 in Participants With Chronic Hepatitis B (CHB) (B-Clear)

Hepatitis B

United States, Germany, Korea, Republic of, Spain, Taiwan, Bulgaria, Italy, Russian Federation, Thailand, Canada, Singapore, France, Malaysia, China, Romania, Hong Kong, Philippines, Japan, Poland, South Africa, United Kingdom, Ar...
GlaxoSmithKline

Completed

Antifibrotic Activity Of GI262570 In Chronic Hepatitis C Subjects

Cirrhosis, Liver

United States, Taiwan, Germany, Israel, Australia, Singapore, Canada, Czechia, Korea, Republic of, Russian Federation, New Zealand, Romania, Puerto Rico, Malaysia
Gilead Sciences

Completed

Efficacy & Safety of Tenofovir Disoproxil Fumarate (TDF) Plus Peginterferon α-2a (Peg-IFN) Versus TDF or Peg-IFN Monotherapy in Chronic Hepatitis B

Chronic Hepatitis B

Korea, Republic of, Hong Kong, Spain, Taiwan, United States, Poland, France, Netherlands, Singapore, Australia, Canada, Italy, United Kingdom, Germany, Portugal, Romania, Greece, Turkey, India
Gilead Sciences

Completed

Study to Compare Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF) in Participants With Chronic Hepatitis B Infection Who Are Positive for Hepatitis B e Antigen

HBeAg-positive Chronic Hepatitis B

Hong Kong, Korea, Republic of, United States, Taiwan, United Kingdom, France, Australia, Spain, Bulgaria, Canada, India, Italy, Japan, New Zealand, Poland, Romania, Russian Federation, Singapore, Turkey
Bristol-Myers Squibb

Completed

Study of Entecavir in Patients With Chronic Hepatitis B Virus (HBV) Infection

Chronic Hepatitis B

Brazil, Canada, China, France, India, Italy, Korea, Republic of, Mexico, Poland, Russian Federation, Taiwan, Thailand, Turkey, United States, Colombia, Germany, Spain, Czechia, Greece, Romania, Argentina, Philippines, Singapore, Portugal

Clinical Trials on Normal Human Subjects in Singapore

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