Clinical Trials on Olivopontocerebellar Atrophies

Total 1088 results

Santhera Pharmaceuticals

No longer available

Expanded Access Program for Idebenone in Patients With Leber's Hereditary Optic Neuropathy Who Completed the LEROS Study (US EAP LHON)

Leber's Hereditary Optic Neuropathy
Stealth BioTherapeutics Inc.

Completed

A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic Neuropathy

Leber's Hereditary Optic Neuropathy

United States
Byron Lam
National Eye Institute (NEI)

Active, not recruiting

Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy (LHON)

Leber's Hereditary Optic Neuropathy

United States
Santhera Pharmaceuticals

Completed

RHODOS Follow-up Single-visit Study (RHODOS-OFU)

Leber's Hereditary Optic Neuropathy

Canada, Germany, United Kingdom
McGill University

Recruiting

Examining Sex-based Differences in Metabolic and Mechanistic Responses to Disuse Induced Muscle Atrophy

Muscle Atrophy | Muscle Disuse Atrophy

Canada
Centre Hospitalier Universitaire de Saint Etienne
Ministry of Health, France; Association Française contre les Myopathies (AFM)...

Completed

Study of Morphology and Functional Magnetic Resonance Imaging (MRI) Muscle Patients With Muscular Dystrophy Type FSHD Benefiting a Physical Training Introduced. (FSHD3)

Muscular Dystrophy | Facioscapulohumeral

France
Santhera Pharmaceuticals

Withdrawn

Study With Idebenone in Patients With Chronic Vision Loss Due to Leber's Hereditary Optic Neuropathy (LHON)

Leber's Hereditary Optic Neuropathy
Katherine Mathews
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Clinical Trial Readiness for the Dystroglycanopathies

Muscular Dystrophy

United States
Centre Hospitalier Universitaire de Nice

Active, not recruiting

Clinical Trial Readiness Network FSHD France: Prospective 24 Months MRI Study (ReSOLVE_France)

Muscular Dystrophy | Facioscapulohumeral

France
Maastricht University Medical Center

Completed

Bedrest, Feeding Pattern, and Insulin Sensitivity

Insulin Resistance | Atrophy, Disuse

Netherlands
Fundación Eduardo Anitua

Not yet recruiting

Plasma Rich in Growth Factors (PRGF) for the Treatment of Lichen Sclerosus Atrophicus of the Vulva (PRGF)

Lichen Sclerosus of Vulva
Center for Vulvovaginal Disorders

Completed

Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus

Lichen Sclerosus of Vulva

United States
Edgewise Therapeutics, Inc.

Completed

Absorption, Metabolism, Excretion and Absolute Bioavailability of EDG-5506 in Healthy Volunteers

Nervous System Diseases | Genetic Diseases, Inborn | Musculoskeletal Diseases | Muscular Diseases | Neuromuscular Diseases | Muscular Dystrophies | Muscular Disorders, Atrophic | Healthy Volunteer

United States
University of Birmingham
University of Nottingham; Biotechnology and Biological Sciences Research Council

Completed

Preventing Bed-rest Induced Muscle Loss in the Elderly

Sarcopenia | Muscle Loss | Prehabilitation | Disuse Atrophy | Protein Metabolism

United Kingdom
Candela Corporation

Completed

The CO2RE® System for Vulvar Lichen Sclerosus

Vulvar Lichen Sclerosus

United States
University of Kansas Medical Center
Hoffmann-La Roche; Seattle Children's Hospital; University of Rochester; University... and other collaborators

Recruiting

Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD) (MOVE FSHD)

FSHD

United States, Canada, United Kingdom
Children's National Research Institute

Active, not recruiting

Pilot Study of Cardiac MR in Patients With Muscular Dystrophy

Genetic Diseases, Inborn | Musculoskeletal Diseases | Muscular Dystrophies | Cardiac Fibrosis

United States
McMaster University

Unknown

n3 PUFA and Muscle-disuse Atrophy in Older Women

Sarcopenia | Muscle Atrophy | Muscle Disuse Atrophy

Canada
Centre d'Investigation Clinique et Technologique...

Unknown

Diaphragm Ultrasound in Neuromuscular Disorders

Muscular Dystrophies

France
Duke University

Completed

Ultrasound in Muscle Biopsy

Muscular Dystrophy | Myositis | Myopathy

United States
AVAVA, Inc.

Recruiting

The MIRIA Acne Scar Study (MIRIA)

Acne Scars - Mixed Atrophic and Hypertrophic

United States
Leadiant Biosciences, Inc.
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other collaborators

Active, not recruiting

Multi-Center Study of ManNAc for GNE Myopathy (MAGiNE)

GNE Myopathy

United States
GlaxoSmithKline

Completed

A Double-blind, Escalating Dose, Randomized, Placebo-controlled Study Assessing PK, Safety, Tolerability in Non-ambulant DMD Subjects (DEMAND I)

Muscular Dystrophies

France, United States
Clinica Dermatologica Arbache ltda

Recruiting

Lichen Sclerosus - Treatment With Triamcinolone Acetonide: Injections (Syringe and Needle) x Micro Injections (MMP Technique)

Lichen Sclerosus of External Female Genital Organs

Brazil
University of Roma La Sapienza
University of Pisa; Universita di Verona

Recruiting

The Nanofat Regenerative Surgery for Management of Genital Lichen Sclerosus in Male and Female Patients (LSNanofat)

Urethral Stricture

Italy
Kolding Sygehus

Completed

Low-Level Laser Therapy: an Efficient Supplement to Treatments of Vulvar Lichen Sclerosus to Improve Quality of Life

Quality of Life
Radboud University Medical Center
Solve FSHD

Recruiting

Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation (MUSCLE+)

Muscular Dystrophy, Facioscapulohumeral

Netherlands
Atamyo Therapeutics

Recruiting

GNT0006 Gene Therapy Trial in Patients With LGMDR9

LGMDR9

Denmark, France, United Kingdom
Centre Hospitalier Universitaire de Nice

Completed

Neurological and Psychiatric Comorbidities Patients With FSHD 1 and 2

Muscular Dystrophy, Facioscapulohumeral

France
Centre Hospitalier Universitaire de Nice

Completed

Clinical, Genetic and Epigenetic Characterization of Patients With FSHD Type 1 and FSHD Type 2

Muscular Dystrophy, Facioscapulohumeral

France
Santhera Pharmaceuticals

Completed

Congenital Muscular Dystrophy Ascending Multiple Dose Cohort Study Analyzing Pharmacokinetics at Three Dose Levels In Children and Adolescents With Assessment of Safety and Tolerability of Omigapil (CALLISTO) (CALLISTO)

Congenital Muscular Dystrophy

United States
National Human Genome Research Institute (NHGRI)
National Center for Advancing Translational Sciences (NCATS)

Completed

An Open Label Phase 2 Study of ManNAc in Subjects With GNE Myopathy

GNE Myopathy

United States
Centre for Human Drug Research, Netherlands
Facio Therapeutics

Completed

Digital Biotyping of FSHD Patients and Controls

Muscular Dystrophy, Facioscapulohumeral

Netherlands
Hoffmann-La Roche

Terminated

Study of an Investigational Drug, RO7239361 (BMS-986089), in Ambulatory Boys With DMD

Muscular Dystrophy (DMD)

United States, Canada
Centre Hospitalier Universitaire de Saint Etienne
Association Française contre les Myopathies (AFM), Paris

Completed

Prospective Study for 24-months of Physical Training Introduced in Lifestyle of Patients With FSHD : Tolerance, Sustainability and Efficiency of Unsupervised Training Program. (FSHD2)

Muscular Dystrophy, Facioscapulohumeral

France
Maastricht University Medical Center

Completed

Bed-rest, Muscle Mass and Insulin Sensitivity

Disuse Atrophy

Netherlands
Grete Andersen, MD
AP Moeller Foundation; The Danish Rheumatism Association; Aase and Ejnar Danielsens... and other collaborators

Completed

Protein Supplementation and Exercise in Patients With FSH Muscular Dystrophy- a Randomized Placebo Controlled Study (FSHD)

Facioscapulohumeral Muscle Dystrophy

Denmark
GenSight Biologics

Completed

RESCUE and REVERSE Long-term Follow-up (RESTORE)

Leber Hereditary Optic Neuropathy

United States, France, Italy, United Kingdom, Germany
GenSight Biologics

Active, not recruiting

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT)

Leber Hereditary Optic Neuropathy

Belgium, Spain, United States, France, United Kingdom, Taiwan, Italy
Santhera Pharmaceuticals

Completed

Post Authorisation Safety Study With Raxone in LHON Patients (PAROS)

Leber's Hereditary Optic Neuropathy (LHON)

Italy, Germany, France, Austria, Greece, Netherlands
GenSight Biologics

Completed

REALITY LHON Registry (REALITY)

Leber Hereditary Optic Neuropathy

United States, France, Italy, Spain, United Kingdom
Huazhong University of Science and Technology
Shiyan Taihe Hospital

Active, not recruiting

A Single Intravitreal Injection of rAAV2-ND4 for the Treatment of Leber's Hereditary Optic Neuropathy

Leber Hereditary Optic Neuropathy

China
GenSight Biologics

Completed

Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients

Leber Hereditary Optic Neuropathy

France
Santhera Pharmaceuticals
European Vision Institute Clinical Research Network

Completed

Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey

Leber Hereditary Optic Neuropathy (LHON)

Belgium, France, Denmark, Italy, Slovenia
University Hospital, Angers

Not yet recruiting

Tolerance and Efficacy Nicotinamide (Vitamin B3) in Dominant Optic Atrophy OPA1 (NICOPA1-TOL)

Nicotinamide Adverse Reaction
Neurophth Therapeutics Inc

Recruiting

Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND1 Mutations

Leber Hereditary Optic Neuropathy (LHON)

China, United States
Wuhan Neurophth Biotechnology Limited Company

Recruiting

Gene Therapy Clinical Trial for the Treatment Of Leber's HereDitary Optic Neuropathy (GOLD)

Leber's Hereditary Optic Neuropathy (LHON)

China
Hôpital Necker-Enfants Malades
European Georges Pompidou Hospital; CLAIROP

Completed

Trial of Befizal® 200 mg for the Treatment of Leber Hereditary Optic Neuropathy (Béfinohl)

Safety Issues | Efficacy, Self

France
Edison Pharmaceuticals Inc

No longer available

Emergency Administration of EPI-743 to a Single Patient With Leber's Hereditary Optic Neuropathy [LHON]

Leber's Hereditary Optic Neuropathy

United States
Medical College of Wisconsin

Terminated

Near-infrared Light-emitting Diode (NIR-LED) Therapy for Leber's Hereditary Optic Neuropathy (LHON) (LHON)

Leber's Hereditary Optic Neuropathy (LHON)

United States

Clinical Trials on Olivopontocerebellar Atrophies

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