Bed-rest, Muscle Mass and Insulin Sensitivity

April 27, 2015 updated by: Lex Verdijk, Maastricht University Medical Center

The Impact of Short-term Bed-rest on Skeletal Muscle Mass and Insulin Sensitivity in Healthy, Young Men

In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

15

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Netherlands
      • Maastricht, Netherlands
        • Maastricht University Medical Centre

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Male
  • Aged from 18-35 years
  • 18.5 < BMI < 30 kg/m2

Exclusion Criteria:

  • Smoking
  • Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
  • Hypertension (according to WHO criteria) and/or cardiovascular disease
  • Any back/leg/knee/neck/postural complaints
  • Use of any prescribed medication
  • Type 2 diabetes mellitus
  • Any family history of thrombosis
  • All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
  • Myocardial infarction within the last 3 years
  • Use of anti-coagulants

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: NA
  • Interventional Model: SINGLE_GROUP
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Bed rest
One week of bed rest.
Behavioral: Bed rest

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change in quadriceps muscle cross-sectional area
Time Frame: One day before and directly after cessation of bed rest.
One day before and directly after cessation of bed rest.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in lower back cross-sectional area
Time Frame: One day before and directly after cessation of bed rest.
One day before and directly after cessation of bed rest.
Change in leg and whole body lean tissue mass
Time Frame: One day before and directly after cessation of bed rest.
One day before and directly after cessation of bed rest.
Change in muscle fiber size
Time Frame: One day before and directly after cessation of bed rest.
One day before and directly after cessation of bed rest.
Change in muscle strength
Time Frame: One day before and directly after cessation of bed rest.
Measured by 1-Repetition Maximum testing
One day before and directly after cessation of bed rest.
Change in insulin sensitivity
Time Frame: One day before and directly after cessation of bed rest.
Measured by hyperinsulinemic-euglycemic clamp
One day before and directly after cessation of bed rest.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Maastricht University Medical Center

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2014

Primary Completion (ACTUAL)

April 1, 2015

Study Registration Dates

First Submitted

April 1, 2014

First Submitted That Met QC Criteria

April 4, 2014

First Posted (ESTIMATE)

April 9, 2014

Study Record Updates

Last Update Posted (ESTIMATE)

April 28, 2015

Last Update Submitted That Met QC Criteria

April 27, 2015

Last Verified

April 1, 2015

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • METC 14-3-013

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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