Clinical Trials on Oral Therapies

Total 1699 results

Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer

Lung Cancer | Radiation Toxicity | Oral Complications | Drug/Agent Toxicity by Tissue/Organ

United States, Canada
Dana-Farber Cancer Institute

Completed

SNP-Based Prediction of Oral Mucositis Risk in Patients Receiving Hematopoietic Stem Cell Transplants (HSCT)

Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma

United States
European Organisation for Research and Treatment...

Terminated

Chemotherapy Plus Radiation Therapy With or Without Amifostine in Treating Patients With Locally Advanced Cancer of the Nasopharynx

Head and Neck Cancer | Radiation Toxicity | Oral Complications | Drug/Agent Toxicity by Tissue/Organ

Spain, France, Belgium, Italy, United Kingdom, Turkey
Fox Chase Cancer Center
National Cancer Institute (NCI)

Completed

Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer

Tongue Cancer | Recurrent Metastatic Squamous Neck Cancer With Occult Primary | Recurrent Salivary Gland Cancer | Recurrent Squamous Cell Carcinoma of the Hypopharynx | Recurrent Squamous Cell Carcinoma of the Larynx | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous... and other conditions

United States
National Cancer Institute (NCI)

Terminated

Gefitinib and Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III or Stage IV Head and Neck Cancer

Stage III Squamous Cell Carcinoma of the Hypopharynx | Stage III Squamous Cell Carcinoma of the Larynx | Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity | Stage III Squamous Cell Carcinoma of the Oropharynx | Stage IV Squamous Cell Carcinoma of the Hypopharynx | Stage IV Squamous... and other conditions

United States
National Institute on Deafness and Other Communication...

Terminated

Patient Evaluation for Head and Neck Surgery Branch Studies

Head and Neck Neoplasms | Carcinoma, Squamous Cell | Laryngeal Cancer | Oral Cancer | Pharyngeal Cancer

United States
Cairo University

Completed

Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma

Hepatitis C

Egypt
Cancer Research UK

Terminated

AMG 319 in HPV Positive and Negative HNSCC

Human Papillomavirus (HPV) | Positive or Negative Head and Neck Squamous Cell Carcinoma (HNSCC) of the Hypopharynx, Oropharynx, Oral Cavity, Supraglottis or Larynx

United Kingdom
MitoImmune Therapeutics

Active, not recruiting

Evaluate the Safety and Efficacy for Oral Mucositis Prevention of MIT-001 in Auto HSCT (Capella)

Lymphoma | Multiple Myeloma | Oral Mucositis | Hematologic Cancer

Korea, Republic of
McMaster University
Public Health Agency of Canada (PHAC)

Active, not recruiting

Beyond Silence: Advancing E-mental Health Solutions to Support Canadian Healthcare Workers

Post-traumatic Stress Disorder | Mental Stress | Mental Health Issue | Moral Injury

Canada
National Cancer Institute (NCI)

Completed

SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

Recurrent Metastatic Squamous Neck Cancer With Occult Primary | Recurrent Salivary Gland Cancer | Recurrent Squamous Cell Carcinoma of the Hypopharynx | Recurrent Squamous Cell Carcinoma of the Larynx | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous Cell Carcinoma... and other conditions

Canada
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Recruiting

First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients

Head Neck Cancer | Oropharynx Squamous Cell Carcinoma | Oral Cavity Squamous Cell Carcinoma | Metastatic Squamous Cell Carcinoma | Hypopharynx Squamous Cell Carcinoma | Larynx Squamous Cell Carcinoma

United States
Cliniques universitaires Saint-Luc- Université...

Recruiting

Activity and Safety of Peptide-based Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck. (HN1901)

Oropharynx Squamous Cell Carcinoma | Oral Cavity Squamous Cell Carcinoma | Hypopharynx Squamous Cell Carcinoma | Larynx Squamous Cell Carcinoma

Belgium
National Cancer Institute (NCI)

Active, not recruiting

Extended Follow Up of Young Women in Costa Rica Who Received Vaccine for Human Papillomavirus Types 16 and 18 and Unvaccinated Controls

Cervical Carcinoma | Oral Cavity Carcinoma | Human Papillomavirus Infection | Anal Carcinoma | Human Papillomavirus-Related Cervical Carcinoma

Costa Rica
International Agency for Research on Cancer
GBH Cancer Memorial Hospital Udaipur, India

Completed

Improving Access to Control of Diseases for Women (IMPACD)

Cervical Cancer | Breast Cancer | Oral Cancer | Cardio-vascular Disease | Stroke Cancer

India
University of Colorado, Denver

Completed

Better Together Physician Coaching to Mitigate Burnout in Male-Identifying Trainees (BTPC)

Burnout, Professional | Self Compassion | Flourishing | Imposter Syndrome | Moral Injury

United States
Instituto do Cancer do Estado de São Paulo
University of Sao Paulo

Completed

Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

Head and Neck Cancer | Oropharyngeal Cancer | Oral Cavity Cancer

Brazil
University of Birmingham
AstraZeneca; Cancer Research UK

Completed

WEE1 Inhibitor With Cisplatin and Radiotherapy: A Trial in Head and Neck Cancer (WISTERIA)

Larynx Cancer | Oral Cavity Squamous Cell Carcinoma | Hypopharynx Squamous Cell Carcinoma

United Kingdom
RWTH Aachen University
Bayer

Completed

Rivaroxaban Compared to Vitamin K Antagonist Upon Development of Cardiovascular Calcification

Atrial Fibrillation or Pulmonary Embolism | Need of Long Term Oral Anticoagulation Therapy (OAT) | Existent Coronary or Valvular Calcification, or Both and Agatston Score > 50 in at Least One Location

Germany
NYU Langone Health
Washington University School of Medicine

Terminated

A Pilot Study of Metabolic Effects of Omentectomy (OMT)

Patients Who Consented to Undergo Laparoscopic Gastric Banding Surgery for Weight Loss and Consent to Participate in This studyBMI ≥35 kg/m2 | Confirmed Type 2 Diabetes Treated With Oral Agents and/or Only Diet Therapy | Age 18-64 Years

United States
University of Colorado, Denver

Active, not recruiting

Better Together Physician Coaching to Mitigate Burnout Amongst Clinicians

Burnout, Professional | Loneliness | Self Compassion | Flourishing | Imposter Syndrome | Moral Injury

United States
National Cancer Institute (NCI)

Completed

Radiation Therapy and Bortezomib and Cetuximab With or Without Cisplatin to Treat Head and Neck Cancer

Head and Neck Cancer | Laryngeal Cancer | Oral Cancer | Carcinoma, Squamous | Pharyngeal Cancer

United States
M.D. Anderson Cancer Center
The University of Texas Health Science Center, Houston; Baylor College of Medicine

Completed

Non Invasive Oral Cancer Screening Among HIV Infected Individuals

Human Immunodeficiency Virus | Malignant Neoplasms of Mesothelial and Soft Tissue

United States
VA Office of Research and Development
Providence VA Medical Center

Completed

Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD

Substance Use Disorder | Post-traumatic Stress Disorder | Moral Injury

United States
University Hospital Freiburg
Charite University, Berlin, Germany; Icahn School of Medicine at Mount Sinai; Ohio State University and other collaborators

Recruiting

Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy (SENIOR)

Oropharynx Cancer | Oral Cavity Cancer | Larynx Cancer | HNSCC | Hypopharynx Cancer

United States, Cyprus, Germany, Switzerland
H. Lee Moffitt Cancer Center and Research Institute
AstraZeneca; Brooklyn ImmunoTherapeutics, LLC

Active, not recruiting

IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma

Squamous Cell Carcinoma of the Head and Neck | Oropharynx Squamous Cell Carcinoma | Squamous Cell Carcinoma | Oral Cavity Squamous Cell Carcinoma | Metastatic Squamous Cell Carcinoma | Hypopharynx Squamous Cell Carcinoma | Paranasal Sinus Squamous Cell Carcinoma | Larynx Squamous Cell Carcinoma

United States
University of Miami
Regeneron Pharmaceuticals

Withdrawn

Phase 2 Trial of Maintenance Cemiplimab for Head and Neck Squamous Cell Carcinoma (HNSCC)

Head and Neck Squamous Cell Carcinoma | HNSCC | Squamous Cell Carcinoma of the Larynx | Squamous Cell Carcinoma of the Oral Cavity | Squamous Cell Carcinoma of Hypopharynx
University of Chicago

Completed

Docetaxel Based Chemotherapy Plus or Minus Induction Chemotherapy to Decrease Events in Head and Neck Cancer (DeCIDE) (DeCIDE)

Paranasal Sinus Neoplasms | Cancer of the Pharynx | Cancer of the Larynx | Cancer of the Nasal Cavity | Cancer of the Oral Cavity

United States, Spain, France, Croatia, Russian Federation
Johnny Kao

Completed

Fluorouracil, Hydroxyurea, Cetuximab and Twice-daily Intensity Radiation Therapy for Advanced Head and Neck Cancer

Head and Neck Cancer | Nose Neoplasms | Paranasal Sinus Neoplasms | Cancer of the Pharynx | Cancer of the Larynx | Cancer of the Oral Cavity

United States
Michigan State University
National Cancer Institute (NCI)

Completed

Improving Adherence to Oral Cancer Agents and Self Care of Symptoms Using an IVR

Melanoma | Leukemia | Breast Neoplasms | Prostatic Neoplasms | Colorectal Neoplasms

United States
Groupe Oncologie Radiotherapie Tete et Cou

Completed

Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC

Oral Cancer | Oropharynx Cancer | Larynx Cancer | Hypopharynx Cancer

France
West China Hospital

Not yet recruiting

A Lithium-containing Mouthwash Prevention and Treatment of Oral Mucositis and Dysgeusia in Patients Undergoing Radiotherapy

Head and Neck Squamous Cell Carcinoma | Malignant Head and Neck Tumors

China
American College of Radiology
RTOG Foundation

Not yet recruiting

Testing the Safety of Giving a Standard Dose of Radiation Over a Shorter Period of Time for Patients Who Had Surgery for Intermediate-Risk Head and Neck Cancer

Head and Neck Cancer | Head and Neck Squamous Cell Carcinoma | Squamous Cell Carcinoma of the Larynx | Squamous Cell Carcinoma of the Oral Cavity | Squamous Cell Carcinoma of the Oropharynx
National and Kapodistrian University of Athens
Ioulia And Irene Tseti Pharmaceutical Laboratories S.A.

Completed

Assessing the Efficacy of a Hydrogen Peroxide Mouthwash for Oral Wound Healing, Oral Hygiene and Xerostomia Relief

Postoperative Pain | Dental Plaque | Wound Heal | Sjogren's Syndrome | Mouth Dryness | Gingival Inflammation | Biopsy Wound | Oral Dryness | Mouth; Wound

Greece
AIO-Studien-gGmbH
Merck Sharp & Dohme LLC

Not yet recruiting

Head and Neck Carcinoma Clinical Research Platform for Molecular and Blood-based Biomarkers, Treatment and Outcome (HEAT)

Squamous Cell Carcinoma of the Larynx | Squamous Cell Carcinoma of the Oral Cavity | Squamous Cell Carcinoma of the Oropharynx | Squamous Cell Carcinoma of the Hypopharynx

Germany
University of California, San Francisco
National Institute of Dental and Craniofacial Research (NIDCR)

Not yet recruiting

People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity

HIV Infections | Oropharyngeal Squamous Cell Carcinoma | Oral Squamous Cell Carcinoma

United States
University of Erlangen-Nürnberg Medical School

Recruiting

De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck (DIREKHT2)

Squamous Cell Carcinoma of the Larynx | Squamous Cell Carcinoma of the Oral Cavity | Squamous Cell Carcinoma of the Oropharynx | Squamous Cell Carcinoma of the Hypopharynx

Germany
Sanford Health
Merck Sharp & Dohme LLC

Active, not recruiting

Pembrolizumab in Combination With CRT for LA-SCCHN

Head and Neck Cancer | Laryngeal Cancer | Oropharynx Cancer | Oral Cavity Cancer | Larynx Cancer | Squamous Cell Carcinoma | Hypopharynx Cancer

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Terminated

Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy

Nasopharyngeal Carcinoma | Current Smoker | Head and Neck Squamous Cell Carcinoma | Oropharyngeal Squamous Cell Carcinoma | Hypopharyngeal Squamous Cell Carcinoma | Laryngeal Squamous Cell Carcinoma | Oral Cavity Squamous Cell Carcinoma

United States
Gustave Roussy, Cancer Campus, Grand Paris

Completed

Very Intense Radiotherapy-Chemotherapy Regimen in Advanced HNSCC

Oral Cancer | Oropharynx Cancer | Larynx Cancer | Hypopharynx Cancer

France
Kyunghee Burkitt, DO, PhD

Not yet recruiting

Vorinostat in Combination With Chemoradiation in Locally Advanced HPV Negative HNSCC (HPV)

Squamous Cell Carcinoma of the Larynx | Squamous Cell Carcinoma of the Oral Cavity | HPV-Related Squamous Cell Carcinoma | Squamous Cell Carcinoma of the Oropharynx | Squamous Cell Carcinoma of the Hypopharynx

United States
Memorial Sloan Kettering Cancer Center

Completed

Adaptive Radiotherapy for Head and Neck Cancer

Head and Neck Cancer | Nasopharynx Cancer | Oropharynx Cancer | Oral Cavity Cancer | Larynx Cancer | Paranasal Sinus Cancer | Hypopharynx Cancer

United States
M.D. Anderson Cancer Center
Millennium Pharmaceuticals, Inc.

Withdrawn

Alisertib and TAK-228 in Participants With Human Papilloma Virus (HPV) Associated Malignancies

Malignant Neoplasms of Female Genital Organs | Malignant Neoplasms of Lip Oral Cavity and Pharynx | Malignant Neoplasms of Digestive Organs | Malignant Neoplasms of Male Genital Organs
University of Washington

Active, not recruiting

Frontline Clinician Psilocybin Study

Depression | COVID-19 | Burnout, Professional | Post Traumatic Stress Disorder | Burnout, Caregiver | Moral Injury

United States
Medical University of South Carolina
National Cancer Institute (NCI)

Recruiting

Multi-Site Trial of Navigation vs Treatment as Usual for Delays in Starting Adjuvant Therapy (ENDURE)

Head and Neck Cancer | Head and Neck Squamous Cell Carcinoma | Oropharynx Cancer | Oral Cavity Cancer | Larynx Cancer

United States
Instituto Nacional de Cancer, Brazil

Completed

Low-level Laser Therapy to Prevent Oral Mucositis in Head and Neck Patients

Squamous Cell Carcinoma of Hypopharynx | Squamous Cell Carcinoma of Oropharynx | Squamous Cell Carcinoma of Nasopharynx

Brazil
Fox Chase Cancer Center

Withdrawn

Everolimus, Erlotinib Hydrochloride, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer Previously Treated With Radiation Therapy

Tongue Cancer | Recurrent Metastatic Squamous Neck Cancer With Occult Primary | Recurrent Salivary Gland Cancer | Recurrent Squamous Cell Carcinoma of the Hypopharynx | Recurrent Squamous Cell Carcinoma of the Larynx | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous... and other conditions

United States
University of Washington
National Cancer Institute (NCI)

Completed

Cisplatin and Radiation Therapy With or Without Erlotinib Hydrochloride in Treating Patients With Stage III or Stage IV Head and Neck Cancer

Stage III Squamous Cell Carcinoma of the Hypopharynx | Stage III Squamous Cell Carcinoma of the Larynx | Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity | Stage III Squamous Cell Carcinoma of the Nasopharynx | Stage III Squamous Cell Carcinoma of the Oropharynx | Stage IV Squamous... and other conditions

United States
National Cancer Institute (NCI)

Completed

Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer

Metastatic Squamous Neck Cancer With Occult Primary | Small Intestine Lymphoma | Recurrent Pancreatic Cancer | Stage IV Pancreatic Cancer | Gastrointestinal Stromal Tumor | Metastatic Gastrointestinal Carcinoid Tumor | Recurrent Gastrointestinal Carcinoid Tumor | Tongue Cancer | Stage IV Colon Cancer | Stage IV Rectal Cancer and other conditions

United States
University of Washington
National Cancer Institute (NCI)

Terminated

Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing Nausea and Vomiting Caused by Cisplatin in Patients With Stage III or Stage IV Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy

Nausea and Vomiting | Stage III Squamous Cell Carcinoma of the Hypopharynx | Stage III Squamous Cell Carcinoma of the Larynx | Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity | Stage III Squamous Cell Carcinoma of the Nasopharynx | Stage III Squamous Cell Carcinoma of the Oropharynx and other conditions

United States

Clinical Trials on Oral Therapies

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