Clinical Trials on PTEN Loss of Function Mutation

Total 1325 results

Faeth Therapeutics

Active, not recruiting

Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations

Advanced Solid Tumor | PIK3CA Mutation | PTEN Loss of Function Mutation

United States
Taiho Oncology, Inc.

Terminated

TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations

Advanced or Metastatic Solid Tumors Irrespective of Gene Alterations | Advanced or Metastatic Solid Tumors With Germline PTEN Inactivating Mutations

United States, United Kingdom, Austria, France
Institut Bergonié

Recruiting

Cancer Risk Assessment in Patients With a Constitutional Alteration of the PTEN Gene (COCO)

PTEN Gene Mutation

France
Stanford University

Not yet recruiting

Sirolimus for Improving Social Abilities in People With PTEN Germline Mutations

PTEN Gene Mutation | PTEN Hamartoma Tumor Syndrome | PTEN Hamartoma Syndrome

United States
Endeavor Biomedicines, Inc.

Active, not recruiting

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

Solid Tumors With PTCH1 Loss-of-function Mutations

United States
University of South Florida
Boston Children's Hospital

Completed

Access to Resources for Patients With PTEN Hamartoma Tumor Syndrome

PTEN Gene Mutation

United States
Novartis Pharmaceuticals

Terminated

Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

c-MET Inhibitor; PI3K Inhibitor, PTEN Mutations, Homozygous Del. of PTEN or PTEN Neg. by IHC, c-Met Ampli. by FISH, INC280, BKM120, Buparlisib; Recurrent GBM

Spain, Switzerland, Germany, United States, Netherlands
Sun Yat-sen University

Recruiting

A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

Lymphoma, Non-Hodgkin | Pediatric Cancer | Lymphoblastic Lymphoma, Childhood | PTEN Loss | NOTCH1 Gene Mutation

China
Regeneron Pharmaceuticals

Recruiting

A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations (ENSEMBLE)

Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF) | Biallelic Mutations in the Gap Junction Beta 2 (GJB2) Gene | Digenic Mutations in GJB2/Gap Junction Beta 6 (GJB6) Genes

United States
Boston Children's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome

PTEN Gene Mutation | PTEN Hamartoma Tumor Syndrome

United States
Memorial Sloan Kettering Cancer Center

Recruiting

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk

BRCA1 Mutation | BRCA2 Mutation | APC Gene Mutation | MLH1 Gene Mutation | RAD51C Gene Mutation | RAD51D Gene Mutation | BRIP1 Gene Mutation | PALB2 Gene Mutation | PTEN Gene Mutation | ATM Gene Mutation | CHEK2 Gene Mutation | BARD1 Gene Mutation | MSH2 Gene Mutation | MSH6 Gene Mutation | PMS2 Gene Mutation | POLD1 Gene... and other conditions

United States
Mel Shiuann-Sheng Lee
Novartis

Completed

Prevention of Periprosthetic Bone Loss After Total Hip Replacement by Annual Bisphosphonate Therapy

Functional Outcomes | Prevention of BMD Loss After THR | Serum Markers of Bone Turnover

Taiwan
Technische Universität Dresden

Not yet recruiting

Automated Screening for Clinically Ascertained Loss of Cerebral Functions (DETECT-IVE)

Irreversible Loss of Brain Function (ILBF)

Germany
Mayo Clinic

Recruiting

Shear-wave Elastography Compared to Respiratory Function Testing

Respiratory Complication | Respiratory Function Loss

United States
Mayo Clinic
National Institute on Drug Abuse (NIDA)

Recruiting

A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Respiratory Complication | Respiratory Function Loss

United States
Sensorion

Recruiting

Natural History in Children up to 10 Years With Moderate to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes (Otoconex)

Sensorineural Hearing Loss, Bilateral | Congenital Deafness | AUNB1 | DFNB1A | DFNB9 | OTOF Gene Mutation | GJB2 Gene Mutation

France
University of Toronto
Kensington Eye Institute

Terminated

The Incidence of Glistenings in the 2017 Intraocular Lenses Made by Alcon and Abbott Medical Optics

Cataracts | Visual Acuity Reduced Transiently | Loss of Visual Contrast Sensitivity | Functional Visual Loss

Canada
Ohio State University
Pfizer; PTEN Research

Active, not recruiting

Sirolimus for Cowden Syndrome With Colon Polyposis

Cowden Syndrome | Polyposis | PTEN Gene Mutation | PTEN Hamartoma Tumor Syndrome | PTEN Hamartoma Syndrome | Bannayan Syndrome | Bannayan Zonana Syndrome

United States
Yonsei University

Unknown

The Comparison of the Clinical Efficacy Between I-gel and LMA-Supreme, the Two Most Recently Developed Supraglottic Airway Devices, in Infants

Elective Surgery of Short Duration (Less Than 2 hr) Undergoing General Anesthesia Using Supraglottic Airway

Korea, Republic of
Coordinación de Investigación en Salud, Mexico

Unknown

Peritonitis and Loss of Residual Renal Function, Technique Failure and Mortality in Peritoneal Dialysis Patients

Loss of Residual Renal Function | Technique Failure in Peritoneal Dialysis

Mexico
VA Office of Research and Development

Recruiting

A Biomechanical Evaluation of the Ossur Power Knee in Persons With Transfemoral Amputation (OPKTFA)

Transfemoral Amputation | Limb Loss | Limb Absence

United States
Université de Sherbrooke

Completed

Functional Recovery Following Orthopedic Wrist Surgery Under Peripheral Nerve Block Versus General Anesthesia (FUNCTION)

Recovery of Function

Canada
Centre Hospitalier Departemental Vendee

Recruiting

Postpartum Pelvic Floor Rehabilitation and Information Provided by the Health Care Providers (PPFR)

Recovery of Function

France
University Hospital, Strasbourg, France

Unknown

Translation and Validation of the French Version of the Postoperative Quality of Recovery Score QoR-15 (QoR-15F)

Recovery of Function

France
Southern Illinois University
Memorial Medical Center; Memorial Medical Center Foundation

Completed

Vascularized Composite Allotransplantation of the Hand and Upper Extremity (Hand Transplant)

Traumatic Amputation of Arm | Traumatic Amputation of Hand

United States
Suzanne Flier, MD

Unknown

3D Echocardiographic Assessment of Epicardial Pacing After Cardiopulmonary Bypass.

Disorder of Pacing Function

Canada
University of Florida

Completed

Physiologic Effects of Topiramate on Cognition

Alteration of Cognitive Function
Tufts University
Boston University; Boston Medical Center; Hebrew SeniorLife

Completed

Effect of Zinc Supplementation on Serum Zinc Level in Nursing Home Elderly

Disorder of Immune Function
University Hospital Schleswig-Holstein
University of Kiel

Completed

Polymorphism of the Cytochrome P450-system in Renal Transplants

Function of Renal Transplant

Germany
Aarhus University Hospital Skejby

Completed

Conventional vs Ultrasound Guided Arteria Cannulation.

Disorder of Cardiac Function

Denmark
Peking University Third Hospital

Unknown

Endoclip Papillaplasty Restores Sphincter of Oddi Function

Sphincter of Oddi Function

China
Guy's and St Thomas' NHS Foundation Trust
Astellas Pharma Europe Ltd.

Unknown

RituxiMab INDuction in Renal Transplantation (ReMIND)

Function of Renal Transplant

United Kingdom
Stanford University

Completed

Perioperative Aminophylline to Improve Early Kidney Function After a Kidney Transplant (RTphylline)

Function of Renal Transplant

United States
Nantes University Hospital

Terminated

Protocol Calcineurin Inhibitor (CNI) Weaning

Function of Renal Transplant

France
National Taiwan University Hospital

Completed

Cognitive Effects of Tai Chi Chuan in Healthy Older Adults and Older Adults

Alteration of Cognitive Function

Taiwan
Northumbria University

Completed

The Effect of Breakfast Size Prior to Morning Exercise on Cognition, Mood and Appetite in Habitually Active Women

Alteration of Cognitive Function

United Kingdom
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Evaluation of Executive Functions in Children With Cochleovestibular Deficit (Vestibulex)

Hearing Loss | Cognitive Function | Executive Function | Vestibular Function

France
VA Office of Research and Development
Johns Hopkins University; Spectrum Research, Inc.

Completed

Self-management to Improve Function Following Amputation (VETPALS)

Amputation, Limb Loss

United States
Regeneron Pharmaceuticals

Recruiting

A Study of DB-OTO, an Adeno-associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations (CHORD)

Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)

Spain, United Kingdom, United States
Imperial College London

Recruiting

Oesophagectomy and Chest Wall and Respiratory Function

Esophageal Cancer | Esophagectomy | Respiratory Function Loss

United Kingdom
National Institute of Neurological Disorders and...

Completed

Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

Motor Function of Healthy Physiology

United States
Chiesi Farmaceutici S.p.A.

Withdrawn

Efficacy and Safety of CUSA-081 in the Restoration of Dysfunctional Central Venous Access Device (CVAD) Functionality (READY 2)

Restoration of Function to CVADs

United States, Bulgaria, Hungary
Mälardalen University

Completed

Reablement Intervention for Older Adults Conducted by a Multi Professional Home Rehabilitation Team

Rehabilitation by Recovery of Function

Sweden
University Hospital, Basel, Switzerland

Recruiting

A Comparison of Right Ventricular Function in the Apical and Subcostal 4 Chamber TTE Views in the Perioperative Setting

Assessment of Right Ventricular Function

Switzerland
Incyte Corporation

Available

Expanded Access Use of Itacitinib to Treat a Single Patient With STAT1 Gain of Function (GOF) Disease

STAT1 Gain-of-Function Disease
University of Minnesota

Enrolling by invitation

Ultrahigh Field Body MR Imaging

Structure and Function of MRI

United States
University of Chile
National Fund for Research and Development in Health, Chile; Fondo Nacional...

Completed

Early Occupational Therapy for Delirium Prevention in Older Patients Admitted to Critical Care Unit

Delirium | Alteration of Cognitive Function | Incompetence, Functional

Chile
Washington University School of Medicine
St. Louis Jewish Community Center; St. Louis Naturally Occurring Retirement...

Completed

Combining Exercise and Cognitive Training to Improve Everyday Function (EXACT)

Effect of Exercise on Cognitive Function

United States
Ajou University School of Medicine

Completed

Cognitive Health Promotion Project in the Community

Dietary Modification | Alteration of Cognitive Function
Wake Forest University
University of Colorado, Denver; University of Pittsburgh; National Institute... and other collaborators

Completed

Physical and Cognitive Function - Look AHEAD Ancillary Study

Diabetes | Weight Loss | Cognitive Function | Physical Function

United States

Clinical Trials on PTEN Loss of Function Mutation

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CROs in Luxembourg

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