Clinical Trials on Physiological Effects of Drugs

Total 2448 results

Universidade Federal do Rio de Janeiro

Recruiting

Immunomodulatory Effect of Dexmedetomidine as an Adjuvant Drug in Laparoscopic Cholecystectomies

Physiological Effects of Drugs

Brazil
Albert Einstein College of Medicine

Completed

Studies of Sulfur Metabolism in Humans

Metabolic Side Effects of Drugs

United States
University of Copenhagen
Carlsberg Foundation

Completed

Metabolic Imprints of Alcoholic Beverages (MetAl)

Metabolic Side Effects of Drugs and Substances

Denmark
Ankara City Hospital Bilkent

Completed

Determination of Minimum Effective Volume of Local Anesthetic in Patients Undergoing Ultrasound-Guided Infraclavicular Approach for Brachial Plexus Blockade

Physiological Effects of Drugs | Peripheral Nervous System Agents | Anesthetics, Local | Underdosing of Local Anesthetics
National Institute of Allergy and Infectious Diseases...

Recruiting

Screening of Volunteers for Clinical Trials of Investigational or Licensed Vaccines or Antiviral Products

Physiological Effects of Drugs | Anti-Infective Agents | Vaccines | Immunologic Factors | Antiviral Agents

United States
University of Texas Southwestern Medical Center

Completed

Memantine for Corticosteroid-Induced Mood and Declarative Memory Changes

Physiological Effects of Drugs

United States
University Hospital, Bonn

Completed

Effects of Oxytocin and Lorazepam on Fear-related Intra-amygdalar Activity

Oxytocin, Lorazepam, Anti-Anxiety Agents, Physiological Effects of Drugs

Germany
Philippe Bégin
The Hospital for Sick Children; Centre de recherche du Centre hospitalier universitaire... and other collaborators

Recruiting

Omalizumab to Accelerate a Symptom-driven Multi-food OIT (BOOM)

Immunotherapy | Physiological Effects of Drugs | Food IgE-mediated Allergy | Omalizumab

Canada
Walter Reed National Military Medical Center
United States Department of Defense; General Services Administration (GSA)

Active, not recruiting

Reducing Concurrent Opioid-Benzodiazepine Prescriptions

Adverse Drug Effect of Opioids | Adverse Drug Effect of Benzodiazepines

United States
University of Chicago

Completed

Behavior Brain Responses (BBR)

Alcohol Drinking | Drinking Behavior | Physiological Effects of Drugs | Central Nervous System Depression

United States
Olympic Seafood AS

Completed

Safety and Tolerability of Krill Powder Supplement in Slightly Overweight People With Moderately Elevated Blood Pressure

Adverse Drug Event | Side Effects of Drugs

Finland
Tanta University

Completed

The Effect of Opioid Free Anesthesia in Bariatric Surgeries (Opioidfree)

Adverse Effect of Drugs and Medicaments in Therapeutic Use | Adverse Effects in the Therapeutic Use of Anaesthetics

Egypt
Janssen Korea, Ltd., Korea

Completed

A Study to Evaluate Treatment Adherence in Schizophrenia With Long Acting Risperidone Microspheres (e-STAR)

Mental Disorders | Schizophrenia | Tranquilizing Agents | Therapeutic Uses | Physiological Effects of Drugs | Psychotropic Drugs | Antipsychotic Agents
Prof Gérard WAEBER
Centre Hospitalier Universitaire Vaudois; University of Lausanne; Center for...

Terminated

A Double Blind Randomised Placebo-controlled Trial to Assess the Role of Iron Repletion in Glucose Homeostasis. (DIAFER)

Iron-deficiency | Safety Issues | Metabolic Disorder, Glucose | Iron Toxicity | Glucose Metabolism Disorders (Including Diabetes Mellitus) | Metabolic Side Effects of Drugs

Switzerland
University of Zurich

Completed

Vitamin D3, Folic Acid and Fexofenadine in Healthy Volunteers

Physiological Effects of Vitamin D

Switzerland
University of Michigan

Completed

Effects of Fish Oil on the Colon Mucosa

Physiological Effects of Fish Oil

United States
The University of Texas Health Science Center,...

Completed

Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine

Morphine | Analgesics, Opioid | Central Nervous System Depressants | Analgesics | Narcotics | Physiological Effect of Drugs

United States
Indiana University
National Institute of General Medical Sciences (NIGMS)

Completed

Bupropion Stereoselective Disposition and CYP2D6-mediated Drug Interactions in Healthy Volunteers

Adverse Effect of Drug Therapy Metabolism Medications (Diagnosis)

United States
Jinnah Postgraduate Medical Centre

Completed

Comparison of Efficacy of Tranexamic Acid Mesotherapy Versus 0.9% Normal Saline for Melasma

Effect of Drugs | Adverse Effects of Medical Drugs

Pakistan
National Institute on Aging (NIA)

Completed

Sodium-glucose Co Transporter 2 (sGLT2) Inhibitor and Endogenous Ketone Production

Physiological Effects of Drugs | Hypoglycemic Agents | Empaglifozin | Sodium-Glucose Transporter 2 Inhibitors

United States
Assiut University

Completed

Efficacy of Repetitive Trans-spinal Magnetic Stimulation on Axial Motor Symptoms in PD (rTSMS)

Adverse Effect of Drug Therapy Levodopa

Egypt
Jørgen Bjerggaard Jensen
Odense University Hospital; Karolinska University Hospital; Zealand University... and other collaborators

Recruiting

NORTH-REG Dwell-Time Study

Side Effect of Drug

Denmark, Sweden, Iceland
Yale University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

The Stimulation To Induce Mothers Study (STIM)

Labor Pain | Oxytocin | Induction of Labor Affected Fetus / Newborn | Physiologic Effects of Drugs

United States
Lobe Sciences Ltd.
Pharmaceutical Research Unit, Jordan

Completed

Evaluation of Safety, Rate and Extent of Absorption of Psilocin Mucate (Psilocin-1)

Side Effect of Drug

Jordan
Companion Dx Reference Lab, LLC

Unknown

Utility of PharmacoGenomics for Reducing Adverse Drug Effects (UPGRADE)

Genetics of Drug Metabolism

United States
Sun Yat-sen University

Not yet recruiting

the SDMEAI Study: a Multi-center Epidemiological Study

Artificial Intelligence | Eye Involvement of Systemic Diseaes | Adverse Drug Effect on Eye
Fundação Bahiana de Infectologia
Hospital de Clinicas de Porto Alegre; Universidade Federal do Rio Grande do... and other collaborators

Recruiting

Dolutegravir and Clinical Outcomes Among ART-recipients in Brazil (CODE)

HIV Infections | Clinical Outcomes | Adverse Drug Event | Effect of Drugs

Brazil
Tanta University

Unknown

The Off Label Use of Glycopyrrolate in the Adults Intensive Care Unit.

Effect of Drugs

Saudi Arabia
Suez Canal University

Unknown

Dexmedetomidine Adjuvant to General Anesthesia of Abdominal Hysterectomy

Effect of Drugs
Beni-Suef University

Unknown

Comparative Effect of Hypotensive Anaesthesia on Event Related Potentials, Quantitative Electroencephalograghy

Effect of Drugs
Luye Pharma Group Ltd.

Completed

Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder

Mental Disorders | Psychotic Disorders | Mood Disorders | Schizophrenia | Schizophrenia Spectrum and Other Psychotic Disorders | Molecular Mechanisms of Pharmacological Action | Tranquilizing Agents | Physiological Effects of Drugs | Psychotropic Drugs | Antipsychotic Agents | Neurotransmitter Agents | Central...

United States
Companion Dx Reference Lab, LLC

Unknown

Pharmacogenomics Registry to Assess Clinical Utility (PREACT)

Drug Side Effects
Nathaniel Jenkins

Completed

Acute Effects of Organic Guayusa Extract

Acute Physiological Effects of Organic Guayusa Extract

United States
Luye Pharma Group Ltd.

Completed

Relative Bioavailability of LY03010 Compared to Listed Drug

Mental Disorders | Psychotic Disorders | Mood Disorders | Schizophrenia | Molecular Mechanisms of Pharmacological Action | Tranquilizing Agents | Physiological Effects of Drugs | Psychotropic Drugs | Antipsychotic Agents | Central Nervous System Depressants | Neurotransmitter Agents | Schizophrenia Spectrum

United States
David Vivas
St Carlos Hospital, Madrid, Spain

Completed

Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate (ECCLIPSE)

Adverse Effect of Antithrombotic Drugs

Spain
First Affiliated Hospital of Zhejiang University
Beijing Xuze Medical Technology Co., LTD.

Completed

PK-PD Comparative Study of Lansoprazole Capsules and Lansoprazole Enteric-coated Capsules in Healthy Chinese Volunteers

Safety Issues | Effect of Drugs

China
First Affiliated Hospital of Zhejiang University
Jiangsu Aosaikang Pharmaceutical Co., Ltd.

Unknown

A Clinical Trial to Evaluate the Safety and Tolerability of Dexlansoprazole Injection in Healthy Chinese Adults（Part 2）

Safety Issues | Effect of Drugs

China
First Affiliated Hospital of Zhejiang University
Beijing Xuze Medical Technology Co., LTD.

Completed

Pharmacokinetic Study of Lansoprazole Capsules in Healthy Chinese Volunteer

Safety Issues | Effect of Drugs

China
First Affiliated Hospital Xi'an Jiaotong University

Not yet recruiting

Remimazolam Improves the Safety in Elderly Patients Undergoing Gastrointestinal Endoscopy

Recovery | Drug Effect | Safety | Psychotropic Drugs | Anesthetics, Intravenous | Anesthetics

China
Wolfson Medical Center

Completed

The Use of STOPP/START Criteria for Medication Intervention Among Elderly Population Living in a Geriatric Hospital (STOPP)

Adverse Drug Effects

Israel
CRG UZ Brussel
KU Leuven; Abbott; Universitätsklinikum Hamburg-Eppendorf

Completed

Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI

Infertility | Infertility, Female | Dydrogesterone | Genital Diseases, Female | Progesterone | Hormones | Physiological Effects of Drugs | Genital Diseases, Male | Hormones, Hormone Substitutes, and Hormone Antagonists | Progestins

Belgium
Seoul National University Hospital
Asan Medical Center; Myongji Hospital

Unknown

The Effect of Ondansetron During Intramuscular Ketamine Use in Children: A Trial in Emergency Department

Side Effect of Drug | Sedation and Analgesia

Korea, Republic of
Second Affiliated Hospital of Wenzhou Medical University

Unknown

Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection

Mental Disorders | Pathologic Processes | Postoperative Complications | Delirium | Neurocognitive Disorders | Dexmedetomidine | Molecular Mechanisms of Pharmacological Action | Physiological Effects of Drugs | Analgesics | Hypnotics and Sedatives

China
Lykos Therapeutics

Not yet recruiting

Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-2)

Psychological Effects of Study Drug
General Hospital of Ningxia Medical University

Not yet recruiting

The Effect of Oxycodone Hydrochloride on CRBD After TURBT Under General Anesthesia

Effect of Drug | Adverse Effect of Opioids

China
St. Antonius Hospital
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Completed

Pharmacokinetics of Morphine and Oxycodone in Frail Elderly Undergoing Cardiac Surgery

Postoperative Pain | Opioid Use | Side Effect of Drug

Netherlands
Lykos Therapeutics

Completed

Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-1)

Psychological Effects of Study Drug

United States
Mayo Clinic

Not yet recruiting

Pharmacogenetic Panel to Prevent Adverse Drug Reactions in Daily Primary Care Practice: (PREPARE-Mayo)

Side Effect of Drug | Pharmacogenomic Drug Interaction | Drug Metabolism, Poor, CYP2D6-Related | Ineffective Drug Action | Drug Metabolism, Poor, CYP2C19-Related

United States
University of Chicago

Completed

Alcohol, Behavior, and Brain Imaging ((DARC))

Substance-Related Disorders | Alcohol Drinking | Drinking Behavior | Binge Drinking | Ethanol | Physiological Effects of Drugs | Central Nervous System Depressants
Centre for Addiction and Mental Health

Completed

Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence

Smoking Cessation | Tobacco Smoking | Tobacco Use Disorder | Substance Use Disorders | Molecular Mechanisms of Pharmacological Action | Tobacco Dependence | Physiological Effects of Drugs

Canada

Clinical Trials on Physiological Effects of Drugs

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