the SDMEAI Study: a Multi-center Epidemiological Study

Effects of Systemic Diseases and Medications on Eye and Artificial Intelligence Model Development: a Multi-center Epidemiological Study

Sponsors

Lead Sponsor: Sun Yat-sen University

Source Sun Yat-sen University
Brief Summary

A variety of diseases in the Department of Rheumatology, Immunology, Nephrology, and Gastroenterology can cause eye lesions, and medications can also bring various adverse reactions, which can seriously reduce the quality of patients' daily life, bring additional economic burdens, and even threaten the lives of patients. This study aims to recruit patients from the aboved-mentioned departments and conduct a cross-sectional and cohort study. On one hand, we plan to compare the epidemiological characteristics of ocular lesions of systemic diseases and eye adverse drug effects in patients with rheumatology, immunology, nephrology and gastroenterology, and summarized some epidemiological indices such as prevalence, high-risk factors, etc. On the other hand, we plan to develop an artificial intelligence model after collecting certain case data. By selecting risk factors related to the occurrence of ocular lesions, we aim to train models that can predict the ocular manifestations of systemic diseases and medications.

Overall Status Not yet recruiting
Start Date 2021-04-22
Completion Date 2026-04-22
Primary Completion Date 2025-04-22
Study Type Observational
Primary Outcome
Measure Time Frame
morbidity 2021.4.22-2025.4.22
Enrollment 1000
Condition
Intervention

Intervention Type: Drug

Intervention Name: Corticosteroids, immunosuppressors, biological agents

Description: We do not prescribe new medications to patients but only observe their adverse effects on the eye.

Eligibility

Sampling Method:

Non-Probability Sample

Criteria:

Inclusion Criteria: - Age 6-80 years old, gender is not limited - patients who have been diagnosed with systemic diseases; - patients who have ever or never used any ocular toxic drugs such as corticosteroids, chloroquine, etc.; - no history of glaucoma, cataract, scleritis, uveitis, ocular trauma, etc. before enrollment; - willing to complete follow-ups for at least 2 years. Exclusion Criteria: - Mainly use local therapies (intraocular, intra-articular and other non-systemic drug routes); - history of intraocular surgery (such as lens implantation, vitrectomy, retinal photocoagulation); - history of glaucoma, cataract, center serous retinopathy, etc.; - history of various diseases (such as scleritis, uveitis, eye trauma, etc.) that may cause opacity of the eye under the posterior capsule; - any other diseases or conditions that affect the observation, such as diabetes, low calcium convulsions, long-term exposure to radiation before enrollment; - subjects with endogenous corticosteroids, or psychiatric diseases.

Gender:

All

Minimum Age:

6 Years

Maximum Age:

80 Years

Healthy Volunteers:

Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Haotian Lin, Ph.D. Principal Investigator Zhongshan Ophthalmic Center, Sun Yat-sen University
Overall Contact

Last Name: Haotian Lin, Ph.D.

Phone: 13802793086

Email: [email protected]

Verification Date

2021-04-01

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Sun Yat-sen University

Investigator Full Name: Haotian Lin

Investigator Title: Vice President of Zhongshan Ophthalmic Center

Has Expanded Access No
Condition Browse
Arm Group

Label: never receive systemic medications

Label: ever user of systemic medications

Label: current user of systemic medications

Patient Data Undecided
Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

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