Clinical Trials on Safety and PK in Healthy Volunteers in United States

Total 551 results

Novartis Pharmaceuticals

Completed

Cardiac Safety of Indacaterol

Chronic Obstructive Pulmonary Disease | Healthy Volunteers

United States
AMAG Pharmaceuticals, Inc.

Terminated

Study Assessing Injection Pain of Makena® (Hydroxyprogesterone Caproate Injection, 250 mg/mL) When Administered Via Subcutaneous Auto-injector vs Intramuscular Injection Via Needle and Syringe in Healthy Post-menopausal Women

Assessing Injection Pain of Makena® (Hydroxyprogesterone Caproate Injection, 250 mg/mL) in Healthy Post-menopausal Women

United States
Hoffmann-La Roche

Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Dose Basimglurant in Healthy Subjects and in Patients With Major Depressive Disorder (MDD)

Major Depressive Disorder, Healthy Volunteer

United States
AZTherapies, Inc.

Completed

Randomized I/II Phase Study of ALZT-OP1 Combination Therapy in Alzheimer's Disease and Normal Healthy Volunteers

Alzheimer Disease | Healthy Volunteers

United States
Invicro

Completed

Phase 1 Evaluation of [18F]MK-6240 PET as an Imaging Marker for Tau Protein

Alzheimer Disease | Healthy Volunteers

United States
University of Pennsylvania
Inovio Pharmaceuticals

Completed

A Study of INO-A002 in Healthy Dengue Virus-naive Adults

Healthy Volunteers

United States
APRINOIA Therapeutics, LLC

Active, not recruiting

A First-in-Human Study to Assess Single Doses of APNmAb005 in Healthy Participants

Alzheimer Disease | Tauopathies | Healthy Volunteers

United States
Precirix

Completed

Study to Evaluate the Safety, Biodistribution, Radiation Dosimetry and Tumor Imaging Potential of [131I]-SGMIB Anti-HER2 VHH1 in Healthy Volunteers and Breast Cancer Patients (CAM-VHH1)

Breast Cancer | Healthy Volunteers

Belgium
Allergan

Completed

Safety, Tolerability and Systemic Pharmacokinetics of AGN-232411 in Healthy Participants and Participants With Dry Eye

Dry Eye Syndromes | Healthy Volunteers

United States
National Institute of Neurological Disorders and...

Completed

Propensity to Develop Plasticity in the Parieto-Motor Networks in Dystonia From the Perspective of Abnormal High-Order Motor Processing

Healthy Volunteers | Cervical Dystonia | Writer's Cramp

United States
Eli Lilly and Company

Completed

A Study of LY2605541 Versus Insulin Glargine on Blood Sugar

Diabetes Mellitus, Type 1 | Healthy Volunteers

United States
University of Michigan
National Center for Complementary and Integrative Health (NCCIH)

Recruiting

Explosive Synchronization of Brain Network Activity in Chronic Pain

Fibromyalgia | Healthy Volunteers

United States
National Institute of Allergy and Infectious Diseases...

Completed

Efficacy and Safety of CR6261 in an H1N1 Influenza Healthy Volunteer Human Challenge Model (CR6261)

H1N1 Influenza Healthy Volunteers

United States
Deerland Enzymes
Kennesaw State University

Recruiting

Efficacy of a Digestive Enzyme Blend (MULO)

Satiety | Indigestion | Digestive Health | Protein Digestion | Carbohydrate Digestion | Fat Digestion

United States
AbbVie

Recruiting

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ABBV-932 in Healthy Adult Participants, Participants With Generalized Anxiety Disorder (GAD) and Participants With Bipolar Disorder (BPD)

Healthy Volunteers | Generalized Anxiety Disorder (GAD) | Bipolar Disorder (BPD)

United States
Angle plc

Completed

Harvest of CTCs From MBC Patients Using the Parsortix™ PC1 System (HOMING)

Healthy Volunteers | Breast Cancer, Metastatic

United States
AstraZeneca

Completed

Effects of Administration of Fostamatinib on Blood Concentrations of an Oral Contraceptive in Healthy Female Subjects

Scientific Terminology Rheumatoid Arthritis, Healthy Female Volunteers, Pharmacokinetics, Oral Contraceptive, Drug-drug Interaction | Laymen Terminology Level of Oral Contraceptive in Blood, Oral Contraceptive, Rheumatoid Arthritis, Drug -Drug Interaction

United Kingdom
Eli Lilly and Company

Completed

A Study of LY2886721 in Healthy Participants and Participants Diagnosed With Alzheimer's Disease

Alzheimer Disease | Healthy Volunteers

United States
Novome Biotechnologies Inc

Terminated

Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects

Healthy Volunteers | Enteric Hyperoxaluria

United States, Canada
Eleusis Therapeutics
Beckley Psytech Pty Ltd

Recruiting

ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression

Depression | Healthy Volunteers | Major Depressive Disorder

United Kingdom
National Human Genome Research Institute (NHGRI)

Active, not recruiting

ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study

Healthy Volunteers | Atherosclerotic Heart Disease

United States
Johns Hopkins Bloomberg School of Public Health
United States Department of Defense; PATH; Naval Medical Research Center

Completed

Human Challenge Model Refinement With Enterotoxigenic Escherichia Coli Strain B7A

Healthy Volunteer

United States
Bayer

Recruiting

A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male Participants

Healthy Volunteers | Heartburn | Indigestion | Stomach Acid Related Symptoms | Nocturnal Stomach Acid Related Symptoms

United Kingdom
MODAG GmbH
Teva Pharmaceutical Industries, Ltd.; Quotient Sciences; Aptuit

Completed

A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)

Healthy Volunteers

United Kingdom
Millennium Pharmaceuticals, Inc.

Completed

A Study of Mobocertinib Capsules in People With Severe Kidney Problems and People With Healthy Kidneys

Renal Impairment | Healthy Volunteers

United States
Mclean Hospital

Withdrawn

Magnetic Resonance Spectroscopy Studies of Acute Hypoxic and Hyperoxic Breathing in Healthy Volunteers

Healthy

United States
National Institute on Alcohol Abuse and Alcoholism...

Recruiting

A Response Modulation Hypothesis of Socioemotional Processing Associated With Alcohol Use Disorder

Alcohol-Related Disorders | Healthy Volunteers | Alcohol Drinking Related Problems

United States
Johns Hopkins University

Recruiting

Feasibility Study on Radiofrequency-Based Selective Electrothermolysis to Investigate Its Effects on Human Skin

Healthy Volunteers | Hidradenitis Suppurativa

United States
MODAG GmbH
Quotient Sciences; Aptuit (Verona) Srl, an Evotec Company

Completed

A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects

Healthy Volunteers

United Kingdom
Regeneron Pharmaceuticals

Recruiting

A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Non-Alcoholic Fatty Liver Disease (NAFLD)

Healthy Volunteers | Non-alcoholic Fatty Liver Disease (NAFLD)

United States
Fraunhofer, Center for Molecular Biotechnology

Completed

Safety and Immunogenicity Of A Recombinant H5N1 Vaccine In Adults

Healthy

United States
Northwell Health

Completed

Evaluating Neuromuscular Stimulation for Restoring Hand Movements

Healthy Volunteers | Spinal Cord Injury Cervical | Physical and Rehabilitation Medicine

United States
Icahn School of Medicine at Mount Sinai
American Heart Association

Completed

Family-based Approach to Promotion of Health - FAMILIA (Project 2) (FAMILIA)

Atherosclerosis | Lifestyle Intervention | Promoting Cardiovascular Health in Adults

United States
MindRhythm, Inc.

Not yet recruiting

500 "Normal" Adult Subjects Who Have Experienced no Known Brain Injury Will Participate in Collecting Data That Will Assist With the Optimization of the Diagnostic Capabilities of the Harmony in Detecting Neurologic Abnormalities. (REFRESH)

Healthy | Cranial Waveform in Normal Patients as a Result of Cardiac Cycle

United States
Gliknik Inc.

Recruiting

Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease

First in Man Study to Evaluate Initial Safety

United Kingdom
Teva takeda

Completed

A Study of TAK-279 in Adults With or Without Kidney Problems

Renal Impairment | Healthy Volunteers

United States
National Institute of Arthritis and Musculoskeletal...

Recruiting

Studies of Dermatologic Diseases Biospecimen Acquisition Protocol

Healthy Volunteers | Carcinoma, Merkel Cell | Normal Volunteers | Dermatologic Conditions

United States
National Institute of Neurological Disorders and...

Completed

Natural History of Multiple Sclerosis and Its Mimickers

Multiple Sclerosis | Healthy Volunteers | Neurologic Disorders

United States
Sanofi Pasteur, a Sanofi Company

Completed

Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2021-2022 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively

Healthy Volunteers | Influenza Immunization

United States
University of Copenhagen

Completed

Pharmacological Properties of Salmeterol

Pharmacokinetics in Healthy Young Men

Denmark
Sanofi Pasteur, a Sanofi Company

Completed

Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2020-2021 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively

Healthy Volunteers | Influenza Immunization

United States
University of Wisconsin, Madison
Wisconsin Partnership Program

Completed

Today Not Tomorrow Pregnancy and Infant Support Program (TNT- PISP)

Infant Death | Infant Mortality | Mental Health | Healthcare Disparities | Social Determinants of Health | Physician-Patient Relations | Minority Health | Prenatal Care | Adverse Childhood Experiences | Prenatal Stress | Racial Bias | Trust | Quality of Care | Maternal Child Health | Health Problems in Pregnancy | Support... and other conditions

United States
Scripps Translational Science Institute

Recruiting

POWERMOM, A Healthy Pregnancy Research Community

Pregnancy Related | Behavior | Weight Change, Body | Health Problems in Pregnancy

United States
DynPort Vaccine Company LLC, A GDIT Company

Completed

Title: Recombinant Plague Vaccine rF1V in Healthy Volunteers

Healthy Volunteers

United States
University of California, Irvine

Withdrawn

Gas Kinetics and Metabolism in Anesthesia During Non Steady State

Anesthetized Healthy Patients (ASA 1 or 2) in the Supine Position, Excluding Head, Neck and Head Surgeries | Anesthetized Patient With Severe Systemic Disease (ASA 3 or 4)

United States
AstraZeneca

Completed

Relative Bioavailability Study to Compare Inhalation of Terbutaline Sulphate 1,5mg Via Turbuhaler M3 With Turbuhaler M2

Healthy Volunteers

United Kingdom
Affinivax, Inc.

Completed

A Study to Assess the Safety, Tolerability and Immunogenicity of ASP3772, a Pneumococcal Vaccine, in Toddlers 12 to 15 Months of Age in Comparison to an Active Comparator

Healthy Volunteers | Pneumococcal Disease

United States
National Institute of Mental Health (NIMH)

Terminated

A Study of the Association Between Autism and Immune Changes in the Brain

Healthy Volunteers | Autism | Autism Spectrum Disorders | Brain Disease

United States
Emergent BioSolutions

Terminated

Hepatitis B Virus Antibody Booster Program for the Production of Hepatitis B Immune Globulin (HBIG)

Healthy Volunteers

United States
University of Oxford

Completed

Study of the Effects of Commercial Air Travel on the Lungs

Healthy Volunteers | Chuvash Polycythaemia

United Kingdom

Clinical Trials on Safety and PK in Healthy Volunteers in United States

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