Clinical Trials on Severe Immunosuppression

Total 3979 results

Kythera Biopharmaceuticals

Completed

Open-Label Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental Area

Moderate or Severe Submental Fullness

United States
Kythera Biopharmaceuticals

Completed

Patient Experience Study of Deoxycholic Acid Injection

Moderate or Severe Submental Fullness

United States
Kythera Biopharmaceuticals

Completed

Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area (REFINE-1)

Moderate or Severe Submental Fullness

United States, Canada
Beckman Coulter, Inc.

Completed

Evaluation of MDW for Early Detection of Sepsis, Clinical Validity

Sepsis | Severe Sepsis | Severe Infection

France, Spain
U.S. Army Medical Research and Development Command

Recruiting

Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever

Viral Hemorrhagic Fever

Germany
Assistance Publique Hopitaux De Marseille

Completed

Evaluation of the Effectiveness of a Diagnostic Kit in the Etiological Diagnosis of Fevers of the Traveler

Fevers of the Traveler

France
Bernhard Nocht Institute for Tropical Medicine

Not yet recruiting

LAssa Fever Adjunct Treatment With DEXamethasone (LADEX)

Lassa Fever
International AIDS Vaccine Initiative
Coalition for Epidemic Preparedness Innovations

Recruiting

A Lassa Fever Vaccine Trial in Adults and Children Residing in West Africa

Lassa Fever

Ghana, Liberia, Nigeria
University of Oxford
London School of Hygiene and Tropical Medicine; Public Health England; National... and other collaborators

Terminated

Cardiovascular Function and Ribavirin Pharmacokinetics and Pharmacodynamics in Patients With Lassa Fever

Lassa Fever

Sierra Leone
International Centre for Diarrhoeal Disease Research...
UNICEF; Nutriset

Completed

Development and Field Testing of Ready-to-use-therapeutic Foods Made of Local Ingredients in Bangladesh for SAM Children

Severe Acute Malnutrition in Childhood

Bangladesh
The Scientific and Technological Research Council...
MonitorCRO

Completed

Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans

Crimean-Congo Hemorrhagic Fever
Heidelberg University

Unknown

Evaluation of Performance of An Aspergillus PCR in Tissue and Pleural Effusion Samples of Immunocompromised Patients

Aspergillosis | Immunosuppression

Germany
University of British Columbia
Paladin Labs Inc.

Recruiting

Tacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release Formulations (LCP-TAC)

Liver Transplantation | Neurotoxicity | Tremor | Tacrolimus | Immunosuppression

Canada
Aqpha Medical B.V.

Not yet recruiting

Safety and Performance of PTMC Dermal Filler

Moderate to Severe Nasolabial Fold
Daewoong Pharmaceutical Co. LTD.

Completed

DWP450 for Treating Moderate to Severe Glabellar Lines

Moderate to Severe Glabellar Lines

China
Galderma R&D

Completed

A Study to Evaluate the Efficacy and Safety of QM1114-DP for the Treatment of Moderate to Severe Glabellar Lines

Moderate to Severe Glabellar Lines

China
AMIpharm Co., Ltd.

Completed

Evaluate the Efficacy and Safety of Polyene Phosphatidylcholine Injection (AYP-101) for the Reduction of Submental Fat (AYP-101)

Moderate or Severe Submental Fullness

Korea, Republic of
EuBiologics Co.,Ltd

Completed

Safety and Efficacy Study of ATGC-100 for the Treatment of Moderate to Severe Glabellar Lines in Adult Subjects

Moderate to Severe Glabellar Lines

Korea, Republic of
Allergan

Completed

Post-Market Study of JUVÉDERM VOLIFT™ With Lidocaine for the Correction of Nasolabial Folds

Moderate to Severe Nasolabial Folds

Germany, Netherlands
Derming SRL

Completed

Efficacy and Tolerance Evaluation of an Anti-age Food Supplement

Moderate-severe Skin Aging/Photoaging
Kythera Biopharmaceuticals

Completed

Phase 2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat

Moderate or Severe Submental Fullness

Australia, Canada, United Kingdom
Kythera Biopharmaceuticals

Completed

Deoxycholic Acid Injection Submental Fat (SMF) Magnetic Resonance Imaging (MRI) and Subject-reported Outcome Measures Study

Moderate or Severe Submental Fullness

United States
Kythera Biopharmaceuticals
Bayer

Completed

Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat

Moderate or Severe Submental Fullness

Belgium, France, Germany, Italy, Spain, United Kingdom
AMIpharm Co., Ltd.

Completed

Determine the Dosing Interval and Optimal Dose of AYP-101 for the Reduction of Submental Fat in Chin Area

Moderate or Severe Submental Fullness

Korea, Republic of
Ipsen

Completed

Efficacy and Safety of Clostridium Botulinum Toxin Type A to Improve Appearance of Moderate to Severe Glabellar Lines (BTX-A-HAC NG)

Moderate to Severe Glabellar Lines

France, Germany
Kythera Biopharmaceuticals
Bayer

Completed

Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat

Moderate or Severe Submental Fullness

Germany, France, Belgium, Spain, United Kingdom
Kythera Biopharmaceuticals

Completed

Phase 1-2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat (ATX-101)

Moderate or Severe Submental Fullness

United Kingdom, Canada, Australia
Kythera Biopharmaceuticals

Completed

Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area

Moderate or Severe Submental Fullness

United States, Canada
Daewoong Pharmaceutical Co. LTD.

Completed

Efficacy and Safety of DWP450 Compared With Botox in Moderate to Severe Glabellar Line

Moderate to Severe Glabellar Line

Korea, Republic of
Bernhard Nocht Institute for Tropical Medicine
Institut National de la Santé Et de la Recherche Médicale, France; University... and other collaborators

Completed

Pharmacokinetics, Tolerability and Safety of Favipiravir Compared to Ribavirin for the Treatment of Lassa Fever (SAFARI)

Lassa Fever

Nigeria
Irrua Specialist Teaching Hospital
University of Bordeaux; Médecins Sans Frontières, Belgium; ANRS, Emerging Infectious... and other collaborators

Not yet recruiting

ISTH/ANRS 0409s INTEGRATE Lassa Fever Study

Lassa Fever
University of Oxford

Completed

Cardiovascular Function and Ribavirin PK/PD in Lassa Fever in Lassa Fever

Lassa Fever

Nigeria
National Institute of Allergy and Infectious Diseases...
The Emmes Company, LLC; US Military HIV Research Program

Completed

Clinical Trial of Ebola Vaccines cAd3-EBO, cAd3-EBOZ and MVA-EbolaZ in Healthy Adults in Uganda

Hemorrhagic Fever, Ebola

Uganda
Universitätsklinikum Hamburg-Eppendorf
University Hospital, Geneva; Wellcome Trust; KEMRI-Wellcome Trust Collaborative... and other collaborators

Completed

Phase I Trial to Assess the Safety, Tolerability and Immunogenicity of a Ebola Virus Vaccine (rVSVΔG-ZEBOV-GP)

Hemorrhagic Fever, Ebola

Germany
University of Oxford
London School of Hygiene and Tropical Medicine; University College, London; KEMRI-Wellcome... and other collaborators

Unknown

First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition (FLACSAM)

Antibiotic Resistance | Malnutrition Severe | Antibiotic Toxicity

Kenya, Uganda
Victor M. Aguayo
Gandhi Medical College, Bhopal; Bundelkhand Medical College, Sagar, Madhya... and other collaborators

Completed

Integrated Program for Children With Severe Acute Malnutrition in Madhya Pradesh, India

Severe Malnutrition

India
Central Adelaide Local Health Network Incorporated
National Health and Medical Research Council, Australia; University of Adelaide and other collaborators

Not yet recruiting

Safety and Immunogenicity of Recombinant Zoster Vaccine for Kidney Transplant Recipients (SIR ZOSTER)

Immunosuppression | Vaccine Response Impaired
Banc de Sang i Teixits
Hospital Universitario La Fe; Vall d'Hebron Institute of Oncology

Completed

Virus-specific Activated T Lymphocytes From a Donor in Hematopoietic Progenitor Transplanted Patients

CMV Viremia | Immunosuppression-related Infectious Disease

Spain
Merz Aesthetics GmbH
Merz Pharmaceuticals GmbH

Completed

Study to Investigate the Safety and Duration of Effect of Different Botulinum Toxin A (NT 201) Dose Groups Following the Treatment of Glabellar Frown Lines

Moderate to Severe Glabellar Frown Lines

United States, Germany
Croma-Pharma GmbH

Active, not recruiting

Saypha® VOLUME Lidocaine for Midface Augmentation (VOLIDO)

Moderate to Severe Midface Volume Deficit

United States
The Hospital for Sick Children

Completed

The Safety of Oka Varicella in Children Prior to Solid Organ Transplantation

Organ Transplantation | Immunosuppression

Canada
University Health Network, Toronto

Completed

High Dose vs. Standard Influenza Vaccine in Adult SOT

Influenza | Immunosuppression

Canada
Major Extremity Trauma Research Consortium

Completed

Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation Protocol (OUTLET)

Severe Distal Tibia Injury | Severe Ankle Injury | Severe Foot Injury | Major Soft Tissue Loss | Major Bone Articular Surface Loss | Major Ankle Articular Surface Loss

United States
Ridgeback Biotherapeutics, LP
Institut National de Recherche Biomédicale. Kinshasa, République Démocratique...

Available

Open-Label Expanded Access for Ebola-Infected Patients to Receive Human mAb Ansuvimab as Therapeutic or for HR PEP

Hemorrhagic Fever, Ebola

Congo, The Democratic Republic of the, Sierra Leone
Gamaleya Research Institute of Epidemiology and...

Completed

Open Study of the Duration of Immunity After Vaccination With GamEvac

Hemorrhagic Fever, Ebola

Russian Federation
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

Study of the Food Effects of Herombopag Olamine Tablets in Healthy Subjects

Adult Patients With Chronic Primary ITP | Adult Patients With SAA Who do Not Respond Well to Immunosuppressive Therapy
Janssen Vaccines & Prevention B.V.
Bavarian Nordic GmbH

Terminated

Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filo

Hemorrhagic Fever, Ebola

France, United Kingdom, Kenya, United States, Uganda, Burkina Faso, Tanzania
Janssen Vaccines & Prevention B.V.
Walter Reed Army Institute of Research (WRAIR)

Completed

Safety, Tolerability and Immunogenicity Study of 2-dose Heterologous Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo

Hemorrhagic Fever, Ebola

United States, Uganda, Kenya, Mozambique, Nigeria, Tanzania
Centers for Disease Control and Prevention
Department of Health and Human Services; University of Sierra Leone; Ministry... and other collaborators

Completed

STRIVE (Sierra Leone Trial to Introduce a Vaccine Against Ebola) (STRIVE)

Hemorrhagic Fever, Ebola

Sierra Leone
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

Study of the Food Effects of Herombopag Olamine Tablets in Healthy Subjects.

Adult Patients With Chronic Primary ITP | Adult Patients With SAA Who do Not Respond Well to Immunosuppressive Therapy

China

Clinical Trials on Severe Immunosuppression

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