Clinical Trials on Third Generation TKI in United Kingdom

Total 1905 results

Regeneron Pharmaceuticals

Active, not recruiting

Study to Evaluate an 8 mg Aflibercept (EYLEA®) Prefilled Syringe (PFS)

Diabetic Macular Edema (DME) | Neovascular Age-Related Macular Degeneration (nAMD)

United States
ORA, Inc.

Completed

Flicker Fusion Thresholds Between Young and Old Subjects at Various Luminance Levels

Age-related Macular Degeneration | Age Factor

United States
AiViva BioPharma, Inc.

Recruiting

Effect of AIV007 by Periocular Administration in Subjects With nAMD or DME

Diabetic Macular Edema | Neovascular Age-related Macular Degeneration

United States
Nottingham University Hospitals NHS Trust

Recruiting

Brain Iron Toxicity and Neurodegeneration - A 7T MRI Study (BITaN)

Mild Cognitive Impairment | Prodromal Alzheimer's Disease

United Kingdom
University of California, San Diego
Regeneron Pharmaceuticals

Completed

EAGLE: Evaluating Genotypes Using Intravitreal Aflibercept Injection (EAGLE)

Macular Degeneration | Wet Macular Degeneration

United States
Guardion Health Sciences, Inc.
Western University of Health Sciences; Eye Clinic of Austin

Completed

Evaluation of a New Eye-specific Multivitamin Formula in Participants at Risk of Age-related Macular Degeneration (AMD) (AMD)

Macular Degeneration | Age-related Macular Degeneration | Retinal Drusen

United States
Duke University

Completed

Alpha MSH in Ocular Disease

Advanced Dry Macular Degeneration

United States
Carl Zeiss Meditec, Inc.
DataMed Devices Inc.

Completed

Measurement and Analysis of Macular Retinal Pigment Epithelium (RPE) Elevations With Cirrus HD-OCT vs. Color Fundus Photography

Drusen Stage Macular Degeneration

United States
Brigham and Women's Hospital
National Eye Institute (NEI)

Active, not recruiting

Age-related Macular Degeneration (AMD) in the Vitamin D and Omega-3 Trial (VITAL)

Age-related Macular Degeneration

United States
Hoffmann-La Roche

Completed

A Study in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema to Evaluate the Safety of the Faricimab Prefilled Syringe

Diabetic Macular Edema | Neovascular Age-related Macular Degeneration

United States
Jeffrey S Heier
Regeneron Pharmaceuticals

Unknown

IAI Versus Sham as Prophylaxis Against Conversion to Neovascular AMD (PRO-CON)

Age-Related Macular Degeneration

United States
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Two Treatment Regimens of 0.5 mg Ranibizumab Intravitreal Injections Guided by Functional and/or Anatomical Criteria, in Patients With Neovascular Age-related Macular Degeneration (OCTAVE)

Neovascular Age-related Macular Degeneration

Germany, Turkey, Austria, Canada, Czechia, United Kingdom, Hungary, Italy, Lithuania, Guatemala, France, Ireland, Argentina, Portugal, Spain, Sweden, Greece, Switzerland, Slovakia, Finland, Netherlands, Colombia, Mexico, Panama
ReNeuron Limited

Active, not recruiting

Safety and Tolerability of hRPC in Retinitis Pigmentosa (hRPCRP)

Retinitis Pigmentosa

United States, United Kingdom, Spain
Ribomic USA Inc

Completed

RBM-007 in Subjects witH ExudatIve Age-related Macular Degeneration (SUSHI)

Age-related Macular Degeneration

United States
Allergan

Completed

Safety and Efficacy of a New Treatment as Adjunctive Therapy to Anti-vascular Endothelial Growth Factor (Anti-VEGF) Treatment in Patients With Age-Related Macular Degeneration (AMD)

Choroidal Neovascularization | Age-Related Maculopathy

France, Korea, Republic of, New Zealand, Italy, Israel, United States, Portugal, Australia, United Kingdom
Retina Research Institute, LLC
Valley Retina Institute

Unknown

Short-term Clinical Effects of Intravitreal Aflibercept Injection 2.0mg as a Predictor of Long-term Results

Age Related Macular Degeneration

United States
Hoffmann-La Roche

Completed

A Study to Investigate Aqueous Humor and Multimodal Imaging Biomarkers in Treatment-Naïve Participants With Diabetic Macular Edema Treated With Faricimab (ALTIMETER)

Diabetic Macular Edema

Germany, United States, United Kingdom, Argentina, Canada, Italy, Poland
Janssen Research & Development, LLC

Completed

Treatment of Advanced Dry Age Related Macular Degeneration With AAVCAGsCD59

Dry Age-related Macular Degeneration

United States
Notal Vision Inc.

Recruiting

Home OCT Fluid Visualization Agreement Study

Neovascular Age-related Macular Degeneration

United States
Clearside Biomedical, Inc.

Completed

Extension Study to Evaluate the Long-term Outcomes of Subjects in the CLS-AX CLS1002-101 Study

Neovascular Age-related Macular Degeneration

United States
Hoffmann-La Roche

Recruiting

Extension Study for the Port Delivery System With Ranibizumab (Portal) (Portal)

Neovascular Age-Related Macular Degeneration

Belgium, United States, United Kingdom, Italy, Argentina, Spain, Israel, Australia, Austria, Brazil, Germany, Switzerland, Taiwan, France
Novartis Pharmaceuticals

Completed

Real-world Evaluation of Prevalence of Ocular Adverse Events in Patients With Neovascular (Wet) Agerelated Macular Degeneration (AMD) Who Received Anti-VEGF Agents (IRIS Registry)

Age-related Macular Degeneration (AMD)

United States
National Eye Institute (NEI)

Completed

Natural History of Geographic Atrophy Associated With Age-Related Macular Degeneration

Age-Related Macular Degeneration

United States
Notal Vision Ltd.
Elman Retina Group

Completed

NOTAL-OCT V.2.5 vs Commercial OCT in AMD Patients

Diabetic Macular Edema | AMD - Age-Related Macular Degeneration

United States
StemCells, Inc.

Terminated

Long-Term Follow-up Safety Study of Human Central Nervous System Stem Cells in Subjects With Geographic Atrophy of Age-Related Macular Degeneration

Age-Related Macular Degeneration | Geographic Atrophy

United States
Kubota Vision Inc.

Completed

Pharmacokinetic and Pharmacodynamic Study of Emixustat in Subjects With Geographic Atrophy Associated With Dry Age-Related Macular Degeneration

Age-Related Macular Degeneration | Geographic Atrophy

United States
Alimera Sciences

Terminated

Fluocinolone Acetonide Intravitreal Inserts in Geographic Atrophy

Age-Related Macular Degeneration

United States
Oregon Health and Science University

Recruiting

OCT Angiography in Wet AMD

Neovascular (Wet) Age-related Macular Degeneration (AMD)

United States
University of Nebraska
Regeneron Pharmaceuticals

Completed

Pharmacokinetic Study of Intravitreal Aflibercept Injection in Eyes With Wet Age-related Macular Degeneration (DRAW)

Neovascular Macular Degeneration

United States
Santen Inc.

Completed

A Phase I/II Safety, Tolerability, Immunogenicity, and Bioactivity Study of DE-122 Injectable Solution for Refractory Exudative Age-related Macular Degeneration (PAVE)

Age-Related Macular Degeneration

United States
NeoVista

Completed

A Study to Evaluate the Neovista Ophthalmic System for the Treatment of Subfoveal CNV in Patients With AMD That Have Failed Primary Anti-VEGF Therapy (ROSE)

Wet Age-related Macular Degeneration

United States
Bioheart, Inc.

Withdrawn

Study to Assess the Safety and Effects of Cells Injected Intravitreal in Dry Macular Degeneration

Dry Macular Degeneration

United States
Wills Eye
Mid Atlantic Retina

Completed

Dorzolamide-timolol in Combination With Anti-vascular Endothelial Growth Factor Injections for Wet Age-related Macular Degeneration (DAWN)

Wet Macular Degeneration | Neovascular Age-related Macular Degeneration

United States
Notal Vision Inc.

Completed

The Evaluation of the Agreement Between the NVHO in the Automatic Fluid Quantification and Cirrus OCT

Neovascular Age-related Macular Degeneration

United States
Orphalan

Completed

Study Comparing Once Daily Dose of 900mg of TETA 4HCL Against Cuprior® (450mg Trientine Base, Twice Daily).

Wilson's Disease

United Kingdom
Avid Radiopharmaceuticals

Completed

Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and Normal Controls.

Frontotemporal Dementia | Alzheimer's Disease

United Kingdom
Novartis Pharmaceuticals

Completed

Safety and Efficacy of Intravitreal LFG316 in Wet Age Related Macular Degeneration (AMD)

Exudative Macular Degeneration | Neovascular Age-elated Macular Degeneration (Wet AMD)

United States
Chengdu Kanghong Biotech Co., Ltd.

Terminated

Efficacy and Safety Trial of Conbercept Intravitreal Injection for Neovascular AMD (PANDA-2)

Neovascular Age-related Macular Degeneration

United States, Bulgaria, China, Czechia, Denmark, France, Hungary, Israel, Italy, Latvia, Slovakia, United Kingdom
Unity Biotechnology, Inc.

Completed

Safety, Tolerability, and Efficacy Study of UBX1325 in Patients With Neovascular Age-Related Macular Degeneration (ENVISION)

Neovascular Age-related Macular Degeneration

United States
AsclepiX Therapeutics, Inc.

Terminated

Safety and Bioactivity of AXT107 in Subjects With Neovascular Age-Related Macular Degeneration (SHASTA)

Neovascular Age-Related Macular Degeneration (nAMD)

United States
Astellas Institute for Regenerative Medicine

Completed

Safety and Tolerability of Sub-retinal Transplantation of hESC Derived RPE (MA09-hRPE) Cells in Patients With Advanced Dry Age Related Macular Degeneration (Dry AMD)

Dry Age Related Macular Degeneration

United States
Southern California Desert Retina Consultants, MC

Completed

Prophylactic Ranibizumab for Exudative Age-related Macular Degeneration (PREVENT)

Age-related Macular Degeneration

United States
Manhattan Eye, Ear & Throat Hospital
QLT Inc.; Novartis

Completed

Study Of Combined VISUDYNE Therapy With Kenalog In CNV Secondary To Age-Related Macular Degeneration

Age-Related Macular Degeneration

United States, Canada
REGENXBIO Inc.

Completed

Safety and Tolerability of RGX-314 (Investigational Product) Gene Therapy for Neovascular AMD Trial

Neovascular Age-related Macular Degeneration | Wet Age-related Macular Degeneration

United States
Johns Hopkins University

Terminated

Anti-VEGF Therapy for Subfoveal Hemorrhage in Patients With Neovascular Age-Related Macular Degeneration

Wet Macular Degeneration | Neovascular Age-related Macular Degeneration | Submacular Hemorrhage

United States
Weill Medical College of Cornell University
Riverside Research Institute

Unknown

Ultrasonic Evaluation of Ocular Tissues

Glaucoma | Age-Related Macular Degeneration | Tumors

United States
Clearside Biomedical, Inc.

Completed

Safety and Tolerability Study of Suprachoroidal Injection of CLS-AX Following Anti-VEGF Therapy in Neovascular AMD (OASIS)

Neovascular Age-related Macular Degeneration

United States
Graybug Vision

Completed

A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Neovascular (Wet) Age-related Macular Degeneration

Neovascular Age-Related Macular Degeneration

United States
US Department of Veterans Affairs

Withdrawn

Investigating Optical and Neural Causes of Vision Loss

Macular Degeneration

United States
Vanderbilt University
National Institutes of Health (NIH)

Completed

Antioxidant Systems and Age-Related Macular Degeneration

Macular Degeneration

United States

Clinical Trials on Third Generation TKI in United Kingdom

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