Clinical Trials on Transcutaneous Valve Therapies in United States

Total 760 results

NODEHealth Foundation

Completed

RecoveryPlus Telerehab Platform Pilot Study

Myocardial Infarction | Myocardial Ischemia | Heart Diseases | Coronary Artery Disease | Angina, Stable | Angina Pectoris | Valve Disease, Heart | Coronary Artery Stenosis | Valve Heart Disease

United States
Ottawa Heart Institute Research Corporation

Enrolling by invitation

Outcome of Patients With Severe Functional TR According to Medical, Transcatheter or Surgical Treatment (TRIGISTRY)

Tricuspid Regurgitation

United States, Spain, Israel, Canada, France, Germany, Netherlands, Switzerland, Austria, Italy
Edwards Lifesciences

Active, not recruiting

CENTERA PMCF: Post-Market Follow-up of the CENTERA Transcatheter Heart Valve System

Aortic Valve Stenosis

Denmark, United Kingdom, Netherlands, Spain, Germany, France
Boston Children's Hospital
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Comparison of Two Pulmonary Valve Replacement Methods to Treat Tetralogy of Fallot

Tetralogy of Fallot | Pulmonary Valve Insufficiency | Ventricular Dysfunction, Right

United States
Edwards Lifesciences

Recruiting

COMPASSION S3 Post-Approval Study

Pulmonary Valve Insufficiency | Complex Congenital Heart Defect | Dysfunctional RVOT Conduit | Pulmonary Valve Degeneration | Pulmonary Valve; Obstruction

United States
Tenaya Therapeutics

Recruiting

Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM (MyPEAK-1)

Hypertrophic Cardiomyopathy

United States
Boston Scientific Corporation

Terminated

RESPOND EDGE Post Market Study (RESPOND EDGE)

Aortic Valve Stenosis

Denmark, United Kingdom, France, Netherlands, Ireland, Finland, Germany, Italy, Sweden
ECRI bv
Bayer; Rigshospitalet, Denmark; Cardialysis BV

Completed

Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT) (GALILEO-4D)

Cardiovascular Diseases | Thrombosis | Aortic Valve Stenosis | Heart Valve Diseases | Ventricular Outflow Obstruction

Germany, United States, Denmark, Switzerland, Netherlands, Sweden, Canada
Boston Children's Hospital

Withdrawn

Systemic Rapamycin (Sirolimus) to Prevent In-Stent Restenosis Following Pulmonary Artery Stent Placement

Peripheral Pulmonary Stenosis | In-stent Stenosis

United States
Edwards Lifesciences

Completed

PREVAIL-TA: Placement of Aortic Balloon Expandable Transcatheter Valves Trial (Europe)

Aortic Valve Stenosis

United Kingdom, Germany, France, Austria
Novartis Pharmaceuticals

Recruiting

A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

Aortic Stenosis

Switzerland, Canada, Israel, United States, United Kingdom
Institut für Pharmakologie und Präventive Medizin
Edwards Lifesciences

Completed

Feasibility And Safety of Early Discharge After Transfemoral Transcatheter Aortic Valve Implantation (FAST-TAVI)

Aortic Stenosis

United Kingdom, Italy, Netherlands
Barts & The London NHS Trust

Recruiting

Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation

Atrial Fibrillation | Functional Mitral Regurgitation | Functional Tricuspid Regurgitation

United Kingdom
University College, London
British Heart Foundation

Unknown

Trimetazidine Therapy in Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy

United Kingdom
Massachusetts General Hospital

Completed

Buspirone Treatment of Anxiety in Williams Syndrome

Anxiety | Williams Syndrome

United States
University of East Anglia
Norfolk and Norwich University Hospitals NHS Foundation Trust; British Medical...

Unknown

Nitrite in Hypertrophic Cardiomyopathy (HCM) Study

Cardiomyopathy, Hypertrophic

United Kingdom
Edwards Lifesciences

Active, not recruiting

ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis

Aortic Valve Stenosis

United States
Northwell Health
GE Healthcare

Withdrawn

The Role of Echocardiographic Contrast (Optison) in Enhancing Tricuspid Regurgitation Spectral Doppler Signals

Hypertension, Pulmonary

United States
MyoKardia, Inc.

Completed

A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction (PIONEER-HCM)

Cardiomyopathy, Hypertrophic Obstructive | Left Ventricular Outflow Tract Obstruction

United States
Boston Scientific Corporation

Active, not recruiting

ACURATE neo2™ Post Market Clinical Follow up Study

Aortic Valve Stenosis | Aortic Diseases | Aortic Valve Calcification

Netherlands, Denmark, United Kingdom, Spain, Italy, Switzerland, Sweden, Germany
Guy's and St Thomas' NHS Foundation Trust
King's College London

Not yet recruiting

Outcome Prediction in Patients With Aortic Stenosis After TAVI (PREDICT-TAVI)

Aortic Stenosis, Severe

United Kingdom
St George's, University of London
King's College Hospital NHS Trust; Guy's and St Thomas' NHS Foundation Trust

Completed

Exercise Training in Hypertrophic Cardiomyopathy: (SAFE-HCM) (SAFE-HCM)

Hypertrophic Cardiomyopathy

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust

Withdrawn

A Comparison of Advanced Imaging Techniques in Aortic Stenosis (AIm-AS)

Aortic Stenosis

United Kingdom
St. Antonius Hospital
Medtronic; St. Antonius Research Fund

Recruiting

The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration (POPular PET TAVI) (POPularPETTAVI)

Aortic Valve Stenosis

Netherlands, Denmark, United Kingdom
Myocor

Unknown

VIVID - Valvular and Ventricular Improvement Via iCoapsys Delivery - Feasibility Study (VIVID)

Heart Failure | Ischemic Heart Disease | Mitral Valve Regurgitation | Mitral Insufficiency | Left Ventricular Dysfunction | Mitral Incompetence

United States
University of Edinburgh
British Heart Foundation

Completed

The Role of Myocardial Fibrosis in Patients With Aortic Stenosis

Aortic Stenosis

United Kingdom
Kaiser Permanente
Donaghue Medical Research Foundation

Completed

Evaluating the Impact of a Value-based Prescription Drug Formulary (VBF-e)

Value-Based Health Insurance

United States
Ceric Sàrl
Symetis SA

Completed

Safety and Efficacy Comparison Of Two TAVI Systems in a Prospective Randomized Evaluation II (SCOPE II)

Aortic Valve Stenosis

Germany, France, Spain, United Kingdom, Denmark, Italy
Istituto Auxologico Italiano
Ministry of Health, Italy

Recruiting

In-depth Characterization of Atriogenic Secondary Tricuspid Regurgitation Due to Atrial Fibrillation (ASTRA)

Atrial Fibrillation, Persistent | Heart Valve Incompetence

Italy
Array Biopharma, now a wholly owned subsidiary...

Withdrawn

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEK162 in Noonan Syndrome Hypertrophic Cardiomyopathy

Cardiomegaly

United States, United Kingdom
Barts & The London NHS Trust
Barts Cardiovascular CTU (Queen Mary University of London)

Not yet recruiting

Non-Invasive Radiation Ablation in Patients With Hypertrophic CardioMyopathy: NIRA-HOCM (NIRA-HOCM)

Hypertrophic Cardiomyopathy

United Kingdom
University of Edinburgh
Sir Jules Thorn Charitable Trust

Active, not recruiting

Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS (EVoLVeD)

Aortic Valve Stenosis | Hypertrophy, Left Ventricular

United Kingdom
Newcastle-upon-Tyne Hospitals NHS Trust
Assistance Publique - Hôpitaux de Paris; Azienda Ospedaliero-Universitaria... and other collaborators

Completed

Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy (SILICOFCM)

Hypertrophic Cardiomyopathy

United Kingdom
Abbott Medical Devices

Completed

First in Human Experience of the St. Jude Medical TAVI Valve and Delivery System (SJM TAVI FIH)

Symptomatic Aortic Stenosis

United Kingdom
University College, London

Completed

Regression of Myocardial Fibrosis After Aortic Valve Replacement (RELIEF-AS)

Aortic Stenosis

United Kingdom
University College, London
Inherited Cardiac Diseases Unit, The Heart Hospital, London

Unknown

Morbidity and Mortality in Patients With Hypertrophic Cardiomyopathy: a CALIBER Study (HCM)

Hypertrophic Cardiomyopathy

United Kingdom
University College, London
Barts & The London NHS Trust

Recruiting

Mechanisms of Excess Risk in Aortic Stenosis (MASTER)

Heart Failure | Aortic Stenosis | Non-Sustained VT

United Kingdom
Dartmouth-Hitchcock Medical Center

Withdrawn

Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery

Coronary Artery Disease | Hypotension | Vasoplegia | Cardiac Valve Disease

United States
University of Leicester
University of Edinburgh

Recruiting

MRI in Randomised Cohorts of Asymptomatic AS

Aortic Stenosis, Severe

United Kingdom
Edwards Lifesciences

Recruiting

Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial (CLASP IID/IIF)

Mitral Regurgitation | Mitral Insufficiency | Functional Mitral Regurgitation | Degenerative Mitral Valve Disease

United States, Canada, Switzerland, Germany
Boston Scientific Corporation

Terminated

REPRISE IV: LOTUS Edge Valve System in Intermediate Surgical Risk Subjects (REPRISE IV)

Aortic Valve Stenosis

United States, Australia
University Hospital Inselspital, Berne

Completed

Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis. (SCOPE I)

Aortic Valve Stenosis

Netherlands, Germany, Switzerland, United Kingdom
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Heart Function and Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

Myocardial Infarction | Ischemic Heart Disease | Angina, Unstable

United States
Duke University
National Heart, Lung, and Blood Institute (NHLBI); Heart Failure Clinical Research...

Terminated

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure (SMMART-HF)

Heart Failure | Mitral Valve Insufficiency

United States, Canada
University Hospitals, Leicester

Completed

Microvascular Dysfunction in Aortic Stenosis (PRIMID-AS)

Aortic Stenosis

United Kingdom
Main Line Health
Medtronic; Sharpe-Strumia Research Foundation

Recruiting

Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)

Aortic Valve Stenosis | Complete Heart Block | High Degree Second Degree Atrioventricular Block | Pacemaker-Induced Cardiomyopathy

United States
University Hospital Birmingham

Unknown

Diastolic Ventricular Interaction and the Effects of Biventricular Pacing in Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy

United Kingdom
Institut für Pharmakologie und Präventive Medizin
Edwards Lifesciences

Active, not recruiting

Inspiris Resilia Durability Registry (INDURE)

Aortic Valve Stenosis

Austria, Belgium, France, Netherlands, United Kingdom, Germany, Italy, Canada, Spain
University of Edinburgh
British Heart Foundation; Life Molecular Imaging SA

Completed

18F-GP1 PET-CT to Detect Bioprosthetic Aortic Valve Thrombosis

Aortic Valve Disease | Thrombosis Cardiac

United Kingdom
Imbria Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Non-obstructive Hypertrophic Cardiomyopathy Trial (IMPROVE-HCM)

Non-obstructive Hypertrophic Cardiomyopathy

United States, United Kingdom

Clinical Trials on Transcutaneous Valve Therapies in United States

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