Clinical Trials on Treatment Efficacy in South Africa

Total 63 results

Centre for the AIDS Programme of Research in South...

Completed

Trial to Assess the Impact of PrEP to Tenofovir Gel on the Efficacy of Tenofovir-containing ART on Viral Suppression (TOAST)

Antiretroviral Treatment Outcomes

South Africa
Qurient Co., Ltd.

Completed

A Phase 2 Study to Evaluate Early Bactericidal Activity, Safety, Tolerability, and Pharmacokinetics of Multiple Oral Doses of Telacebec (Q203)

Treatment-naïve, Sputum Smear-positive Patients With Drug-sensitive Pulmonary TB

South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); Medical Research Council, South Africa

Recruiting

Siyakhana Peer: Evaluating a Peer Recovery Coach Model to Reduce Substance Use Stigma in South African HIV Care

Substance-Related Disorders | HIV | Substance Use | Substance Use Disorders | Treatment Adherence | Treatment Adherence and Compliance | Stigmatization | Delivery of Health Care | Stigma, Social | Attitude of Health Personnel | Community Health Workers | Health Personnel | Health Personnel Attitude | Health Care Seeking... and other conditions

South Africa
Boston Medical Center
Boston University; National Institute of Allergy and Infectious Diseases (NIAID) and other collaborators

Completed

The Impact of Alcohol Consumption on Tuberculosis Treatment Outcomes

Tuberculosis | Alcohol Consumption | Treatment Adverse Effect

South Africa
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride

Acute Intermittent Porphyria | Anti-Psychotic | Management of Manifestations of Psychotic Disorders | Treatment of Schizophrenia | Control Nausea and Vomiting | Relief of Restlessness and Apprehension Before Surgery | Adjunct in the Treatment of Tetanus | Control Manifestations of the Manic Type... and other conditions

South Africa
Harriet Shezi Children's Clinic

Unknown

Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra (RBT)

Children With Confirmed HIV Infection | Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose | Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment

South Africa
University of Maryland, College Park
National Institute of Mental Health (NIMH); Medical Research Council, South...

Completed

Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa (Siyakhana)

Substance-Related Disorders | Depression | Tuberculosis | Hiv | Mental Health Disorder | Mental Disorder | Health Care Utilization | Treatment Adherence and Compliance | Social Stigma | Attitude of Health Personnel | Community Health Workers | Health Care Delivery

South Africa
Desmond Tutu HIV Foundation
National Institute of Mental Health (NIMH); University of Pennsylvania; National...

Recruiting

Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging

HIV Infections | Treatment Adherence | Men

South Africa
Medical University of South Carolina
National Alliance for Research on Schizophrenia and Depression; Medtronic

Active, not recruiting

Epidural Cortical Stimulation for Depression (EpCS-D)

Treatment Resistant Depression

United States
Medical University of South Carolina
Dart Therapeutics. LLC

Recruiting

Low-Intensity Focused Ultrasound for Treatment-Resistant Depression

Major Depressive Disorder | Treatment Resistant Depression

United States
Dinka Dugassa
Ethiopian Public Health Institute

Completed

Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivax (CQ+PQ)

Malaria | Efficacy | Vivax Malaria | Chloroquine

Ethiopia
Suzhou Kintor Pharmaceutical Inc,

Completed

Proxalutamide (GT0918) Treatment for Outpatients With Mild or Moderate COVID-19 Illness

Efficacy and Safety

United States
The George Institute
The University of New South Wales

Not yet recruiting

Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression (TREK)

Treatment Resistant Depression

Australia
BeiGene

Completed

Phase 1a/1b BGB-290 for Advanced Solid Tumors.

For Participants With Advanced Solid Tumors Failed With Previous Lines of Treatment

Australia
Janssen Research & Development, LLC

Completed

A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression (SUSTAIN-2)

Treatment-resistant Depression

United States, Australia, France, United Kingdom, Belgium, Germany, Taiwan, Spain, Argentina, Mexico, Poland, Bulgaria, Malaysia, South Africa, Turkey, Finland, Korea, Republic of, Brazil, Austria, Sweden, Lithuania
Medical University of South Carolina
National Cancer Institute (NCI)

Recruiting

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse (ADAPT)

Treatment | Cigarette Smoking | Smoking Behaviors

United States
Arthrex, Inc.

Recruiting

Evaluate the Continued Safety and Performance of the Foot and Ankle Products

Hyperpronated Foot | Reconstruction Surgeries of the Foot | Fixation of Fractures and Fusion (Bunionectomy Osteotomies) of the Foot/Ankle | Fixation of Small Bone Fragments of the Foot/Ankle | Lisfranc Arthrodesis | Mono or Bi-cortical Osteotomies in the Forefoot | First Metatarsophalangeal Arthrodesis and other conditions

Germany, United States, South Africa
Eli Lilly and Company

Completed

A Study in Relapse Prevention of Treatment-Resistant Depression

Treatment Resistant Depression

United States, Argentina, Russian Federation, South Africa, India, Turkey, Puerto Rico, Mexico
LivaNova

Recruiting

The RECOVER sUb-study, Which Leverages quaNtitative and Credible Research tOols From Verily, Will providE Assessment measuRes for Depressive Episodes (UNCOVER)

Treatment Resistant Depression

United States
Janssen Research & Development, LLC

Completed

A Study of Ketamine in Patients With Treatment-resistant Depression

Major Depressive Disorder

United States
Beckley Psytech Limited

Recruiting

BPL-003 Efficacy and Safety in Treatment Resistant Depression

Treatment Resistant Depression

Spain, Germany, United States, Poland, Australia, United Kingdom
LivaNova

Recruiting

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)

Treatment Resistant Depression

United States
Sheffield Teaching Hospitals NHS Foundation Trust
University of Manchester

Unknown

The Use of Virtual Reality for the Treatment of Visual Vertigo.

Treatment of Visual Vertigo

United Kingdom
Sheffield Hallam University

Completed

Immersive Virtual Reality for Dysphagia (IVRys)

Dysphagia | Virtual Reality | Treatment Compliance

United Kingdom
Amgen

Completed

Registry Study for Talimogene Laherparepvec

Any Tumor Type Eligible for Treatment With Talimogene Laherparepvec in Amgen or BioVEX-sponsored Clinical Trial

Canada, Spain, United States, Germany, Austria, France, Greece, Hungary, Italy, Korea, Republic of, Poland, Russian Federation, South Africa, Switzerland, United Kingdom
Case Comprehensive Cancer Center

Terminated

Older Patients With Newly Diagnosed Breast Cancer or Colon Cancer

Breast Cancer | Colorectal Cancer | Cognitive/Functional Effects | Psychosocial Effects of Cancer and Its Treatment

United States
European Organisation for Research and Treatment...
ETOP IBCSG Partners Foundation; German Adjuvant Breast Cancer Group

Completed

Assessing Women's Attitudes About the Risk of Infertility Related to Adjuvant Therapy for Early Breast Cancer

Breast Cancer | Psychosocial Effects of Cancer and Its Treatment | Sexuality and Reproductive Issues | Sexual Dysfunction and Infertility

Belgium, Switzerland, Peru, Italy, Germany, Netherlands, United Kingdom, Serbia, Chile, Poland, Croatia, Turkey, South Africa, Lebanon, Portugal
Cyberonics, Inc.

Completed

Treatment-Resistant Depression Registry

Major Depressive Disorder

United States
ACADIA Pharmaceuticals Inc.

Terminated

Extension Study of Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment

Adjunctive Treatment of Major Depressive Disorder

United States, Serbia, Finland, Poland, Russian Federation, Slovakia, South Africa, Ukraine, United Kingdom
AstraZeneca

Completed

Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients (RUBY)

Major Depressive Disorder | Treatment Resistant Depression

Bulgaria, Italy, United Kingdom, Germany, Hungary, Romania, Austria, Belgium, Denmark, Portugal, Slovakia, Australia, Spain
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression (TRANSFORM-3)

Depressive Disorder, Treatment-Resistant

United States, France, Belgium, Spain, Poland, Bulgaria, South Africa, Finland, Brazil, Sweden, United Kingdom, Lithuania
Massachusetts General Hospital
Patient-Centered Outcomes Research Institute

Completed

Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD (ASCERTAINTRD)

Treatment Resistant Major Depressive Disorder

United States, Canada
ACADIA Pharmaceuticals Inc.

Completed

Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment

Adjunctive Treatment of Major Depressive Disorder

United States, Serbia, Finland, Poland, Russian Federation, Ukraine, United Kingdom, Slovakia, South Africa
Janssen Research & Development, LLC

Completed

A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression (SUSTAIN-3)

Depressive Disorder, Treatment-Resistant

United States, France, Poland, United Kingdom, Belgium, Germany, Taiwan, Spain, Argentina, Mexico, Bulgaria, Malaysia, South Africa, Turkey, Canada, Korea, Republic of, Brazil, Estonia, Hungary, Lithuania, Slovakia, Sweden, Czechia, A... and more
AbbVie
Genentech, Inc.

Terminated

Study of ABT-199 (GDC-0199) in Combination With Azacitidine or Decitabine (Chemo Combo) in Subjects With Acute Myelogenous Leukemia (AML)

Acute Myelogenous Leukemia | Myelogenous Leukemia | Treatment Naive AML

United States, Australia, France, Germany
VA Office of Research and Development

Completed

Consortium to Disseminate and Understand Implementation of Opioid Use Disorder Treatment (CONDUIT)

Opioid Medication Assisted Treatment

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Citalopram in Treating Postmenopausal Women With Hot Flashes

Breast Cancer | Hot Flashes | Psychosocial Effects of Cancer and Its Treatment

United States
ETOP IBCSG Partners Foundation

Completed

Cognitive Function in Postmenopausal Women With Breast Cancer Receiving Hormone Therapy on Clinical Trial IBCSG-1-98

Breast Cancer | Fatigue | Cognitive/Functional Effects | Psychosocial Effects of Cancer and Its Treatment

Belgium, Switzerland, United Kingdom, Australia, Italy, New Zealand
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Chemotherapy Decisions and Outcomes in Older Women With Newly Diagnosed Breast Cancer

Breast Cancer | Psychosocial Effects of Cancer and Its Treatment

United States
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Radiation Therapy in Treating Patients With Prostate Cancer

Sexual Dysfunction | Prostate Cancer | Radiation Toxicity | Psychosocial Effects of Cancer and Its Treatment

United States, Canada
AMAG Pharmaceuticals, Inc.
Registrat-Mapi

Completed

A Prospective, Noninterventional Follow-Up Study of Children Aged 23 to 25 Months, Born to Mothers Who Received Hydroxyprogesterone Caproate Injection, 250 mg/mL, or Vehicle for Prevention of Preterm Birth

Children Whose Mothers Received 17P and Those Who Received Vehicle in the 17P Efficacy Trial

United States, Spain, Russian Federation, Canada, Czechia, Hungary, Ukraine
German Breast Group
Pfizer; AGO Study Group; Breast International Group; NSABP Foundation Inc

Completed

A Study of Palbociclib in Addition to Standard Endocrine Treatment in Hormone Receptor Positive Her2 Normal Patients With Residual Disease After Neoadjuvant Chemotherapy and Surgery (PENELOPE-B)

Breast Cancer | Hormonreceptor Positive | Her2-normal | Postneoadjuvant Treatment With CDK 4/6 Inhibitor | CPS-EG Score

United States, Australia, Austria, Canada, France, Germany, Ireland, Japan, Korea, Republic of, Spain, United Kingdom
ACADIA Pharmaceuticals Inc.

Completed

Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Major Depressive Disorder (CLARITY)

Adjunctive Treatment of Major Depressive Disorder

United States
Pfizer

Completed

A Trial In Diabetic Patients To Assess Effect Of CE-326,597 On Glucose Control And Body Weight

Weight Management | Treatment Of Obesity

Canada, United States, Bulgaria, Spain, Mexico, India, Puerto Rico
BlueWind Medical

Recruiting

BlueWind RENOVA iStim™ System for the Treatment of OAB (OASIS)

Treatment of Patients Suffering From Overactive Bladder (OAB)

United States, Belgium, Netherlands, United Kingdom
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Terminated

Home-Based Programs for Improving Sleep in Cancer Survivors

Fatigue | Cancer Survivor | Sleep Disorders | Psychosocial Effects of Cancer and Its Treatment

United States
Pfizer

Completed

Dose Ranging Study of Rimegepant (BMS-927711) for the Acute Treatment of Migraine

Migraine | Acute Treatment of Migraine

United States
Axsome Therapeutics, Inc.

Completed

A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Treatment Resistant Major Depressive Disorder (STRIDE-1)

Treatment Resistant Major Depressive Disorder

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S9832: Effectiveness of Telephone Counseling By Breast Cancer Survivors on the Well-Being of Women With Recurrent Breast Cancer

Breast Cancer | Psychosocial Effects of Cancer and Its Treatment

United States, Canada
Pfizer

Recruiting

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

Acute Treatment of Migraine

United States, Spain, Poland

Clinical Trials on Treatment Efficacy in South Africa

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