Clinical Trials on Vital Sign in South Africa

Total 1416 results

Barbara Ensoli, MD
Italian Ministry of Foreign Affairs - Dir. Gen. for Cooperation and Development

Completed

Study to Assess the Seroprevalence of Anti-Tat Antibodies in HIV-infected Patients (ISS OBS T-004)

HIV Infection

South Africa
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride

Acute Intermittent Porphyria | Anti-Psychotic | Management of Manifestations of Psychotic Disorders | Treatment of Schizophrenia | Control Nausea and Vomiting | Relief of Restlessness and Apprehension Before Surgery | Adjunct in the Treatment of Tetanus | Control Manifestations of the Manic Type... and other conditions

South Africa
University of Washington
Harvard Medical School (HMS and HSDM); National Institute of Mental Health... and other collaborators

Completed

The Prevention Options for Women Evaluation Research (POWER) Cohort

HIV/AIDS

Kenya, South Africa
Brown University
Rhode Island Hospital; University of Cape Town; Medical Research Council, South... and other collaborators

Active, not recruiting

Our Family Our Future: A Resilience-oriented Family Intervention to Prevent Adolescent HIV/STI Infection and Depression in South Africa

Depression | Sexually Transmitted Diseases | Human Immunodeficiency Virus

South Africa
Population Council
United States Agency for International Development (USAID); Bill and Melinda...

Completed

Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission

HIV Infections | Sexually Transmitted Diseases | AIDS | HIV Seroconversion

South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); University of Miami; Weill Medical College... and other collaborators

Recruiting

Project Khanya: Peer-Delivered Intervention to Improve HIV Medication Adherence and Substance Use in South Africa

Alcohol-Related Disorders | Substance Use | Drug Use | Human Immunodeficiency Virus

South Africa
FHI 360
University of Cape Town; City University of New York, School of Public Health

Completed

Comparison of Two Intrauterine Devices (IUDs) Among Cape Town HIV-positive Women

HIV

South Africa
University of Massachusetts, Worcester
National Institute of Allergy and Infectious Diseases (NIAID); Aurum Institute and other collaborators

Recruiting

Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) (METHOD)

Tuberculosis | Pulmonary Tuberculosis | HIV Coinfection

South Africa
GlaxoSmithKline

Completed

Assess the Immune Response Following Primary Vaccination With GSK Biologicals' Tritanrix™-HepB/Hib-MenAC vs Tritanrix™-HepB/Hiberix™ Given at 6,10 & 14 Wks of Age to Infants Who Received Hepatitis B Vaccine at Birth

Diphtheria; Haemophilus Influenzae Type b; Hepatitis B; Tetanus; Whole Cell Pertussis

South Africa
HIV Vaccine Trials Network

Completed

Safety of and Immune Response to Vaccination With 2 Experimental HIV Vaccines in Healthy Adults (HVTN 097)

HIV Infection

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Safety, Tolerability and Acceptability of Long-Acting Cabotegravir (CAB LA) for the Prevention of HIV Among Adolescent Females - A Sub-study of HPTN 084

HIV Infections

Zimbabwe, South Africa, Uganda
Medical University of Graz
Lagos State University; Walter Sisulu University; Management Sciences for Health and other collaborators

Enrolling by invitation

Effects of COVID-19 on Endothelium in HIV-Positive Patients in Sub-Saharan Africa (ENDOCOVID)

Covid19 | Hiv | ART

Nigeria, South Africa
FHI 360
United States Agency for International Development (USAID); Makerere University and other collaborators

Completed

Interactions Between Antiretrovirals (ARVs) and Combined Oral Contraceptives (COCs)

HIV Infections | HIV/AIDS

South Africa, Uganda
Massachusetts General Hospital
National Institute of Mental Health (NIMH); Match Research

Completed

Support for Perinatal Adherence and Depression (INSPireD)

Depression | Human Immunodeficiency Virus

United States, South Africa
National Institute for Communicable Diseases, South...
Centers for Disease Control and Prevention; Fogarty International Center of... and other collaborators

Active, not recruiting

Household Study of COVID-19, Influenza and RSV Burden, Transmission Dynamics and Viral Interaction in South Africa (PHIRST-C)

Influenza | SARS-CoV-2 Infection | Respiratory Syncytial Virus (RSV)

South Africa
Boehringer Ingelheim

Completed

A Study of Single Dose Nevirapine (NVP) Combined With Combivir® for the Prevention of Mother to Child Transmission (pMTCT) - Treatment Options Preservation Study (TOPS)

Acquired Immunodeficiency Syndrome

South Africa
Serum Institute of India Pvt. Ltd.
Bill and Melinda Gates Foundation

Not yet recruiting

Clinical Study to Evaluate SIIPL qHPV Vaccine (CERVAVAC®) in Women Living With HIV Aged 15-25 Years

Human Papillomavirus Infection

Kenya, Mozambique, South Africa
Foundation for Professional Development (Pty) Ltd
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes

HIV/AIDS | Pregnancy | Cost-effectiveness | Antenatal Care | Chlamydia Trachomatis | Vaginal Microbiome | Birth Outcomes | Sexually Transmitted Infection | Neisseria Gonorrhoeae | Trichomonas Vaginalis

South Africa
Cynthia S Firnhaber
Merck Sharp & Dohme LLC

Completed

A Study to Examine the Human Papillomavirus Types Exposure in Women From Southern Africa and Brasil

HIV Infections | HIV

Botswana, Brazil, South Africa
International Partnership for Microbicides, Inc.

Completed

A Safety and Tolerability Study of Dapivirine (TMC120) Vaginal Microbicide Gel

HIV Infections

Rwanda, South Africa, Tanzania
HIV Vaccine Trials Network
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes... and other collaborators

Active, not recruiting

Evaluating the Safety and Immunogenicity of HIV-1 Vaccines Based on Chimpanzee Serotypes of Ad Expressing Clade C gp140 and a CH505TF gp120 Protein Boost in Healthy, HIV- Uninfected Adult Participants (HVTN139)

HIV Infections

South Africa
French National Agency for Research on AIDS and...
Gilead Sciences; European and Developing Countries Clinical Trials Partnership...

Completed

Tenofovir/Emtricitabine for PMTCT in Africa and Asia (ANRS 12109 TEmAA) (TEmAA)

HIV Infection | Pregnancy

Cambodia, South Africa, Côte D'Ivoire
University of California, San Francisco
Bill and Melinda Gates Foundation; Medical Research Council, South Africa; Ibis... and other collaborators

Withdrawn

Effectiveness of the Diaphragm for HIV Prevention

HIV Infection

South Africa, Zimbabwe
Klaus Reither
Radboud University Medical Center; Charite University, Berlin, Germany; University... and other collaborators

Completed

Diagnostic Accuracy of CAD4TB and C-reactive Protein Assay as Triage Tests for Pulmonary Tuberculosis (TB TRIAGE+)

Covid-19 | HIV | Pulmonary Tuberculosis | Tuberculosis Diagnosis

Lesotho, South Africa
Drugs for Neglected Diseases
University of Cape Town; Medecins Sans Frontieres, Netherlands; UBS Optimus Foundation and other collaborators

Completed

Pharmacokinetics of Lopinavir/Ritonavir Superboosting in Infants and Young Children Co-infected With HIV and TB

Acquired Immunodeficiency Syndrome | Tuberculosis

South Africa
NYU Langone Health
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Interferon-Gamma on Cavitary Pulmonary Tuberculosis in the Lungs

Tuberculosis | AIDS-related Complex

United States, South Africa
South African National Blood Service

Unknown

Therapeutic Use of Convalescent Plasma in the Treatment of Patients With Moderate to Severe COVID-19

COVID-19 | SARS-CoV-2 Infection | Severe Acute Respiratory Syndrome Coronavirus 2

South Africa
Derek Yellon

Completed

Can RIC Prevent Deterioration to Critical Care in Covid19

Ischemia | Covid19

Brazil, South Africa, United Kingdom
International AIDS Vaccine Initiative
Targeted Genetics Corporation

Completed

Safety and Immunogenicity Study of tgAAC09, an HIV Vaccine in an Adeno-associated Virus (AAV) Capsid (TGC14F)

HIV Infections | Human Immunodeficiency Virus Infections

Uganda, South Africa, Zambia
CONRAD
United States Agency for International Development (USAID); Bill and Melinda...

Terminated

Cellulose Sulfate and HIV Transmission Among Women

HIV Infection

India, South Africa, Benin, Uganda
National Institute of Allergy and Infectious Diseases...
National Institute on Drug Abuse (NIDA); Eunice Kennedy Shriver National Institute... and other collaborators

Completed

HIV Prevention Preparedness Study

HIV Infections | HIV Seronegativity

South Africa, Zambia, Tanzania
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Faster Identification of TB and Evaluation of Drug Resistance in HIV-infected People (FASTER)

HIV Infections

Peru, Brazil, South Africa
FHI 360

Completed

FEM-PrEP (Truvada®): Study to Assess the Role of Truvada® in Preventing HIV Acquisition in Women

HIV Infections

Kenya, South Africa, Tanzania
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC; University of Stellenbosch

Withdrawn

Testing the Addition of Paclitaxel and Carboplatin Given After Standard Chemotherapy and Radiation for Cervical Cancer in HIV-positive Women

HIV Infection | Cervical Adenocarcinoma | Cervical Adenosquamous Carcinoma | Cervical Squamous Cell Carcinoma, Not Otherwise Specified | FIGO Stage IIB Cervix Carcinoma | FIGO Stage III Cervix Carcinoma | FIGO Stage IVA Cervix Carcinoma

South Africa, Zimbabwe
Ottawa Hospital Research Institute
Ontario Lung Association

Withdrawn

A RCT of Prednisone as Adjunctive Therapy for Hospitalized Patients With Pulmonary TB and HIV Co-infection

HIV Infections | Tuberculosis

Canada, South Africa
University of Liverpool
University of Southampton; Liverpool University Hospitals NHS Foundation Trust and other collaborators

Active, not recruiting

AGILE (Early Phase Platform Trial for COVID-19)

Covid19

United Kingdom, South Africa
University College, London
London School of Hygiene and Tropical Medicine; MRC/UVRI and LSHTM Uganda Research... and other collaborators

Active, not recruiting

Long-Acting Treatment in Adolescents (LATA) (LATA)

HIV Infections | Hiv | HIV-1-infection | Paediatric Human Immunodeficiency Virus Infection

Uganda, Zimbabwe, Kenya, South Africa
Desmond Tutu HIV Foundation
National Institute of Mental Health (NIMH); University of Pennsylvania; National...

Recruiting

Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging

HIV Infections | Treatment Adherence | Men

South Africa
Novavax
Bill and Melinda Gates Foundation

Completed

A Study Looking at the Effectiveness and Safety of a COVID-19 Vaccine in South African Adults

COVID-19 | SARS-CoV-2 Infection

South Africa
French National Agency for Research on AIDS and...
University of Bergen; The Research Council of Norway; European and Developing... and other collaborators

Completed

Comparison of Efficacy and Safety of Infant Peri-exposure Prophylaxis With Lopinavir/Ritonavir Versus Lamivudine to Prevent HIV-1 Transmission by Breastfeeding

HIV Infections

Burkina Faso, South Africa, Uganda, Zambia
University of Cape Town
Radboud University Medical Center; University of Stellenbosch; Foundation for... and other collaborators

Recruiting

Evaluating the Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Community-based Active Case Finding for TB and COVID-19

HIV Infections | COVID-19 | Tuberculosis

South Africa, Zambia, Zimbabwe
Wake Forest University Health Sciences
National Institute of Mental Health (NIMH)

Not yet recruiting

Adolescents Living With HIV (ALWH): Social Networks, Adherence and Retention

HIV/AIDS

United States, South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); University of Cape Town

Completed

Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa

Alcohol-Related Disorders | Drug Use | Human Immunodeficiency Virus

United States, South Africa
Qurient Co., Ltd.

Terminated

A Phase 2 Study to Evaluate Biomarker Change, Efficacy, Pharmacokinetics, Safety and Tolerability of Telacebec (Q203) in Covid-19 Patients

COVID-19 Virus Infection

South Africa
The Aurum Institute NPC
Johns Hopkins University; Weill Medical College of Cornell University; University...

Recruiting

Safety and Tolerability of 1 Month Daily (1HP) and 3 Months Weekly (3HP) Isoniazid and Rifapentine With Pharmacokinetics of Dolutegravir (DTG) in Pregnant People With HIV (DOLPHIN Moms)

Pregnancy | HIV Seropositivity | Tuberculosis Infection

South Africa
Janssen Research & Development, LLC

Completed

A Study to Assess the Acceptability of the Darunavir/Cobicistat (DRV/COBI) Fixed-dose Combination (FDC) Tablet in Human Immunodeficiency Virus (HIV)-1 Infected Children

Human Immunodeficiency Virus (HIV)

United States, Spain, South Africa
Willem Daniel Francois Venter
Bill and Melinda Gates Foundation

Completed

Dose Optimisation of Stavudine for the Treatment of HIV Infection (D4T)

Human Immunodeficiency Virus | Acquired Immune Deficiency Syndrome

South Africa, India, Uganda
PENTA Foundation

Active, not recruiting

Early Anti-Retroviral Treatment in HIV- Infected Children

HIV Infections

South Africa, Mali, Mozambique
Columbia University
Centers for Disease Control and Prevention

Completed

Pediatric Enhanced Surveillance Study (PESS)

Human Immunodeficiency Virus (HIV) | Acquired Immune Deficiency Syndrome (AIDS)

South Africa
International Partnership for Microbicides, Inc.

Completed

A Safety and Acceptability Study of a Vaginal Ring Microbicide Delivery Method

HIV Infections

South Africa, Tanzania

Clinical Trials on Vital Sign in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in China

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Rare Diseases

Drug Interventions

Dietary Supplements

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