Clinical Trials on Xerostomia, Hyposalivation, Saliva Substitute, Radiation-induced Toxicity, Nasopharyngeal Cancer

Total 87 results

Universiti Kebangsaan Malaysia Medical Centre

Completed

Saliva Substitute Mouthwash in NPC Survivors With Xerostomia: A Randomized Controlled Trial

Xerostomia, Hyposalivation, Saliva Substitute, Radiation-induced Toxicity, Nasopharyngeal Cancer

Malaysia
Rigshospitalet, Denmark

Enrolling by invitation

Mesenchymal Stem Cells for Radiation-induced Xerostomia

Mesenchymal Stem Cells | Radiation Toxicity | Hyposalivation | Dry Mouth | Mesenchymal Stromal Cells | Xerostomia Due to Radiotherapy | Long Term Adverse Effects

Denmark
Wake Forest University Health Sciences

Completed

Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer (ACUPUNCTURE)

Head and Neck Cancer | Radiation Toxicity | Radiation-Induced Xerostomia | Oral Complications of Chemotherapy and Head/Neck Radiation

United States
Qazvin University Of Medical Sciences
Imam Khomeini Hospital

Completed

Comparative Analysis of BioXtra on Xerostomia (BioXtra)

Radiation-Induced Xerostomia

Iran, Islamic Republic of
MeiraGTx, LLC

Active, not recruiting

Long-Term Follow-Up Study of AAV2hAQP1 for Radiation Induced Xerostomia

Radiation-induced Xerostomia

United States, Canada
Thomas Kuhnt
Verband Deutscher Druckkammerzentren

Terminated

Hyperbaric Oxygen for the Treatment of a Dry Mouth Which Occurred After Radiotherapy

Radiation-induced Xerostomia

Germany
MeiraGTx, LLC
National Institute of Dental and Craniofacial Research (NIDCR)

Active, not recruiting

Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction

Squamous Cell Head and Neck Cancer | Radiation Induced Xerostomia | Salivary Hypofunction

United States
King Saud University

Completed

The Management of RT-induced Hyposalivation Using LLLT (REACH-LLLT)

Head and Neck Cancer

Saudi Arabia
Ain Shams University

Recruiting

The Efficacy of Hibiscus Sabdariffa in Xerostomia

Radiation-induced Xerostomia

Egypt
Ain Shams University

Recruiting

Management of Radiotherapy-related Xerostomia With Green Tea and Peppermint

Radiation-induced Xerostomia

Egypt
Sun Yat-sen University

Completed

Impact on Xerostomia for Nasopharyngeal Carcinoma Patients Treated With or Without Superficial Parotid Lobe-sparing Intensity-modulated Radiotherapy

Nasopharyngeal Carcinoma | Radiation-induced Xerostomia

China
MeiraGTx UK II Ltd

Completed

A Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia

Head and Neck Cancer | Radiation-Induced Parotid Gland Hypofunction | Xerostomia Due to Radiotherapy

United States, Canada
Royal Marsden NHS Foundation Trust

Unknown

Parotid-Sparing Intensity-Modulated Radiation Therapy Compared With Conventional Radiation Therapy in Treating Patients With Oropharyngeal or Hypopharyngeal Cancer Who Are at High Risk of Radiation-Induced Xerostomia

Head and Neck Cancer | Xerostomia | Radiation Toxicity

United Kingdom
Dental Innovation Foundation Under Royal Patronage
Mahidol University; Ministry of Health, Thailand; Srinakharinwirot University

Completed

Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients

Dry Mouth | Radiation-Induced Xerostomia | Cancer of Head Neck

Thailand
Dental Innovation Foundation Under Royal Patronage
Mahidol University; Ministry of Health, Thailand; Thammasat University; Srinakharinwirot...

Completed

Efficacy of Novel Edible Gel-based Artificial Saliva in Cancer Patients

Cancer | Cancer of Head and Neck | Dry Mouth | Radiation-induced Xerostomia

Thailand
European Organisation for Research and Treatment...

Terminated

Chemotherapy Plus Radiation Therapy With or Without Amifostine in Treating Patients With Locally Advanced Cancer of the Nasopharynx

Head and Neck Cancer | Radiation Toxicity | Oral Complications | Drug/Agent Toxicity by Tissue/Organ

Spain, France, Belgium, Italy, United Kingdom, Turkey
Odense University Hospital
Danish Cancer Society; Odense Patient Data Explorative Network

Completed

The Use of Chewing Gum for Xerostomia and Hyposalivation After Radiotherapy for Oral and Oropharyngeal Tumors

Head and Neck Cancer | Xerostomia | Hyposalivation | Radiation Therapy Complication

Denmark
Mayo Clinic
National Cancer Institute (NCI)

Terminated

Electroacupuncture in Treating Chronic Dry Mouth Caused By Radiation Therapy in Patients With Head and Neck Cancer

Head and Neck Cancer | Xerostomia | Radiation Toxicity

United States
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Completed

Radiation Therapy With or Without Chemotherapy in Reducing Mouth Dryness in Patients With Nasopharyngeal Cancer

Head and Neck Cancer | Radiation Toxicity | Oral Complications of Radiation Therapy

United States
Dana-Farber Cancer Institute
National Cancer Institute (NCI); AstraZeneca; MedImmune LLC

Completed

Randomized Amifostine For SCCHN

Head and Neck Cancer | Mucositis | Xerostomia | Radiation Toxicity | Chemotherapeutic Agent Toxicity

United States
Cyprus University of Technology
German Oncology Center, Cyprus; Bank of Cyprus Oncology Center BOCOC

Recruiting

The Effectiveness of a Thyme and Honey Spray for Oral Toxicities (HONEY)

Xerostomia | Radiation Toxicity | Oral Mucositis | Cancer of the Head and Neck

Cyprus
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Completed

Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer

Head and Neck Cancer | Xerostomia | Radiation Toxicity

United States, Canada
Helsinn Healthcare SA
Latis S.r.l.

Terminated

Effects of Aqualief® in Patients With Xerostomia as Consequence of Radiotherapy for Head and Neck Cancer

Xerostomia | Mouth Dryness | Hyposalivation | Asialia

Italy
Rigshospitalet, Denmark

Active, not recruiting

Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth (MESRIX-SAFETY)

Mesenchymal Stem Cells | Xerostomia | Salivary Gland Diseases | Oropharynx Cancer | Hyposalivation | Dry Mouth | Mesenchymal Stromal Cells | Xerostomia Due to Radiotherapy | Stem Cells

Denmark
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Acupuncture for Prevention of Radiation-Induced Xerostomia

Nasopharyngeal Cancer | Xerostomia | Mouth Dryness

China
University Health Network, Toronto
University College London Hospitals; Brigham and Women's Hospital; University... and other collaborators

Recruiting

The STOP-MED CTRCD Trial (STOP-MED)

Heart Failure | Cancer | Cardiotoxicity | Cardiac Toxicity | Antineoplastics Toxicity

Canada, United States, United Kingdom, Australia
University of Santiago de Compostela

Completed

Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention

Head and Neck Cancer | Oral Cancer | Oral Mucositis | Osteoradionecrosis | Hyposalivation | Osteonecrosis Due to Drugs, Jaw | Osteonecroses, Bisphosphonate

Spain
Wake Forest University Health Sciences
University of Pennsylvania; NYU Langone Health; Brigham and Women's Hospital; National... and other collaborators

Active, not recruiting

Observational Study of Dental Outcomes in Head and Neck Cancer Patients (ORARAD)

Head and Neck Cancer | Xerostomia | Osteoradionecrosis | Dental Disease

United States
Odense University Hospital

Recruiting

COr Loco-regional Advanced Lung Cancer Treated With Chemo-radiotherapy (COLA) (COLA)

Radiation Toxicity | Cardiac Disease | Cardiac Toxicity | Lung Cancer Stage III | Lung Cancer Stage II

Denmark
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery

Unspecified Adult Solid Tumor, Protocol Specific | Metastatic Cancer | Neurotoxicity | Radiation Toxicity | Cognitive/Functional Effects

United States
Washington University School of Medicine
St. Jude Children's Research Hospital

Completed

Translating ECHOS2 Into an mHealth Platform (ECHOS2)

Childhood Cancer | Pediatric Cancer | Cardiac Toxicity

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Combination Chemotherapy and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

Lung Cancer | Radiation Toxicity | Drug/Agent Toxicity by Tissue/Organ

United States
Washington University School of Medicine
National Cancer Institute (NCI)

Completed

Amifostine, Chemotherapy, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

Lung Cancer | Radiation Toxicity | Drug/Agent Toxicity by Tissue/Organ

United States
University of Florida

Unknown

Amifostine to Prevent Side Effects in Patients Who Are Receiving Chemotherapy and Radiation Therapy for Limited-Stage Small Cell Lung Cancer

Lung Cancer | Radiation Toxicity | Drug/Agent Toxicity by Tissue/Organ

United States
University of Illinois at Chicago

Unknown

Amifostine Plus Chemotherapy and Radiation Therapy in Treating Patients With Advanced, Unresectable Head and Neck Cancer

Head and Neck Cancer | Radiation Toxicity | Drug/Agent Toxicity by Tissue/Organ

United States
Jiarong Chen, MD

Unknown

Comparison of Transdermal Fentanyl and Morphine for Oral Mucositis Pain in Nasopharyngeal Cancer Patients

Pain | Head and Neck Cancer | Nasopharyngeal Carcinoma | Radiation Induced Oral Mucositis
University of Tennessee

Completed

Amifostine to Treat Side Effects of Treatment in Patients Receiving Radiation Therapy and Cisplatin for Advanced Head and Neck Cancer

Head and Neck Cancer | Radiation Toxicity | Oral Complications | Drug/Agent Toxicity by Tissue/Organ

United States
Institute of Cancer Research, United Kingdom

Unknown

Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors

Head and Neck Cancer | Ototoxicity | Radiation Toxicity

United Kingdom
Fujian Cancer Hospital

Unknown

Appaconitine Patch for Oral Mucositis Pain Caused by Chemoradiotherapy in Patients With Nasopharyngeal Cancer

Radiation Induced Oral Mucositis

China
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer

Lung Cancer | Radiation Toxicity | Oral Complications | Drug/Agent Toxicity by Tissue/Organ

United States, Canada
Military Institute of Medicine, Poland

Recruiting

Radiation-induced Cardiac Toxicity After Non-small Cell Lung Cancer Radiotherapy

Non-small Cell Lung Cancer | Radiation Toxicity | Cardiac Toxicity

Poland
Lawson Health Research Institute
Canadian Institutes of Health Research (CIHR)

Unknown

Detecting Radiation-Induced Cardiac Toxicity After Non-Small Cell Lung Cancer Radiotherapy (RICT-LUNG)

Non-small Cell Lung Cancer | Radiation Toxicity

Canada
Unither Pharmaceuticals, France

Completed

A New Oral salIvary equivAlent Compared to Two moisturizinG Mouth sprAys in Patients With xeRostomiA: NIAGARA Study (NIAGARA)

Head and Neck Cancer | Xerostomia | Hyposalivation | Sjögren Syndrome

France
Henry Ford Health System
Helen L. Kay Charitable Trust

Completed

Prevention Using Exercise Rehabilitation to Offset Cardiac Toxicities Induced Via Chemotherapy (HF-PROACTIVE)

Leukemia | Breast Cancer | Gastric Cancer | Doxorubicin Induced Cardiomyopathy

United States
Abramson Cancer Center at Penn Medicine

Enrolling by invitation

Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy (CLARITY)

Cardiotoxicity | Radiation Toxicity | Lung Cancer Stage III | Lung Cancer Stage II

United States
Air Force Military Medical University, China

Completed

Association Between Telomere Length and Cardiac Dysfunction

Acute Leukemia | Childhood Cancer | Cardiac Toxicity

China
Rutgers, The State University of New Jersey

Recruiting

Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted

Cardiac Toxicity | Early-stage Breast Cancer

United States
Shantou University Medical College

Completed

Triple Antiemetic Regimen for Chemoradiotherapy in Cervical Cancer or Nasopharyngeal Cancer

Cervical Cancer | Nasopharyngeal Cancer | Chemotherapy-induced Nausea and Vomiting | Radiation-Induced Nausea and Vomiting | Antiemetic

China
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Completed

Octreotide in Preventing or Reducing Diarrhea in Patients Receiving Chemoradiotherapy for Anal or Rectal Cancer

Colorectal Cancer | Anal Cancer | Drug/Agent Toxicity by Tissue/Organ | Radiation Enteritis

United States
Assiut University

Not yet recruiting

Cardiac Toxicity of Hypo Fractionated Radiotherapy in Left Breast Cancer

Breast Cancer Female

Clinical Trials on Xerostomia, Hyposalivation, Saliva Substitute, Radiation-induced Toxicity, Nasopharyngeal Cancer

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