Search clinical trials for: DEFB1 protein, human

Total 17227 results

Rush University Medical Center
University of Alberta; University of Nebraska Lincoln

Completed

Use of a Novel Synbiotic to Change Human Gut Bacteria and Improve Health in Obese Adults

Intestinal Microbiota and Barrier Function

United States
University of Alabama at Birmingham
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

Early Protein Supplementation in Extremely Preterm Infants Fed Human Milk

Microbial Colonization | Growth Failure | Breast Milk Expression | Feeding Disorder Neonatal | Prematurity; Extreme

United States
Ain Shams University

Unknown

Human Epididymis Protein 4 in Women With Severe Preeclampsia / HELLP Syndrome

Preeclampsia
AB2 Bio Ltd.

Completed

Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease

Still's Disease, Adult-Onset

Germany, France, Switzerland
KK Women's and Children's Hospital

Not yet recruiting

Targeted Fortification of Pasteurized Donor Human Milk

Growth Failure | Very Low Birth Weight Infant | Donor Breast Milk

Singapore
Sichuan Clover Biopharmaceuticals, Inc.

Terminated

A Phase I Study Evaluating SCB-313 for the Treatment of Subjects With Peritoneal Carcinomatosis

Peritoneal Carcinomatosis

China
Clover Biopharmaceuticals AUS Pty Ltd

Completed

Study With SCB-313 (Recombinant Human TRAIL-Trimer Fusion Protein) for Treatment of Malignant Pleural Effusions

Malignant Pleural Effusions

Australia
The Hospital for Sick Children

Completed

Bovine vs. Human Milk-Based Fortifier Study

Very Low Birth Weight Infant (<1250g)

Canada
St. Louis University

Completed

Noninferiority Trial of Liquid Human Milk Fortifier (HMF) Hydrolyzed Protein Versus Liquid HMF With Supplemental Liquid Protein

Premature Birth of Newborn | Human Milk

United States
Sichuan Clover Biopharmaceuticals, Inc.

Completed

Study With SCB-313 (Recombinant Human TRAIL-Trimer Fusion Protein) for Treatment of Malignant Ascites

Malignant Ascites

China
Clover Biopharmaceuticals AUS Pty Ltd

Completed

Study With SCB-313 (Recombinant Human TRAIL-Trimer Fusion Protein) for Treatment of Peritoneal Malignancies

Peritoneal Malignancies

Australia
ImmuneOnco Biopharmaceuticals (Shanghai) Inc.

Terminated

Exploratory Study of IMM01 for Injection in the Treatment of Refractory or Recurrent Hematologic Malignancy

Hematologic Malignancy

China
Columbia University

Recruiting

Targeted Fortification of Donor Breast Milk in Preterm Infants

Growth Failure | Growth Retardation | Prematurity; Extreme | Infant Nutrition Disorders | Failure to Thrive in Newborn

United States
Sohag University

Recruiting

ATG5 as a Serum Marker of Autophagy in Psoriatic Patient

Psoriasis Vulgaris | Autophagy

Egypt
Shire

Completed

A Study to Evaluate the Safety and Effect of Escalating Doses of CINRYZE

Hereditary Angioedema

United States
OncoImmune, Inc.

Completed

Efprezimod Alfa (CD24Fc, MK-7110) as a Non-antiviral Immunomodulator in COVID-19 Treatment (MK-7110-007) (SAC-COVID)

Coronavirus Disease 2019 (COVID-19)

United States
Hengenix Biotech Inc

Completed

Evaluate the Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of HLX71 (Recombinant Human Angiotensin-converting Enzyme 2-Fc Fusion Protein for COVID-19) in Healthy Adult Subjects

COVID 19

United States
Chengdu Kanghong Biotech Co., Ltd.
University of Wisconsin, Madison

Completed

A Randomized, Double-masked, Multicenter,Sham-controlled, Safety and Efficacy Study of KH902 in Patients With Wet AMD (PHOENIX)

Neovascular Age-related Macular Degeneration

China
Shire
Halozyme Therapeutics

Completed

A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human Hyaluronidase

Hereditary Angioedema

United States
Shire

Completed

Subcutaneous CINRYZE With Recombinant Human Hyaluronidase for Prevention of Angioedema Attacks

Hereditary Angioedema (HAE)

United States, Germany, Spain, Sweden
University Hospital, Gentofte, Copenhagen

Recruiting

LEAP2 on Postprandial Glucose Metabolism and Food Intake n Obese Males (LEAP2-OBCT)

Obesity

Denmark
Hamad Medical Corporation

Recruiting

Effect of Human Plasma Protein Transfusion With and Without Crystalloids During Major Liver Resection Surgeries

Coagulation; Intravascular | Fluid Electrolyte Disorders

Qatar
Rigshospitalet, Denmark

Recruiting

Diagnosing Ovarian Cysts - the DOC Study

Ovarian Cysts | Ovarian Neoplasms | Ovarian Cancer | Ovarian Cancer Stage

Denmark
Purdue University

Completed

Impact of Protein Quantity Within the USDA Healthy Style Eating Pattern on Sleep

Sleep | Body Composition

United States
EMD Serono

Terminated

Onercept in the Treatment and Re-Treatment of Subjects With Moderate to Severe Plaque Psoriasis

Arthritis, Psoriatic

United States, Canada
Sichuan Clover Biopharmaceuticals, Inc.

Recruiting

A Clinical Trial Evaluating SCB-219M in in Chemotherapy-induced Thrombocytopenia (CIT)

Chemotherapy-induced Thrombocytopenia (CIT)

China
Beijing VDJBio Co., LTD.

Recruiting

Clinical Study of Recombinant Humanized CTLA-4-FC Fusion Protein Injection in Healthy Subjects

Health Volunteer

China
University of Padova

Completed

Effect of Ingestion of Human, Cow, and Modified-cow Milk, on Glucose and Hormone Responses in Humans. (PROLAT)

Hormone | Insulin Tolerance | Aminoacidaemia
OncoImmune, Inc.
University of Maryland, Baltimore

Terminated

Efprezimod Alfa (CD24Fc, MK-7110) Administration to Decrease Low-Density Lipoprotein (LDL) and Inflammation in Human Immunodeficiency Virus (HIV) Patients (CALIBER) (MK-7110-003) (CALIBER)

HIV Infections | Dyslipidemias

United States
Medtronic Spinal and Biologics

Completed

rhBMP-2/CRM/CD HORIZON® Spinal System Pilot Study (2-Level)

Degenerative Disc Disease
Medtronic Spinal and Biologics

Completed

A Pilot Study of rhBMP-2/ACS With the INTERFIX™ Device for the AnteriorLumbar Interbody Fusion in Patients With Degenerative Disc Disease

Degenerative Disc Disease
Bioverativ Therapeutics Inc.
Swedish Orphan Biovitrum

Completed

Study of Recombinant Factor IX Fc Fusion Protein (rFIXFc) in Participants With Hemophilia B

Severe Hemophilia B

Sweden, United States, France, Italy, Russian Federation, United Kingdom, Germany, China, Poland, Japan, Australia, Brazil, Canada, India, South Africa, Hong Kong, Belgium
Baxalta now part of Shire
American Thrombosis and Hemostasis Network; UDC Rare Bleeding and Clotting...

Completed

Ceprotin Treatment Registry

Protein C Deficiency

United States, United Kingdom, Germany, Italy, Netherlands, Austria
Institute of Liver and Biliary Sciences, India

Unknown

Effects of Maintaining Steady Albumin Levels (TAT 4) on Survival and Liver Related Complications in Cirrhosis With Ascites

Liver Cirrhosis

India
Baxalta now part of Shire

Completed

Retrospective Study to Capture Dosing and Treatment Outcome Data in Participants With Severe Congenital Protein C Deficiency Who Were Treated With Protein C Concentrate Under an Emergency Use IND

Protein C Deficiency

United States
Shire

Completed

Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks (CHANGE 3)

Hereditary Angioedema

United States
Baxalta now part of Shire

Completed

Efficacy and Safety Study of Protein C Concentrate in Subjects With Severe Congenital Protein C Deficiency

Protein C Deficiency

United States
Shire

Completed

Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks (CHANGE 2)

Hereditary Angioedema

United States
Shire

Completed

Pharmacokinetics of C1 Esterase Inhibitor in Hereditary Angioedema Subjects

Hereditary Angioedema

United States
Société des Produits Nestlé (SPN)

Completed

A Study to Investigate the Effect of Protein in Infant Formula on Insulin Response in Adults (IDEFIX)

To Compare the Metabolic Effects of Different Infant Milks
Shire

Completed

C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks

Hereditary Angioedema

United States
Shire

Completed

Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of Recombinant Human C1 Esterase Inhibitor in Healthy Adult Subjects

Hereditary Angioedema (HAE)

United States
Shire

Completed

Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1 Esterase Inhibitor for the Prevention of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema

Hereditary Angioedema (HAE)

Spain, Israel, United States, Hungary, Germany, Canada, Romania
Hospital Universitario La Paz

Completed

Weight Gain in Extremely Premature Infant With Targeted Versus Adjusted Fortification (FORTIN)

Preterm | Very Low Birth Weight Infant | Food, Fortified | Feeding, Breast

Spain
Shenyang Sunshine Pharmaceutical Co., LTD.

Recruiting

Phase III Clinical Study of Recombinant Erythropoiesis Stimulating Protein Injection (rESP) in the Treatment of Anemia in Hemodialysis Patients With Chronic Renal Failure

Hemodialysis | Kidney Failure, Chronic

China
Medtronic Spinal and Biologics

Terminated

Pivotal Study of rhBMP-2/ACS/Allograft Bone Dowel for Anterior Lumbar Interbody Fusion in Patients With Symptomatic Degenerative Disc Disease

Degenerative Disc Disease
Medtronic Spinal and Biologics

Completed

A Pilot Study of rhBMP-2/ACS/Allograft Bone Dowel for Anterior Lumbar Interbody Fusion in Patients With Symptomatic Degenerative Disc Disease

Degenerative Disc Disease
Medtronic Spinal and Biologics

Completed

Pilot Study of rhBMP-2/BCP in Patients With Spinal Degeneration With Instability Requiring Surgical Fusion

Degenerative Disc Disease
Zhengzhou Gensciences Inc
Jiangsu Gensciences lnc.

Completed

Phase III Expansion Trial for Determining the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia A (RH-107-III02)

Hemophilia A

China
Medtronic Spinal and Biologics

Terminated

A Pivotal Study of rhBMP-2/ACS/INTER FIX™ Device for Posterior Lumbar Interbody Fusion in Patients With Degenerative Disc Disease

Degenerative Disc Disease

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