Search clinical trials for: mineralocorticoid receptor antagonist

Total 37532 results

Actelion
Henry Ford Health System; Covance; Medidata Solutions; Almac Clinical Technologies and other collaborators

Terminated

An Upcoming Clinical Study to Measure the Safety and Impact of a Drug Called Macitentan in Teenage and Adult Fontan Patients. (RUBATO OL)

Congenital Heart Disease With Fontan Circulation

United Kingdom, Taiwan, France, Poland, China, Australia, Czechia, Canada, United States, Denmark, New Zealand
Actelion

Completed

Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (MERIT-1)

Chronic Thromboembolic Pulmonary Hypertension

United Kingdom, Belgium, Ukraine, Germany, Switzerland, Hungary, China, Korea, Republic of, Mexico, Czechia, France, Lithuania, Poland, Russian Federation, Thailand, Turkey
Franz Rischard, DO
University of Pittsburgh; National Jewish Health

Unknown

CompRehensive Phenotypic Characterization of Patients With Scleroderma-Associated ILD and PH (CRUSADE)

Pulmonary Hypertension | Interstitial Lung Disease | Scleroderma

United States
Actelion

Completed

Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument

Pulmonary Arterial Hypertension

United States
St. Joseph's Healthcare Hamilton
McMaster University; Hamilton Academic Health Sciences Organization

Recruiting

Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder

Bipolar Disorder | Premenstrual Dysphoric Disorder

Canada
Population Health Research Institute
Canadian Institutes of Health Research (CIHR); Boston Scientific Corporation

Active, not recruiting

Colchicine and Spironolactone in Patients With MI / SYNERGY Stent Registry (CLEAR SYNERGY)

ST Elevation Myocardial Infarction | Non ST Elevation Myocardial Infarction

Canada
Hospital Civil de Guadalajara

Completed

The Effect in Renal Function on Patients With Type 1 Cardiorenal Syndrome Treated With Two Strategies of Furosemide.

Cardiorenal Syndrome

Mexico
Yonsei University

Withdrawn

A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)

Congestive Heart Failure
Texas Tech University Health Sciences Center

Withdrawn

Aliskiren and Renin Inhibition in Diastolic Heart Failure (ARID-HF)

Diastolic Heart Failure

United States
Bayer

Completed

Study on Safety and Efficacy of an Oral Contraceptive in Long Cycles

Contraception

Netherlands, Canada, Germany
King Abdullah International Medical Research Center

Recruiting

The Efficacy of Leukotriene Inhibitor in Adult Patients With Moderate SARS-COV-2 Symptoms (COVID19) (PROMISE)

Moderate Covid19

Saudi Arabia
Actelion

Recruiting

A Study of Macitentan in Healthy Chinese Adult Male Participants

Healthy

China
University of Maryland, Baltimore

Withdrawn

Macitentan to Prevent PRVO (MAC-PRO)

Pulmonary Embolism

United States
Actelion

Completed

Clinical Study Assessing the Efficacy and Safety of Macitentan in Fontan-palliated Subjects (RUBATO)

Congenital Heart Disease

United States, United Kingdom, Taiwan, Germany, France, Poland, China, Australia, Czechia, Canada, Denmark, New Zealand
Actelion

Recruiting

A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH) (TOMORROW)

Pulmonary Arterial Hypertension

United States, Korea, Republic of, Spain, Malaysia, China, Hungary, Mexico, Poland, Australia, Austria, Brazil, Canada, Colombia, France, Israel, Philippines, Portugal, Russian Federation, South Africa, Thailand, Ukraine, Vietnam, F...
Actelion

Withdrawn

A Study of Macitentan in Children Below 2 Years of Age

Arterial Hypertension, Pulmonary

Poland, Germany
Actelion

Completed

Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (MERIT-2)

Chronic Thromboembolic Pulmonary Hypertension

Poland, Ukraine, United Kingdom, China, Russian Federation, Belgium, Germany, Thailand, Hungary, France, Lithuania, Czechia, Mexico, Switzerland, Turkey
Actelion

Completed

A Study of Two Macitentan Formulations in Healthy Adult Participants

Healthy

Belgium
Actelion

Completed

Macitentan Use in an Idiopathic Pulmonary Fibrosis Clinical Study (MUSIC)

Idiopathic Pulmonary Fibrosis

United States, Israel, Spain, Australia, France, Canada, Turkey, Germany, Italy, South Africa, Slovenia, Sweden
Oncolix, Inc.

Unknown

Study of Prolanta™ in Recurrent or Persistent Epithelial Ovarian Cancer (ProlantaOC)

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cancer

United States
Actelion

Completed

Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension (SERAPHIN)

Pulmonary Arterial Hypertension

United States, United Kingdom, Belarus, Argentina, Australia, Austria, Belgium, Bulgaria, Canada, Chile, China, Colombia, Croatia, France, Germany, Hong Kong, Hungary, India, Israel, Italy, Malaysia, Mexico, Netherlands, Norway, Peru, Poland and more
Nanjing First Hospital, Nanjing Medical University

Completed

Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure (PADN-5)

Pulmonary Hypertension

China
Hebei Medical University

Completed

Spironolactone Combined With Captopril and Carvedilol for the Treatment of Pulmonary Arterial Hypertension

Hypertension, Pulmonary

China
Actelion

Terminated

A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension (MACiTEPH)

Chronic Thromboembolic Pulmonary Hypertension

United States, Germany, Japan, Korea, Republic of, Taiwan, Canada, United Kingdom, China, Austria, Italy, Bulgaria, Turkey, Spain, Thailand, Israel, Ukraine, Hungary, Mexico, Czechia, Russian Federation, France, Saudi Arabia, Singapore and more
Actelion

Completed

OPsumit USers Registry (OPUS)

Pulmonary Arterial Hypertension

United States, Puerto Rico
Actelion

Completed

A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies. (UMBRELLA)

Pulmonary Arterial Hypertension | Chronic Thromboembolic Pulmonary Hypertension

Belgium, France, Poland, Russian Federation, Belarus, Turkey, Ukraine
University of California, Los Angeles

Withdrawn

Macitentan in the Treatment of Organ Rejection After Lung Transplantation

Lung Transplant Rejection

United States
Actelion

Completed

Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome (MAESTRO)

Pulmonary Arterial Hypertension

China, Malaysia, United States, Austria, Bulgaria, Chile, France, Germany, Greece, Israel, Mexico, Philippines, Poland, Portugal, Romania, Russian Federation, Serbia, Spain, Turkey, United Kingdom, Vietnam
University of Roma La Sapienza

Unknown

Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure

Heart Failure | Renal Insufficiency

Italy
Actelion

Completed

Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Due to Left Ventricular Dysfunction (MELODY-1)

Pulmonary Hypertension

United States, Austria, Belgium, Canada, Czechia, France, Germany, Israel, Italy, Spain, Switzerland
Peking University Third Hospital
Peking University; University of Michigan

Unknown

Spironolactone Versus Indapamide in Obese and Hypertensive Patients

Hypertension

China
Yonsei University

Withdrawn

A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1)

Congestive Heart Failure
Bayer

Completed

Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic Acid) Followed by a 20 Week Elimination Phase of Folate

Contraception

Germany
Radboud University Medical Center

Completed

Eplerenone, ACE Inhibition and Albuminuria

Diabetic Nephropathy

Netherlands
Bristol-Myers Squibb

Completed

A Study to Investigate the Effects of BMS-986278 on Drospirenone and Ethinyl Estradiol Drug Levels in Healthy Female Participants

Healthy Volunteers

Canada
GlaxoSmithKline

Completed

Examining the Effect of Different Diuretics on Fluid Retention in Diabetics Treated With Rosiglitazone.

Diabetes Mellitus

France, Poland, Germany, Netherlands, Spain, Greece, Slovakia, Italy, United Kingdom, Denmark, Belgium, Norway, Canada, Israel
Hospital de Clinicas de Porto Alegre

Completed

Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea (DESALT)

Obstructive Sleep Apnea

Brazil
Regional Hospital Holstebro

Completed

The Effect of Amiloride and Spironolactone in Healthy Persons (SPAS)

High Blood Pressure

Denmark
Actelion
EPS Corporation; Imepro Inc.; General Laboratory, BML, Inc.; Mitsubishi Logistics...

Terminated

A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH).

Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Japan
University Hospital Ostrava

Not yet recruiting

Determination of Drug Levels for Pharmacotherapy of Heart Failure

Cardiovascular Diseases | Heart Failure With Reduced Ejection Fraction

Czechia
Radboud University Medical Center

Unknown

The Effect of Anakinra on Insulin Secretion

Glucose Intolerance | Diabetes Mellitus Type 2 | Impaired Insulin Secretion

Netherlands
Estetra

Completed

Safety, Compliance and Pharmacokinetics of Estetrol Monohydrate/Drospirenone 15/3 mg in Post-menarchal Female Adolescents

Safety

Estonia, Finland, Georgia, Latvia, Poland, Sweden
University of Mississippi Medical Center

Terminated

A Study of the Effects of Eplerenone and Amlodipine on Blood Pressure and Basal Metabolic Rate in Obese Hypertensives

Hypertension | Obesity

United States
Denusa Wiltgen
Hospital de Clinicas de Porto Alegre; Coordenação de Aperfeiçoamento de Pessoal... and other collaborators

Completed

Pharmacogenetic Study of Different Hormone Therapies in Recent Menopause Women

Postmenopause

Brazil
Federico II University

Completed

Oral Contraceptive and Cardiovascular Risk in PCOS

Polycystic Ovary Syndrome

Italy
Maastricht University Medical Center
Shire

Completed

Extended-release Guanfacine Hydrochloride in Children/Adolescents With Attention-deficit/Hyperactivity (SPD503-315)

Attention Deficit Disorder

Netherlands
Johns Hopkins University
Fast Grants

Terminated

Prazosin to Prevent COVID-19 (PREVENT-COVID Trial) (PREVENT)

COVID-19

United States
Actelion

Completed

Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients (DUAL-1)

Systemic Sclerosis | Ulcers

Canada, United States, Belarus, Hungary, Croatia, Australia, Denmark, Ukraine, Bulgaria, Chile, Colombia, Czech Republic, Finland, Germany, India, Italy, Poland, Russian Federation
Actelion

Terminated

Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome (MAESTRO-OL)

Pulmonary Arterial Hypertension

China, Malaysia, United States, Austria, Bulgaria, Chile, France, Germany, Greece, Mexico, Philippines, Poland, Portugal, Romania, Russian Federation, Serbia, Spain, United Kingdom, Vietnam
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Effects and Safety of Sacubitril/Valsartan on Refractory Hypertension

Resistant Hypertension

China

Search clinical trials for: mineralocorticoid receptor antagonist

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Ecuador

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations