Search clinical trials for: Purinergic Agonists

Total 15106 results

AstraZeneca

Completed

ADHERE-S (NIS Brilique)

ACS (Acute Coronary Syndrome)

Serbia
Chinese University of Hong Kong

Completed

Uninterrupted Clopidogrel Therapy Before Elective Colonoscopy Will Increase the Risk of Post-polypectomy Bleeding

Gastrointestinal Bleeding

China
Icahn School of Medicine at Mount Sinai
Doris Duke Charitable Foundation

Completed

Does Continued Use of Clopidogrel Into Surgery Cause Increased Perioperative Bleeding?

Clopidogrel

United States
Sheba Medical Center

Completed

Sub Lingual Versus Traditional Oral Administration of Ticagrelor in Acute Coronary Syndrome/Non ST-elevation Myocardial Infarction - A Platelet Reactivity Study

Non ST Elevation Myocardial Infarction | Acute Coronary Syndromes

Israel
Sanofi
Bristol-Myers Squibb

Completed

Food Effect Study on Pharmacodynamic and Bioavailability of Clopidogrel 300/75 mg in Healthy Subjects

Healthy

United States, France
Sanofi
Bristol-Myers Squibb

Completed

Pharmacodynamic and Pharmacokinetic Study of 2 Different Dose Regimen of Clopidogrel in CYP2C19 Genotyped Healthy Subjects

Healthy

Germany
Deutsches Herzzentrum Muenchen
Technical University of Munich

Completed

75 or 150 mg Clopidogrel Maintenance Doses Following PCI (ISAR-CHOICE-2)

Coronary Disease

Germany
Weill Medical College of Cornell University
Canadian Institutes of Health Research (CIHR)

Not yet recruiting

One-Month DAPT in CABG Patients (ODIN)

Chronic Coronary Disease

United States, Austria, Canada, Germany, Sweden
Insel Gruppe AG, University Hospital Bern

Not yet recruiting

Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy (ELAPSE)

Ischemic Stroke | Atrial Fibrillation
University of Florida
Scott R. MacKenzie Foundation

Completed

PD and PK Profiles of Switching Between Cangrelor and Ticagrelor Following Ticagrelor Pre-treatment (SWAP-5)

Coronary Artery Disease

United States
George Washington University
National Institute on Minority Health and Health Disparities (NIMHD); Shenandoah... and other collaborators

Withdrawn

Impact of Anti-platelet Drug Exposure on Platelet mRNA Splicing in Healthy Subjects

Thrombosis; Artery

United States
Nanjing First Hospital, Nanjing Medical University

Withdrawn

Ticagrelor Versus High-dose Clopidogrel in Patients With High Platelet Reactivity on Clopidogrel After PCI (PL-PLATELET)

Coronary Artery Disease

China
Indiana University

Terminated

Antiplatelet Therapy Guided by Thrombelastography in Patients With Acute Coronary Syndromes (TEGCOR Study)

Coronary Artery Disease | Thrombosis

United States
University of Alabama at Birmingham
AstraZeneca

Completed

Ticagrelor and Eptifibatide Bolus-Only Versus Ticagrelor and Eptifibatide Bolus Plus Abbreviated Infusion

Acute Coronary Syndrome

United States
Kyunghee University Medical Center

Unknown

Ticagrelor and Anti-inflammatory Effects

Chronic Kidney Disease

Korea, Republic of
David Antoniucci
A.R. CARD Onlus Foundation

Completed

Rapid Activity of Platelet Inhibitor Drugs Study 2

Myocardial Infarction

Italy
The Medicines Company

Completed

Cangrelor Ticagrelor Transition Study

Coronary Artery Disease

United States
Gennaro Sardella

Unknown

Standard Clopidogrel Versus Prasugrel Low Dose Therapy in Elderly Patients With Acute Coronary Syndrome (RESET ELDERLY)

Coronary Artery Disease

Italy
Sanofi
Bristol-Myers Squibb

Completed

Clopidogrel Optimal Loading Dose Usage to Reduce Recurrent EveNTs/Optimal Antiplatelet Strategy for InterventionS (CURRENT/OASIS7)

Acute Coronary Disease | Angina Unstable

United States, France, Canada, Brazil, Poland, Romania, Russian Federation, Germany, Italy, Netherlands, Sweden, Switzerland, Turkey, Bulgaria, Estonia, India, Malaysia, Singapore, Belgium, Czech Republic, Mexico, Argentina, Chile, Cr... and more
First Affiliated Hospital of Harbin Medical University

Completed

Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable CAD.

Platelet Reactivity

China
Assistance Publique - Hôpitaux de Paris
AstraZeneca; Action Research Group

Completed

Assessment of Loading With the P2Y12 Inhibitor Ticagrelor or Clopidogrel to Halt Ischemic Events in Patients Undergoing Elective Coronary Stenting (ALPHEUS)

Myocardial Infarction | Myocardial Ischemia | Cardiovascular Diseases | Coronary Artery Disease | Stent Thrombosis

France
Hospital do Coracao

Completed

Ticagrelor in Patients With ST Elevation Myocardial Infarction Treated With Pharmacological Thrombolysis (TREAT)

Acute ST Segment Elevation Myocardial Infarction | Thrombolysis in Myocardial Infarction Flow

Peru, New Zealand, Canada, Australia, Brazil, China, Argentina, Colombia, Russian Federation, Ukraine
Campus Bio-Medico University

Completed

Clopidogrel Versus Ticagrelor in Type-2 Diabetes

Coronary Artery Disease | Diabetes Mellitus
Thorax Centrum Twente

Completed

Change of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome (CHANGE DAPT)

Acute Coronary Syndrome | Percutaneous Coronary Intervention | Drug-Eluting Stents

Netherlands
University of Patras

Completed

Differential Effect of Ticagrelor Versus Prasugrel Maintenance Dose on Endothelial Function of Peripheral Vessels in Patients With Coronary Artery Disease

Coronary Artery Disease | Endothelial Function

Greece
University Hospital of Limerick

Completed

Peripheral Endothelial Function Assessment of Patients on Ticagrelor vs. Clopidogrel Who Have Undergone PCI

Myocardial Ischemia | Coronary Artery Disease | Endothelial Dysfunction

Ireland
University of Patras

Completed

Ticagrelor Loading Dose Versus Clopidogrel Loading and Reloading With Ticagrelor.

Platelet Reactivity

Greece
General Hospital of Chinese Armed Police Forces

Unknown

Efficacy and Safety Study of Ticagrelor

Acute Coronary Syndrome

China
University of Florida
AstraZeneca

Completed

Impact of Ticagrelor Re-load on Pharmacodynamic Profiles

Coronary Artery Disease

United States
University of Patras

Completed

Prasugrel 5mg Versus High Dose Clopidogrel in Clopidogrel Resistant Patients Aged ≥75 Years and/or Weighing <60 kg Post Percutaneous Coronary Intervention (PCI)

Platelet Reactivity

Greece
Brighton and Sussex University Hospitals NHS Trust

Terminated

PRISTINE - Personalised Approach to Improve aSThma prescrIbing iN childrEn (PRISTINE)

Asthma

United Kingdom
University of Maryland, Baltimore

Completed

CES1 Crossover Trial of Clopidogrel and Ticagrelor

Myocardial Infarction | Thrombosis | Platelet Dysfunction

United States
Pfizer

Completed

Multiple Escalating Oral Doses Study of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus

Diabetes Mellitus Type 2

United States
Universiti Sains Malaysia

Completed

Impact of CYP2C19 Genotype-guided Clopidogrel and Ticagrelor Treatment on Platelet Function Test and Metabolomics Profile

Coronary Artery Disease (CAD)

Malaysia
Seung-Jung Park
Roche Pharma AG; AstraZeneca; KBM pharm

Completed

Comparison of Low-Dose, Standard-Dose Ticagrelor and Clopidogrel for Inhibition of Platelet Reactivity in Patients With Acute Coronary Syndromes (OPTIMA)

Acute Coronary Syndrome

Korea, Republic of
First Affiliated Hospital of Harbin Medical University

Unknown

Effects of Different Doses of Ticagrelor on Platelet Aggregation and Endothelial Function in Diabetic Patients With Stable Coronary Artery Disease

Coronary Artery Disease

United States, China
Spanish Society of Cardiology
AstraZeneca

Unknown

Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) (TICS-DM)

Coronary Artery Disease | Diabetes Mellitus. Type 2

Spain
Jinan Central Hospital

Unknown

Comparison of Ticagrelor And Clopidogrel on Inflammatory Biomarkers And Vascular Endothelial Function (TIGERCAVE)

ST-Segment Elevation Myocardial Infarction

China
First Hospital of China Medical University
AstraZeneca

Unknown

Ticagrelor and Clopidogrel on Reperfusion in Patients With AMI

Myocardial Infarction | No-Reflow Phenomenon

China
University of Patras

Completed

Ticagrelor Versus Prasugrel in Acute Coronary Syndromes After Percutaneous Coronary Intervention

Coronary Artery Disease | Acute Coronary Syndrome

Greece
University of Oklahoma

Completed

The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization

Coronary Artery Disease | Chest Pain

United States
University of Patras

Completed

Prasugrel Versus High Dose Clopidogrel in Patients With Stable Coronary Artery Disease and High Platelet Reactivity While on Chronic Clopidogrel Treatment

Coronary Artery Disease (CAD)

Greece
University of Pecs

Terminated

Doubling the Maintenance Dose of Clopidogrel in Patients With High On-Clopidogrel Platelet Reactivity (DOSER)

Stable Angina Pectoris | Ad Hoc Percutaneous Coronary Intervention

Hungary
Sanofi
Daiichi Pharmaceuticals

Completed

Efficacy and Safety in Patients With Acute Coronary Syndrome Without ST-Segment Elevation

Platelet Aggregation Inhibitors | NSTEACS

Japan
Deutsches Herzzentrum Muenchen
Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)

Completed

Prospective, Randomized Trial of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome (ISAR-REACT 5)

Acute Coronary Syndrome (ACS)

Germany, Italy
Azienda Ospedaliero Universitaria di Sassari
AstraZeneca

Completed

Ticagrelor Administered as Standard Tablet or Orodispersible Formulation (TASTER)

ST Elevation Myocardial Infarction | NSTEMI - Non-ST Segment Elevation MI

Italy
University of Florida
Scott R. MacKenzie Foundation

Completed

Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-function: a Validation Study

Coronary Artery Disease

United States
University of Florida

Completed

A Pharmacodynamic Study Comparing Prasugrel Versus Ticagrelor in Patients Undergoing PCI With CYP2C19 Loss-of-function:

Coronary Artery Disease

United States
Actelion

Completed

A Clinical Study to Assess the Effect of Clopidogrel on the Pharmacokinetics of Selexipag and Its Active Metabolite in Healthy Male Subjects

Healthy Subjects

Belgium
Faculty Hospital Kralovske Vinohrady

Completed

Comparison of Prasugrel and Ticagrelor in the Treatment of Acute Myocardial Infarction (PRAGUE-18)

Myocardial Infarction | Platelet Aggregation Inhibitors | Angioplasty, Balloon, Coronary

Czechia

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