Search clinical trials for: Viral Protease Inhibitors

Total 64701 results

Janssen Research & Development, LLC

Completed

A Study of Darunavir in the Presence of Cobicistat When Administered as a Fixed Dose Combination Compared to the Co-administration of the Separate Available Formulations of Darunavir and Cobicistat Under Fed Conditions in Healthy Participants

Healthy

Belgium
Hoffmann-La Roche

Completed

A Study of Ritonavir-Boosted Invirase (Saquinavir) in Treatment-Naïve HIV-1 Infected Patients

HIV Infections

United Kingdom
Barbara Ensoli, MD, PhD

Completed

Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma

Kaposi's Sarcoma

Italy
Glaxo Wellcome

Completed

A Comparison of 141W94 and Indinavir in HIV-Infected Patients

HIV Infections

United States
Pfizer

Completed

Food Effect Study to Evaluate the Effect of High-Fat Meal on the Relative Bioavailability of PF-07321332 Boosted With Ritonavir in Healthy Adult Participants

Healthy Participants

United States
University of Maryland, Baltimore

Terminated

Pilot Study of Effect of Kaletra on CD4 Response in HIV Positive (+) Patients With Viral Suppression KIMBO Study

HIV

United States
ANRS, Emerging Infectious Diseases
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Prevention of Perinatal Transmission of HIV-1 Without Nucleoside Reverse Transcriptase Inhibitors (MONOGEST)

Maternal-fetal Infection Transmission

France
ViiV Healthcare

Terminated

A Dose Ranging Study Of GW640385 Boosted With Ritonavir (Rtv) In Comparison To A RTV-Boosted Protease Inhibitor (PI) In HIV-1 Infected PI-Experienced Adults

HIV-1 Infection | Infection, Human Immunodeficiency Virus I

United States, France, Germany, Canada, Italy, Australia, Belgium, Portugal, Puerto Rico, Romania, United Kingdom
GlaxoSmithKline

Terminated

A Repeat Dose Pharmacokinetic (PK) and Safety Study of GSK2838232 With and Without Ritonavir (RTV) Conducted in Healthy Subjects

Infection, Human Immunodeficiency Virus

United States
Hoffmann-La Roche

Completed

A Relative Bioavailability Study of Danoprevir and Ritonavir in Healthy Volunteers

Healthy Volunteer

New Zealand
Hoffmann-La Roche

Completed

A Study of Invirase (Saquinavir)/Ritonavir in HIV-Infected Infants and Children.

HIV Infections

Spain, Thailand, Argentina
Yale University
Bristol-Myers Squibb; Merck Sharp & Dohme LLC

Completed

Pilot Study of a Raltegravir Based NRTI Sparing Regimen

HIV Infections | Human Immunodeficiency Virus | AIDS | Acquired Immune Deficiency Syndrome

United States
The Third Xiangya Hospital of Central South University
Xiangya Hospital of Central South University

Unknown

Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension

China
Boehringer Ingelheim

Completed

Pharmacokinetic Interaction Study of Steady-state Tipranavir/Ritonavir (TPV/r) With Single-dose Valaciclovir (VAL) in Healthy Volunteers

Healthy
Hospitales Universitarios Virgen del Rocío

Completed

Darunavir Levels, Virological Efficacy, Proviral ADN and Resistances in Patients on Darunavir/Ritonavir Monotherapy (MonDar)

HIV-infection

Spain
ViiV Healthcare
GlaxoSmithKline

Completed

A Study To Assess GW433908 (Fosamprenavir) Containing Regimens In HIV-1 Infected Subjects

Infection, Human Immunodeficiency Virus

United States, Spain, France, United Kingdom, Chile, Brazil, Italy, Portugal
Kirby Institute

Completed

Raltegravir and Atazanavir Dosing Strategy Study (SPARTA)

HIV Infection

Australia
Bristol-Myers Squibb

Completed

Comparison of Two Anti-HIV Regimens That Include One of Two Forms of Didanosine (ddI)

HIV Infections

United States, Canada
Abbott

Completed

Study in Healthy Adults to Evaluate the Bioavailability of Two Test Tablet Formulations of ABT-450

Healthy

United States
Abbott

Completed

A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients

HIV Infections

United States
Merck Sharp & Dohme LLC

Unknown

The Safety and Effectiveness of Indinavir Plus Ritonavir Plus Two NRTIs in HIV-Infected Patients Who Need Early Intervention Treatment

HIV Infections

United States
University of Wisconsin, Madison
Wisconsin Partnership Program

Recruiting

Lopinavir/Ritonavir in PLWH With High-Grade AIN

High-Grade Anal Intraepithelial Neoplasia

United States
Pfizer

Suspended

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

COVID-19

United States, United Kingdom, Japan, South Africa, Bulgaria, Puerto Rico, Mexico, Hungary
Pfizer

Terminated

A Study to Measure the Amount of Study Medicine in Blood in Adult Participants With COVID-19 and Severe Kidney Disease

COVID-19

United States
ViiV Healthcare
GlaxoSmithKline

Completed

Study Of An Investigational Regimen Including FDA Approved HIV Drugs In HIV-Infected Pediatric Subjects

HIV Infections | Infection, Human Immunodeficiency Virus

United States, Portugal, Russian Federation, Mexico, Argentina, South Africa, Puerto Rico
Promomed, LLC
Sponsor GmbH

Completed

Open Multicentre Study of the Safety and Efficacy Against COVID-19 of Nirmatrelvir/Ritonavir in the Adult Population

COVID-19

Russian Federation
Pfizer

Withdrawn

A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19 (EPIC-HOS)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Coronavirus Disease 2019 (COVID-19) | Immunocompromised | Hospitalization | Child, Hospitalized

United States, Bulgaria
Unity Health Toronto

Active, not recruiting

COVID-19 Ring-based Prevention Trial With Lopinavir/Ritonavir (CORIPREV-LR)

Coronavirus Infections | Post-exposure Prophylaxis

Canada
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Ritonavir and Indinavir in Children Failing Other Anti-HIV Treatment

HIV Infections

United States, Puerto Rico
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Safety of Saquinavir and High Doses of Lopinavir/Ritonavir in Children With HIV

HIV Infections

United States, Puerto Rico
National Institute of Allergy and Infectious Diseases...

Completed

The Effects of Staggered Dosing on Interactions Between Paired Combinations of Nelfinavir, Ritonavir, and Saquinavir

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

A Study to Evaluate the Safety and Tolerance of Combination Anti-HIV Drug Therapy (Indinavir, Lamivudine, and Zidovudine) in HIV-Positive Pregnant Women and Their Infants

HIV Infections | Pregnancy

United States
Radboud University Medical Center
Hoffmann-La Roche

Completed

The Pharmacokinetic Study of Saquinavir New Tablet Formulation in HIV-infected Pregnant Women.

HIV Infections

United Kingdom, Netherlands, Germany, Spain, Thailand
Sunshine Lake Pharma Co., Ltd.

Completed

The Safety, Antiviral Activity, and Pharmacokinetics of Morphothiadine Mesilate Capsules

Chronic Hepatitis B

China
The HIV Netherlands Australia Thailand Research...
The Government Pharmaceutical Organization

Completed

TDM of Generic Lopinavir/Ritonavir 200/50 mg

HIV

Thailand
Tongji Hospital

Unknown

A Randomized,Open,Controlled Clinical Study to Evaluate the Efficacy of ASC09F and Ritonavir for 2019-nCoV Pneumonia

2019-nCoV Pneumonia

China
Germans Trias i Pujol Hospital
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la...

Completed

Clinical Trial to Assess the Security of the Dose Reduction of Ritonavir in HIV-Infected Patients in Treatment With Tipranavir/Ritonavir 500/200 mg Every 12 Hours

HIV Infections

Spain
Janssen Sciences Ireland UC

Completed

TMC114-TiDP29-C232 - Study Providing Continued Access to Treatment With Darunavir (DRV)/Ritonavir (Rtv) for Children Coming From Any of the Three Ongoing Tibotec Sponsored Pediatric Studies With DRV

HIV-1 Infections

France, Ukraine, South Africa, United Kingdom, Argentina, Brazil, India, Spain
Cantonal Hospital of St. Gallen
Swiss National Science Foundation; Swiss HIV Cohort Study

Terminated

HIV - Monotherapy in Switzerland (MOST-ch) (MOST)

HIV Infections

Switzerland
First Affiliated Hospital of Zhejiang University
Ascletis Pharmaceutical Co., Ltd.

Completed

Bioequivalence Study (Preliminary Study) of Ritonavir Versus NORVIR in Healthy Chinese Subjects

Healthy Volunteer

China
GlaxoSmithKline

Completed

A Study Comparing The Safety, Tolerability and Efficacy of Trizivir VS Combivir & Atazanavir In Subjects With HIV

HIV Infection | Infection, Human Immunodeficiency Virus I

United States, Mexico
Janssen-Cilag Ltd.

Completed

Early Access to Low-dose Ritonavir (TMC114/r) and Other Antiretrovirals (ARVs) for Treatment-naive or Early Treatment Experienced in HIV-1 Patients

HIV-1

Taiwan
Boehringer Ingelheim

Completed

Pharmacokinetic Study in Healthy Adult Volunteers to Assess the Interactions Between Steady-State Tipranavir and Atazanavir in the Presence of Ritonavir

Healthy
Boehringer Ingelheim

Terminated

Effect of Steady State TPV/r on Intracellular Concentrations of Zidovudine and Carbovir for Patients With HIV

HIV Infections
Janssen-Cilag S.p.A.

Completed

Non-interventional Study on Use of Darunavir With Ritonavir in Clinical Practice

HIV Infections
Kirby Institute

Completed

Pharmacokinetics of Lopinavir/Ritonavir at Three Different Doses. (ENCORE3)

Acquired Immunodeficiency Syndrome

United Kingdom
Kirby Institute
Hoffmann-La Roche

Completed

A 48-Week, Randomised, Study to Describe the Pharmacokinetic Profile and Durability of Atazanavir-Saquinavir-Ritonavir Once Daily and Describe the Pharmacokinetic Profile of Saquinavir-Ritonavir Using Saquinavir 500mg Formulation: the ASK-500 Study (ASK-500)

HIV Infections

Australia
Dupont Merck

Completed

A Study of Three Different Anti-HIV Drug Combinations in HIV-Infected Patients

HIV Infections

United States, Puerto Rico
Pfizer

Recruiting

A Study to Learn About the Study Medicine (Nirmatrelvir Plus Ritonavir) in Pregnant Women With COVID-19

COVID-19

United States
Ascletis Pharmaceuticals Co., Ltd.

Completed

Efficacy and Safety of Ravidasvir + Danoprevir/r 12-week Oral Therapy in Treatment-Naive Non Cirrhotic G1 CHC Taiwan

Chronic Hepatitis C

3

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