Search clinical trials for: adavosertib 65 mg

Total 10376 results

Merck Sharp & Dohme LLC

Terminated

A Dose Escalation Study of Adavosertib(MK1775) in Combination With 5-FU or 5-FU/CDDP in Patients With Advanced Solid Tumor (1775-005

Solid Tumors
Gangnam Severance Hospital

Completed

Remimazolam Bolus for General Anesthesia

Loss of Consciousness

Korea, Republic of
University of Connecticut

Completed

Effects of TA-65, a Telomerase Activator on Metabolic Syndrome

Metabolic Syndrome X

United States
NYU Langone Health

Completed

TA-65 Pharmacokinetic Study

Healthy

United States
Contamac Ltd
Hartwig Research Center

Completed

Three-month Clinical Evaluation of Silicone Hydrogel Definitive 65 Contact Lenses

Ametropia

Germany
Baylor College of Medicine
Pharmacosmos Therapeutics, Inc.

Recruiting

IV Iron Trial for Anemia Related to Uterine Bleeding in Female Patients Presenting to the Emergency Department

Anemia, Iron Deficiency | Uterine Bleeding

United States
AstraZeneca

Active, not recruiting

To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.

Metastatic Triple Negative Breast Cancer

United States, Belgium, Italy, Spain, United Kingdom, Canada, Czechia, Poland, France, Korea, Republic of, Germany, Taiwan, Portugal, Netherlands, Ireland
Contamac Ltd
Hartwig Research Center

Completed

One-month Clinical Evaluation of Silicone Hydrogel Definitive 65 HPT Contact Lenses

Ametropia

Germany
University of British Columbia
Rick Hansen Institute

Recruiting

Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study (CASPER)

Spinal Cord Injuries | Acute Spinal Cord Injury | Acute Spinal Paralysis | SPINAL Fracture

Canada, United States
Abbott Medical Devices

Active, not recruiting

Shock Efficacy Study Comparing Fixed Tilt and Fixed Pulse Width in a General Implantable-Cardioverter Population (EFICAZ)

Ventricular Arrythmia

Spain
AstraZeneca
Parexel

Terminated

Human Absorption, Distribution, Metabolism, and Excretion Study of [14C]Adavosertib (ADME)

Advanced Solid Tumors

United Kingdom
Merck Sharp & Dohme LLC

Terminated

A Study of Adavosertib (MK-1775) in Combination With Topotecan/Cisplatin in Participants With Cervical Cancer (MK-1775-008)

Cervical Cancer
University Hospital of North Norway

Completed

Dynamic Infrared Thermography in Breast Cancer Diagnostics

Breast Cancer

Norway
AstraZeneca

Completed

Study of Adavosertib(AZD1775) in Japanese Patients With Advanced Solid Tumours

Advanced Solid Tumours

Japan
Elsan

Withdrawn

Home Care Services Screening for Frailty.

Frailty

France
University of Connecticut

Terminated

The Effects of the Telomerase Activator TA-65 on Insulin Resistance, Inflammation, and Metabolic Syndrome

Metabolic Syndrome | Insulin Resistance

United States
University of Salamanca

Active, not recruiting

Effectiveness of Power Training in Older Women With Pre-sarcopenia (POSARC)

Old Age; Debility | Pre-sarcopenia

Spain
Sahmyook University

Completed

The Activation and Walking Speed of the Prefrontal Cortex of the Elderly Mild Cognitive Impairment During Dual Task.

Mild Cognitive Impairment | Dual Task

Korea, Republic of
Chippewa Valley Eye Clinic
TA-Sciences

Completed

Telomerase Activator and Retinal Amyloid

Alzheimer Disease

United States
Medical College of Wisconsin
Penn State University; University of Louisville

Not yet recruiting

TA-65 and Aging Associated Microvascular Dysfunction

Vascular Diseases | Aging | Telomere Shortening
Centers for Disease Control and Prevention

Completed

Iron Supplementation Among Low-Income Postpartum Women

Anemia

United States
Merck Sharp & Dohme LLC

Completed

A Dose Escalation Study of Adavosertib (MK-1775) in Combination With Either Gemcitabine, Cisplatin, or Carboplatin in Adults With Advanced Solid Tumors (MK-1775-001)

Solid Tumors
Université de Sherbrooke

Active, not recruiting

Optimal VAsopressor TitraTION in Patients 65 Years and Older (OVATION-65)

Hypotension | Usual Care | Vasopressors | Mean Arterial Pressure Targets

Canada
Assiut University

Enrolling by invitation

Diagnostic Performance of Ultrasound for Primary Survey of Traumatic Long Bone Fractures

Trauma

Egypt
The University of Texas Health Science Center,...
Trauma Research and Combat Casualty Care Collaborative (TRC4)

Not yet recruiting

Hemodynamic Management Following Acute Traumatic Spinal Cord Injury

Spinal Cord Injuries

United States
Oklahoma State University

Recruiting

Exercise-Induced Gut Permeability in Normal-weight Obesity

Obesity | Normal-weight Obesity

United States
AstraZeneca

Completed

Phase Ib Study to Determine MTD of AZD1775 Monotherapy in Patients With Locally Advanced or Metastatic Solid Tumours.

Ovarian Cancer | Locally Advanced Solid Tumours | Metastatic Solid Tumours

United States
AstraZeneca
Parexel

Terminated

A Study to Assess the Safety and Tolerability of Adavosertib for Patients With Advanced Solid Tumours

Advanced Solid Tumours

United Kingdom, United States
University Hospital, Angers

Not yet recruiting

Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure (MAPAKI)

Shock
Merck Sharp & Dohme LLC

Completed

A Study of Adavosertib (MK-1775) in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004)

Ovarian Cancer
Samsung Medical Center

Terminated

Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients With MYC Family Amplification or CDKN2A Mutation Combined With TP53 Mutation

Small Cell Lung Cancer

Korea, Republic of
Samsung Medical Center

Completed

Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients

Small Cell Lung Cancer

Korea, Republic of
AstraZeneca
Parexel

Completed

A Study of Adavosertib as Treatment for Uterine Serous Carcinoma (ADAGIO)

Uterine Serous Carcinoma

United States, Italy, Spain, France, Canada
University College, London

Not yet recruiting

Ambroxol to Slow Progression in Parkinson Disease (ASPro-PD)

Parkinson Disease

United Kingdom
Dana-Farber Cancer Institute
AstraZeneca

Active, not recruiting

AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine Carcinosarcoma

Uterine Cancer

United States
Boston Children's Hospital
Brigham and Women's Hospital; Boston Medical Center; Nutrition Science Initiative and other collaborators

Completed

Metabolic Fuels Study

Obesity

United States
AstraZeneca

Completed

Safety, Tolerance, PK, and Anti-tumour Activity of AZD1775 Monotherapy in Patients With Advanced Solid Tumours

Ovarian Cancer, TNBC, SCLC, Other Solid Tumours

United States, Canada
AbbVie

Completed

A Study to Compare US Marketed Creon Manufactured With a Modernized Process at an Alternate Manufacturing Site and Manufactured With the Approved Manufacturing Process at an Alternate Active Pharmaceutical Ingredient Site, in Participants With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis

Cystic Fibrosis

United States
Centre Hospitalier le Mans

Recruiting

Early Transcranial Doppler Goal Directed Therapy After Cardiac Arrest: a Pilot Study (GOODYEAR)

Cardiac Arrest | Ischemic Reperfusion Injury | Cerebral Lesion | Ischemic Encephalopathy

France
Mahidol University

Completed

Clinical Comparison of the Stain Removal Efficacy of Two Air Polishing Powders

Stain Removal Efficacy

Thailand
University Hospital, Angers

Recruiting

Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock (SEPSIR)

Septic Shock

France
National Cancer Institute (NCI)

Completed

AZD1775 for Advanced Solid Tumors

Solid Tumors

United States
CHU de Quebec-Universite Laval

Completed

Evaluation of Sodium Fluorescein Use During Intraoperative Cystoscopy After Total Laparoscopic Hysterectomy

Ureteral Injury

Canada
Masonic Cancer Center, University of Minnesota

Active, not recruiting

Reduced Intensity (RIC) Conditioning And Transplantation of HLA-Haplo-HCT

Hematologic Malignancies

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I)

Hematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma

United States
St. Joseph's Hospital and Medical Center, Phoenix
Barbara Ann Karmanos Cancer Institute; American Society of Clinical Oncology; Translational Genomics Research Institute and other collaborators

Completed

A Phase 0 Study of AZD1775 in Recurrent GBM Patients

Glioblastoma | GBM

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

Clear Cell Renal Cell Carcinoma | Metastatic Renal Cell Carcinoma | Locally Advanced Malignant Solid Neoplasm | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Metastatic Malignant Solid Neoplasm | Locally Advanced Clear Cell Renal Cell Carcinoma

United States
National Cancer Institute (NCI)

Completed

AZD1775 in Treating Patients With Advanced Refractory Solid Tumors With CCNE1 Amplification

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm

United States
University of Birmingham
AstraZeneca; Cancer Research UK

Completed

WEE1 Inhibitor With Cisplatin and Radiotherapy: A Trial in Head and Neck Cancer (WISTERIA)

Larynx Cancer | Oral Cavity Squamous Cell Carcinoma | Hypopharynx Squamous Cell Carcinoma

United Kingdom
University Hospital, Montpellier
Paul Valérie University Montpellier; Regional Center for Cancer Screening (CRCDC)... and other collaborators

Active, not recruiting

A Proximity-incentive Strategy for Cervical Cancer Screening (RIDECA)

Cervical Cancer | Human Papilloma Virus | Uterine Cervical Disease

France

Search clinical trials for: adavosertib 65 mg

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