Search clinical trials for: Glucarpidase

Total 15 results

Fox Chase Cancer Center

Suspended

HM-178: Assessing Methods for Improvement in Methotrexate Toxicity Management and Detection of Central Nervous System Involvement of Aggressive Lymphoma

Lymphoma

United States
National Cancer Institute (NCI)
Children's Oncology Group

Completed

Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate

Unspecified Childhood Solid Tumor, Protocol Specific | Unspecified Adult Solid Tumor, Protocol Specific | Neurotoxicity

United States, Canada, Australia, Switzerland
Nordic Society for Pediatric Hematology and Oncology
Lund University Hospital

Completed

Glucarpidase Effect on Severe Delayed HDM-clearance in Children Treated With High-dose Mtx in ALL (NOPHOCPG2)

Acute Lymphoblastic Leukemia (ALL)

Finland, Denmark, Iceland, Norway, Sweden
BTG International Inc.

Completed

Study of Glucarpidase (CPG2) for the Management of Patients With Delayed Methotrexate Clearance

Neoplasms

Germany
M.D. Anderson Cancer Center
BTG International Inc.

Terminated

Voraxaze for Delayed Methotrexate Clearance

Solid Tumor | Hematologic Malignancy

United States
BTG International Inc.
CTI Clinical Trial and Consulting Services

Approved for marketing

Treatment Protocol of Voraxaze for Patients Experiencing or at Risk of Methotrexate Toxicity

Neoplasms
Fundacion CRIS de Investigación para Vencer el...
BTG International Inc.; BioClever 2005 S.L.; Eurofins ADME, S.L.; NTShub, S.L.

Recruiting

Reduction of MTX Levels After Glucarpidase Treatment in DLBCL Patients at Risk of CNS

Diffuse Large B-Cell Lymphoma | Drug Toxicity

Spain
BTG International Inc.
M.D. Anderson Cancer Center

Terminated

High Dose Methotrexate With Leucovorin Rescue With or Without Glucarpidase in Osteosarcoma

Osteosarcoma
OHSU Knight Cancer Institute
Oregon Health and Science University; BTG International Inc.

Recruiting

Glucarpidase After High-Dose Methotrexate in Patients With Osteosarcoma

Osteosarcoma

United States
Assistance Publique - Hôpitaux de Paris
BTG International Inc.

Recruiting

Dose Dense Re-challenge of High Dose Methotrexate With Glucarpidase for Relapsed Primary Central Nervous System Lymphoma (METHOGLU)

Primary Central Nervous System Lymphoma

France
Protherics Medicines Development Limited
Resonance Inc

Recruiting

Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate

Acute Kidney Injury | Drug Toxicity

Spain, France, Italy
University College, London
Richard Scowcroft Foundation

Terminated

Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays?

Osteosarcoma | Spindle Cell Sarcoma of Bone

United Kingdom
Memorial Sloan Kettering Cancer Center
University of Alabama at Birmingham

Recruiting

LTA Pilot Study of Glucarpidase in Patients With Central Nervous System Lymphoma

Central Nervous System Lymphoma

United States
BTG International Inc.

Completed

Open-label Leucovorin Pharmacokinetic Study in Patients Receiving High Dose Methotrexate With or Without Voraxaze (LVPK)

Lymphoma | Leukemia | Osteosarcoma

United States
University College, London
Cancer Research UK

Completed

Methotrexate, Glucarpidase, and Leucovorin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma

Lymphoma | Mucositis | Neurotoxicity | Chemotherapeutic Agent Toxicity

United Kingdom

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