Search clinical trials for: high-dose metformin

Total 13133 results

Boehringer Ingelheim

Completed

Safety, Pharmacokinetics, and Pharmacodynamics of BIRT 2584 XX Administered as Multiple Doses and Safety and Pharmacokinetics of BIRT 2584 XX Administered With and Without Food as Single Dose to Healthy Male Volunteers

Healthy
Boehringer Ingelheim

Completed

Pharmacokinetics, Safety and Efficacy of BIIL 284 BS in Patients With Rheumatoid Arthritis (RA)

Arthritis, Rheumatoid
GEN İlaç ve Sağlık Ürünleri A.Ş.
Sulfateq B.V.

Recruiting

A First-In-Human Study of Single and Multiple Ascending Doses of Oral SUL-238 in Healthy Subjects

Healthy Subjects

Turkey
Purdue University
Grain processing corporation

Completed

The Attenuating Effect of Soluble Fiber Consumption on Postprandial Glycemia in Humans

Type2 Diabetes | Postprandial Hyperglycemia | Blood Sugar; High

United States
Cortria Corporation

Completed

A Study to Evaluate the Lipid Regulating Effects of TRIA-662

Hyperlipidemia
University of Colorado, Colorado Springs

Completed

Does Flaxseed Supplementation Improve Glycemic Control in Individuals With Pre-diabetes?

PreDiabetes

United States
Natural Wellness Egypt

Completed

Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus

Type2 Diabetes Mellitus

Egypt
USDA Grand Forks Human Nutrition Research Center

Completed

The Juice Study: Sensitivity of Skin Carotenoid Status to Detect Change in Intake

Overweight

United States
ST Pharm Co., Ltd.

Recruiting

A Clinical Trial of STP0404 in Treatment-Naïve Adults With HIV-1 Infection

HIV-1-infection

United States
Centre Georges Francois Leclerc

Recruiting

Study Evaluating the Efficacy and the Tolerance of Pelvic-prostatic Hypo-fractionated Radiotherapy Followed by Boost in Patients With Prostate Adenocarcinoma Adverse Intermediate Risk or High Localized Risk (SHORT)

To Evaluate the Rate of Digestive and Urinary Toxicity

France
Shanghai General Hospital, Shanghai Jiao Tong University...

Unknown

High Dose Radiation Therapy With Concurrent Chemotherapy in Locally Advanced Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Sidney Kimmel Comprehensive Cancer Center at Johns...

Recruiting

Intraoperative Radiation Therapy After Stereotactic Body Radiation Therapy and Chemotherapy in Treatment of Pancreatic Adenocarcinoma

Pancreatic Cancer

United States
University of Wisconsin, Madison
National Center for Complementary and Integrative Health (NCCIH)

Completed

Immunotherapy Administered Under the Tongue to Treat Dust Mite Allergy

Asthma

United States
Sanofi Pasteur, a Sanofi Company

Completed

Study to Assess the Immune Response and the Safety Profile of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Taiwanese Adults 65 Years of Age and Older

Influenza (Healthy Volunteers)

Taiwan
Alladapt Immunotherapeutics, Inc.

Completed

ADP101 for Oral Immunotherapy in Food-Allergic Children and Adults

Food Allergy

United States
Gazi University

Completed

Comparison of High Power Pain Threshold Ultrasound and Ischemic Compression Techniques for Treatment of Trigger Points

Trigger Point Pain, Myofascial

Turkey
WinSanTor, Inc

Completed

A 24-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Peripheral Neuropathy

Peripheral Neuropathy | Painful Diabetic Neuropathy | Diabetic Neuropathies, Painful

Canada
Lawson Health Research Institute

Recruiting

Low-Dose Weekly vs High-Dose Cisplatin (RADIO)

Locally Advanced Head and Neck Squamous Cell Carcinoma

Canada
Zhejiang Echon Biopharm Limited

Active, not recruiting

Safety and Efficacy Study of GB001 Recombinant Peptide Spray in Subjects With Mild Recurrent Aphthous Ulcers

Healthy

China
Tatyana Zubkova

Completed

Evaluation of RSV/Flu-01E Vaccine for the Prevention of RSV Infection in Volunteers Aged 18 to 59 Years and Over 60 Years

Respiratory Syncytial Virus Infections

Russian Federation
Sahlgrenska University Hospital, Sweden
MetaboGen AB

Completed

Tolerability and Risk of Adverse Events With a Probiotic Supplement

Healthy Individuals

Sweden
Access Business Group
Clinical Research Laboratories

Completed

Evaluation of Skin Attributes Following Dietary Supplement Consumption

Skin Condition
PepTcell Limited

Completed

HIV Vaccine Study in HIV Positive Patients

HIV Infections

United Kingdom
Yale University

Completed

Neuroimmune Effects of Opioid Administration (NOA)

Drug Effect

United States
Shionogi

Completed

Safety and Efficacy of S-707106 in Subjects With Type 2 Diabetes Mellitus and Inadequate Glycemic Control With Metformin Therapy

Type 2 Diabetes Mellitus

United States
J JESUS VENEGAS, MD
Instituto Mexicano del Seguro Social; National Council of Science and Technology...

Completed

Effect of Metformin and Rosiglitazone Over no Diabetic With Metabolic Syndrome Patients.

Insulin Resistance
Virchow Group
Adocia

Completed

Comparative Study of 3 Dose Regimens of BioChaperone to Becaplermin Gel for the Treatment of Diabetic Foot Ulcer

Diabetic Foot Ulcers

India
M.D. Anderson Cancer Center

Recruiting

High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies

Melanoma | Pancreatic Cancer | Cholangiocarcinoma Metastatic | Liver Malignant Tumors

United States
National Institute of Allergy and Infectious Diseases...

Completed

Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine

Healthy Volunteer

United States
Shanghai General Hospital, Shanghai Jiao Tong University...

Unknown

High-dose Intensity Modulated Radiotherapy and Concurrent Chemotherapy in Esophageal Cancer

Esophageal Cancer

China
GlaxoSmithKline

Completed

24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes

Non-Insulin-Dependent Diabetes Mellitus
Guangzhou Patronus Biotech Co., Ltd.
Yantai Patronus Biotech Co., Ltd.

Active, not recruiting

Safety and Immunogenicity of COVID-19 Vaccine in Population Aged 18 Years and Above

COVID-19

China
Medical University of Graz

Terminated

High-dose Vitamin D3 in Pancreas Cancer (VITdCUT)

Quality of Life | Vitamin D Deficiency | Pancreas Cancer

Austria
Richard H. Haas
Thrasher Research Fund

Completed

Pharmacokinetic and Safety Trial of Intravenous Levetiracetam in the Treatment of Neonatal Seizures (Keppra)

Seizures | Disorder of Fetus or Newborn

United States
Affiris AG
Medical University Innsbruck; Forschungszentrum Juelich; PROSENEX AmbulatoriumbetriebsGMBH

Completed

Study Assessing Tolerability and Safety of AFFITOPE® PD03A in Patients With Early Parkinson's Disease (AFF011)

Parkinson Disease | Neurodegenerative Diseases

Austria
University of Oxford

Completed

Safety and Immunogenicity Study of Three Candidate HIV-1 Vaccines, Administered in Combination to Healthy HIV-1 Uninfected Adults (HIV-CORE 002)

HIV-1 Infections

United Kingdom
Southern Methodist University
National Cancer Institute (NCI); University of Kansas Medical Center; University...

Recruiting

Factorial Trial Testing Guided Thinking Tasks to Optimize a Physical Activity Intervention

Physical Inactivity

United States
Ain Shams University

Completed

High-dose L-Carnitine and Diaphragmatic Function Assessed by Ultrasonography in Patients With Respiratory Failure.

Respiratory Failure

Egypt
Boehringer Ingelheim

Completed

Evaluation of the Pharmacokinetic Interaction of Steady State Tipranavir and Ritonavir or Tipranavir and Ritonavir With Single Dose Didanosine in Healthy Volunteers

Healthy
Duke University
Boston Medical Center; Centers for Disease Control and Prevention; Children's...

Completed

FLUAD® vs. Fluzone® High-Dose Study

Quality of Life | Pain | Adverse Drug Event | Injection Site Reaction | Side Effect of Drug

United States
Themis Bioscience GmbH

Completed

Safety and Immunogenicity of a Novel Vaccine Formulation MV-ZIKA-RSP (V187-001) (MV-ZIKA-RSP)

Zika Virus Infection

Austria
Terence Flotte
Massachusetts General Hospital; University of Massachusetts, Worcester

Active, not recruiting

A Dose-escalation and Safety & Efficacy Study of AXO-AAV-GM2 in Tay-Sachs or Sandhoff Disease

Tay-Sachs Disease | Sandhoff Disease

United States
Heilpflanzenwohl AG

Completed

BEFORE Study, Efficacy of Refigura

Weight Loss | Overweight and Obesity | Efficacy, Self

Germany
Boehringer Ingelheim
Eli Lilly and Company

Completed

A 16 Weeks Study on Efficacy and Safety of Two Doses of Empagliflozin (BI 10773) (Once Daily Versus Twice Daily) in Patients With Type 2 Diabetes Mellitus and Preexisting Metformin Therapy

Diabetes Mellitus, Type 2

United States, Australia, Canada, Estonia, France, Georgia, Germany, Guatemala, Italy, Latvia, Lithuania, Mexico, New Zealand, Poland, Russian Federation, South Africa, Spain, Ukraine
Bioprojet

Completed

Randomized Clinical Trial Evaluating BP1.3656 Versus Placebo For Alcohol Use Disorder Treatment

Alcohol Use Disorder

France, Bulgaria, Russian Federation
Boehringer Ingelheim

Completed

A Study in Healthy People to Measure the Amount of BI 655130 in the Blood After Injecting Different Doses Into Different Parts of the Body

Healthy

Belgium
Supernus Pharmaceuticals, Inc.

Completed

Efficacy and Safety of SPN-812 (Viloxazine Extended-release Capsule) in Children With ADHD

Attention-Deficit/Hyperactivity Disorder (ADHD)

United States
Hormozgan University of Medical Sciences

Completed

Effect of Dosage of Metformin on Menstruation and Lipid Profile in Women With Polycystic Ovary Syndrome

Polycystic Ovary Syndrome

Iran, Islamic Republic of
Sanofi Pasteur, a Sanofi Company

Completed

Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2021-2022 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively

Healthy Volunteers | Influenza Immunization

United States
Sinovac Research and Development Co., Ltd.

Suspended

Immunogenicity and Safety Study of the 3rd Booster Dose Using the High or Medium Dose of Inactivated (CoronaVac®) Vaccine in Healthy Adults in Turkey

COVID-19

Turkey

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